Identification of a monoclonal antibody against the leptin receptor that acts as an antagonist and blocks human monocyte and T cell activation

Journal of Immunological Methods

Volumn 312, Issue 1-2, 2006, Pages 190-200

  Fazeli, Mehdi ^a   Zarkesh Esfahani, Hamid ^e   Wu, Zida ^b   Maamra, Mabrouka ^a   Bidlingmaier, Martin ^c   Pockley, A Graham ^a   Watson, Philip ^a   Matarese, Giuseppe ^d   Strasburger, Christian J ^b   Ross, Richard J M ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d CNR   (Italy)

^e UNIVERSITY OF ISFAHAN   (Iran)

Author keywords

Antagonist; Antibodies; antigen binding fragment; c sis inducible element; Cytokine receptors; Fab; Jak STAT; Janus kinase signal transducers and activators of transcription; leptin; leptin receptor; mAb; MAPK; mitogen activated protein kinase; monoclonal antibody; Monocytes; ob; ObR; PBMC; peripheral blood mononuclear cell; SIE; T cells; TNF ; tumor necrosis factor alpha.

Indexed keywords

9F8 MONOCLONAL ANTIBODY; CD3 ANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; LEPTIN RECEPTOR; MONOCLONAL ANTIBODY; RECEPTOR ANTIBODY; RECOMBINANT ANTIBODY; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY SPECIFICITY; ARTICLE; BIOASSAY; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG ACTIVITY; DRUG PURIFICATION; EMBRYO; ENDOPLASMIC RETICULUM; ESCHERICHIA COLI; FEMALE; HUMAN; HUMAN CELL; MOLECULAR CLONING; MONOCYTE; MOUSE; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION;

ANTIBODIES, MONOCLONAL; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; LYMPHOCYTE ACTIVATION; MONOCYTES; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 33747050687     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jim.2006.03.011     Document Type: Article

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