Inhibitory effects of leptin-related synthetic peptide 116-130 on food intake and body weight gain in female C57BL/6J ob/ob mice may not be mediated by peptide activation of the long isoform of the leptin receptor

Diabetes

Volumn 48, Issue 11, 1999, Pages 2204-2209

  Grasso, Patricia ^a   White, David W ^b   Tartaglia, Louis A ^b   Leinung, Matthew C ^a   Lee, Daniel W ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

^b MILLENNIUM PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; GLUCOSE; LEPTIN; LEPTIN RECEPTOR; SYNTHETIC PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; ENERGY BALANCE; FEMALE; FOOD INTAKE; GLUCOSE BLOOD LEVEL; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; WEIGHT GAIN;

ANIMALS; BLOOD GLUCOSE; BODY TEMPERATURE REGULATION; CARRIER PROTEINS; CELL LINE; COS CELLS; FEEDING BEHAVIOR; FEMALE; HOMOZYGOTE; HYPOTHALAMUS; LEPTIN; LIGANDS; MICE; MICE, INBRED C57BL; MICE, OBESE; PEPTIDE FRAGMENTS; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; TRANSFECTION; WEIGHT GAIN;

EID: 0032712894     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.48.11.2204     Document Type: Article

References (23)

1. Zhang Y, Procenca R, Maffei M, Barone M, Leopold L, Friedman JM: Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432, 1994
2. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P: Recombinant mouse OB-protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549, 1995
3. Masuzaki M, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, Nishimura H, Yoshimasa Y, Tanaka I, Mori T, Nakao K: Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat Med 3:1029-1033, 1997
4. Bjorbaek C, Shigeo U, daSilva B, Flier JS: Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 272:32683-32695, 1997
5. Halaas JL, Gajiwala KS, Maffie M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM: Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546, 1995
6. Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F: Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543, 1995
7. Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP: Evidence that the diabetes gene encodes the leptin receptor: identification of mutation in the leptin receptor gene in db/db mice. Cell 84:491-495, 1996
8. White DW, Kuropatuinski KK, Devos R, Baumann H, Tartaglia LA: Leptin receptor (OB-R) signaling. J Biol Chem 272:4065-4071, 1997
9. Tartaglia LA: The leptin receptor. J Biol Chem 272:6093-6096, 1997
10. Ihle JN: Cytokine receptor signaling. Nature (London) 377:591-594, 1995
11. Ihle JN, Witthuhn BA, Quelle FW, Yamamoto K, Thierfelder WE, Krieder B: Signaling by the cytokine receptor superfamily: JAKs and STATs. Trends Biochem Sci 19:222-227,1994
12. Baumann H, Morella KK, White DW, Dembski M, Bailon PS, Kim H, Lai C-F, Tartaglia LA: The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc Natl Acad Sci USA 93:8374-8378, 1996
13. Lee G-H, Proenca R, Montez JM, Carrol KM, Darvishzadeh JG, Lee JI, Friedman JM: Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632-635, 1996
14. Pas and other db/db mice. J Biol Chem 273:10078-10082, 1998
15. Grasso P, Leinung MC, Ingher SP, Lee DW: In vivo effects of leptin-related synthetic peptides on body weight and food intake in female ob/ob mice. Endocrinology 138:1413-1418, 1997
16. Merrifield RD: Solid phase peptide synthesis. I. The synthesis of a tetrapeptide. J Am Chem Soc 85:2149-2154, 1963
17. Baumann H, Prowse KR, Marinkovic S, Won K-A, Jahreis GP: Stimulation of hepatic acute phase response by cytokines and glucocorticoids. Ann N Y Acad Sci 557:280-297, 1989
18. Mellon PL, Windle JJ, Goldsmith PC, Padula CA, Roberts JL, Weiner RI: Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis. Neuron 5:1-10, 1990
19. White DW, Wang Y, Chura SC Jr, Morgenstern JP, Leibel RL, Bauman H, Tartaglia LA: Constitutive and impaired signaling of leptin receptors containing the Gln → Pro extracellular domain fatty mutation. Proc Natl Acad Sci U S A 94:10657-10662, 1997
20. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark PT, Deeds J, Muir C, Sanker S, Moriaity A, Moore KJ, Smitko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI: Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271, 1995
21. Kamohara S, Burcelin R, Haalas JL, Friedman LM, Charron MJ: Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 389:374-377, 1997
22. Lonnqvist F, Arner P, Nordfors L, Shelling M: Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1:950-953, 1995
23. Considine RV, Considine EL, Williams CJ, Hyde TM, Caro JF: The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and the absence of the db/db mouse and fa/fa rat mutations. Diabetes 19:992-994, 1996