Leptin and leptin receptor expression in the myometrium and uterine myomas: Is leptin involved in tumor development?

International Journal of Oncology

Volumn 27, Issue 6, 2005, Pages 1505-1509

  Markowska, Anna ^a   Belloni, Anna Sandra ^b   Ructnski, Marcin ^a   Parenti, Anna R ^b   Nardelli, Giovan Battista ^b   Drews, Krzysztof ^a   Nussdorfer, Gastone G ^b   Malendowicz, Ludwik K ^a  

^a POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Cell proliferation; Leptin; Leptin receptors; Uterine myomas

Indexed keywords

CELL SURFACE RECEPTOR; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA;

ARTICLE; CELL CULTURE; CELL PROLIFERATION; CHEMISTRY; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; FEMALE; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MYOMA; MYOMETRIUM; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UTERUS CANCER; WESTERN BLOTTING;

BLOTTING, WESTERN; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LEPTIN; MYOMA; MYOMETRIUM; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR CELLS, CULTURED; UTERINE NEOPLASMS;

EID: 27744493498     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L and Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 374: 479, 1995.
2. Mantzoros CS: The role of human obesity and disease: a review of current evidence. Ann Intern Med 130: 671-680,1999.
3. Ahima RS and Flier JS: Leptin. Annu Rev Physiol 62: 413-437, 2000.
4. Ahima RS, Saper CB, Flier IS and Elmquist IK: Leptin regulation of neuroendocrine system. Front Neuroendocrine] 21: 263-307, 2000.
5. Scappaticci FA: Mechanisms and future directions for angiogenesis-based cancer therapies. I Clin Oncol 20: 3906-3927, 2002.
6. Sweeny G: Leptin signaling. Cell Signal 14: 655-663, 2002.
7. Stewart EA: Uterine fibroids. Lancet 357: 293-298,2001.
8. Vollenhoven B, Lawrence AS and Healy DL: Uterine fibroids: a clinical review. Br J Obstet Gynecol 97: 285-289,1999.
9. Parazzini F, Negri E and La Vecchina C: Uterine myomas and smoking: result from an Italian study. J Reprod Med 41: 316-320, 1996.
10. Sato F, Nishi M, Kudo R and Miyake H: Body fat distribution and uterine leiomyomas. J Epidemiol 8: 176-180,1998.
11. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian IP, Marco CC, McKee LI, Bauer TL and Caro IF: Serum immunoreactive-leptin concentrations in normal-weight and obese human. N Engl I Med 334:292-295,1996.
12. Baumgartner RN, Waters DL, Morley IE, Patrick P, Montoya D and Garry PI: Age-related changes in sex hormones affects the sex difference in serum leptin independently of changes in body fat. Metabolism 48: 378-384,1999.
13. Mann DR, lohnson AOK, Gimpel T and Castracane VD: Changes in circulating leptin, leptin receptor, and gonadal hormones from infancy until advanced age in humans. I Clin Endocrinol Metab 88: 3339-3345,2003.
14. Yoshimitsu N, Douchi T and Nagata Y: Perioperative changes in circulating leptin levels in women undergoing total abdominal hysterectomy. Endocrine 148: 509-513, 2001.
15. Albertin G, Carraro G, Petrelli L, Guidolin D, Neri G and Nussdorfer GG: Endothelin-1 and adrenomedullin enhance the growth of human adrenocortical carcinoma-derived SW-13 cell line by stimulating proliferation and inhibiting apoptosis. Int J Mol Med 15: 469-474, 2005.
16. Mazzocchi G, Rossi GP, Neri G, Malendowicz LK, Albertin G and Nussdorfer GG: 116-Hydroxysteroid dehydrogenase expression and activity in the human adrenal cortex. FASEB 112: 1533-1539, 1998.
17. Ziolkowska A, Rucinski M, Neri G, Di Liddo R, Nussdorfer GG and Malendowicz LK: Expression of the beacon gene in the rat adrenal gland: direct inhibitory effect of beacon [47-73] on aldosterone secretion from dispersed adrenal zona glomerulosa cells. Int I Mol Med 13: 215-219,2004.
18. Mazzocchi G, Malendowicz LK, Ziolkowska A, Spinazzi R, Rebuffat P, Aragona F, Ferrazzi E, Parnigotto PP and Nussdorfer GG: Adrenomedullin (AM) and AM receptor type 2 expression is up-regulated in prostate carcinomas (PC), and AM stimulates in vitro growth of a PC-derived cell line by enhancing proliferation and decreasing apoptosis rates. Int J Oncol 25: 1781-1787,2004.
19. Spinazzi R, Rucinski M, Neri G, Malendowicz LK and Nussdorfer GG: Preproorexin and orexin receptors are expressed in Cortisol secreting adrenocortical adenomas, and orexins stimulate in vitro Cortisol secretion and growth of tumor cells. J Clin Endocrinol Metab 90: 3544-3549, 2005.
20. Belloni AS, Guidolin D, Ceretta S, Bova S and Nussdorfer GG: Acute effects of endothelins on endogenous adrenomedullin system in the rat heart: immunocytochemical and autoradiographic studies. Int I Mol Med 13: 669-674, 2004.
21. Mazzocchi G, Neri G, Rucinski M, Rebuffat P, Spinazzi R, Malendowicz LK and Nussdorfer GG: Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects. Peptides 25: 1269-1277, 2004.
22. Malendowicz LK, Rebuffat P, Tortorella C, Nussdorfer GG, Ziolkowska A and Hochol A: Effects of met-enkephalin on cell proliferation in different models of adrenocortical-cell growth. Int J Mol Med 15: 841-845, 2005.
23. Nowicki M, Adamkiewicz G, Brye W and Kokot F: The influence of luteinizing hormone-releasing hormone analog on serum leptin and body composition in women with solitary uterine myoma. Am J Obstet Gynecol 186: 340-344,2002.
24. Oda A, Taniguchi T and Yokoyma M: Leptin stimulates rat aortic smooth muscle cell proliferation and migration. Kobe J Med Sci 47: 141-150,2001.
25. Malendowicz LK, Neri G, Jedrzejczak N, Hochol A and Nussdorfer GG: Effects of recombinant murine leptin(1-147) and leptin fragment 116-130 on steroid secretion and proliferative activity of the regenerating rat adrenal cortex. Endocr Res 26: 109-118,2000.
26. Wu MH, Chuang PC, Chen HM, Lin CC and Tsai SJ: Increased leptin expression in endometriosis cells in associated with endometrial stromal cell proliferation and leptin gene up-regulation. Mol Hum Reprod 8: 456-564, 2002.
27. Markowska A, Neri G, Hochol A, Nowak M, Nussdorfer GG and Malendowicz LK: Effects of leptin and leptin fragments on steroid secretion and proliferative activity of regenerating rat adrenal cortex. Int J Mol Med 13: 139-141,2004.
28. Andersen J: Growth factors and cytokines in uterine leiomyomas. Semin Reprod Endocrinol 14: 268-282,1996.
29. Senturk LM, Sozen J, Gutierrez L and Arici A: Interleukin-8 production and interleukin-8 receptor expression in human myometrium and leiomyoma. Am J Obstet Gynecol 184: 559-566,2001.
30. Park HY, Kwon HM, Lim HI, Hong BK, Lee IY, Park BE, Jang Y, Cho SY and Kim HS: Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro. Exp Mol Med 33: 95-102, 2001.
31. Ribatti D, Nico B, Belloni AS, Vacca A, Roncali L and Nussdorfer GG: Angiogenic activity of leptin in the chick embryo chorioallantoic membrane is in part mediated by endogenous fibroblast growth factor-2. Int J Mol Med 8: 265-268,2001.
32. Lima-Couy I, Cervero A, Bonilla-Musoles F, Pellicer A and Simon C: Endometrial leptin and leptin receptor expression in women with severe/moderate endometriosis. Mol Hum Reprod 10:777-782,2004.
33. Petridou E, Belechri M, Dessypris N, Konkoulomatis P, Diakomanolis E, Spanos E and Trichopoulos D: Leptin and body mass index in relation to endometrial cancer risk. Ann Nutrit Metab 46: 147-151, 2000.
34. Metalliotakis IM, Koumantaki YG, Neonaki MA, Goumenon AG, Koumantakis GE, Kyriakou DS and Koumantakis EE: Increase in serum leptin concentrations among women with endometriosis during danazol and leuprolide depot treatments. Am J Obstet Gynecol 183: 58-62, 2000.
35. Donnez J, Pirard C, Smets M, Polet R, Feger C and Squifflet J: Unusual growth of myoma during pregnancy. Fertil Steril 78: 632-633,2002.
36. Messinis IE, Milingos S, Zikopoulos K, Kollios G, Seferiadis K and Lolis D: Leptin concentrations in the follicular phase of spontaneous cycles and cycles superovulated with follicle stimulating hormone. HumReprod 13: 1152-1156,1998.
37. Teirmaa T, Luukkaa V, Rouru J, Koulu M and Huupponen R: Correlation between circulating leptin and luteinizing hormone during the menstrual cycle in normal-weight women. Eur J Endocrinol 139: 190-197,1998.
38. Cella F, Giordano G and Cordera R: Serum leptin concentrations during the menstrual cycle in normal-weight women: effects of an oral triphasic estrogen progestin medication. Eur J Endocrinol 142: 174-178,2000.