Development of a pharmacologically improved peptide agonist of the leptin receptor

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1783, Issue 10, 2008, Pages 1745-1754

  Otvos Jr , Laszlo ^a   Terrasi, Marianna ^a   Cascio, Sandra ^a   Cassone, Marco ^a   Abbadessa, Giovanni ^a   De Pascali, Francesco ^a   Scolaro, Laura ^a   Knappe, Daniel ^b   Stawikowski, Maciej ^c   Cudic, Predrag ^c   Wade, John D ^d   Hoffmann, Ralf ^b   Surmacz, Eva ^a  

^a TEMPLE UNIVERSITY   (United States)

^b UNIVERSITY OF LEIPZIG   (Germany)

^c FLORIDA ATLANTIC UNIVERSITY   (United States)

^d UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Blood brain penetration; Leptin deficient diseases; Neurohormone; Peptidomimetic; Serum stability; Signaling

Indexed keywords

CARBOHYDRATE; DEFICIENS PROTEIN; GLYCOPEPTIDE; GLYCYLTYROSYLSERYLTHREONYLGLUTAMYLVALYLVALYLALANYLLEUCYLSERYLARGINYL LEUCINE; GLYCYLTYROSYLSERYLTHREONYLGLUTAMYLVALYLVALYLALANYLLEUCYLSERYLARGINYL LEUCYLGLUTAMINE; ISOLEUCYLGLUTAMINYLLYSYLVALYLGLUTAMINYLASPARTYLASPARTYLTHREONYLLYSYL THREONYLLEUCYLISOLEUCYLLYSYLTHREONYLISOLEUCYLVALINE; ISOLEUCYLGLUTAMINYLLYSYLVALYLGLUTAMINYLASPARTYLASPARTYLTHREONYLLYSYL THREONYLLEUCYLISOLEUCYLLYSYLTHREONYLISOLEUCYLVALYLGLYCYLGLYCYLGLYCINE; LEPTIN; LEPTIN RECEPTOR; LEPTIN RECEPTOR AGONIST; LEPTIN RECEPTOR ANTAGONIST; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NEUROHORMONE; PEPTIDE DERIVATIVE; SERYLARGINYLASPARAGINYLVALYLISOLEUCYLGLUTAMINYLISOLEUCYLSERYL ASPARAGINYLASPARTYLLEUCYLGLUTAMYLASPARAGINYLLEUCYLARGINYLASPARTYLLEUCYL ISOLEUCYLHISTIDYLVALINE; SERYLGLYCYLTYROSYLALANYLALANYLGLUTAMYLVALYLVALYLALANYL LEUCYLSERYLARGINYLLEUCYLGLUTAMINYLGLYCYLSERINE; SERYLGLYCYLTYROSYLSERYLTHREONYLGLUTAMYLVALYLVALYLALANYLLEUCYL SERYLARGINYLLEUCYLGLUTAMINYLGLYCYLSERINE; TYROSYLSERYLTHREONYLGLUTAMYLVALYLVALYLALANYLLEUCYLSERYLARGINYLLEUCINE; TYROSYLSERYLTHREONYLGLUTAMYLVALYLVALYLALANYLLEUCYLSERYLARGINYLLEUCYL GLUTAMINE; UNCLASSIFIED DRUG; VALYLASPARTYLLYSYLGLYCYLSERYLTYROSYLLEUCYLPROLYLARGINYLPROLYLTHREONYL PROLYLPROLYLARGINYLPROLYLISOLEUCYLTYROSYLASPARAGINYLARGINYLASPARAGINE; VALYLTHREONYLGLYCYLALANYLALANYLPHENYLALANYLISOLEUCYLPROLYLGLYCYL LEUCYLHISTIDYLPROLYLISOLEUCYLLEUCINE; VALYLTHREONYLGLYCYLISOLEUCYLASPARTYLPHENYLALANYLISOLEUCYLPROLYL GLYCYLISOLEUCYLHISTIDYLPROLYLISOLEUCYLLEUCINE;

ARTICLE; ASTROCYTE; BIOASSAY; BLOOD BRAIN BARRIER; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN MCF 7; CHIMERA; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HUMAN CELL; PEPTIDE SYNTHESIS; PHARMACODYNAMICS; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN DEFICIENCY; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; ANIMALS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; FEMALE; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOLECULAR SEQUENCE DATA; PEPTIDES; RECEPTORS, LEPTIN;

MUS;

EID: 50849130228     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2008.05.007     Document Type: Article

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