Ring-substituted analogs of 3,3′-diindolylmethane(DIM) induce apoptosis and necrosis in androgen-dependent and -independent prostate cancer cells

Investigational New Drugs

Volumn 32, Issue 1, 2014, Pages 25-36

  Goldberg, A A ^a   Titorenko, V I ^b   Beach, A ^b   Abdelbaqi, K ^a   Safe, S ^c,d   Sanderson, J T ^a  

^a UNIVERSITÉ LAVAL   (Canada)

^b Dept of Electrical and Computer Engineering   (Canada)

^c TEXAS A AND M UNIVERSITY   (United States)

^d TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

Androgen dependent; Androgen independent; Apoptosis; Caspase activity; Concentrations; Diindolylmethane derivatives; Intracellular; LNCaP; Necrosis; PC 3; Prostate cancer

Indexed keywords

ANDROGENS; APOPTOSIS; CASPASE 3; CASPASE 8; CELL LINE, TUMOR; CELL PROLIFERATION; DIHYDROTESTOSTERONE; EXTRACELLULAR SPACE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INDOLES; INTRACELLULAR SPACE; MALE; NECROSIS; PROSTATIC NEOPLASMS; RECEPTORS, DEATH DOMAIN; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 84898848365     PISSN: 01676997     EISSN: 15730646     Source Type: Journal    
DOI: 10.1007/s10637-013-9979-y     Document Type: Article

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