-
1
-
-
0041914332
-
The role of PTEN in the progression and survival of prostate cancer
-
Deocampo,N.D. et al. (2003) The role of PTEN in the progression and survival of prostate cancer. Minerva Endocrinol., 28, 145-153.
-
(2003)
Minerva Endocrinol
, vol.28
, pp. 145-153
-
-
Deocampo, N.D.1
-
2
-
-
0141927222
-
Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer
-
Gao,N. et al. (2003) Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer. Biochem. Biophys. Res. Commun., 310, 1124-1132.
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.310
, pp. 1124-1132
-
-
Gao, N.1
-
3
-
-
79952183554
-
PI3K signaling pathway is activated by PIK3CA mRNA overexpression and copy gain in prostate tumors, but PIK3CA, BRAF
-
Agell,L. et al. (2011) PI3K signaling pathway is activated by PIK3CA mRNA overexpression and copy gain in prostate tumors, but PIK3CA, BRAF, KRAS and AKT1 mutations are infrequent events. Mod. Pathol, 24, 443-452.
-
(2011)
KRAS and AKT1 mutations are infrequent events. Mod. Pathol
, vol.24
, pp. 443-452
-
-
Agell, L.1
-
4
-
-
67650074847
-
Genetic alterations in the PI3K pathway in prostate cancer
-
Sun,X. et al. (2009) Genetic alterations in the PI3K pathway in prostate cancer. Anticancer Res., 29, 1739-1743.
-
(2009)
Anticancer Res
, vol.29
, pp. 1739-1743
-
-
Sun, X.1
-
5
-
-
0034749615
-
Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state
-
Murillo,H. et al. (2001) Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state. Endocrinology, 142, 4795-4805.
-
(2001)
Endocrinology
, vol.142
, pp. 4795-4805
-
-
Murillo, H.1
-
6
-
-
67650917081
-
PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer
-
Sircar,K. et al. (2009) PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer. J. Pathol., 218, 505-513.
-
(2009)
J. Pathol.
, vol.218
, pp. 505-513
-
-
Sircar, K.1
-
7
-
-
53849146755
-
Is PTEN loss associated with clinical outcome measures in human prostate cancer?
-
McCall,P. et al. (2008) Is PTEN loss associated with clinical outcome measures in human prostate cancer? Br. J. Cancer, 99, 1296-1301.
-
(2008)
Br. J. Cancer
, vol.99
, pp. 1296-1301
-
-
McCall, P.1
-
8
-
-
10744222860
-
Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
-
Wang,S. et al. (2003) Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell, 4, 209-221.
-
(2003)
Cancer Cell
, vol.4
, pp. 209-221
-
-
Wang, S.1
-
9
-
-
62749124909
-
Role of the Akt pathway in prostate cancer
-
de Souza,P.L. et al. (2009) Role of the Akt pathway in prostate cancer. Curr. Cancer Drug Targets, 9, 163-175.
-
(2009)
Curr. Cancer Drug Targets
, vol.9
, pp. 163-175
-
-
de Souza, P.L.1
-
10
-
-
79952293503
-
Activation of mTORC2 by association with the ribosome
-
Zinzalla,V. et al. (2011) Activation of mTORC2 by association with the ribosome. Cell, 144, 757-768.
-
(2011)
Cell
, vol.144
, pp. 757-768
-
-
Zinzalla, V.1
-
11
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov,D.D. et al. (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science, 307, 1098-1101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
-
12
-
-
33751348056
-
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
-
Guertin,D.A. et al. (2006) Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev. Cell, 11, 859-871.
-
(2006)
Dev. Cell
, vol.11
, pp. 859-871
-
-
Guertin, D.A.1
-
13
-
-
43249086546
-
Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors
-
O'Donnell,A. et al. (2008) Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors. J. Clin. Oncol., 26, 1588-1595.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 1588-1595
-
-
O'Donnell, A.1
-
14
-
-
32944457518
-
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
-
O'Reilly,K.E. et al. (2006) mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res., 66, 1500-1508.
-
(2006)
Cancer Res
, vol.66
, pp. 1500-1508
-
-
O'Reilly, K.E.1
-
15
-
-
23844438209
-
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
-
Sun,S.Y. et al. (2005) Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res., 65, 7052-7058.
-
(2005)
Cancer Res
, vol.65
, pp. 7052-7058
-
-
Sun, S.Y.1
-
16
-
-
43249131245
-
Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors
-
Tabernero,J. et al. (2008) Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors. J. Clin. Oncol., 26, 1603-1610.
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 1603-1610
-
-
Tabernero, J.1
-
17
-
-
24944480788
-
The Akt-mTOR tango and its relevance to cancer
-
Hay,N. (2005) The Akt-mTOR tango and its relevance to cancer. Cancer Cell, 8, 179-183.
-
(2005)
Cancer Cell
, vol.8
, pp. 179-183
-
-
Hay, N.1
-
19
-
-
33749447286
-
AKT and cancer-is it all mTOR?
-
Rosen,N. et al. (2006) AKT and cancer-is it all mTOR? Cancer Cell, 10, 254-256.
-
(2006)
Cancer Cell
, vol.10
, pp. 254-256
-
-
Rosen, N.1
-
20
-
-
34547907805
-
Expanding mTOR signaling
-
Yang,Q. et al. (2007) Expanding mTOR signaling. Cell Res., 17, 666-681.
-
(2007)
Cell Res
, vol.17
, pp. 666-681
-
-
Yang, Q.1
-
21
-
-
11844304072
-
Restraining PI3K: mTOR signalling goes back to the membrane
-
Harrington,L.S. et al. (2005) Restraining PI3K: mTOR signalling goes back to the membrane. Trends Biochem. Sci., 30, 35-42.
-
(2005)
Trends Biochem. Sci.
, vol.30
, pp. 35-42
-
-
Harrington, L.S.1
-
22
-
-
33947538050
-
Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
-
Wan,X. et al. (2007) Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene, 26, 1932-1940.
-
(2007)
Oncogene
, vol.26
, pp. 1932-1940
-
-
Wan, X.1
-
23
-
-
33947330747
-
Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth
-
Hietakangas,V. et al. (2007) Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Genes Dev., 21, 632-637.
-
(2007)
Genes Dev
, vol.21
, pp. 632-637
-
-
Hietakangas, V.1
-
24
-
-
33847172809
-
Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloeemodin
-
Guo,J. et al. (2007) Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloeemodin. Cancer Biol. Ther., 6, 85-88.
-
(2007)
Cancer Biol. Ther.
, vol.6
, pp. 85-88
-
-
Guo, J.1
-
25
-
-
8644266658
-
Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells
-
Acevedo-Duncan,M. et al. (2004) Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells. Int. Immunopharmacol., 4, 1775-1784.
-
(2004)
Int. Immunopharmacol.
, vol.4
, pp. 1775-1784
-
-
Acevedo-Duncan, M.1
-
26
-
-
77954350740
-
3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase
-
Lee,D.E. et al. (2010) 7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase. J. Biol. Chem., 285, 21458-21466.
-
(2010)
J. Biol. Chem.
, vol.7
, pp. 21458-21466
-
-
Lee, D.E.1
-
27
-
-
0019788391
-
Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters: mitogen-resistant variants are sensitive to promotion
-
Colburn,N.H. et al. (1981) Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters: mitogen-resistant variants are sensitive to promotion. Proc. Natl Acad. Sci. USA, 78, 6912-6916.
-
(1981)
Proc. Natl Acad. Sci. USA
, vol.78
, pp. 6912-6916
-
-
Colburn, N.H.1
-
28
-
-
42649128395
-
Suppression of C-myc expression associates with antiproliferation of aloe-emodin on gastric cancer cells
-
Guo,J. et al. (2008) Suppression of C-myc expression associates with antiproliferation of aloe-emodin on gastric cancer cells. Cancer Invest., 26, 369-374.
-
(2008)
Cancer Invest
, vol.26
, pp. 369-374
-
-
Guo, J.1
-
29
-
-
0037031787
-
The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines
-
Kuo,P.L. et al. (2002) The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines. Life Sci., 71, 1879-1892.
-
(2002)
Life Sci
, vol.71
, pp. 1879-1892
-
-
Kuo, P.L.1
-
30
-
-
58649114084
-
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
-
Guertin,D.A. et al. (2009) mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell, 15, 148-159.
-
(2009)
Cancer Cell
, vol.15
, pp. 148-159
-
-
Guertin, D.A.1
-
31
-
-
77952305228
-
Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo
-
Roulin,D. et al. (2010) Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo. Mol. Cancer, 9, 57.
-
(2010)
Mol. Cancer
, vol.9
, pp. 57
-
-
Roulin, D.1
-
32
-
-
78549271170
-
mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis
-
Zhang,F. et al. (2010) mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis. Cancer Res., 70, 9360-9370.
-
(2010)
Cancer Res
, vol.70
, pp. 9360-9370
-
-
Zhang, F.1
-
33
-
-
79955615939
-
IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation
-
Xie,X. et al. (2011) IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc. Natl Acad. Sci. USA, 108, 6474-6479.
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 6474-6479
-
-
Xie, X.1
-
34
-
-
0034212761
-
Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors
-
Pecere,T. et al. (2000) Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Res., 60, 2800-2804.
-
(2000)
Cancer Res
, vol.60
, pp. 2800-2804
-
-
Pecere, T.1
|