Selection of non-competitive leptin antagonists using a random nanobody-based approach

Biochemical Journal

Volumn 441, Issue 1, 2012, Pages 425-434

  Zabeau, Lennart ^a   Verhee, Annick ^a   Catteeuw, Dominiek ^a   Faes, Liesbeth ^a   Seeuws, Sylvie ^b   Decruy, Tine ^b   Elewaut, Dirk ^b   Peelman, Frank ^a   Tavernier, Jan ^a  

^a GHENT UNIVERSITY   (Belgium)

^b GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Body weight; Leptin receptor (LR); Nanobody; Receptor activation; Signalling

Indexed keywords

CYTOKINE RECEPTOR HOMOLOGY 2 ANTIBODY; FIBRONECTIN TYPE III ANTIBODY; HORMONE INHIBITOR; IMMUNOGLOBULIN ANTIBODY; INSULIN; LEPTIN RECEPTOR ANTAGONIST; LIGAND; NEUROPEPTIDE Y; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BODY FAT DISTRIBUTION; BODY WEIGHT; FOOD INTAKE; HORMONE BINDING; HUMAN; HUMAN CELL; HYPOTHALAMUS; INSULIN BLOOD LEVEL; LIGAND BINDING; LIVER SIZE; MOUSE; NANOTECHNOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION;

ADIPOSE TISSUE; ANIMALS; ANTIBODIES; CAMELIDS, NEW WORLD; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; HYPERINSULINISM; LEPTIN; LIVER; MICE; MICE, INBRED C57BL; NANOSTRUCTURES; NEUROPEPTIDE Y; ORGAN SIZE; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION; WEIGHT GAIN;

EID: 84055223513     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20110438     Document Type: Article

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