Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody

Structure

Volumn 20, Issue 3, 2012, Pages 487-497

  Carpenter, Byron ^a,c   Hemsworth, Glyn R ^a   Wu, Zida ^b   Maamra, Mabrouka ^a   Strasburger, Christian J ^b   Ross, Richard J ^a   Artymiuk, Peter J ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; FIBRONECTIN; LEPTIN; LEPTIN BLOCKING MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANTIGEN ANTIBODY COMPLEX; ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DIMERIZATION; GLYCOSYLATION; HUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION;

ANTIBODIES, MONOCLONAL; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; LEPTIN; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, LEPTIN;

EID: 84857978585     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2012.01.019     Document Type: Article

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