Therapeutic potential of leptin receptor modulators

European Journal of Medicinal Chemistry

Volumn 78, Issue , 2014, Pages 97-105

  Leggio, Antonella ^a   Catalano, Stefania ^a   De Marco, Rosaria ^a   Barone, Ines ^a   Andò, Sebastiano ^a   Liguori, Angelo ^a  

^a UNIVERSITY OF CALABRIA   (Italy)

Author keywords

Agonists; Antagonists; Leptin; Leptin receptor; Leptin receptor modulators; Leptin related diseases

Indexed keywords

ANTIOBESITY AGENT; LEPTIN; LEPTIN MUTEIN; LEPTIN PEPTIDE MODULATOR; LEPTIN RECEPTOR; LEPTIN RECEPTOR ANTIBODY; NANOBODY; NORVALINE; POLYCLONAL ANTIBODY; RECEPTOR ANTIBODY; RECOMBINANT RECEPTOR; SMALL MOLECULE LEPTIN MODULATOR; UNCLASSIFIED DRUG; HETEROCYCLIC COMPOUND; MOLECULAR LIBRARY;

DRUG ACTIVITY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; NONHUMAN; REVIEW; SIGNAL TRANSDUCTION; SYSTEMATIC REVIEW; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR LIBRARY; PHARMACOLOGY; THERAPEUTIC USE;

ANIMALS; HETEROCYCLIC COMPOUNDS; HUMANS; LEPTIN; MODELS, MOLECULAR; RECEPTORS, LEPTIN; SMALL MOLECULE LIBRARIES;

EID: 84897053105     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.03.048     Document Type: Review

References (95)

1. Y. Zhang, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J.M. Friedman Positional cloning of the mouse obese gene and its human homologue Nature 372 1994 425 432
2. T. Madej, M.S. Boguski, and S.H. Bryant Threading analysis suggests that the obese gene product may be a helical cytokine FEBS Letters 373 1995 13 18
3. F. Zhang, M.B. Basinski, J.M. Beals, S.L. Briggs, L.M. Churgay, D.K. Clawson, R.D. DiMarchi, T.C. Furman, J.E. Hale, H.M. Hsiung, B.E. Schoner, D.P. Smith, X.Y. Zhang, J.-P. Wery, and R.W. Schevitz Crystal structure of the obese protein leptin-E100 Nature 387 1997 206 209
4. F. Peelman, K. Van Beneden, L. Zabeau, H. Iserentant, P. Ulrichts, D. Defeau, A. Verhee, D. Catteeuw, D. Elewaut, and J. Tavernier Mapping of the leptin binding sites and design of a leptin antagonist Journal of Biological Chemistry 279 2004 41038 41046
5. M.W. Schwartz, S.C. Woods, D. Porte Jr., R.J. Seeley, and D.G. Baskin Central nervous system control of food intake Nature 404 2000 661 671
6. C.F. Elias, C. Aschkenasi, C. Lee, J. Kelly, R.S. Ahima, C. Bjorbæk, J.S. Flier, C.B. Saper, and J.K. Elmquist Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area Neuron 23 1999 775 786
7. L.A. Tartaglia, M. Demski, X. Weng, N. Deng, J. Culpepper, S. Sanker, A. Moriarty, K.J. Moore, J.S. Smutko, G.G. Mays, E.A. Woolf, C.A. Monroe, and R.I. Tepper Identification and expression cloning of a leptin receptor, OB-R Cell 83 1995 1263 1271
8. G.-H. Lee, R. Proenca, J.M. Montez, K.M. Carrol, J.G. Darvishzadeh, J.I. Lee, and J.M. Friedman Abnormal splicing of the leptin receptor in diabetic mice Nature 379 1996 632 635
9. B.B. Kahn, and J.S. Flier Obesity and insulin resistance Journal of Clinical Investigation 106 2000 473 481
10. T.A. Dardeno, S.H. Chou, H.S. Moon, J.P. Chamberland, C.G. Fiorenza, and C.S. Mantzoros Leptin in human physiology and therapeutics Frontiers in Neuroendocrinology 31 2010 377 393
11. S. Margetic, C. Gazzola, G.G. Pegg, and R.A. Hill Leptin: a review of its peripheral actions and interactions International Journal of Obesity 26 2002 1407 1433
12. M. Karmazyn, D.M. Purdham, V. Rajapurohitam, and A. Zeidan Leptin as a cardiac hypertrophic factor: a potential target for therapeutics Trends in Cardiovascular Medicine 17 2007 206 211
13. F. Peelman, W. Waelput, H. Iserentant, D. Lavens, S. Eyckerman, L. Zabeau, and J. Tavernier Leptin: linking adipocyte metabolism with cardiovascular and autoimmune diseases Progress in Lipid Research 43 2004 283 301
14. A. La Cava, and G. Matarese The weight of leptin in immunity Nature Reviews Immunology 4 2004 371 379
15. G. Matarese, S. Moschos, and C.S. Mantzoros Leptin in immunology Journal of Immunology 174 2005 3137 3142
16. K. Ikejima, Y. Takei, H. Honda, M. Hirose, M. Yoshikawa, Y.J. Zhang, T. Lang, T. Fukuda, S. Yamashina, T. Kitamura, and N. Sato Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat Gastroenterology 122 2002 1399 1410
17. C. Garofalo, and E. Surmacz Leptin and cancer Journal of Cellular Physiology 207 2006 12 22
18. S. Andò, and S. Catalano The multifactorial role of leptin in driving the breast cancer microenvironment Nature Reviews Endocrinology 8 2012 263 275
19. X. Hu, S.C. Juneja, N.J. Maihle, and M.P. Cleary Leptin-A growth factor in normal and malignant breast cells and for normal mammary gland development Journal of the National Cancer Institute 94 2002 1704 1711
20. P. Somasundar, A.K. Yu, L. Vona-Davis, and D.W. McFadden Differential effects of leptin on cancer in vitro Journal of Surgical Research 113 2003 50 55
21. L. Mauro, S. Catalano, G. Bossi, M. Pellegrino, I. Barone, S. Morales, C. Giordano, V. Bartella, I. Casaburi, and S. Andò Evidences that leptin up-regulates E-cadherin expression in breast cancer: effects on tumor growth and progression Cancer Research 67 2007 3412 3421
22. S. Catalano, C. Giordano, P. Rizza, G. Gu, I. Barone, D. Bonofiglio, F. Giordano, R. Malivindi, D. Gaccione, M. Lanzino, F. De Amicis, and S. Andò Evidence that leptin through STAT and CREB signaling enhances cyclin D1 expression and promotes human endometrial cancer proliferation Journal of Cellular Physiology 218 2009 490 500
23. Z. Liu, T. Uesaka, H. Watanabe, and N. ato High fat diet enhances colonic cell proliferation and carcinogenesis in rats by elevating serum leptin International Journal of Oncology 19 2001 1009 1014
24. S. Catalano, S. Marsico, C. Giordano, L. Mauro, P. Rizza, M.L. Panno, and S. Andò Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line Journal of Biological Chemistry 278 2003 28668 28676
25. S. Catalano, L. Mauro, S. Marsico, C. Giordano, P. Rizza, V. Rago, D. Montanaro, M. Maggiolini, M.L. Panno, and S. Andò Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor α in MCF-7 cells Journal of Biological Chemistry 279 2004 19908 19915
26. I. Barone, S. Catalano, L. Gelsomino, S. Marsico, C. Giordano, S. Panza, D. Bonofiglio, G. Bossi, K.R. Covington, S. Fuqua, and S. Andò Leptin mediates tumor-stromal interactions that promote the invasive growth of breast cancer cells Cancer Research 72 2012 1416 1427
27. E. Fiorio, A. Mercanti, M. Terrasi, R. Micciolo, A. Remo, A. Auriemma, A. Molino, V. Parolin, B. Di Stefano, F. Bonetti, A. Giordano, G.L. Cetto, and E. Surmacz Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis BMC Cancer 8 2008 305
28. D. Soma, J. Kitayama, H. Yamashita, H. Miyato, M. Ishikawa, and H. Nagawa Leptin augments proliferation of breast cancer cells via transactivation of HER2 Journal of Surgical Research 149 2008 9 14
29. C. Giordano, D. Vizza, S. Panza, I. Barone, D. Bonofiglio, M. Lanzino, D. Sisci, F. De Amicis, S.A.W. Fuqua, S. Catalano, and S. Andò Leptin increases HER2 protein levels through a STAT3-mediated up-regulation of Hsp90 in breast cancer cells Molecular Oncology 7 2013 379 391
30. N.K. Saxena, L. Taliaferro-Smith, B.B. Knight, D. Merlin, F.A. Anania, R.M. O'Regan, and D. Sharma Bidirectional crosstalk between leptin and insulin-like growth factor-i signaling promotes invasion and migration of breast cancer cells via transactivation of epidermal growth factor receptor Cancer Research 68 2008 9712 9722
31. E. Surmacz Leptin and adiponectin: emerging therapeutic targets in breastcancer Journal of Mammary Gland Biology and Neoplasia 18 2013 321 332
32. D. Cirillo, A.M. Ranchiglio, R. La Montagna, A. Giordano, and N. Normanno Leptin signaling in breast cancer: an overview Journal of Cellular Biochemistry 105 2008 956 964
33. H. Iserant, F. Peelman, D. Defeau, J. Vandekerckhove, L. Zabeau, and J. Tavernier Mapping of the interface between leptin and the leptin receptor CRH2 domain Journal of Cell Science 118 2005 2519 2527
34. L. Niv-Spector, N. Raver, M. Friedman-Einat, J. Grosclaude, E.E. Gussakovsky, O. Livnah, and A. Gertler Mapping leptin-interacting sites in recombinant leptin-binding domain (LBD) subcloned from chicken leptin receptor Biochemical Journal 390 2005 475 484
35. L. Zabeau, D. Defeau, J. Van der Heyden, H. Iserentant, J. Vandekerckhove, and J. Tavernier Functional analysis of leptin receptor activation using a Janus kinase/signal transducer and activator of transcription complementation assay Molecular Endocrinology 18 2004 150 161
36. T.M. Fong, R.R. Huang, M.R. Tota, C. Mao, T. Smith, J. Varnerin, V.V. Karpitskiy, J.E. Krause, and L.H. Van der Ploeg Localization of leptin binding domain in the leptin receptor Molecular Pharmacology 53 1998 234 240
37. F. Peelman, H. Iserentant, A.S. De Smet, J. Vandekerckhove, L. Zabeau, and J. Tavernier Mapping of binding site III in the leptin receptor and modeling of a hexameric leptin-leptin receptor complex Journal of Biological Chemistry 281 2006 15496 15504
38. L. Zabeau, D. Defeau, H. Iserentant, J. Vandekerckhove, F. Peelman, and J. Tavernier Leptin receptor activation depends on critical cysteine residues in its fibronectin type III subdomains Journal of Biological Chemistry 280 2005 22632 22640
39. C. Couturier, and R. Jockers Activation of the leptin receptor by a ligand-induced conformational change of constitutive receptor dimers Journal of Biological Chemistry 278 2003 26604 26611
40. Y. Gong, R. Ishida-Takahashi, E.C. Villanueva, D.C. Fingar, H. Munzberg, and M.G. Myers Jr. The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms Journal of Biological Chemistry 282 2007 31019 31027
41. L. Jiang, J. You, X. Yu, Q. Wang, G. Yang, W. Li, C. Li, and Y. Liu Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis Proceedings of the National Academy of Sciences of the United States of America 105 2008 18619 18624
42. S.H. Bates, W.H. Srearns, T.A. Dundon, M. Schubert, A.W. Tso, Y. Wang, A.S. Banks, H.J. Lavery, A.K. Haq, E. Maratos-Flier, B.G. Neel, M.W. Schwartz, and M.G. Myers Jr. STAT3 signaling is required for leptin regulation of energy balance but not reproduction Nature 421 2003 856 859
43. C. Li, and J.M. Friedman Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction Proceedings of the National Academy of Sciences of the United States of America 96 1999 9677 9682
44. E.E. Zhang, E. Chapeau, K. Hagihara, and G.S. Feng Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism Proceedings of the National Academy of Sciences of the United States of America 101 2004 16064 16069
45. C.R. Bjorbaek, R.M. Buchholz, S.M. Davis, S.H. Bates, D.D. Pierroz, H. Gu, B.J. Neel, M.G. Myers Jr., and J.S. Flier Divergent roles of SHP-2 in ERK activation by leptin receptors Journal of Biological Chemistry 276 2001 4747 4755
46. 985 Journal of Biological Chemistry 275 2000 40649 40657
47. 1138 of the leptin receptor and suppressor of cytokine signaling 3 Molecular Endocrinology 19 2005 925 938
48. S.A. Verploegen, G. Plaetinck, R. Devos, J. Van der Heyden, and Y. Guisez A human leptin mutant induces weight gain in normal mice FEBS Letters 405 1997 237 240
49. L. Brunner, S. Whitebread, I. Leconte, A. Stricker-Krongrad, F. Cumin, M. Chiesi, and N. Levens A peptide leptin antagonist reduces food intake in rodents International Journal of Obesity 23 1999 463 469
50. L. Niv-Spector, D. Gonen-Berger, I. Gourdou, E. Biener, E.E. Gussakovsky, Y. Benomar, K.V. Ramanujan, M. Taouis, B. Herman, I. Callebaut, J. Djiane, and A. Gertler Identification of the hydrophobic strand in the A-B loop of leptin as major binding site III: implications for large-scale preparation of potent recombinant human and ovine leptin antagonists Biochemical Journal 391 2005 221 230
51. G. Salomon, L. Niv-Spector, E.E. Gussakovsky, and A. Gertler Large-scale preparation of biologically active mouse and rat leptins and their L39A/D40A/F41A muteins which act as potent antagonists Protein Expression and Purification 47 2006 128 136
52. A. Gertler, E. Elinav, Z. Halpern, High Affinity Leptins and Leptin Antagonists, Patent WO2011/132189 A2, 2011.
53. M. Shpilman, L. Niv-Spector, M. Katz, C. Varol, G. Solomon, M. Ayalon-Soffer, E. Boder, Z. Halpern, E. Elinav, and A. Gertler Development and characterization of high affinity leptins and leptin antagonists Journal of Biological Chemistry 286 2011 4429 4442
54. L. Niv-Spector, M. Shpilman, Y. Boisclair, and A. Gertler Large-scale preparation and characterization of non-pegylated and pegylated superactive ovine leptin antagonist Protein Expression and Purification 81 2012 186 192
55. P. Grasso, M.C. Leinung, S.P. Ingher, and D.W. Lee In vivo effects of leptin-related synthetic peptides on body weight and food intake in female ob/ob mice: localization of leptin activity to domains between amino acid residues 106-140 Endocrinology 138 1997 1413 1418
56. P. Grasso, D.W. White, L.A. Tartaglia, M.C. Leinung, and D.W. Lee Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor Diabetes 48 1999 2204 2209
57. 116-130 stimulates prolactin and luteinizing hormone secretion in fasted adult male rats Neuroendocrinology 70 1999 213 220
58. L.K. Malendowicz, G.G. Nussdorfer, and A. Markowska Effects of recombinant murine leptin on steroid secretion of dispersed rat adrenocortical cells Journal of Steroid Biochemistry and Molecular Biology 63 1997 123 125
59. M. Rozhavskaya-Arena, D.W. Lee, M.C. Leinung, and P. Grasso Design of a synthetic leptin agonist: effects on energy balance, glucose homeostasis, and thermoregulation Endocrinology 141 2000 2501 2507
60. W.K. Samson, T.C. Murphy, D. Robison, T. Vargas, E. Tau, and J.K. Chang A 35 amino acid fragment of leptin inhibits feeding in the rat Endocrinology 137 1996 5182 5185
61. A. Markowska, A.S. Belloni, M. Rucinski, A.R. Parenti, G.B. Nardelli, K. Drews, G.G. Nussdorfer, and L.K. Malendowicz Leptin and leptin receptor expression in the myometrium and uterine myomas: is leptin involved in tumor development? International Journal of Oncology 27 2005 1505 1509
62. R.R. Gonzalez, and P.C. Leavis A peptide derived from the human leptin molecule is a potent inhibitor of the leptin receptor function in rabbit endometrial cells Endocrine 21 2003 185 195
63. R.R. Gonzales, B.R. Rueda, M.P. Ramos, R.D. Littell, S. Glasser, and P.C. Leavis Leptin-induced increase in leukemia inhibitory factor and its receptor by human endometrium is partially mediated by interleukin 1 receptor signaling Endocrinology 145 2004 3850 3857
64. R.R. Gonzalez, A. Watters, Y. Xu, U.P. Singh, D.R. Mann, B.R. Rueda, and M.L. Penichet Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer Breast Cancer Research 11 2009 R36
65. R.R Gonzalez, P.C. Leavis, Leptin Peptide Antagonists, Patent WO 110461 A3, 2005.
66. M.P. Ramos, B.R. Rueda, P.C. Leavis, and R.R. Gonzales Leptin serves as an upstream activator of an obligatory signaling cascade in the embryo-implantation process Endocrinology 146 2005 694 701
67. P.C. Leavis, Novel Retro-inverso Leptin Peptide Antagonists, Patent WO 129228 A2, 2012.
68. L. Otvos Jr., M. Terrasi, S. Cascio, M. Cassone, G. Abadessa, F. De Pascali, L. Scolaro, D. Knappe, M. Stawikowski, P. Cudic, J.D. Wade, R. Hoffmann, and E. Surmacz Development of a pharmacologically improved peptide agonist of the leptin receptor Biochimica et Biophysica Acta 1783 2008 1745 1754
69. L. Otvos Jr., I. Kovalszky, L. Scolaro, A. Sztodola, J. Olah, M. Cassone, D. Knappe, R. Hoffmann, S. Lovas, M.P.D. Hatfield, G. Beko, S. Zhang, G.D. Wade, and E. Surmacz Peptide-based leptin receptor antagonists for cancer treatment and appetite regulation Biopolymers (Peptide Science) 96 2011 117 125
70. L. Otvos Jr., I. Kovalszky, M. Riolfi, R. Ferla, J. Olah, A. Sztodola, K. Nama, A. Molino, Q. Piubello, J.D. Wade, and E. Surmacz Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer European Journal of Cancer 47 2011 1578 1584
71. L. Otvos Jr., and E. Surmacz Targeting the leptin receptor: a potential new mode of treatment for breast cancer Expert Review of Anticancer Therapy 11 2011 1147 1150
72. L. Scolaro, C. Parrino, R. Coroniti, L. Otvos Jr., and E. Surmacz Exploring leptin antagonism in ophthalmic cell models Plos One 8 2013 e76437
73. S. Beccari, I. Kovalszky, G.D. Wade, L. Otvos Jr., and E. Surmacz Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity Peptides 44 2013 127 134
74. D. Bevec, F. Cavalli, V. Cavalli, G. Bacher, Use of glpl (7-36) Alone or in Combination with Leptin 22-56 as a Therapeutic Agent, Patent WO 2009/043477 A3, 2009.
75. D. Bevec, F. Cavalli, V. Cavalli, G. Bacher, Use of Leptin (22-56) as a Therapeutic Agent, Patent US 2010/0210536 A1, 2010.
76. J.-P. Castaigne, M. Demeule, D. Boivin, B. Lawrence, C. Che, Leptin and Leptin Analog Conjugates and Fusion Proteins and Uses Thereof, Patent WO 153642 A1, 2011.
77. J.-P. Castaigne, M. Demeule, D. Boivin, B. Lawrence, C. Che, Leptin and Leptin Analog Conjugates and Uses Thereof, Patent WO 063123, 2010.
78. V.X. de Oliveira Jr., M.A. Fazio, E.L. Santos, J.B. Pesquero, and A. Miranda In vitro evaluation of leptin fragments activity on the ob receptor Journal of Peptide Science 14 2008 617 625
79. M.N. Martins, M.M. Telles, J.C. Zemdegs, I.S. Andrade, E.B. Ribeiro, and A. Miranda Evaluation of new leptin fragments on food intake and body weight of normal rats Regulatory Peptides 153 2009 77 82
80. C.C. Dias, A. Nogueira-Pedro, C.M.V. Barbosa, A.C. Ribeiro-Filho, F. Wasinski, R.C. Araujo, V.X. de Oliveira Jr., A. Miranda, and E.J. Paredes-Gamero Hematopoietic stem cell expansion caused by a synthetic fragment of leptin Peptides 50 2013 24 27
81. V. Kraynov, A.-M.A. Putman, N. Knudsen, J. Pinkstaff, H. Myler, L. Sullivan, Modified Leptin Polypeptides and Their Uses, Patent WO 100225 A2, 2009.
82. A. Deb, M. Zamanian-Daryoush, Z. Xu, S. Kadereit, and B.R. Williams Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3 EMBO Journal 20 2001 2487 2496
83. T. Hosoi, N. Matsunami, T. Nagahama, Y. Okuma, K. Ozawa, T. Takizawa, and Y. Nomura 2-Aminopurine inhibits leptin receptor signal transduction European Journal of Pharmacology 553 2006 61 66
84. I. Simpson, M. Higginbottom, E. Chapman, A.V.-A. Horgan, Small Molecule Leptin Receptor Modulators, Patent WO 147221, 2009.
85. M. Higginbottom, I. Simpson, J. Horton, C. Tyzack, A.V.-A. Horgan, New Pyridine Derivatives as Leptin Receptor Modulator Mimetics, Patent WO 147216, 2009.
86. N. Kawaji, A. Yoshida, T. Motoyashiki, T. Morita, and H. Ueki Anti-leptin receptor antibody mimics the stimulation of lipolysis induced by leptin in isolated mouse fat pads Journal of Lipid Research 42 2001 1671 1677
87. V. Sanna, A. Di Giacomo, A. La Cava, R.I. Lechler, S. Fontana, S. Zappacosta, and G. Matarese Leptin surge precedes onset of autoimmune encephalomyelitis and correlates with development of pathogenic T cell responses Journal of Clinical Investigation 111 2003 241 250
88. P.O. Iversen, C.A. Drevon, and J.E. Reseland Prevention of leptin binding to its receptor suppresses rat leukemic cell growth by inhibiting angiogenesis Blood 100 2002 4123 4128
89. A. Zeidan, S. Javados, S. Chakrabarti, and M. Karmazyn Leptin-induced cardiomyocyte hypertrophy involves selective caveolae and RhoA/ROCK-dependent p38 MAPK translocation to nuclei Cardiovascular Research 77 2008 64 72
90. + regulatory T cells Proceedings of the National Academy of Sciences of the United States of America 102 2005 5150 5155
91. V. De Rosa, C. Procaccini, A. La Cava, P. Chieffi, G.F. Nicoletti, S. Fontana, S. Zappacosta, and G. Matarese Leptin neutralization interferes with pathogenic T cell autoreactivity in autoimmune encephalomyelitis Journal of Clinical Investigation 116 2006 447 455
92. M. Fazeli, H. Zarkesh-Esfahani, Z. Wu, M. Maamra, M. Bidlingmaier, A.G. Pockley, P. Watson, G. Matarese, C.J. Strasburger, and R.J.M. Ross Identification of a monoclonal antibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation Journal of Immunological Methods 312 2006 190 200
93. R. Fusco, M. Galgani, C. Procaccini, R. Franco, G. Pirozzi, L. Fucci, P. Laccetti, and G. Matarese Cellular and molecular crosstalk between leptin receptor and estrogen receptor-alpha in breast cancer: molecular basis for a novel therapeutic setting Endocrine-Related Cancer 17 2010 373 382
94. B. Carpenter, G.R. Hemsworth, Z. Wu, M. Maamra, C.J. Strasburger, R.J. Ross, and P.J. Artymiuk Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody Structure 20 2012 487 497
95. L. Zabeau, A. Verhee, D. Catteeuw, L. Faes, S. Seeuws, T. Decruy, D. Elewaut, F. Peelman, and J. Tavernier Selection of non-competitive leptin antagonists using a random nanobody-based approach Biochemical Journal 441 2012 425 434