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Volumn 3, Issue 1, 2006, Pages 41-49

Mechanisms of disease: Roles of OPG, RANKL and RANK in the pathophysiology of skeletal metastasis

Author keywords

[No Author keywords available]

Indexed keywords

AMGEN; BISPHOSPHONIC ACID DERIVATIVE; DENOSUMAB; FC RECEPTOR; INTERLEUKIN 8; LECTIN; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PAMIDRONIC ACID; RECOMBINANT INTERLEUKIN 8; RECOMBINANT PROTEIN; TUMOR MARKER; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

EID: 30944436527     PISSN: 17434254     EISSN: 17434262     Source Type: Journal    
DOI: 10.1038/ncponc0381     Document Type: Review
Times cited : (117)

References (79)
  • 1
    • 0036675220 scopus 로고    scopus 로고
    • Metastasis to bone: Causes, consequences and therapeutic opportunities
    • Mundy GR (2002) Metastasis to bone: Causes, consequences and therapeutic opportunities. Nat Rev Cancer 2: 584-593
    • (2002) Nat Rev Cancer , vol.2 , pp. 584-593
    • Mundy, G.R.1
  • 2
    • 24744455693 scopus 로고    scopus 로고
    • Histological, immunophenotypic and histomorphometric characterisation of prostate cancer bone metastasis
    • (Eds Keller ET and Chung LWK) Boston: Kluwer Academic Publishers
    • Roudier MP et al. (2004) Histological, immunophenotypic and histomorphometric characterisation of prostate cancer bone metastasis. In The Biology of Skeletal Metastases, 311-339 (Eds Keller ET and Chung LWK) Boston: Kluwer Academic Publishers
    • (2004) The Biology of Skeletal Metastases , pp. 311-339
    • Roudier, M.P.1
  • 3
    • 27644471852 scopus 로고    scopus 로고
    • Clinical use of markers of bone turnover in metastatic bowie disease
    • Seibel MJ (2005) Clinical use of markers of bone turnover in metastatic bowie disease. Nat Clin Pract Oncol 2: 504-517
    • (2005) Nat Clin Pract Oncol , vol.2 , pp. 504-517
    • Seibel, M.J.1
  • 4
    • 0025969367 scopus 로고
    • Bone metastases: Pathophysiology and management policy
    • Nielsen OS et al. (1991) Bone metastases: Pathophysiology and management policy. J Clin Oncol 9: 509-524
    • (1991) J Clin Oncol , vol.9 , pp. 509-524
    • Nielsen, O.S.1
  • 5
    • 0029837583 scopus 로고    scopus 로고
    • Advances in bone biology: The osteoclast
    • Roodman GD (1996) Advances in bone biology: The osteoclast. Endocr Rev 17: 308-332
    • (1996) Endocr Rev , vol.17 , pp. 308-332
    • Roodman, G.D.1
  • 6
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
    • Simonet WS et al. (1997) Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 89: 309-319
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1
  • 7
    • 0030989969 scopus 로고    scopus 로고
    • Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis
    • Tsuda E et al. (1997) Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun 234: 137-142
    • (1997) Biochem Biophys Res Commun , vol.234 , pp. 137-142
    • Tsuda, E.1
  • 8
    • 0032079445 scopus 로고    scopus 로고
    • Osteoprotegerin deficient mice develop early onset osteoporosis and arterial calcification
    • Bucay N et al. (1998) Osteoprotegerin deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 12: 1260-1268
    • (1998) Genes Dev , vol.12 , pp. 1260-1268
    • Bucay, N.1
  • 9
    • 0009660825 scopus 로고    scopus 로고
    • Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): A mechanism by which OCIF/OPG inhibits osteoclastogenesis in vitro
    • Yasuda H (1998) Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): A mechanism by which OCIF/OPG inhibits osteoclastogenesis in vitro. Endocrinology 139: 1329-1337
    • (1998) Endocrinology , vol.139 , pp. 1329-1337
    • Yasuda, H.1
  • 10
    • 0032584208 scopus 로고    scopus 로고
    • Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/ RANKL
    • Yesuda H et al. (1998) Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/ RANKL. Proc Natl Acad Sci USA 95: 3597-3602
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 3597-3602
    • Yesuda, H.1
  • 11
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey DL et al. (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93: 165-176
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1
  • 12
    • 0030714605 scopus 로고    scopus 로고
    • A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
    • Anderson DM et al. (1997) A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 390: 175-179
    • (1997) Nature , vol.390 , pp. 175-179
    • Anderson, D.M.1
  • 13
    • 0031439265 scopus 로고    scopus 로고
    • TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor
    • Wong BR et al. (1997) TRANCE (tumor necrosis factor [TNF]-related activation-induced cytokine), a new TNF family member predominantly expressed in T cells, is a dendritic cell-specific survival factor. J Exp Med 186: 2075-2080
    • (1997) J Exp Med , vol.186 , pp. 2075-2080
    • Wong, B.R.1
  • 14
    • 0032495975 scopus 로고    scopus 로고
    • Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures
    • Matsuzaki K et al. (1998) Osteoclast differentiation factor (ODF) induces osteoclast-like cell formation in human peripheral blood mononuclear cell cultures. Biochem Biophys Res Commun 246: 199-204
    • (1998) Biochem Biophys Res Commun , vol.246 , pp. 199-204
    • Matsuzaki, K.1
  • 15
    • 0033519221 scopus 로고    scopus 로고
    • The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts
    • Burgess TL et al. (1999) The ligand for osteoprotegerin (OPGL) directly activates mature osteoclasts. J Cell Biol 145: 527-538
    • (1999) J Cell Biol , vol.145 , pp. 527-538
    • Burgess, T.L.1
  • 16
    • 0034596229 scopus 로고    scopus 로고
    • Osteoprotegerin ligand regulates osteoclast adherence to the bone surface in mouse calvaria
    • O'Brien EA et al. (2000) Osteoprotegerin ligand regulates osteoclast adherence to the bone surface in mouse calvaria. Biochem Biophys Res Commun 274: 281-290
    • (2000) Biochem Biophys Res Commun , vol.274 , pp. 281-290
    • O'Brien, E.A.1
  • 17
    • 0033888977 scopus 로고    scopus 로고
    • Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo
    • Lacey DL et al. (2000) Osteoprotegerin ligand modulates murine osteoclast survival in vitro and in vivo. Am J Pathol 157: 435-448
    • (2000) Am J Pathol , vol.157 , pp. 435-448
    • Lacey, D.L.1
  • 18
    • 13044316551 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand
    • Hsu H et al. (1999) Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand. Proc Natl Acad Sci USA 96: 3540-3545
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3540-3545
    • Hsu, H.1
  • 19
    • 0346837985 scopus 로고    scopus 로고
    • A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases
    • Body J-J et al. (2003) A phase I study of AMGN-0007, a recombinant osteoprotegerin construct, in patients with multiple myeloma or breast carcinoma related bone metastases. Cancer 97 (Suppl): S887-S892
    • (2003) Cancer , vol.97 , Issue.SUPPL.
    • Body, J.-J.1
  • 20
    • 0037130183 scopus 로고    scopus 로고
    • Osteoprotegerin deficiency and juvenile Paget's disease
    • Whyte MP et al. (2002) Osteoprotegerin deficiency and juvenile Paget's disease. N Engl J Med 347: 175-184
    • (2002) N Engl J Med , vol.347 , pp. 175-184
    • Whyte, M.P.1
  • 21
    • 0033987358 scopus 로고    scopus 로고
    • Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis
    • Hughes AE et al. (2000) Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis. Nat Genet 24: 45-48
    • (2000) Nat Genet , vol.24 , pp. 45-48
    • Hughes, A.E.1
  • 22
    • 9244252016 scopus 로고    scopus 로고
    • The molecular triad OPG/RANK/RANKL: Involvement in the orchestration of pathophysiological bone remodeling
    • Theoleyre T et al. (2004) The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling. Cytokine Growth Factor Rev 15: 457-475
    • (2004) Cytokine Growth Factor. Rev , vol.15 , pp. 457-475
    • Theoleyre, T.1
  • 23
    • 0037108435 scopus 로고    scopus 로고
    • Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells
    • Standal T et al. (2002) Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells. Blood 100: 3002-3007
    • (2002) Blood , vol.100 , pp. 3002-3007
    • Standal, T.1
  • 24
    • 18844440663 scopus 로고    scopus 로고
    • Syndecan-1 is involved in osteoprotegerin-induced chemotaxis in human peripheral blood monocytes
    • Mosheimer BA et al. (2005) Syndecan-1 is involved in osteoprotegerin-induced chemotaxis in human peripheral blood monocytes. J Clin Endocrinol Metab 90: 2964-2971
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 2964-2971
    • Mosheimer, B.A.1
  • 25
    • 11344267803 scopus 로고    scopus 로고
    • Prostate cancer bone metastases promote both osteolytic and osteoblastic activity
    • Keller ET and Brown J (2004) Prostate cancer bone metastases promote both osteolytic and osteoblastic activity. J Cell Biochem 91: 718-729
    • (2004) J Cell Biochem , vol.91 , pp. 718-729
    • Keller, E.T.1    Brown, J.2
  • 26
    • 19744373951 scopus 로고    scopus 로고
    • OPG, RANKL, and RANK in cancer metastasis: Expression and regulation
    • (Eds Keller ET and Chung LWK) Boston: Kluwer Academic Publishers
    • Brown JM et al. (2004) OPG, RANKL, and RANK in cancer metastasis: expression and regulation. In The Biology of Skeletal Metastases, 149-172 (Eds Keller ET and Chung LWK) Boston: Kluwer Academic Publishers
    • (2004) The Biology of Skeletal Metastases , pp. 149-172
    • Brown, J.M.1
  • 27
    • 0030879065 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • Mundy GR (1997) Mechanisms of bone metastasis. Cancer 80 (Suppl): S1546-S1556
    • (1997) Cancer , vol.80 , Issue.SUPPL.
    • Mundy, G.R.1
  • 28
    • 30944440765 scopus 로고    scopus 로고
    • Osteoprotegerin, receptor activator of NFκB (RANK) and RANK ligand in cancer
    • (Ed Mohan RM) Kerala: Global Research Network
    • Keller ET and Brown JM (2003) Osteoprotegerin, receptor activator of NFκB (RANK) and RANK ligand in cancer. In Research Advances in Cancer 3, 81-93 (Ed Mohan RM) Kerala: Global Research Network
    • (2003) Research Advances in Cancer , vol.3 , pp. 81-93
    • Keller, E.T.1    Brown, J.M.2
  • 29
    • 84889487403 scopus 로고    scopus 로고
    • The role of RANK, RANK ligand and osteoprotegerin in the lytic effects and growth of bone metastases
    • (Eds Jasmin C et al.) Chichester: John Wiley and Sons, Ltd
    • Dunstan CR (2005) The role of RANK, RANK ligand and osteoprotegerin in the lytic effects and growth of bone metastases. In Textbook of Bone Metastases, 51-62 (Eds Jasmin C et al.) Chichester: John Wiley and Sons, Ltd
    • (2005) Textbook of Bone Metastases , pp. 51-62
    • Dunstan, C.R.1
  • 30
    • 11344261227 scopus 로고    scopus 로고
    • Expression of receptor activator of NF-kappa B is inversely correlated with metastatic phenotype in breast carcinoma
    • Bhatia P at al. (2005) Expression of receptor activator of NF-kappa B is inversely correlated with metastatic phenotype in breast carcinoma. Clin Cancer Res 11: 162-165
    • (2005) Clin Cancer Res , vol.11 , pp. 162-165
    • Bhatia, P.1
  • 31
    • 0035990985 scopus 로고    scopus 로고
    • Differential gene expression of TGF-beta family members and osteopontin in breast tumor tissue: Analysis by real-time quantitative PCR
    • Reinholz MM et al. (2002) Differential gene expression of TGF-beta family members and osteopontin in breast tumor tissue: Analysis by real-time quantitative PCR. Breast Cancer Res Treat 74: 255-269
    • (2002) Breast Cancer Res Treat , vol.74 , pp. 255-269
    • Reinholz, M.M.1
  • 32
    • 0035319658 scopus 로고    scopus 로고
    • Osteoprotegerin and RANK ligand expression in prostate cancer
    • Brown JM et al. (2001) Osteoprotegerin and RANK ligand expression in prostate cancer. Urology 57: 611-616
    • (2001) Urology , vol.57 , pp. 611-616
    • Brown, J.M.1
  • 33
    • 0037389602 scopus 로고    scopus 로고
    • Expression of receptor activator of nuclear factor κB ligand on bone marrow plasma cells correlates with osteotytic bone disease in patients with multiple myeloma
    • Heider U et al. (2003) Expression of receptor activator of nuclear factor κB ligand on bone marrow plasma cells correlates with osteotytic bone disease in patients with multiple myeloma. Clin Cancer Res 9: 1436-1440
    • (2003) Clin Cancer Res , vol.9 , pp. 1436-1440
    • Heider, U.1
  • 34
    • 0141482103 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor-κB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo
    • Farrugia AN et al. (2003) Receptor activator of nuclear factor-κB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo. Cancer Res 63: 5438-5445
    • (2003) Cancer Res , vol.63 , pp. 5438-5445
    • Farrugia, A.N.1
  • 35
    • 0041854146 scopus 로고    scopus 로고
    • Expression of osteoprotegerin correlates with aggressiveness and poor prognosis of gastric carcinoma
    • Ito R et al. (2003) Expression of osteoprotegerin correlates with aggressiveness and poor prognosis of gastric carcinoma. Virchows Arch 443: 146-151
    • (2003) Virchows Arch , vol.443 , pp. 146-151
    • Ito, R.1
  • 36
    • 0035949510 scopus 로고    scopus 로고
    • Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
    • Pearse RN et al. (2001) Multiple myeloma disrupts the TRANCE/ osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression. Proc Natl Acad Sci USA 98: 11581-11586
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 11581-11586
    • Pearse, R.N.1
  • 37
    • 0035992402 scopus 로고    scopus 로고
    • Serum osteoprotegerin levels in healthy controls and cancer patients
    • Lipton A et al. (2002) Serum osteoprotegerin levels in healthy controls and cancer patients. Clin Cancer Res 8: 2306-2310
    • (2002) Clin Cancer Res , vol.8 , pp. 2306-2310
    • Lipton, A.1
  • 38
    • 0035496947 scopus 로고    scopus 로고
    • Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease
    • on behalf of The Nordic Myeloma Study Group
    • Seidel C et al. on behalf of The Nordic Myeloma Study Group (2001) Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease. Blood 98: 2269-2271
    • (2001) Blood , vol.98 , pp. 2269-2271
    • Seidel, C.1
  • 39
    • 1642524472 scopus 로고    scopus 로고
    • Serum syndecan-1, basic fibroblast growth factor and osteoprotegerin in myeloma patients at diagnosis and during the course of the disease
    • Kyrtsonis MC et al. (2004) Serum syndecan-1, basic fibroblast growth factor and osteoprotegerin in myeloma patients at diagnosis and during the course of the disease. Eur J Haematol 72: 252-258
    • (2004) Eur J Haematol , vol.72 , pp. 252-258
    • Kyrtsonis, M.C.1
  • 40
    • 19944426910 scopus 로고    scopus 로고
    • Osteoprotegerin and osteopontin serum values in postmenopausal advanced breast cancer patients treated with anastrozole
    • Martinetti A et al. (2004) Osteoprotegerin and osteopontin serum values in postmenopausal advanced breast cancer patients treated with anastrozole. Endocr Relat Cancer 11: 771-779
    • (2004) Endocr Relat Cancer , vol.11 , pp. 771-779
    • Martinetti, A.1
  • 41
    • 4744340115 scopus 로고    scopus 로고
    • Prognostic significance of serum osteoprotegerin levels in patients with bladder carcinoma
    • Mizutani Y et al. (2004) Prognostic significance of serum osteoprotegerin levels in patients with bladder carcinoma. Cancer 101: 1794-1802
    • (2004) Cancer , vol.101 , pp. 1794-1802
    • Mizutani, Y.1
  • 42
    • 0034796433 scopus 로고    scopus 로고
    • Serum osteoprotegerin levels are increased in patients with advanced prostate cancer
    • Brown JM et al. (2001) Serum osteoprotegerin levels are increased in patients with advanced prostate cancer. Clin Cancer Res 7: 2977-2983
    • (2001) Clin Cancer Res , vol.7 , pp. 2977-2983
    • Brown, J.M.1
  • 43
    • 1942443234 scopus 로고    scopus 로고
    • Serum osteoprotegerin (OPG) levels are associated with disease progression and response to androgen ablation in patients with prostate cancer
    • Eaton CL et al. (2004) Serum osteoprotegerin (OPG) levels are associated with disease progression and response to androgen ablation in patients with prostate cancer. Prostate 59: 304-310
    • (2004) Prostate , vol.59 , pp. 304-310
    • Eaton, C.L.1
  • 44
    • 4043064387 scopus 로고    scopus 로고
    • Comparison of 10 serum bone turnover markers in prostate carcinoma patients with bone metastatic spread: Diagnostic and prognostic implications
    • Jung K et al. (2004) Comparison of 10 serum bone turnover markers in prostate carcinoma patients with bone metastatic spread: Diagnostic and prognostic implications. Int J Cancer 111: 783-791
    • (2004) Int J Cancer , vol.111 , pp. 783-791
    • Jung, K.1
  • 45
    • 0242440212 scopus 로고    scopus 로고
    • Serum osteoprotegerin and receptor activator of nuclear factor-kappa B ligand as indicators of disturbed osteoclastogenesis in patients with prostate cancer
    • Jung K et al. (2003) Serum osteoprotegerin and receptor activator of nuclear factor-kappa B ligand as indicators of disturbed osteoclastogenesis in patients with prostate cancer. J Urol 170: 2302-2305
    • (2003) J Urol , vol.170 , pp. 2302-2305
    • Jung, K.1
  • 46
    • 0043245842 scopus 로고    scopus 로고
    • Soluble receptor activator of nuclear factor κB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: Proposal for a novel prognostic index
    • Terpos E et al. (2003) Soluble receptor activator of nuclear factor κB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index. Blood 102: 1064-1069
    • (2003) Blood , vol.102 , pp. 1064-1069
    • Terpos, E.1
  • 47
    • 0142182080 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis
    • Grimaud E et al. (2003) Receptor activator of nuclear factor kappaB ligand (RANKL)/osteoprotegerin (OPG) ratio is increased in severe osteolysis. Am J Pathol 163: 2021-2031
    • (2003) Am J Pathol , vol.163 , pp. 2021-2031
    • Grimaud, E.1
  • 48
    • 0037443533 scopus 로고    scopus 로고
    • RANK ligand and osteoprotegerin in myeloma bone disease
    • Sezer O et al. (2003) RANK ligand and osteoprotegerin in myeloma bone disease. Blood 101: 2094-2098
    • (2003) Blood , vol.101 , pp. 2094-2098
    • Sezer, O.1
  • 49
    • 0041814539 scopus 로고    scopus 로고
    • Multiple myeloma biology: Lessons from the 5TMM models
    • Vanderkerken K et al. (2003) Multiple myeloma biology: Lessons from the 5TMM models. Immunol Rev 194: 196-206
    • (2003) Immunol Rev , vol.194 , pp. 196-206
    • Vanderkerken, K.1
  • 50
    • 0037303260 scopus 로고    scopus 로고
    • RANK-Fc: A therapeutic antagonist for RANK-L in myeloma
    • Sordillo EM and Pearse RN (2003) RANK-Fc: A therapeutic antagonist for RANK-L in myeloma. Cancer 97 (Suppl): S802-S812
    • (2003) Cancer , vol.97 , Issue.SUPPL.
    • Sordillo, E.M.1    Pearse, R.N.2
  • 51
    • 1642634597 scopus 로고    scopus 로고
    • Native osteoprotegerin gene transfer inhibits the development of murine osteolytic bone disease induced by tumor xenografts
    • Doran PM et al. (2004) Native osteoprotegerin gene transfer inhibits the development of murine osteolytic bone disease induced by tumor xenografts. Exp Hematol 32: 351-359
    • (2004) Exp Hematol , vol.32 , pp. 351-359
    • Doran, P.M.1
  • 52
    • 0034652458 scopus 로고    scopus 로고
    • Osteoprotegerin prevents and reverses hypercalcemia in a murine model of humoral hypercalcemia of malignancy
    • Capparelli C et al. (2000) Osteoprotegerin prevents and reverses hypercalcemia in a murine model of humoral hypercalcemia of malignancy. Cancer Res 60: 783-787
    • (2000) Cancer Res , vol.60 , pp. 783-787
    • Capparelli, C.1
  • 53
    • 0035360265 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis
    • Morony S et al. (2001) Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis. Cancer Res 61: 4432-4436
    • (2001) Cancer Res , vol.61 , pp. 4432-4436
    • Morony, S.1
  • 54
    • 0035021176 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone
    • Zhang J et al. (2001) Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone. J Clin Invest 107: 1235-1244
    • (2001) J Clin Invest , vol.107 , pp. 1235-1244
    • Zhang, J.1
  • 55
    • 3342982829 scopus 로고    scopus 로고
    • A single dose controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in post-menopausal women
    • Bakker PJ et al. (2004) A single dose controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in post-menopausal women. J Bone Miner Res 19: 1059-1066
    • (2004) J Bone Miner Res , vol.19 , pp. 1059-1066
    • Bakker, P.J.1
  • 56
    • 12144286198 scopus 로고    scopus 로고
    • Novel and selective small molecule stimulators of osteoprotegerin expression inhibit bone resorption
    • Onyia JE et al. (2004) Novel and selective small molecule stimulators of osteoprotegerin expression inhibit bone resorption. J Pharmacol Exp Ther 309: 369-379
    • (2004) J Pharmacol Exp Ther , vol.309 , pp. 369-379
    • Onyia, J.E.1
  • 57
    • 0036295812 scopus 로고    scopus 로고
    • Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts
    • Viereck V et al. (2002) Bisphosphonates pamidronate and zoledronic acid stimulate osteoprotegerin production by primary human osteoblasts. Biochem Biophys Res Commun 291: 680-686
    • (2002) Biochem Biophys Res Commun , vol.291 , pp. 680-686
    • Viereck, V.1
  • 58
    • 0035815256 scopus 로고    scopus 로고
    • Bisphosphonates regulate cell growth and gene expression in the UMR 106-01 clonal rat osteosarcoma cell line
    • Mackie PS et al. (2001) Bisphosphonates regulate cell growth and gene expression in the UMR 106-01 clonal rat osteosarcoma cell line. Br J Cancer 84: 951-958
    • (2001) Br J Cancer , vol.84 , pp. 951-958
    • Mackie, P.S.1
  • 59
    • 3042843179 scopus 로고    scopus 로고
    • The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-α converting enzyme (TACE)
    • Pan B et al. (2004) The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-α converting enzyme (TACE). J Bone Miner Res 19: 147-154
    • (2004) J Bone Miner Res , vol.19 , pp. 147-154
    • Pan, B.1
  • 60
    • 0037236978 scopus 로고    scopus 로고
    • Zoledronic acid exhibits inhibitory effects on osteoblastic and osteolytic metastases of prostate cancer
    • Erratum in: Clin Cancer Res 9: 1574-1575
    • Corey E et al. (2003) Zoledronic acid exhibits inhibitory effects on osteoblastic and osteolytic metastases of prostate cancer. Clin Cancer Res 9: 295-306; Erratum in: Clin Cancer Res 9: 1574-1575
    • (2003) Clin Cancer Res , vol.9 , pp. 295-306
    • Corey, E.1
  • 61
    • 0034105966 scopus 로고    scopus 로고
    • Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord
    • Honore P et al. (2000) Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord. Nat Med 6: 521-528
    • (2000) Nat Med , vol.6 , pp. 521-528
    • Honore, P.1
  • 62
    • 0035872471 scopus 로고    scopus 로고
    • Osteoprotegerin diminishes advanced bone cancer pain
    • Luger NM et al. (2001) Osteoprotegerin diminishes advanced bone cancer pain. Cancer Res 61: 4038-4047
    • (2001) Cancer Res , vol.61 , pp. 4038-4047
    • Luger, N.M.1
  • 63
    • 23044509872 scopus 로고    scopus 로고
    • The RANKL inhibitor osteoprotegerin (OPG) causes greater suppression of bone resorption and hypercalcemia compared to bisphosphonates in two models of humoral hypercalcemia of malignancy
    • Morony S et al. (2005) The RANKL inhibitor osteoprotegerin (OPG) causes greater suppression of bone resorption and hypercalcemia compared to bisphosphonates in two models of humoral hypercalcemia of malignancy. Endocrinology 146: 3235-3243
    • (2005) Endocrinology , vol.146 , pp. 3235-3243
    • Morony, S.1
  • 64
    • 0032404069 scopus 로고    scopus 로고
    • Osteoclastogenesis inhibitory factor exhibits hypocalcemic effects in normal mice and in hypercalcemic nude mice carrying tumors associated with humoral hypercalcemia of malignancy
    • Akatsu T et al. (1998) Osteoclastogenesis inhibitory factor exhibits hypocalcemic effects in normal mice and in hypercalcemic nude mice carrying tumors associated with humoral hypercalcemia of malignancy. Bone 23: 495-498
    • (1998) Bone , vol.23 , pp. 495-498
    • Akatsu, T.1
  • 65
    • 0344844468 scopus 로고    scopus 로고
    • Soluble receptor activator of nuclear factor κB Fc diminishes prostate cancer progression in bone
    • Zhang J at al. (2003) Soluble receptor activator of nuclear factor κB Fc diminishes prostate cancer progression in bone. Cancer Res 63: 7883-7890
    • (2003) Cancer Res , vol.63 , pp. 7883-7890
    • Zhang, J.1
  • 66
    • 0037086077 scopus 로고    scopus 로고
    • Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells
    • Holen I et al. (2002) Osteoprotegerin (OPG) is a survival factor for human prostate cancer cells. Cancer Res 62: 1619-1623
    • (2002) Cancer Res , vol.62 , pp. 1619-1623
    • Holen, I.1
  • 67
    • 0037374460 scopus 로고    scopus 로고
    • Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells
    • Shipman CM and Croucher PI (2003) Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor related apoptosis-inducing ligand/ Apo2 ligand and can function as a paracrine survival factor for human myeloma cells. Cancer Res 63: 912-916
    • (2003) Cancer Res , vol.63 , pp. 912-916
    • Shipman, C.M.1    Croucher, P.I.2
  • 68
    • 16644399496 scopus 로고    scopus 로고
    • Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation
    • Hausler KD et al. (2004) Secreted frizzled-related protein-1 inhibits RANKL-dependent osteoclast formation. J Bone Miner Res 19: 1873-1881
    • (2004) J Bone Miner Res , vol.19 , pp. 1873-1881
    • Hausler, K.D.1
  • 69
    • 0035805590 scopus 로고    scopus 로고
    • A novel osteoclast-derived C-type lectin that inhibits osteoclast formation
    • Zhou H et al. (2001) A novel osteoclast-derived C-type lectin that inhibits osteoclast formation. J Biol Chem 276: 14916-14923
    • (2001) J Biol Chem , vol.276 , pp. 14916-14923
    • Zhou, H.1
  • 70
    • 24744463719 scopus 로고    scopus 로고
    • Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts
    • Hu YS et al. (2004) Isolation of a human homolog of osteoclast inhibitory lectin that inhibits the formation and function of osteoclasts. J Bone Miner Res 19: 89-99
    • (2004) J Bone Miner Res , vol.19 , pp. 89-99
    • Hu, Y.S.1
  • 71
    • 0037073798 scopus 로고    scopus 로고
    • Osteoclast inhibitory lectin, a family of new osteoclast inhibitors
    • Zhou H et al. (2002) Osteoclast inhibitory lectin, a family of new osteoclast inhibitors. J Biol Chem 277: 48808-48815
    • (2002) J Biol Chem , vol.277 , pp. 48808-48815
    • Zhou, H.1
  • 72
    • 0042707678 scopus 로고    scopus 로고
    • Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease
    • Bendre MS et al. (2003) Interleukin-8 stimulation of osteoclastogenesis and bone resorption is a mechanism for the increased osteolysis of metastatic bone disease. Bone 33: 28-37
    • (2003) Bone , vol.33 , pp. 28-37
    • Bendre, M.S.1
  • 73
    • 0037395314 scopus 로고    scopus 로고
    • Receptor activator of NF-κB ligand (RANKL) is expressed in chondroblastoma: Possible involvement in osteoclastic giant cell recruitment
    • Huang L et al. (2003) Receptor activator of NF-κB ligand (RANKL) is expressed in chondroblastoma: Possible involvement in osteoclastic giant cell recruitment. Mol Pathol 56: 116-120
    • (2003) Mol Pathol , vol.56 , pp. 116-120
    • Huang, L.1
  • 74
    • 0742271587 scopus 로고    scopus 로고
    • Expression of parathyroid hormone-related protein (PTHrP), osteoclast differentiation factor (ODF)/receptor activator of nuclear factor-κB ligand (RANKL) and osteoclastogenesis inhibitory factor (OCIF)/osteoprotegerin (OPG) in ameloblastomas
    • Kumamoto H and Ooya K (2004) Expression of parathyroid hormone-related protein (PTHrP), osteoclast differentiation factor (ODF)/receptor activator of nuclear factor-κB ligand (RANKL) and osteoclastogenesis inhibitory factor (OCIF)/osteoprotegerin (OPG) in ameloblastomas. J Oral Pathol Med 33: 46-52
    • (2004) J Oral Pathol Med , vol.33 , pp. 46-52
    • Kumamoto, H.1    Ooya, K.2
  • 75
    • 0034078583 scopus 로고    scopus 로고
    • Expression of osteoclast differentiation signals by stromal elements of giant cell tumors
    • Atkins GJ et al. (2000) Expression of osteoclast differentiation signals by stromal elements of giant cell tumors. J Bone Miner Res 15: 640-649
    • (2000) J Bone Miner Res , vol.15 , pp. 640-649
    • Atkins, G.J.1
  • 76
    • 0036200116 scopus 로고    scopus 로고
    • Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors
    • Good CR et al. (2002) Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors. J Surg Oncol 79: 174-179
    • (2002) J Surg Oncol , vol.79 , pp. 174-179
    • Good, C.R.1
  • 77
    • 85056911363 scopus 로고    scopus 로고
    • Immunocytochemistry reveals RANKL expression of myeloma cells
    • Sezer O et al. (2002) Immunocytochemistry reveals RANKL expression of myeloma cells. Blood 99: 4646-4647
    • (2002) Blood , vol.99 , pp. 4646-4647
    • Sezer, O.1
  • 78
    • 0035895083 scopus 로고    scopus 로고
    • Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
    • Giuliani N et al. (2001) Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. Blood 98: 3527-3533
    • (2001) Blood , vol.98 , pp. 3527-3533
    • Giuliani, N.1
  • 79
    • 0036845366 scopus 로고    scopus 로고
    • Tumour cells produce receptor activator of NF-κB ligand (RANKL) in skeletal metastases
    • Huang L et al. (2002) Tumour cells produce receptor activator of NF-κB ligand (RANKL) in skeletal metastases. J Clin Pathol 55: 877-878
    • (2002) J Clin Pathol , vol.55 , pp. 877-878
    • Huang, L.1


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