Development and characterization of high affinity leptins and leptin antagonists

Journal of Biological Chemistry

Volumn 286, Issue 6, 2011, Pages 4429-4442

  Shpilman, Michal ^a   Niv Spector, Leonora ^a   Katz, Meirav ^b   Varol, Chen ^b   Solomon, Gili ^a   Ayalon Soffer, Michal ^c   Boder, Eric ^d   Halpern, Zamir ^b   Elinav, Eran ^b   Gertler, Arieh ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^c Bioline Innovations   (Israel)

^d University of Tennessee Knoxville   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTAGONISTIC ACTIVITY; BIOLOGICAL PROCESS; BODY WEIGHT; CHARGED AMINO ACIDS; ENERGY METABOLISM; FOOD CONSUMPTION; HIGH AFFINITY; IMMUNE RESPONSE; IN-VITRO; IN-VIVO; LEPTIN BINDING; LEPTIN RECEPTORS; LEPTINS; RANDOM MUTAGENESIS; SOLUBLE RECEPTOR; STRUCTURAL ELEMENTS; SURFACE DISPLAYS; THERAPEUTIC USE;

AMINO ACIDS; BINDING ENERGY; FOOD SUPPLY; METABOLISM; MUTAGENESIS;

HORMONES;

ALANINE; ASPARTIC ACID; LEPTIN; LEPTIN RECEPTOR; LEUCINE; MACROGOL; RECOMBINANT LEPTIN ANTAGONIST; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; DRUG DERIVATIVE; MACROGOL DERIVATIVE; PEGYLATED LEPTIN;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DETERMINATION; DRUG FORMULATION; DRUG PURIFICATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; FOOD INTAKE; GENE INSERTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR RECOGNITION; MOUSE; MUTAGENESIS; MUTATIONAL ANALYSIS; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RESIDUE ANALYSIS; WEIGHT GAIN; YEAST; ANIMAL; BODY WEIGHT; CELL STRAIN HEK293; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; EATING; GENETICS; METABOLISM; MISSENSE MUTATION;

MUS;

AMINO ACID SUBSTITUTION; ANIMALS; BODY WEIGHT; EATING; HEK293 CELLS; HUMANS; LEPTIN; MALE; MICE; MUTAGENESIS; MUTATION, MISSENSE; POLYETHYLENE GLYCOLS; PROTEIN BINDING; RECEPTORS, LEPTIN;

EID: 79952999216     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.196402     Document Type: Article

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