Evaluation of new leptin fragments on food intake and body weight of normal rats

Regulatory Peptides

Volumn 153, Issue 1-3, 2009, Pages 77-82

  Martins, M N C ^a   Telles, M M ^a   Zemdegs, J C S ^a   Andrade, I S ^a   Ribeiro, E B ^a   Miranda, A ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Energy balance; Food intake; Leptin fragments; Synthetic peptides

Indexed keywords

DECAPEPTIDE; LEPTIN; LEPTIN RECEPTOR; PEPTIDE FRAGMENT; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; BODY WEIGHT; CIRCULAR DICHROISM; CONTROLLED STUDY; FOOD INTAKE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE DETERMINATION; MALE; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN SECONDARY STRUCTURE; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; RAT;

ANIMALS; BODY WEIGHT; EATING; HUMANS; INJECTIONS, INTRAVENTRICULAR; LEPTIN; MALE; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR;

RATTUS;

EID: 59849105943     PISSN: 01670115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.regpep.2008.11.013     Document Type: Article

References (43)

1. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., Bauer T.L., and Caro J.F. Serum immunoreactive leptin concentrations in normal-weight and obese humans. New Engl J Med 334 (1996) 292-295
2. Zhang Y.Y., Proenca R., Maffei M., Barone M., Leopold L., and Friedman J.M. Positional cloning of the mouse obese gene and its human homolog. Nature 372 (1994) 425-432
3. Friedman J.M., and Halaas J.L. Leptin and the regulation of body weight in mammals. Nature 395 (1998) 763-770
4. Lee D.W., Leinung M.C., Rozhavskaya-Arena M., and Grasso P. Leptin and the treatment of obesity: its current status. Eur J Pharmacol 440 (2002) 129-139
5. Klok M.D., Jakobsdottir S., and Drent M.L. The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes Rev 8 (2007) 21-34
6. Lalonde J., Samson P., Poulin S., Deshaies Y., and Richard D. Additive effects of leptin and topiramate in reducing fat deposition in lean and obese ob/ob mice. Physiol Behav 80 (2004) 415-420
7. Canavan B., Salem R.O., Schurgin S., Koutkia P., Lipinska I., Laposata M., and Grinspoon S. Effects of physiological leptin administration on markers of inflammation, platelet activation, and platelet aggregation during caloric deprivation. J Clin Endocrinol Metab 90 (2005) 5779-5785
8. Schwartz M.W., and Porte Jr. D. Diabetes, obesity, and the brain. Science 307 (2005) 375-379
9. Koh K.K., Park S.M., and Quon M.J. Leptin and cardiovascular disease: response to therapeutic interventions. Circulation 117 (2008) 3238-3249
10. Signore A.P., Zhang F., Weng Z., Gao Y., and Chen J. Leptin neuroprotection in the CNS: mechanisms and therapeutic potentials. J Neurochem 106 (2008) 1977-1990
11. Farooqi I.S., Keogh J.M., Kamath S., Jones S., Gibson W.T., Trussell R., Jebb S.A., Lip G.Y., and O'Rahilly S. Partial leptin deficiency and human adiposity. Nature 414 (2001) 34-35
12. Rahmouni K., Fath M.A., Seo S., Thedens D.R., Berry C.J., Weiss R., Nishimura D.Y., and Sheffield V.C. Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome. J Clin Invest 118 (2008) 1458-1467
13. Kalra S.P. Central leptin insufficiency syndrome: an interactive etiology for obesity, metabolic and neural diseases and for designing new therapeutic interventions. Peptides 29 (2008) 127-138
14. Coleman D.L. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14 (1978) 141-148
15. Licinio J., Caglayan S., Ozata M., Yildiz B.O., de Miranda P.B., O'Kirwan F., Whitby R., Liang L., Cohen P., Bhasin S., Krauss R.M., Veldhuis J.D., Wagner A.J., DePaoli A.M., McCann S.M., and Wong M.L. Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proc Natl Acad Sci U S A 101 (2004) 4531-4536
16. Tartaglia L.A., Dembski M., Weng X., Deng N.H., Culpepper J., Devos R., Richards G.J., Campfield L.A., Clark F.T., Deeds J., Muir C., Sanker S., Moriarty A., Moore K.J., Smutko J.S., Mays G.G., Woolf E.A., Monroe C.A., and Tepper R.I. Identification and expression cloning of a leptin receptor, OB-R. Cell 83 (1995) 1263-1271
17. Isse N., Ogawa Y., Tamura N., Masuzaki H., Mori K., Okazaki T., Satoh N., Shigemoto M., Yoshimasa Y., Nishi S., Hosoda K., Inazawa J., and Nakao K. Structural organization and chromosomal assignment of the human obese gene. J Biol Chem 270 (1995) 27728-27733
18. Sahu A. Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Front Neuroendocrinol 24 (2003) 225-253
19. Polotsky V.Y., Wilson J.A., Smaldone M.C., Haines A.S., Hurn P.D., Tankersley C.G., Smith P.L., Schwartz A.R., and O'Donnell C.P. Female gender exacerbates respiratory depression in leptin-deficient obesity. Am J Respir Crit Care Med 164 (2001) 1470-1475
20. Schwartz M.W., Seeley R.J., Campfield L.A., Burn P., and Baskin D.G. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98 (1996) 1101-1106
21. Bates S.H., Dundon T.A., Seifert M., Carlson M., Maratos-Flier E., and Myers Jr. M.G. LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin. Diabetes 53 (2004) 3067-3073
22. van Dijk G. The role of leptin in the regulation of energy balance and adiposity. J Neuroendocrinol 13 (2001) 913-921
23. Zhang F.M., Basinski M.B., Beals J.M., Briggs S.L., Churgay L.M., Clawson D.K., DiMarchi R.D., Furman T.C., Hale J.E., Hsiung H.M., Schoner B.E., Smith D.P., Zhang X.Y., Wery J.P., and Schevitz R.W. Crystal structure of the obese protein leptin-E100. Nature 387 (1997) 206-209
24. Kline A.D., Becker G.W., Churgay L.M., Landen B.E., Martin D.K., Muth W.L., Rathnachalam R., Richardson J.M., Schoner B., Ulmer M., and Hale J.E. Leptin is a four-helix bundle: secondary structure by NMR. FEBS Lett 407 (1997) 239-242
25. Samson W.K., Murphy T.C., Robison D., Vargas T., Tau E., and Chang J.K. A 35 amino acid fragment of leptin inhibits feeding in the rat. Endocrinology 137 (1996) 5182-5185
26. Grasso P., Leinung M.C., Ingher S.P., and Lee D.W. In vivo effects of leptin-related synthetic peptides on body weight and food intake in female ob/ob mice: localization of leptin activity to domains between amino acid residues 106-140. Endocrinology 138 (1997) 1413-1418
27. Grasso P., Leinung M.C., and Lee D.W. Epitope mapping of secreted mouse leptin utilizing peripherally administered synthetic peptides. Regul Pept 85 (1999) 93-100
28. Grasso P., Rozhavskaya-Arena M., Leinung M.C., and Lee D.W. [D-LEU-4]-OB3, a synthetic leptin agonist, improves hyperglycemic control in C57BL/6J ob/ob mice. Regul Pept 101 (2001) 123-129
29. Grasso P., White D.W., Tartaglia L.A., Leinung M.C., and Lee D.W. Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor. Diabetes 48 (1999) 2204-2209
30. Lee D.W., Leinung M.C., Rozhavskaya-Arena M., and Grasso P. Leptin agonists as a potential approach to the treatment of obesity. Drug Future 26 (2001) 873-881
31. Rozhavskaya-Arena M., Lee D.W., Leinung M.C., and Grasso P. Design of a synthetic leptin agonist: effects on energy balance, glucose homeostasis, and thermoregulation. Endocrinology 141 (2000) 2501-2507
32. Oliveira V.X., Fazio M.A., Miranda M.T.M., da Silva J.M., Bittencourt J.C., Elias C.F., and Miranda A. Leptin fragments induce Fos immunoreactivity in rat hypothalamus. Regul Pept 127 (2005) 123-132
33. Oliveira V.X.J., Fazio M.A., Santos E.L., Pesquero J.B., and Miranda A. In vitro evaluation of leptin fragments activity on the ob receptor. J Pept Sci 14 (2008) 617-625
34. Miranda A., Lahrichi S.L., Gulyas J., Koerber S.C., Craig A.G., Corrigan A., Rivier C., Vale W., and Rivier J. Constrained corticotropin-releasing factor antagonists with i-(i+3) Glu-Lys bridges. J Med Chem 40 (1997) 3651-3658
35. Porto L.C., Sardinha F.L., Telles M.M., Guimaraes R.B., Albuquerque K.T., Andrade I.S., Oyama L.M., Nascimento C.M., Santos O.F., and Ribeiro E.B. Impairment of the serotonergic control of feeding in adult female rats exposed to intra-uterine malnutrition. Br J Nutr (2008) 1-7
36. Choi Y.H., Li C., Hartzell D.L., Little D.E., Della-Fera M.A., and Baile C.A. ICV leptin effects on spontaneous physical activity and feeding behavior in rats. Behav Brain Res 188 (2008) 100-108
37. Martinez J.A., Garcia-Granero M., and Fruhbeck G. Role of fragment peptides from ob protein on body weight and thermogenesis control: a screening. Rev Esp Fisiol 52 (1996) 123-124
38. Fruhbeck G., Garcia-Granero M., and Martinez J.A. Age-related differences in the thermogenic and ponderal effects following the administration of fragment peptides from the rat ob protein. Regul Pept 73 (1998) 83-87
39. Grasso P., Leinung M.C., and Lee D.W. Epitope mapping of secreted mouse leptin utilizing peripherally administered synthetic peptides. Regul Pept 85 (1999) 93-100
40. Gonzalez L.C., Pinilla L., Tena-Sempere M., and Aguilar E. Leptin (116-130) stimulates prolactin and luteinizing hormone secretion in fasted adult male rats. Neuroendocrinology 70 (1999) 213-220
41. Tena-Sempere M., Pinilla L., Gonzalez L.C., Navarro J., Dieguez C., Casanueva F.F., and Aguilar E. In vitro pituitary and testicular effects of the leptin-related synthetic peptide leptin(116-130) amide involve actions both similar to and distinct from those of the native leptin molecule in the adult rat. Eur J Endocrinol 142 (2000) 406-410
42. Lee D.W., Leinung M.C., and Grasso P. The effects of age on uptake, serum half-life and bioavailability of mouse [D-Leu-4]OB3, a synthetic peptide amide with leptin-like activity, in male C57BL/6J mice. Regul Pept 150 (2008) 62-65
43. Hanew K. The effects of human leptin fragment(126-140) on pituitary functions in man. Eur J Endocrinol 149 (2003) 407-412