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Volumn 33, Issue 7, 2012, Pages 1406-1411

Aloe-emodin suppresses prostate cancer by targeting the mTOR complex 2

Author keywords

[No Author keywords available]

Indexed keywords

ALOE EMODIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN KINASE B; PROTEIN KINASE C ALPHA;

EID: 84865161024     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgs156     Document Type: Article
Times cited : (52)

References (34)
  • 1
    • 0041914332 scopus 로고    scopus 로고
    • The role of PTEN in the progression and survival of prostate cancer
    • Deocampo,N.D. et al. (2003) The role of PTEN in the progression and survival of prostate cancer. Minerva Endocrinol., 28, 145-153.
    • (2003) Minerva Endocrinol , vol.28 , pp. 145-153
    • Deocampo, N.D.1
  • 2
    • 0141927222 scopus 로고    scopus 로고
    • Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer
    • Gao,N. et al. (2003) Role of PI3K/AKT/mTOR signaling in the cell cycle progression of human prostate cancer. Biochem. Biophys. Res. Commun., 310, 1124-1132.
    • (2003) Biochem. Biophys. Res. Commun. , vol.310 , pp. 1124-1132
    • Gao, N.1
  • 3
    • 79952183554 scopus 로고    scopus 로고
    • PI3K signaling pathway is activated by PIK3CA mRNA overexpression and copy gain in prostate tumors, but PIK3CA, BRAF
    • Agell,L. et al. (2011) PI3K signaling pathway is activated by PIK3CA mRNA overexpression and copy gain in prostate tumors, but PIK3CA, BRAF, KRAS and AKT1 mutations are infrequent events. Mod. Pathol, 24, 443-452.
    • (2011) KRAS and AKT1 mutations are infrequent events. Mod. Pathol , vol.24 , pp. 443-452
    • Agell, L.1
  • 4
    • 67650074847 scopus 로고    scopus 로고
    • Genetic alterations in the PI3K pathway in prostate cancer
    • Sun,X. et al. (2009) Genetic alterations in the PI3K pathway in prostate cancer. Anticancer Res., 29, 1739-1743.
    • (2009) Anticancer Res , vol.29 , pp. 1739-1743
    • Sun, X.1
  • 5
    • 0034749615 scopus 로고    scopus 로고
    • Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state
    • Murillo,H. et al. (2001) Role of PI3K signaling in survival and progression of LNCaP prostate cancer cells to the androgen refractory state. Endocrinology, 142, 4795-4805.
    • (2001) Endocrinology , vol.142 , pp. 4795-4805
    • Murillo, H.1
  • 6
    • 67650917081 scopus 로고    scopus 로고
    • PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer
    • Sircar,K. et al. (2009) PTEN genomic deletion is associated with p-Akt and AR signalling in poorer outcome, hormone refractory prostate cancer. J. Pathol., 218, 505-513.
    • (2009) J. Pathol. , vol.218 , pp. 505-513
    • Sircar, K.1
  • 7
    • 53849146755 scopus 로고    scopus 로고
    • Is PTEN loss associated with clinical outcome measures in human prostate cancer?
    • McCall,P. et al. (2008) Is PTEN loss associated with clinical outcome measures in human prostate cancer? Br. J. Cancer, 99, 1296-1301.
    • (2008) Br. J. Cancer , vol.99 , pp. 1296-1301
    • McCall, P.1
  • 8
    • 10744222860 scopus 로고    scopus 로고
    • Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
    • Wang,S. et al. (2003) Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell, 4, 209-221.
    • (2003) Cancer Cell , vol.4 , pp. 209-221
    • Wang, S.1
  • 9
    • 62749124909 scopus 로고    scopus 로고
    • Role of the Akt pathway in prostate cancer
    • de Souza,P.L. et al. (2009) Role of the Akt pathway in prostate cancer. Curr. Cancer Drug Targets, 9, 163-175.
    • (2009) Curr. Cancer Drug Targets , vol.9 , pp. 163-175
    • de Souza, P.L.1
  • 10
    • 79952293503 scopus 로고    scopus 로고
    • Activation of mTORC2 by association with the ribosome
    • Zinzalla,V. et al. (2011) Activation of mTORC2 by association with the ribosome. Cell, 144, 757-768.
    • (2011) Cell , vol.144 , pp. 757-768
    • Zinzalla, V.1
  • 11
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov,D.D. et al. (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science, 307, 1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1
  • 12
    • 33751348056 scopus 로고    scopus 로고
    • Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
    • Guertin,D.A. et al. (2006) Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev. Cell, 11, 859-871.
    • (2006) Dev. Cell , vol.11 , pp. 859-871
    • Guertin, D.A.1
  • 13
    • 43249086546 scopus 로고    scopus 로고
    • Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors
    • O'Donnell,A. et al. (2008) Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors. J. Clin. Oncol., 26, 1588-1595.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 1588-1595
    • O'Donnell, A.1
  • 14
    • 32944457518 scopus 로고    scopus 로고
    • mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
    • O'Reilly,K.E. et al. (2006) mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res., 66, 1500-1508.
    • (2006) Cancer Res , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1
  • 15
    • 23844438209 scopus 로고    scopus 로고
    • Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
    • Sun,S.Y. et al. (2005) Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res., 65, 7052-7058.
    • (2005) Cancer Res , vol.65 , pp. 7052-7058
    • Sun, S.Y.1
  • 16
    • 43249131245 scopus 로고    scopus 로고
    • Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors
    • Tabernero,J. et al. (2008) Dose- and schedule-dependent inhibition of the mammalian target of rapamycin pathway with everolimus: a phase I tumor pharmacodynamic study in patients with advanced solid tumors. J. Clin. Oncol., 26, 1603-1610.
    • (2008) J. Clin. Oncol. , vol.26 , pp. 1603-1610
    • Tabernero, J.1
  • 17
    • 24944480788 scopus 로고    scopus 로고
    • The Akt-mTOR tango and its relevance to cancer
    • Hay,N. (2005) The Akt-mTOR tango and its relevance to cancer. Cancer Cell, 8, 179-183.
    • (2005) Cancer Cell , vol.8 , pp. 179-183
    • Hay, N.1
  • 19
    • 33749447286 scopus 로고    scopus 로고
    • AKT and cancer-is it all mTOR?
    • Rosen,N. et al. (2006) AKT and cancer-is it all mTOR? Cancer Cell, 10, 254-256.
    • (2006) Cancer Cell , vol.10 , pp. 254-256
    • Rosen, N.1
  • 20
    • 34547907805 scopus 로고    scopus 로고
    • Expanding mTOR signaling
    • Yang,Q. et al. (2007) Expanding mTOR signaling. Cell Res., 17, 666-681.
    • (2007) Cell Res , vol.17 , pp. 666-681
    • Yang, Q.1
  • 21
    • 11844304072 scopus 로고    scopus 로고
    • Restraining PI3K: mTOR signalling goes back to the membrane
    • Harrington,L.S. et al. (2005) Restraining PI3K: mTOR signalling goes back to the membrane. Trends Biochem. Sci., 30, 35-42.
    • (2005) Trends Biochem. Sci. , vol.30 , pp. 35-42
    • Harrington, L.S.1
  • 22
    • 33947538050 scopus 로고    scopus 로고
    • Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
    • Wan,X. et al. (2007) Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene, 26, 1932-1940.
    • (2007) Oncogene , vol.26 , pp. 1932-1940
    • Wan, X.1
  • 23
    • 33947330747 scopus 로고    scopus 로고
    • Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth
    • Hietakangas,V. et al. (2007) Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Genes Dev., 21, 632-637.
    • (2007) Genes Dev , vol.21 , pp. 632-637
    • Hietakangas, V.1
  • 24
    • 33847172809 scopus 로고    scopus 로고
    • Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloeemodin
    • Guo,J. et al. (2007) Growth inhibitory effects of gastric cancer cells with an increase in S phase and alkaline phosphatase activity repression by aloeemodin. Cancer Biol. Ther., 6, 85-88.
    • (2007) Cancer Biol. Ther. , vol.6 , pp. 85-88
    • Guo, J.1
  • 25
    • 8644266658 scopus 로고    scopus 로고
    • Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells
    • Acevedo-Duncan,M. et al. (2004) Aloe-emodin modulates PKC isozymes, inhibits proliferation, and induces apoptosis in U-373MG glioma cells. Int. Immunopharmacol., 4, 1775-1784.
    • (2004) Int. Immunopharmacol. , vol.4 , pp. 1775-1784
    • Acevedo-Duncan, M.1
  • 26
    • 77954350740 scopus 로고    scopus 로고
    • 3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase
    • Lee,D.E. et al. (2010) 7,3',4'-Trihydroxyisoflavone inhibits epidermal growth factor-induced proliferation and transformation of JB6 P+ mouse epidermal cells by suppressing cyclin-dependent kinases and phosphatidylinositol 3-kinase. J. Biol. Chem., 285, 21458-21466.
    • (2010) J. Biol. Chem. , vol.7 , pp. 21458-21466
    • Lee, D.E.1
  • 27
    • 0019788391 scopus 로고
    • Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters: mitogen-resistant variants are sensitive to promotion
    • Colburn,N.H. et al. (1981) Dissociation of mitogenesis and late-stage promotion of tumor cell phenotype by phorbol esters: mitogen-resistant variants are sensitive to promotion. Proc. Natl Acad. Sci. USA, 78, 6912-6916.
    • (1981) Proc. Natl Acad. Sci. USA , vol.78 , pp. 6912-6916
    • Colburn, N.H.1
  • 28
    • 42649128395 scopus 로고    scopus 로고
    • Suppression of C-myc expression associates with antiproliferation of aloe-emodin on gastric cancer cells
    • Guo,J. et al. (2008) Suppression of C-myc expression associates with antiproliferation of aloe-emodin on gastric cancer cells. Cancer Invest., 26, 369-374.
    • (2008) Cancer Invest , vol.26 , pp. 369-374
    • Guo, J.1
  • 29
    • 0037031787 scopus 로고    scopus 로고
    • The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines
    • Kuo,P.L. et al. (2002) The antiproliferative activity of aloe-emodin is through p53-dependent and p21-dependent apoptotic pathway in human hepatoma cell lines. Life Sci., 71, 1879-1892.
    • (2002) Life Sci , vol.71 , pp. 1879-1892
    • Kuo, P.L.1
  • 30
    • 58649114084 scopus 로고    scopus 로고
    • mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice
    • Guertin,D.A. et al. (2009) mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell, 15, 148-159.
    • (2009) Cancer Cell , vol.15 , pp. 148-159
    • Guertin, D.A.1
  • 31
    • 77952305228 scopus 로고    scopus 로고
    • Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo
    • Roulin,D. et al. (2010) Targeting mTORC2 inhibits colon cancer cell proliferation in vitro and tumor formation in vivo. Mol. Cancer, 9, 57.
    • (2010) Mol. Cancer , vol.9 , pp. 57
    • Roulin, D.1
  • 32
    • 78549271170 scopus 로고    scopus 로고
    • mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis
    • Zhang,F. et al. (2010) mTOR complex component Rictor interacts with PKCzeta and regulates cancer cell metastasis. Cancer Res., 70, 9360-9370.
    • (2010) Cancer Res , vol.70 , pp. 9360-9370
    • Zhang, F.1
  • 33
    • 79955615939 scopus 로고    scopus 로고
    • IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation
    • Xie,X. et al. (2011) IkappaB kinase epsilon and TANK-binding kinase 1 activate AKT by direct phosphorylation. Proc. Natl Acad. Sci. USA, 108, 6474-6479.
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 6474-6479
    • Xie, X.1
  • 34
    • 0034212761 scopus 로고    scopus 로고
    • Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors
    • Pecere,T. et al. (2000) Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. Cancer Res., 60, 2800-2804.
    • (2000) Cancer Res , vol.60 , pp. 2800-2804
    • Pecere, T.1


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