Mapping of the leptin binding sites and design of a leptin antagonist

Journal of Biological Chemistry

Volumn 279, Issue 39, 2004, Pages 41038-41046

  Peelman, Frank ^a   Van Beneden, Katrien ^b   Zabeau, Lennart ^a   Iserentant, Hannes ^a   Ulrichts, Peter ^a   Defeau, Delphine ^a   Verhee, Annick ^a   Catteeuw, Dominiek ^a   Elewaut, Dirk ^b   Tavernier, Jan ^a  

^a DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^b GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; MAPPING; MEMBRANES; MUTAGENESIS;

BINDING SITES; LEPTIN RECEPTOR (LR); RECEPTOR SYSTEMS;

BIOCHEMISTRY;

CYTOKINE RECEPTOR; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 6; LEPTIN; LEPTIN RECEPTOR; LEPTIN RECEPTOR ANTAGONIST; MUTANT PROTEIN; RECOMBINANT PROTEIN; S120A T121A LEPTIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL LINE; CELL STRAIN COS1; CONTROLLED STUDY; CYTOKINE RECEPTOR HOMOLOGY DOMAIN 2; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CELL LINE; COS CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; GENES, REPORTER; HUMANS; LEPTIN; LUCIFERASES; MICE; MICE, INBRED DBA; MODELS, BIOLOGICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

ANIMALIA;

EID: 4644358139     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M404962200     Document Type: Article

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