Designer peptide antagonist of the leptin receptor with peripheral antineoplastic activity

Peptides

Volumn 44, Issue , 2013, Pages 127-134

  Beccari, Serena ^a   Kovalszky, Ilona ^b   Wade, John D ^c   Otvos Jr , Laszlo ^d   Surmacz, Eva ^a  

^a TEMPLE UNIVERSITY   (United States)

^b SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d Temple University   (United States)

Author keywords

Antagonist peptide; Blood brain barrier; Cancer; Leptin receptor; Peripheral activity

Indexed keywords

ALLO ACA; CYCLIN D1; DESIGNER DRUG; DEXTRO SERINE; JANUS KINASE; LEPTIN; LEPTIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEPTIDOMIMETIC AGENT; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOSERINE; PHOSPHOSERINE ALANINE; PROTEIN KINASE B; STAT3 PROTEIN; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HT29; COLON ADENOCARCINOMA; COLORECTAL CANCER; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG IDENTIFICATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; ANIMALS; ANTINEOPLASTIC AGENTS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HT29 CELLS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MCF-7 CELLS; MICE; MICE, INBRED C57BL; MOLECULAR MIMICRY; PEPTIDES; RECEPTORS, LEPTIN; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; TISSUE DISTRIBUTION; WEIGHT GAIN;

ANIMALIA;

EID: 84877040289     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2013.03.027     Document Type: Article

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