XZH-5 Inhibits STAT3 Phosphorylation and Enhances the Cytotoxicity of Chemotherapeutic Drugs in Human Breast and Pancreatic Cancer Cells

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Liu, Aiguo ^a,b   Liu, Yan ^b,f   Jin, Zhigang ^d   Hu, Qun ^a   Lin, Li ^a,b   Jou, David ^b   Yang, Jing ^d   Xu, Zhenghu ^e   Wang, Hong ^e   Li, Chenglong ^c   Lin, Jiayuh ^b,c  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b NATIONWIDE CHILDREN S HOSPITAL   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^e MIAMI UNIVERSITY   (United States)

^f VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN D1; DOXORUBICIN; GEMCITABINE; INTERLEUKIN 6; MESSENGER RNA; PROTEIN BCL 2; PROTEIN INHIBITOR; STAT3 PROTEIN; SURVIVIN; TYROSINE; UNCLASSIFIED DRUG; XZH 5;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL MIGRATION; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG TARGETING; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PANCREAS CANCER; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; CYCLIN D1; FEMALE; HELA CELLS; HISTIDINE; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INTERLEUKIN-6; MICE; MICE, SCID; PANCREATIC NEOPLASMS; PHENYLUREA COMPOUNDS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR;

EID: 84867046550     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046624     Document Type: Article

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