Androgen up-regulates vascular endothelial growth factor expression in prostate cancer cells via an Sp1 binding site

Molecular Cancer

Volumn 12, Issue 1, 2013, Pages

  Eisermann, Kurtis ^a,c   Broderick, Carly J ^a   Bazarov, Anton ^a   Moazam, Mustafa M ^b   Fraizer, Gail C ^a  

^a KENT STATE UNIVERSITY   (United States)

^b AKRON CHILDREN'S HOSPITAL   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN RECEPTOR; TRANSCRIPTION FACTOR SP1; VASCULOTROPIN;

ARTICLE; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MUTAGENESIS; PROMOTER REGION; PROSTATE CANCER; PROTEIN BINDING; PROTEIN EXPRESSION; UPREGULATION;

ANDROGEN RECEPTOR ANTAGONISTS; ANILIDES; BASE SEQUENCE; BINDING SITES; CELL LINE, TUMOR; CHROMATIN; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; METRIBOLONE; NITRILES; PROMOTER REGIONS, GENETIC; PROSTATIC NEOPLASMS; PROTEIN BINDING; RECEPTORS, ANDROGEN; RESPONSE ELEMENTS; SP1 TRANSCRIPTION FACTOR; TESTOSTERONE CONGENERS; TOSYL COMPOUNDS; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84873041658     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-12-7     Document Type: Article

References (30)

1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA: Cancer J Clin 2010, 60(5):277-300.
2. Levine AC, Liu XH, Greenberg PD, Eliashvili M, Schiff JD, Aaronson SA, Holland JF, Kirschenbaum A. Androgens induce the expression of vascular endothelial growth factor in human fetal prostatic fibroblasts. Endocrinology 1998, 139(11):4672-4678. 10.1210/en.139.11.4672, 9794479.
3. Joseph IB, Nelson JB, Denmeade SR, Isaacs JT. Androgens regulate vascular endothelial growth factor content in normal and malignant prostatic tissue. Clin Cancer Res 1997, 3(12 Pt 1):2507-2511.
4. Li J, Wang E, Rinaldo F, Datta K. Upregulation of VEGF-C by androgen depletion: the involvement of IGF-IR-FOXO pathway. Oncogene 2005, 24(35):5510-5520. 10.1038/sj.onc.1208693, 15897888.
5. Stewart RJ, Panigrahy D, Flynn E, Folkman J. Vascular Endothelial Growth Factor expression and tumor angiogenesis are regulated by androgens in hormone responsive human prostate carcinoma: evidence for androgen dependent destabilization of vascular endothelial growth factor transcripts. J Urol 2001, 165(2):688-693. 10.1097/00005392-200102000-00095, 11176459.
6. Ruiz M, Pettaway C, Song R, Stoeltzing O, Ellis L, Bar-Eli M. Activator protein 2α inhibits tumorigenicity and represses vascular endothelial growth factor transcription in prostate cancer cells. Cancer Res 2004, 64(2):631. 10.1158/0008-5472.CAN-03-2751, 14744778.
7. Hanson J, Gorman J, Reese J, Fraizer G. Regulation of vascular endothelial growth factor, VEGF, gene promoter by the tumor suppressor, WT1. Front Biosci 2007, 12:2279-2290. 10.2741/2230, 2562899, 17127464.
8. McCarty G, Awad O, Loeb DM. WT1 protein directly regulates expression of vascular endothelial growth factor and is a mediator of tumor response to hypoxia. J Biol Chem 2011, 286:43634-43643. 10.1074/jbc.M111.310128, 3243556, 22030397.
9. Lee KH, Kim JR. Hepatocyte growth factor induced up-regulations of VEGF through Egr-1 in hepatocellular carcinoma cells. Clin Exp Metastasis 2009, 26(7):685-692. 10.1007/s10585-009-9266-7, 19526316.
10. Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD, Semenza GL. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 1996, 16(9):4604-4613. 231459, 8756616.
11. Eisermann K, Tandon S, Bazarov A, Brett A, Fraizer G, Piontkivska H. Evolutionary conservation of zinc finger transcription factor binding sites in promoters of genes co-expressed with WT1 in prostate cancer. BMC Genomics 2008, 9:337. 10.1186/1471-2164-9-337, 2515153, 18631392.
12. Finkenzeller G, Sparacio A, Technau A, Marme D, Siemeister G. Sp1 recognition sites in the proximal promoter of the human vascular endothelial growth factor gene are essential for platelet-derived growth factor-induced gene expression. Oncogene 1997, 15(6):669-676. 10.1038/sj.onc.1201219, 9264407.
13. Stoner M, Wormke M, Saville B, Samudio I, Qin C, Abdelrahim M, Safe S. Estrogen regulation of vascular endothelial growth factor gene expression in ZR-75 breast cancer cells through interaction of estrogen receptor a and SP proteins. Oncogene 2004, 23:1052-1063. 10.1038/sj.onc.1207201, 14647449.
14. Akiyama H, Tanaka T, Maeno T, Kanai H, Kimura Y, Kishi S, Kurabayashi M. Induction of VEGF gene expression by retinoic acid through Sp1-binding sites in retinoblastoma Y79 cells. Invest Ophthalmol Vis Sci 2002, 43(5):1367.
15. Maeno T, Tanaka T, Sando Y, Suga T, Maeno Y, Nakagawa J, Hosono T, Sato M, Akiyama H, Kishi S. Stimulation of vascular endothelial growth factor gene transcription by all trans retinoic acid through spl and sp3 sites in human bronchioloalveolarcarcinoma cells. Am J Respir Cell Mol Biol 2002, 26(2):246-253. 10.1165/ajrcmb.26.2.4509, 11804877.
16. Shi Q, Le X, Abbruzzese JL, Peng Z, Qian CN, Tang H, Xiong Q, Wang B, Li XC, Xie K. Constitutive Sp1 activity is essential for differential constitutive expression of vascular endothelial growth factor in human pancreatic adenocarcinoma 1. Cancer Res 2001, 61(10):4143-4154.
17. Black AR, Black JD, Azizkhan-Clifford J. Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer. J Cell Physiol 2001, 188(2):143-160. 10.1002/jcp.1111, 11424081.
18. Li L, He S, Sun JM, Davie JR. Gene regulation by Sp1 and Sp3. Biochem Cell Biol 2004, 82(4):460-471. 10.1139/o04-045, 15284899.
19. Ryuto M, Ono M, Izumi H, Yoshida S, Weich HA, Kohno K, Kuwano M. Induction of vascular endothelial growth factor by tumor necrosis factor α in human glioma cells. J Biol Chem 1996, 271(45):28220. 10.1074/jbc.271.45.28220, 8910439.
20. Tanaka T, Kanai H, Sekiguchi K, Aihara Y, Yokoyama T, Arai M, Kanda T, Nagai R, Kurabayashi M. Induction of VEGF gene transcription by IL-1 [beta] is mediated through stress-activated MAP kinases and Sp1 sites in cardiac myocytes. J Mol Cell Cardiol 2000, 32(11):1955-1967. 10.1006/jmcc.2000.1228, 11040101.
21. Benckert C, Jonas S, Cramer T, von Marschall Z, Schäfer G, Peters M, Wagner K, Radke C, Wiedenmann B, Neuhaus P. Transforming growth factor β1 stimulates vascular endothelial growth factor gene transcription in human cholangiocellular carcinoma cells. Cancer Res 2003, 63(5):1083.
22. Abdelrahim M, Smith R, Burghardt R, Safe S. Role of Sp proteins in regulation of vascular endothelial growth factor expression and proliferation of pancreatic cancer cells. Cancer Res 2004, 64(18):6740-6749. 10.1158/0008-5472.CAN-04-0713, 15374992.
23. Mabjeesh NJ, Willard MT, Frederickson CE, Zhong H, Simons JW. Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3′-kinase/protein kinase B in prostate cancer cells. Clin Cancer Res 2003, 9(7):2416.
24. Eisermann K, Bazarov A, Brett A, Knapp E, Piontkivska H, Fraizer G. Uncovering Androgen responsive regulatory networks in prostate cancer. Proceedings of the Ohio Collaborative Conference on Bioinformatics 2009, 99-103. Washington, DC: IEEE Computer Society, 978-0-7695-3685-9.
25. Lu S, Jenster G, Epner DE. Androgen induction of cyclin-dependent kinase inhibitor p21 gene: role of androgen receptor and transcription factor Sp1 complex. Mol Endocrinol 2000, 14(5):753-760. 10.1210/me.14.5.753, 10809237.
26. Cleutjens KBJM, van der Korput HAGM, van Eekelen CCEM, van Rooij HCJ, Faber PW, Trapman J. An androgen response element in a far upstream enhancer region is essential for high, androgen-regulated activity of the prostate-specific antigen promoter. Mol Endocrinol 1997, 11(2):148. 10.1210/me.11.2.148, 9013762.
27. Schäfer G, Cramer T, Suske G, Kemmner W, Wiedenmann B, Höcker M. Oxidative stress regulates vascular endothelial growth factor-a gene transcription through Sp1-and Sp3-dependent activation of two proximal GC-rich promoter elements. J Biol Chem 2003, 278(10):8190. 10.1074/jbc.M211999200, 12509426.
28. Perez-Stable CM, Pozas A, Roos BA. A role for GATA transcription factors in the androgen regulation of the prostate-specific antigen gene enhancer. Mol Cell Endocrinol 2000, 167(1-2):43-53.
29. Chen PH, Tsao YP, Wang CC, Chen SL. Nuclear receptor interaction protein, a coactivator of androgen receptors (AR), is regulated by AR and Sp1 to feed forward and activate its own gene expression through AR protein stability. Nucleic Acids Res 2008, 36(1):51-66. 2248731, 17984071.
30. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25(4):402-408. 10.1006/meth.2001.1262, 11846609.