-
1
-
-
0028303977
-
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
-
Akira, S.; Nishio, Y.; Inoue, M.; Wang, X.J.; Wei, S.; Matsusaka, T.; Yoshida, K.; Sudo, T.; Naruto, M.; Kishimoto, T. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway. Cell, 1994, 77(1), 63-71.
-
(1994)
Cell
, vol.77
, Issue.1
, pp. 63-71
-
-
Akira, S.1
Nishio, Y.2
Inoue, M.3
Wang, X.J.4
Wei, S.5
Matsusaka, T.6
Yoshida, K.7
Sudo, T.8
Naruto, M.9
Kishimoto, T.10
-
2
-
-
16344380754
-
A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
-
DOI 10.1073/pnas.0409894102
-
Song, H.; Wang, R.; Wang, S.; Lin, J. A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc. Natl. Acad. Sci. U S A., 2005, 102(13), 4700-4705. (Pubitemid 40471517)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.13
, pp. 4700-4705
-
-
Song, H.1
Wang, R.2
Wang, S.3
Lin, J.4
-
3
-
-
68549117088
-
Cooperative interaction between protein inhibitor of activated signal transducer and activator of transcription-3 with epidermal growth factor receptor blockade in lung cancer
-
Kluge, A.; Dabir, S.; Kern, J.; Nethery, D.; Halmos, B.; Ma, P.; Dowlati, A. Cooperative interaction between protein inhibitor of activated signal transducer and activator of transcription-3 with epidermal growth factor receptor blockade in lung cancer. Int. J. Cancer., 2009, 125(7), 1728-1734.
-
(2009)
Int. J. Cancer.
, vol.125
, Issue.7
, pp. 1728-1734
-
-
Kluge, A.1
Dabir, S.2
Kern, J.3
Nethery, D.4
Halmos, B.5
Ma, P.6
Dowlati, A.7
-
4
-
-
34548317417
-
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
-
DOI 10.1038/nature06096, PII NATURE06096
-
Minegishi, Y.; Saito, M.; Tsuchiya, S.; Tsuge, I.; Takada, H.; Hara, T.; Kawamura, N.; Ariga, T.; Pasic, S.; Stojkovic, O.; Metin, A.; Karasuyama, H. Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome. Nature, 2007, 448(7157), 1058-1062. (Pubitemid 47345590)
-
(2007)
Nature
, vol.448
, Issue.7157
, pp. 1058-1062
-
-
Minegishi, Y.1
Saito, M.2
Tsuchiya, S.3
Tsuge, I.4
Takada, H.5
Hara, T.6
Kawamura, N.7
Ariga, T.8
Pasic, S.9
Stojkovic, O.10
Metin, A.11
Karasuyama, H.12
-
5
-
-
67649445779
-
Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer
-
Kunigal, S.; Lakka, S.S.; Sodadasu, P.K.; Estes, N.; Rao, J.S. Stat3-siRNA induces Fas-mediated apoptosis in vitro and in vivo in breast cancer. Int. J. Oncol., 2009, 34(5), 1209-1220.
-
(2009)
Int. J. Oncol.
, vol.34
, Issue.5
, pp. 1209-1220
-
-
Kunigal, S.1
Lakka, S.S.2
Sodadasu, P.K.3
Estes, N.4
Rao, J.S.5
-
6
-
-
55249102690
-
Stat3 as a molecular target in RNA interference-based treatment of oral squamous cell carcinoma
-
Klosek, S.K.; Nakashiro, K.; Hara, S.; Goda, H.; Hamakawa, H. Stat3 as a molecular target in RNA interference-based treatment of oral squamous cell carcinoma. Oncol. Rep., 2008, 20(4), 873-878.
-
(2008)
Oncol. Rep.
, vol.20
, Issue.4
, pp. 873-878
-
-
Klosek, S.K.1
Nakashiro, K.2
Hara, S.3
Goda, H.4
Hamakawa, H.5
-
7
-
-
1042302005
-
The stats of cancer - New molecular targets come of age
-
Yu, H.; Jove, R. The STATs of cancer-new molecular targets come of age. Nat. Rev. Cancer, 2004, 4(2), 97-105. (Pubitemid 38198738)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.2
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
8
-
-
34250658084
-
Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity
-
DOI 10.1073/pnas.0609757104
-
Siddiquee, K.; Zhang, S.; Guida, W.C.; Blaskovich, M.A.; Greedy, B.; Lawrence, H.R.; Yip, M.L.; Jove, R.; McLaughlin, M.M.; Lawrence, N.J.; Sebti, S.M.; Turkson, J. Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc. Natl. Acad. Sci. U S A., 2007, 104(18), 7391-7396. (Pubitemid 47185916)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.18
, pp. 7391-7396
-
-
Siddiquee, K.1
Zhang, S.2
Guida, W.C.3
Blaskovich, M.A.4
Greedy, B.5
Lawrence, H.R.6
Yip, M.L.R.7
Jove, R.8
McLaughlin, M.M.9
Lawrence, N.J.10
Sebti, S.M.11
Turkson, J.12
-
9
-
-
38649129118
-
An oxazole-based small-molecule stat3 inhibitor modulates stat3 stability and processing and induces antitumor cell effects
-
DOI 10.1021/cb7001973
-
Siddiquee, K.A.; Gunning, P.T.; Glenn, M.; Katt, W.P.; Zhang, S.; Schrock, C.; Sebti, S.M.; Jove, R.; Hamilton, A.D.; Turkson, J. An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. ACS. Chem. Biol., 2007, 2(12), 787-798. (Pubitemid 351166054)
-
(2007)
ACS Chemical Biology
, vol.2
, Issue.12
, pp. 787-798
-
-
Siddiquee, K.A.Z.1
Gunning, P.T.2
Glen, M.3
Katt, W.P.4
Zhang, S.5
Schroeck, C.6
Sebti, S.M.7
Jove, R.8
Hamilton, A.D.9
Turkson, J.10
-
10
-
-
33644983005
-
Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: A potential novel therapy for head and neck cancer
-
Jing, N.; Zhu, Q.; Yuan, P.; Li, Y.; Mao, L.; Tweardy, D.J. Targeting signal transducer and activator of transcription 3 with G-quartet oligonucleotides: a potential novel therapy for head and neck cancer. Mol. Cancer Ther., 2006, 5(2), 279-286.
-
(2006)
Mol. Cancer Ther.
, vol.5
, Issue.2
, pp. 279-286
-
-
Jing, N.1
Zhu, Q.2
Yuan, P.3
Li, Y.4
Mao, L.5
Tweardy, D.J.6
-
11
-
-
34548576919
-
Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides
-
Weerasinghe, P.; Garcia, G.E.; Zhu, Q.; Yuan, P.; Feng, L.; Mao, L.; Jing, N. Inhibition of Stat3 activation and tumor growth suppression of non-small cell lung cancer by G-quartet oligonucleotides. Int. J. Oncol., 2007, 31(1), 129-136.
-
(2007)
Int. J. Oncol.
, vol.31
, Issue.1
, pp. 129-136
-
-
Weerasinghe, P.1
Garcia, G.E.2
Zhu, Q.3
Yuan, P.4
Feng, L.5
Mao, L.6
Jing, N.7
-
12
-
-
38849199799
-
STAT3 as a target for inducing apoptosis in solid and hematological tumors
-
DOI 10.1038/cr.2008.18, PII CR200818
-
Al Zaid Siddiquee, K.; Turkson, J. STAT3 as a target for inducing apoptosis in solid and hematological tumors. Cell Res., 2008, 18(2), 254-267. (Pubitemid 351206162)
-
(2008)
Cell Research
, vol.18
, Issue.2
, pp. 254-267
-
-
Al Zaid Siddiquee, K.1
Turkson, J.2
-
13
-
-
47749150266
-
Crystal structure of unphosphorylated STAT3 core fragment
-
Ren, Z.; Mao, X.; Mertens, C.; Krishnaraj, R.; Qin, J.; Mandal, P.K.; Romanowski, M.J.; McMurray, J.S.; Chen, X. Crystal structure of unphosphorylated STAT3 core fragment. Biochem. Biophys. Res. Commun., 2008, 374(1), 1-5.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.374
, Issue.1
, pp. 1-5
-
-
Ren, Z.1
Mao, X.2
Mertens, C.3
Krishnaraj, R.4
Qin, J.5
Mandal, P.K.6
Romanowski, M.J.7
McMurray, J.S.8
Chen, X.9
-
14
-
-
33947417336
-
Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: Clinical implications
-
DOI 10.1158/1078-0432.CCR-06-2313
-
Huang, S. Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications. Clin. Cancer Res., 2007, 13(5), 1362-1366. (Pubitemid 46450423)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.5
, pp. 1362-1366
-
-
Huang, S.1
-
15
-
-
0036731485
-
STATs: Transcriptional control and biological impact
-
DOI 10.1038/nrm909
-
Levy, D.E.; Darnell, J.E., Jr. Stats: transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol., 2002, 3(9), 651-662. (Pubitemid 34987786)
-
(2002)
Nature Reviews Molecular Cell Biology
, vol.3
, Issue.9
, pp. 651-662
-
-
Levy, D.E.1
Darnell Jr., J.E.2
-
16
-
-
3543055012
-
Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity
-
Turkson, J.; Kim, J.S.; Zhang, S.; Yuan, J.; Huang, M.; Glenn, M.; Haura, E.; Sebti, S.; Hamilton, A.D.; Jove, R. Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Mol. Cancer Ther., 2004, 3(3), 261-269. (Pubitemid 39193701)
-
(2004)
Molecular Cancer Therapeutics
, vol.3
, Issue.3
, pp. 261-269
-
-
Turkson, J.1
Kim, J.S.2
Zhang, S.3
Yuan, J.4
Huang, M.5
Glenn, M.6
Haura, E.7
Sebti, S.8
Hamilton, A.D.9
Jove, R.10
-
17
-
-
0036251154
-
Stat proteins and oncogenesis
-
DOI 10.1172/JCI200215617
-
Bromberg, J. Stat proteins and oncogenesis. J. Clin. Invest., 2002, 109(9), 1139-1142. (Pubitemid 34496590)
-
(2002)
Journal of Clinical Investigation
, vol.109
, Issue.9
, pp. 1139-1142
-
-
Bromberg, J.1
-
18
-
-
0032921172
-
The STAT family of proteins in cytokine signaling
-
DOI 10.1016/S0079-6107(98)00051-0, PII S0079610798000510
-
Shuai, K. The STAT family of proteins in cytokine signaling. Prog. Biophys. Mol. Biol., 1999, 71(3-4), 405-422. (Pubitemid 29156310)
-
(1999)
Progress in Biophysics and Molecular Biology
, vol.71
, Issue.3-4
, pp. 405-422
-
-
Shuai, K.1
-
19
-
-
38449098731
-
The role of signal transducers and activators of transcription in colon cancer
-
DOI 10.2741/2893
-
Klampfer, L. The role of signal transducers and activators of transcription in colon cancer. Front. Biosci., 2008, 13, 2888-2899. (Pubitemid 351589205)
-
(2008)
Frontiers in Bioscience
, vol.13
, Issue.8
, pp. 2888-2899
-
-
Klampfer, L.1
-
20
-
-
5444237088
-
STAT proteins as novel targets for cancer drug discovery
-
DOI 10.1517/14728222.8.5.409
-
Turkson, J. STAT proteins as novel targets for cancer drug discovery. Expert. Opin.Ther. Targets., 2004, 8(5), 409-422. (Pubitemid 39359648)
-
(2004)
Expert Opinion on Therapeutic Targets
, vol.8
, Issue.5
, pp. 409-422
-
-
Turkson, J.1
-
21
-
-
62149113324
-
Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1
-
Pandey, M.K.; Sung, B.; Ahn, K.S.; Aggarwal, B.B. Butein suppresses constitutive and inducible signal transducer and activator of transcription (STAT) 3 activation and STAT3-regulated gene products through the induction of a protein tyrosine phosphatase SHP-1. Mol. Pharmacol., 2009, 75(3), 525-533.
-
(2009)
Mol. Pharmacol.
, vol.75
, Issue.3
, pp. 525-533
-
-
Pandey, M.K.1
Sung, B.2
Ahn, K.S.3
Aggarwal, B.B.4
-
22
-
-
70349323403
-
Targeting signal transducer and activator of transcription signaling pathway in leukemias
-
Benekli, M.; Baumann, H.; Wetzler, M. Targeting signal transducer and activator of transcription signaling pathway in leukemias. J. Clin. Oncol., 2009, 27(26), 4422-4432.
-
(2009)
J. Clin. Oncol.
, vol.27
, Issue.26
, pp. 4422-4432
-
-
Benekli, M.1
Baumann, H.2
Wetzler, M.3
-
23
-
-
77649207043
-
Activation of JAK2/STAT3 signaling by osteopontin promotes tumor growth in human breast cancer cells
-
Behera, R.; Kumar, V.; Lohite, K.; Karnik, S.; Kundu, G.C. Activation of JAK2/STAT3 signaling by osteopontin promotes tumor growth in human breast cancer cells. Carcinogenesis, 2010, 31(2), 192-200.
-
(2010)
Carcinogenesis
, vol.31
, Issue.2
, pp. 192-200
-
-
Behera, R.1
Kumar, V.2
Lohite, K.3
Karnik, S.4
Kundu, G.C.5
-
24
-
-
33644773438
-
STAT3 as a therapeutic target in head and neck cancer
-
DOI 10.1517/14712598.6.3.231
-
Leeman, R.J.; Lui, V.W.; Grandis, J.R. STAT3 as a therapeutic target in head and neck cancer. Expert. Opin. Biol. Ther., 2006, 6(3), 231-241. (Pubitemid 43344743)
-
(2006)
Expert Opinion on Biological Therapy
, vol.6
, Issue.3
, pp. 231-241
-
-
Leeman, R.J.1
Lui, V.W.Y.2
Grandis, J.R.3
-
25
-
-
10944245682
-
Targeting the STAT pathway in head and neck cancer: Recent advances and future prospects
-
DOI 10.2174/1568009043332736
-
Nikitakis, N.G.; Siavash, H.; Sauk, J.J. Targeting the STAT pathway in head and neck cancer: recent advances and future prospects. Curr. Cancer Drug Targets, 2004, 4(8), 637-651. (Pubitemid 40013571)
-
(2004)
Current Cancer Drug Targets
, vol.4
, Issue.8
, pp. 637-651
-
-
Nikitakis, N.G.1
Siavash, H.2
Sauk, J.J.3
-
26
-
-
21544473172
-
Targeting STAT3 affects melanoma on multiple fronts
-
DOI 10.1007/s10555-005-1580-1
-
Kortylewski, M.; Jove, R.; Yu, H. Targeting STAT3 affects melanoma on multiple fronts. Cancer Metastasis Rev., 2005, 24(2), 315-327. (Pubitemid 40922802)
-
(2005)
Cancer and Metastasis Reviews
, vol.24
, Issue.2
, pp. 315-327
-
-
Kortylewski, M.1
Jove, R.2
Yu, H.3
-
27
-
-
65349191756
-
New approaches to target the androgen receptor and STAT3 for prostate cancer treatments
-
He, M.; Young, C.Y. New approaches to target the androgen receptor and STAT3 for prostate cancer treatments. Mini. Rev. Med. Chem., 2009, 9(3), 395-400.
-
(2009)
Mini. Rev. Med. Chem.
, vol.9
, Issue.3
, pp. 395-400
-
-
He, M.1
Young, C.Y.2
-
28
-
-
33744525493
-
Transcriptional anti-angiogenesis therapy of human pancreatic cancer
-
DOI 10.1016/j.cytogfr.2006.01.002, PII S1359610106000049
-
Xie, K.; Wei, D.; Huang, S. Transcriptional anti-angiogenesis therapy of human pancreatic cancer. Cytokine Growth Factor Rev., 2006, 17(3), 147-156. (Pubitemid 43816895)
-
(2006)
Cytokine and Growth Factor Reviews
, vol.17
, Issue.3
, pp. 147-156
-
-
Xie, K.1
Wei, D.2
Huang, S.3
-
29
-
-
0034721813
-
Inhibition of interleukin-6 signaling by galiellalactone
-
Weidler, M.; Rether, J.; Anke, T.; Erkel, G. Inhibition of interleukin-6 signaling by galiellalactone. FEBS. Lett., 2000, 484(1), 1-6.
-
(2000)
FEBS. Lett.
, vol.484
, Issue.1
, pp. 1-6
-
-
Weidler, M.1
Rether, J.2
Anke, T.3
Erkel, G.4
-
30
-
-
39449098191
-
Galiellalactone is a novel therapeutic candidate against hormone-refractory prostate cancer expressing activated Stat3
-
DOI 10.1002/pros.20699
-
Hellsten, R.; Johansson, M.; Dahlman, A.; Dizeyi, N.; Sterner, O.; Bjartell, A. Galiellalactone is a novel therapeutic candidate against hormonerefractory prostate cancer expressing activated Stat3. Prostate, 2008, 68(3), 269-280. (Pubitemid 351273056)
-
(2008)
Prostate
, vol.68
, Issue.3
, pp. 269-280
-
-
Hellsten, R.1
Johansson, M.2
Dahlman, A.3
Dizeyi, N.4
Sterner, O.5
Bjartell, A.6
-
31
-
-
0037077413
-
Galiellalactone and its biogenetic precursors as chemotaxonomic markers of the Sarcosomataceae (Ascomycota)
-
DOI 10.1016/S0031-9422(02)00193-0, PII S0031942202001930
-
Kopcke, B.; Weber, R.W.; Anke, H. Galiellalactone and its biogenetic precursors as chemotaxonomic markers of the Sarcosomataceae (Ascomycota). Phytochemistry, 2002, 60(7), 709-714. (Pubitemid 34857122)
-
(2002)
Phytochemistry
, vol.60
, Issue.7
, pp. 709-714
-
-
Kopcke, B.1
Weber, R.W.S.2
Anke, H.3
-
32
-
-
18844370367
-
Cucurbitacin Q: A selective STAT3 activation inhibitor with potent antitumor activity
-
DOI 10.1038/sj.onc.1208470
-
Sun, J.; Blaskovich, M.A.; Jove, R.; Livingston, S.K.; Coppola, D.; Sebti, S.M. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene, 2005, 24(20), 3236-3245. (Pubitemid 40695105)
-
(2005)
Oncogene
, vol.24
, Issue.20
, pp. 3236-3245
-
-
Sun, J.1
Blaskovich, M.A.2
Jove, R.3
Livingston, S.K.4
Coppola, D.5
Sebti, S.M.6
-
33
-
-
25444513779
-
A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells
-
DOI 10.1074/jbc.M502694200
-
Turkson, J.; Zhang, S.; Mora, L.B.; Burns, A.; Sebti, S.; Jove, R. A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells. J. Biol. Chem., 2005, 280(38), 32979-32988. (Pubitemid 41368347)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.38
, pp. 32979-32988
-
-
Turkson, J.1
Zhang, S.2
Mora, L.B.3
Burns, A.4
Sebti, S.5
Jove, R.6
-
34
-
-
12344328541
-
Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity
-
Turkson, J.; Zhang, S.; Palmer, J.; Kay, H.; Stanko, J.; Mora, L.B.; Sebti, S.; Yu, H.; Jove, R. Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity. Mol. Cancer. Ther., 2004, 3(12), 1533-1542. (Pubitemid 40136708)
-
(2004)
Molecular Cancer Therapeutics
, vol.3
, Issue.12
, pp. 1533-1542
-
-
Turkson, J.1
Zhang, S.2
Palmer, J.3
Kay, H.4
Stanko, J.5
Mora, L.B.6
Sebti, S.7
Yu, H.8
Jove, R.9
-
35
-
-
0035977055
-
Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation
-
Turkson, J.; Ryan, D.; Kim, J.S.; Zhang, Y.; Chen, Z.; Haura, E.; Laudano, A.; Sebti, S.; Hamilton, A.D.; Jove, R. Phosphotyrosyl peptides block Stat3-mediated DNA binding activity, gene regulation, and cell transformation. J. Biol. Chem., 2001, 276(48), 45443-45455.
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.48
, pp. 45443-45455
-
-
Turkson, J.1
Ryan, D.2
Kim, J.S.3
Zhang, Y.4
Chen, Z.5
Haura, E.6
Laudano, A.7
Sebti, S.8
Hamilton, A.D.9
Jove, R.10
-
36
-
-
0037294154
-
Identification of a high-affinity phosphopeptide inhibitor of Stat3
-
DOI 10.1016/S0960-894X(02)01050-8
-
Ren, Z.; Cabell, L.A.; Schaefer, T.S.; McMurray, J.S. Identification of a high-affinity phosphopeptide inhibitor of Stat3. Bioorg. Med. Chem. Lett., 2003, 13(4), 633-636. (Pubitemid 36298456)
-
(2003)
Bioorganic and Medicinal Chemistry Letters
, vol.13
, Issue.4
, pp. 633-636
-
-
Ren, Z.1
Cabell, L.A.2
Schaefer, T.S.3
McMurray, J.S.4
-
37
-
-
0033767577
-
Therapeutic applications of transcription factor decoy oligonucleotides
-
Mann, M.J.; Dzau, V.J. Therapeutic applications of transcription factor decoy oligonucleotides. J. Clin. Invest., 2000, 106(9), 1071-1075.
-
(2000)
J. Clin. Invest.
, vol.106
, Issue.9
, pp. 1071-1075
-
-
Mann, M.J.1
Dzau, V.J.2
-
38
-
-
1842558596
-
Molecular therapy to inhibit NFκB activation by transcription factor decoy oligonucleotides
-
DOI 10.1016/j.coph.2003.10.008, PII S1471489204000207
-
Morishita, R.; Tomita, N.; Kaneda, Y.; Ogihara, T. Molecular therapy to inhibit NFkappaB activation by transcription factor decoy oligonucleotides. Curr. Opin. Pharmacol., 2004, 4(2), 139-146. (Pubitemid 38444048)
-
(2004)
Current Opinion in Pharmacology
, vol.4
, Issue.2
, pp. 139-146
-
-
Morishita, R.1
Tomita, N.2
Kaneda, Y.3
Ogihara, T.4
-
39
-
-
34548016800
-
STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes
-
Zhang, X.; Zhang, J.; Wei, H.; Tian, Z. STAT3-decoy oligodeoxynucleotide inhibits the growth of human lung cancer via down-regulating its target genes. Oncol. Rep., 2007, 17(6), 1377-1382.
-
(2007)
Oncol. Rep.
, vol.17
, Issue.6
, pp. 1377-1382
-
-
Zhang, X.1
Zhang, J.2
Wei, H.3
Tian, Z.4
-
40
-
-
35748976581
-
STAT3-decoy ODN inhibits cytokine autocrine of murine tumor cells
-
Liu, X.; Li, J.; Zhang, J. STAT3-decoy ODN inhibits cytokine autocrine of murine tumor cells. Cell. Mol. Immunol., 2007, 4(4), 309-313.
-
(2007)
Cell. Mol. Immunol.
, vol.4
, Issue.4
, pp. 309-313
-
-
Liu, X.1
Li, J.2
Zhang, J.3
-
41
-
-
0037386568
-
Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth
-
DOI 10.1073/pnas.0534764100
-
Leong, P.L.; Andrews, G.A.; Johnson, D.E.; Dyer, K.F.; Xi, S.; Mai, J.C.; Robbins, P.D.; Gadiparthi, S.; Burke, N.A.; Watkins, S.F.; Grandis, J.R. Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proc. Natl. Acad. Sci. U S A., 2003, 100(7), 4138-4143. (Pubitemid 36418170)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.7
, pp. 4138-4143
-
-
Leong, P.L.1
Andrews, G.A.2
Johnson, D.E.3
Dyer, K.F.4
Xi, S.5
Mai, J.C.6
Robbins, P.D.7
Gadiparthi, S.8
Burke, N.A.9
Watkins, S.F.10
Grandis, J.R.11
-
42
-
-
37549062631
-
Design synthesis, and studies of small molecule STAT3 inhibitors
-
Bhasin, D.; Cisek, K.; Pandharkar, T.; Regan, N.; Li, C.; Pandit, B.; Lin, J.; Li, P.K. Design, synthesis, and studies of small molecule STAT3 inhibitors. Bioorg. Med. Chem. Lett., 2008, 18(1), 391-395.
-
(2008)
Bioorg. Med. Chem. Lett.
, vol.18
, Issue.1
, pp. 391-395
-
-
Bhasin, D.1
Cisek, K.2
Pandharkar, T.3
Regan, N.4
Li, C.5
Pandit, B.6
Lin, J.7
Li, P.K.8
-
43
-
-
34548526140
-
Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells
-
Chen, C.L.; Loy, A.; Cen, L.; Chan, C.; Hsieh, F.C.; Cheng, G.; Wu, B.; Qualman, S.J.; Kunisada, K.; Yamauchi-Takihara, K.; Lin, J. Signal transducer and activator of transcription 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells. BMC. Cancer., 2007, 7, 111.
-
(2007)
BMC. Cancer.
, vol.7
, pp. 111
-
-
Chen, C.L.1
Loy, A.2
Cen, L.3
Chan, C.4
Hsieh, F.C.5
Cheng, G.6
Wu, B.7
Qualman, S.J.8
Kunisada, K.9
Yamauchi-Takihara, K.10
Lin, J.11
-
44
-
-
58149267888
-
LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
-
Fuh, B.; Sobo, M.; Cen, L.; Josiah, D.; Hutzen, B.; Cisek, K.; Bhasin, D.; Regan, N.; Lin, L.; Chan, C.; Caldas, H.; DeAngelis, S.; Li, C.; Li, P.K.; Lin, J. LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model. Br. J. Cancer., 2009, 100(1), 106-112.
-
(2009)
Br. J. Cancer.
, vol.100
, Issue.1
, pp. 106-112
-
-
Fuh, B.1
Sobo, M.2
Cen, L.3
Josiah, D.4
Hutzen, B.5
Cisek, K.6
Bhasin, D.7
Regan, N.8
Lin, L.9
Chan, C.10
Caldas, H.11
Deangelis, S.12
Li, C.13
Li, P.K.14
Lin, J.15
-
45
-
-
77951884693
-
LLL-3 a STAT3 inhibitor, represses BCR-ABL-positive cell proliferation, activates apoptosis and improves the effects of Imatinib mesylate
-
Mencalha, A.L.; Du Rocher, B.; Salles, D.; Binato, R.; Abdelhay, E. LLL-3, a STAT3 inhibitor, represses BCR-ABL-positive cell proliferation, activates apoptosis and improves the effects of Imatinib mesylate. Cancer Chemother. Pharmacol., 2010, 65(6), 1039-1046.
-
(2010)
Cancer Chemother. Pharmacol.
, vol.65
, Issue.6
, pp. 1039-1046
-
-
Mencalha, A.L.1
Du Rocher, B.2
Salles, D.3
Binato, R.4
Abdelhay, E.5
-
46
-
-
73949111590
-
A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells
-
Lin, L.; Hutzen, B.; Li, P.K.; Ball, S.; Zuo, M.; DeAngelis, S.; Foust, E.; Sobo, M.; Friedman, L.; Bhasin, D.; Cen, L.; Li, C.; Lin, J. A novel small molecule, LLL12, inhibits STAT3 phosphorylation and activities and exhibits potent growth-suppressive activity in human cancer cells. Neoplasia, 2010, 12(1), 39-50.
-
(2010)
Neoplasia
, vol.12
, Issue.1
, pp. 39-50
-
-
Lin, L.1
Hutzen, B.2
Li, P.K.3
Ball, S.4
Zuo, M.5
Deangelis, S.6
Foust, E.7
Sobo, M.8
Friedman, L.9
Bhasin, D.10
Cen, L.11
Li, C.12
Lin, J.13
-
47
-
-
77954730368
-
A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy
-
Pang, M.; Ma, L.; Gong, R.; Tolbert, E.; Mao, H.; Ponnusamy, M.; Chin, Y.E.; Yan, H.; Dworkin, L.D.; Zhuang, S. A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy. Kidney Int., 2010, 78(3), 257-268.
-
(2010)
Kidney Int.
, vol.78
, Issue.3
, pp. 257-268
-
-
Pang, M.1
Ma, L.2
Gong, R.3
Tolbert, E.4
Mao, H.5
Ponnusamy, M.6
Chin, Y.E.7
Yan, H.8
Dworkin, L.D.9
Zhuang, S.10
-
48
-
-
77649178678
-
A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes. Biochem
-
Zhang, X.; Yue, P.; Fletcher, S.; Zhao, W.; Gunning, P.T.; Turkson, J. A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes. Biochem. Pharmacol., 2010, 79(10), 1398-1409.
-
(2010)
Pharmacol.
, vol.79
, Issue.10
, pp. 1398-1409
-
-
Zhang, X.1
Yue, P.2
Fletcher, S.3
Zhao, W.4
Gunning, P.T.5
Turkson, J.6
-
49
-
-
33750982120
-
Stattic: A Small-Molecule Inhibitor of STAT3 Activation and Dimerization
-
DOI 10.1016/j.chembiol.2006.09.018, PII S1074552106003784
-
Schust, J.; Sperl, B.; Hollis, A.; Mayer, T.U.; Berg, T. Stattic: a smallmolecule inhibitor of STAT3 activation and dimerization. Chem. Biol., 2006, 13(11), 1235-1242. (Pubitemid 44750735)
-
(2006)
Chemistry and Biology
, vol.13
, Issue.11
, pp. 1235-1242
-
-
Schust, J.1
Sperl, B.2
Hollis, A.3
Mayer, T.U.4
Berg, T.5
-
50
-
-
77950190311
-
Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells
-
Lin, L.; Hutzen, B.; Zuo, M.; Ball, S.; Deangelis, S.; Foust, E.; Pandit, B.; Ihnat, M.A.; Shenoy, S.S.; Kulp, S.; Li, P.K.; Li, C.; Fuchs, J.; Lin, J. Novel STAT3 phosphorylation inhibitors exhibit potent growth-suppressive activity in pancreatic and breast cancer cells. Cancer Res., 2010, 70(6), 2445-2454.
-
(2010)
Cancer Res.
, vol.70
, Issue.6
, pp. 2445-2454
-
-
Lin, L.1
Hutzen, B.2
Zuo, M.3
Ball, S.4
Deangelis, S.5
Foust, E.6
Pandit, B.7
Ihnat, M.A.8
Shenoy, S.S.9
Kulp, S.10
Li, P.K.11
Li, C.12
Fuchs, J.13
Lin, J.14
-
51
-
-
64849111865
-
Targeting STAT3 in cancer: How successful are we?
-
Yue, P.; Turkson, J. Targeting STAT3 in cancer: how successful are we? Expert. Opin. Investig. Drugs., 2009, 18(1), 45-56.
-
(2009)
Expert. Opin. Investig. Drugs.
, vol.18
, Issue.1
, pp. 45-56
-
-
Yue, P.1
Turkson, J.2
-
52
-
-
77950945187
-
An unnatural amino acid that mimics phosphotyrosine
-
Ge, J.; Wu, H.; Yao, S.Q. An unnatural amino acid that mimics phosphotyrosine. Chem. Commun (Camb)., 2010, 46(17), 2980-2982.
-
(2010)
Chem. Commun (Camb).
, vol.46
, Issue.17
, pp. 2980-2982
-
-
Ge, J.1
Wu, H.2
Yao, S.Q.3
-
53
-
-
0032499801
-
Three-dimensional structure of the Stat3β homodimer bound to DNA
-
DOI 10.1038/28101
-
Becker, S.; Groner, B.; Muller, C.W. Three-dimensional structure of the Stat3beta homodimer bound to DNA. Nature, 1998, 394(6689), 145-151. (Pubitemid 28325960)
-
(1998)
Nature
, vol.394
, Issue.6689
, pp. 145-151
-
-
Becker, S.1
Groner, B.2
Muller, C.W.3
-
54
-
-
62849104063
-
Chemical probes that competitively and selectively inhibit Stat3 activation
-
Xu, X.; Kasembeli, M.M.; Jiang, X.; Tweardy, B.J.; Tweardy, D.J. Chemical probes that competitively and selectively inhibit Stat3 activation. PLoS. One., 2009, 4(3), e4783.
-
(2009)
PLoS. One.
, vol.4
, Issue.3
-
-
Xu, X.1
Kasembeli, M.M.2
Jiang, X.3
Tweardy, B.J.4
Tweardy, D.J.5
-
55
-
-
38649086742
-
Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target
-
DOI 10.1021/cb700186x
-
Timofeeva, O.A.; Gaponenko, V.; Lockett, S.J.; Tarasov, S.G.; Jiang, S.; Michejda, C.J.; Perantoni, A.O.; Tarasova, N.I. Rationally designed inhibitors identify STAT3 N-domain as a promising anticancer drug target. ACS. Chem. Biol., 2007, 2(12), 799-809. (Pubitemid 351166055)
-
(2007)
ACS Chemical Biology
, vol.2
, Issue.12
, pp. 799-809
-
-
Timofeeva, O.A.1
Gaponenko, V.2
Lockett, S.J.3
Tarasov, S.G.4
Jiang, S.5
Michejda, C.J.6
Perantoni, A.O.7
Tarasova, N.I.8
|