메뉴 건너뛰기




Volumn 5, Issue 3, 2014, Pages 337-365

Recent developments in protein and peptide parenteral delivery approaches

Author keywords

[No Author keywords available]

Indexed keywords

CARBON NANOTUBE; DRUG CARRIER; GLUCOSE; LIPOSOME; MANNOSE; NANOPARTICLE; PEPTIDE; PROTEIN;

EID: 84896766008     PISSN: 20415990     EISSN: 20416008     Source Type: Journal    
DOI: 10.4155/tde.14.5     Document Type: Review
Times cited : (149)

References (175)
  • 1
    • 85157104666 scopus 로고    scopus 로고
    • Biologics research promises bolster future
    • Biologics research promises bolster future. www.phrma.org/media/releases/ biologics-research-promises-bolster-future-medicine
  • 2
    • 85012823572 scopus 로고    scopus 로고
    • Delivery of drugs-peptides and proteins
    • Moo-Young M (Ed.). Elsevier, BV, Amsterdam, The Netherlands
    • Schiffter HA. The Delivery of Drugs-Peptides and Proteins. In: Comprehensive Biotechnology. Moo-Young M (Ed.). Elsevier BV, Amsterdam, The Netherlands, 587-604 (2011).
    • (2011) Comprehensive Biotechnology , pp. 587-604
    • Schiffter, H.A.1
  • 3
    • 84876023989 scopus 로고    scopus 로고
    • Inhaled proteins: Challenges and perspectives
    • Depreter F, Pilcer G, Amighi K. Inhaled proteins: challenges and perspectives. Int. J. Pharm. 447(1-2), 251-280 (2013).
    • (2013) Int. J. Pharm. , vol.447 , Issue.1-2 , pp. 251-280
    • Depreter, F.1    Pilcer, G.2    Amighi, K.3
  • 4
    • 64549157603 scopus 로고    scopus 로고
    • Inhaled insulin-does it become reality?
    • Siekmeier R, Scheuch G. Inhaled insulin-does it become reality? J. Physiol. Pharmacol. 59(Suppl. 6), 81-113 (2008).
    • (2008) J. Physiol. Pharmacol. , vol.59 , Issue.SUPPL. 6 , pp. 81-113
    • Siekmeier, R.1    Scheuch, G.2
  • 5
    • 84860193946 scopus 로고    scopus 로고
    • Intranasal delivery of biologics to the central nervous system
    • Lochhead JJ, Thorne RG. Intranasal delivery of biologics to the central nervous system. Adv. Drug Deliv. Rev. 64(7), 614-628 (2012).
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , Issue.7 , pp. 614-628
    • Lochhead, J.J.1    Thorne, R.G.2
  • 6
    • 3442879344 scopus 로고    scopus 로고
    • Protein and peptide parenteral controlled delivery
    • Pawar R, Ben-Ari A, Domb AJ. Protein and peptide parenteral controlled delivery. Expert Opin. Biol. Ther. 4(8), 1203-1212 (2004).
    • (2004) Expert Opin. Biol. Ther. , vol.4 , Issue.8 , pp. 1203-1212
    • Pawar, R.1    Ben-Ari, A.2    Domb, A.J.3
  • 7
    • 0036875275 scopus 로고    scopus 로고
    • Intracameral tissue plasminogen activator use in a large series of eyes with valved glaucoma drainage implants
    • Zalta AH, Sweeney CP, Zalta AK, Kaufman AH. Intracameral tissue plasminogen activator use in a large series of eyes with valved glaucoma drainage implants. Arch. Ophthalmol. 120(11), 1487-1493 (2002).
    • (2002) Arch. Ophthalmol. , vol.120 , Issue.11 , pp. 1487-1493
    • Zalta, A.H.1    Sweeney, C.P.2    Zalta, A.K.3    Kaufman, A.H.4
  • 9
    • 33746872198 scopus 로고    scopus 로고
    • Novel delivery technologies for protein and peptide therapeutics
    • Kumar TR, Soppimath K, Nachaegari SK. Novel delivery technologies for protein and peptide therapeutics. Curr. Pharm. Biotechnol. 7(4), 261-276 (2006).
    • (2006) Curr. Pharm. Biotechnol. , vol.7 , Issue.4 , pp. 261-276
    • Kumar, T.R.1    Soppimath, K.2    Nachaegari, S.K.3
  • 10
    • 55749111387 scopus 로고    scopus 로고
    • The pharmacology of PEGylation: Balancing PD with PK to generate novel therapeutics
    • Fishburn CS. The pharmacology of PEGylation: balancing PD with PK to generate novel therapeutics. J. Pharm. Sci. 97(10), 4167-4183 (2008).
    • (2008) J. Pharm. Sci. , vol.97 , Issue.10 , pp. 4167-4183
    • Fishburn, C.S.1
  • 12
    • 33748918574 scopus 로고    scopus 로고
    • Nanomedicine: Clinical applications of polyethylene glycol conjugated proteins and drugs
    • Parveen S, Sahoo SK. Nanomedicine: clinical applications of polyethylene glycol conjugated proteins and drugs. Clin. Pharmacokinet. 45(10), 965-988 (2006).
    • (2006) Clin. Pharmacokinet. , vol.45 , Issue.10 , pp. 965-988
    • Parveen, S.1    Sahoo, S.K.2
  • 13
    • 0032870935 scopus 로고    scopus 로고
    • Bioconjugation in pharmaceutical chemistry
    • Veronese FM, Morpurgo M. Bioconjugation in pharmaceutical chemistry. Farmaco 54(8), 497-516 (1999).
    • (1999) Farmaco , vol.54 , Issue.8 , pp. 497-516
    • Veronese, F.M.1    Morpurgo, M.2
  • 14
    • 0035284411 scopus 로고    scopus 로고
    • Peptide and protein PEGylation: A review of problems and solutions
    • Veronese FM. Peptide and protein PEGylation: a review of problems and solutions. Biomaterials 22(5), 405-417 (2001).
    • (2001) Biomaterials , vol.22 , Issue.5 , pp. 405-417
    • Veronese, F.M.1
  • 15
    • 84869789997 scopus 로고    scopus 로고
    • PEGylation extends circulation half-life while preserving in vitro and in vivo activity of tissue inhibitor of metalloproteinases-1 (TIMP-1)
    • Batra J, Robinson J, Mehner C et al. PEGylation extends circulation half-life while preserving in vitro and in vivo activity of tissue inhibitor of metalloproteinases-1 (TIMP-1). PloS ONE 7(11), e50028 (2012).
    • (2012) PloS ONE , vol.7 , Issue.11
    • Batra, J.1    Robinson, J.2    Mehner, C.3
  • 16
    • 84875415951 scopus 로고    scopus 로고
    • Chemical and enzymatic site specific PEGylation of hGH
    • Da Silva Freitas D, Mero A, Pasut G. Chemical and enzymatic site specific PEGylation of hGH. Bioconjug. Chem. 24(3), 456-463 (2013).
    • (2013) Bioconjug. Chem. , vol.24 , Issue.3 , pp. 456-463
    • Da Silva Freitas, D.1    Mero, A.2    Pasut, G.3
  • 17
    • 84875428215 scopus 로고    scopus 로고
    • Site-specific PEGylation of human thyroid stimulating hormone to prolong duration of action
    • Qiu H, Boudanova E, Park A et al. Site-specific PEGylation of human thyroid stimulating hormone to prolong duration of action. Bioconjug. Chem. 24(3), 408-418 (2013).
    • (2013) Bioconjug. Chem. , vol.24 , Issue.3 , pp. 408-418
    • Qiu, H.1    Boudanova, E.2    Park, A.3
  • 18
    • 77649183731 scopus 로고    scopus 로고
    • Biochemical and biopharmaceutical properties of PEGylated uricase
    • Freitas Dda S, Spencer PJ, Vassao RC, Abrahao-Neto J. Biochemical and biopharmaceutical properties of PEGylated uricase. Int. J. Pharm. 387(1-2), 215-222 (2010).
    • (2010) Int. J. Pharm. , vol.387 , Issue.1-2 , pp. 215-222
    • Freitas Dda, S.1    Spencer, P.J.2    Vassao, R.C.3    Abrahao-Neto, J.4
  • 19
    • 84873676932 scopus 로고    scopus 로고
    • Phenyl linker-induced dense PEG conformation improves the efficacy of C-terminally monoPEGylated staphylokinase
    • Xue X, Li D, Yu J, Ma G, Su Z, Hu T. Phenyl linker-induced dense PEG conformation improves the efficacy of C-terminally monoPEGylated staphylokinase. Biomacromolecules 14(2), 331-341 (2013).
    • (2013) Biomacromolecules 14 , Issue.2 , pp. 331-341
    • Xue, X.1    Li, D.2    Yu, J.3    Ma, G.4    Su, Z.5    Hu, T.6
  • 20
    • 84871571137 scopus 로고    scopus 로고
    • PEGylation of membrane proteins like bacteriorhodopsin as a tool to increase their stability toward ethanol
    • Busch AP, Neebe M, Hampp N. PEGylation of membrane proteins like bacteriorhodopsin as a tool to increase their stability toward ethanol. J Phys. Chem. B 116(50), 14613-14617 (2012).
    • (2012) J Phys. Chem. B , vol.116 , Issue.50 , pp. 14613-14617
    • Busch, A.P.1    Neebe, M.2    Hampp, N.3
  • 21
    • 80052901092 scopus 로고    scopus 로고
    • The effect of PEGylation on the stability of small therapeutic proteins
    • Palm T, Esfandiary R, Gandhi R. The effect of PEGylation on the stability of small therapeutic proteins. Pharm. Dev. Technol. 16(5), 441-448 (2011).
    • (2011) Pharm. Dev. Technol. , vol.16 , Issue.5 , pp. 441-448
    • Palm, T.1    Esfandiary, R.2    Gandhi, R.3
  • 22
    • 84870918540 scopus 로고    scopus 로고
    • PEGylation enhancement of pH stability of uricase via inhibitive tetramer dissociation
    • Tian H, Guo Y, Gao X, Yao W. PEGylation enhancement of pH stability of uricase via inhibitive tetramer dissociation. J. Pharm. Pharmacol. 65(1), 53-63 (2013).
    • (2013) J. Pharm. Pharmacol. , vol.65 , Issue.1 , pp. 53-63
    • Tian, H.1    Guo, Y.2    Gao, X.3    Yao, W.4
  • 23
    • 84860704433 scopus 로고    scopus 로고
    • Evidence for metabolic cleavage of a PEGylated protein in vivo using multiple analytical methodologies
    • Elliott VL, Edge GT, Phelan MM et al. Evidence for metabolic cleavage of a PEGylated protein in vivo using multiple analytical methodologies. Mol. Pharm. 9(5), 1291-1301 (2012).
    • (2012) Mol. Pharm. , vol.9 , Issue.5 , pp. 1291-1301
    • Elliott, V.L.1    Edge, G.T.2    Phelan, M.M.3
  • 24
    • 0035086519 scopus 로고    scopus 로고
    • Rational design of a potent, long-lasting form of interferon: A 40 kDa branched polyethylene glycol-conjugated interferon a-2a for the treatment of hepatitis C
    • Bailon P, Palleroni A, Schaffer CA et al. Rational design of a potent, long-lasting form of interferon: a 40 kDa branched polyethylene glycol-conjugated interferon a-2a for the treatment of hepatitis C. Bioconjug. Chem. 12(2), 195-202 (2001).
    • (2001) Bioconjug. Chem. , vol.12 , Issue.2 , pp. 195-202
    • Bailon, P.1    Palleroni, A.2    Schaffer, C.A.3
  • 26
    • 84877965971 scopus 로고    scopus 로고
    • PEGylation of interferon a2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases
    • Kaminskas LM, Ascher DB, Mcleod VM et al. PEGylation of interferon a2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases. J. Control. Release 168(2), 200-208 (2013).
    • (2013) J. Control. Release , vol.168 , Issue.2 , pp. 200-208
    • Kaminskas, L.M.1    Ascher, D.B.2    McLeod, V.M.3
  • 27
    • 84870239118 scopus 로고    scopus 로고
    • A new site-specific monoPEGylated filgrastim derivative prepared by enzymatic conjugation: Production and physicochemical characterization
    • Scaramuzza S, Tonon G, Olianas A et al. A new site-specific monoPEGylated filgrastim derivative prepared by enzymatic conjugation: production and physicochemical characterization. J. Control. Release 164(3), 355-363 (2012).
    • (2012) J. Control. Release , vol.164 , Issue.3 , pp. 355-363
    • Scaramuzza, S.1    Tonon, G.2    Olianas, A.3
  • 28
    • 84864127212 scopus 로고    scopus 로고
    • PEGylation of an osteoclast inhibitory peptide: Suitable candidate for the treatment of osteoporosis
    • Akhtar J, Mallaredy V, Dandapat J, Maiti P, Sahoo SK, Singh S. PEGylation of an osteoclast inhibitory peptide: suitable candidate for the treatment of osteoporosis. Int. J. Pharm. 434(1-2), 429-436 (2012).
    • (2012) Int. J. Pharm. , vol.434 , Issue.1-2 , pp. 429-436
    • Akhtar, J.1    Mallaredy, V.2    Dandapat, J.3    Maiti, P.4    Sahoo, S.K.5    Singh, S.6
  • 29
    • 84860713519 scopus 로고    scopus 로고
    • Characterization, efficacy, pharmacokinetics, and biodistribution of 5 kDa mPEG modified tetrameric canine uricase variant
    • Zhang C, Fan K, Luo H et al. Characterization, efficacy, pharmacokinetics, and biodistribution of 5 kDa mPEG modified tetrameric canine uricase variant. Int.J. Pharm. 430(1-2), 307-317 (2012).
    • (2012) Int.J. Pharm. , vol.430 , Issue.1-2 , pp. 307-317
    • Zhang, C.1    Fan, K.2    Luo, H.3
  • 30
    • 84856894168 scopus 로고    scopus 로고
    • PEGylation of interferon-b-1a. A promising strategy in multiple sclerosis
    • Kieseier BC, Calabresi PA. PEGylation of interferon-b-1a. a promising strategy in multiple sclerosis. CNS Drugs 26(3), 205-214 (2012).
    • (2012) CNS Drugs , vol.26 , Issue.3 , pp. 205-214
    • Kieseier, B.C.1    Calabresi, P.A.2
  • 31
    • 80052565466 scopus 로고    scopus 로고
    • PEGylation enhances the therapeutic potential for insulin-like growth factor i in central nervous system disorders
    • Saenger S, Goeldner C, Frey JR et al. PEGylation enhances the therapeutic potential for insulin-like growth factor I in central nervous system disorders. Growth Horm. IGF Res. 21(5), 292-303 (2011).
    • (2011) Growth Horm. IGF Res. , vol.21 , Issue.5 , pp. 292-303
    • Saenger, S.1    Goeldner, C.2    Frey, J.R.3
  • 32
    • 80155188453 scopus 로고    scopus 로고
    • Design, modeling, expression, and chemoselective PEGylation of a new nanosize cysteine analog of erythropoietin
    • Cohan RA, Madadkar-Sobhani A, Khanahmad H et al. Design, modeling, expression, and chemoselective PEGylation of a new nanosize cysteine analog of erythropoietin. Int. J. Nanomed. 6, 1217-1227 (2011).
    • (2011) Int. J. Nanomed. , vol.6 , pp. 1217-1227
    • Cohan, R.A.1    Madadkar-Sobhani, A.2    Khanahmad, H.3
  • 33
    • 80052541057 scopus 로고    scopus 로고
    • PEGylation improves pharmacokinetic profile, liver uptake and efficacy of interferon g in liver fibrosis
    • Bansal R, Post E, Proost JH, De Jager-Krikken A, Poelstra K, Prakash J. PEGylation improves pharmacokinetic profile, liver uptake and efficacy of interferon g in liver fibrosis. J. Control. Release 154(3), 233-240 (2011).
    • (2011) J. Control. Release , vol.154 , Issue.3 , pp. 233-240
    • Bansal, R.1    Post, E.2    Proost, J.H.3    De Jager-Krikken, A.4    Poelstra, K.5    Prakash, J.6
  • 34
    • 84867843384 scopus 로고    scopus 로고
    • Novel comb-shaped PEG modification enhances the osteoclastic inhibitory effect and bone delivery of osteoprotegerin after intravenous administration in ovariectomized rats
    • Miyaji Y, Kasuya Y, Furuta Y et al. Novel comb-shaped PEG modification enhances the osteoclastic inhibitory effect and bone delivery of osteoprotegerin after intravenous administration in ovariectomized rats. Pharm. Res. 29(11), 3143-3155 (2012).
    • (2012) Pharm. Res. , vol.29 , Issue.11 , pp. 3143-3155
    • Miyaji, Y.1    Kasuya, Y.2    Furuta, Y.3
  • 36
    • 85157047668 scopus 로고    scopus 로고
    • EP-2684950 A1
    • Fan K, Hu C, Luo H et al.: EP-2684950 A1 (2012).
    • (2012)
    • Fan, K.1    Hu, C.2    Luo, H.3
  • 37
    • 23444455640 scopus 로고    scopus 로고
    • Improving the therapeutic efficacy of peptides and proteins: A role for polysialic acids
    • Gregoriadis G, Jain S, Papaioannou I, Laing P. Improving the therapeutic efficacy of peptides and proteins: a role for polysialic acids. Int. J. Pharm. 300(1-2), 125-130 (2005).
    • (2005) Int. J. Pharm. , vol.300 , Issue.1-2 , pp. 125-130
    • Gregoriadis, G.1    Jain, S.2    Papaioannou, I.3    Laing, P.4
  • 38
    • 0034490003 scopus 로고    scopus 로고
    • Polysialic acids: Potential in improving the stability and pharmacokinetics of proteins and other therapeutics
    • Gregoriadis G, Fernandes A, Mital M, Mccormack B. Polysialic acids: potential in improving the stability and pharmacokinetics of proteins and other therapeutics. Cell. Mol. Life Sci. 57(13-14), 1964-1969 (2000).
    • (2000) Cell. Mol. Life Sci. , vol.57 , Issue.13-14 , pp. 1964-1969
    • Gregoriadis, G.1    Fernandes, A.2    Mital, M.3    McCormack, B.4
  • 39
    • 0029921037 scopus 로고    scopus 로고
    • Synthesis, characterization and properties of sialylated catalase
    • Fernandes AI, Gregoriadis G. Synthesis, characterization and properties of sialylated catalase. Biochim. Biophys. Acta 1293(1), 90-96 (1996).
    • (1996) Biochim. Biophys. Acta , vol.1293 , Issue.1 , pp. 90-96
    • Fernandes, A.I.1    Gregoriadis, G.2
  • 40
    • 0030835335 scopus 로고    scopus 로고
    • Polysialylated asparaginase: Preparation, activity and pharmacokinetics
    • Fernandes AI, Gregoriadis G. Polysialylated asparaginase: preparation, activity and pharmacokinetics. Biochim. Biophys. Acta 1341(1), 26-34 (1997).
    • (1997) Biochim. Biophys. Acta , vol.1341 , Issue.1 , pp. 26-34
    • Fernandes, A.I.1    Gregoriadis, G.2
  • 41
    • 0035901757 scopus 로고    scopus 로고
    • The effect of polysialylation on the immunogenicity and antigenicity of asparaginase: Implication in its pharmacokinetics
    • Fernandes AI, Gregoriadis G. The effect of polysialylation on the immunogenicity and antigenicity of asparaginase: implication in its pharmacokinetics. Int. J. Pharm. 217(1-2), 215-224 (2001).
    • (2001) Int. J. Pharm. , vol.217 , Issue.1-2 , pp. 215-224
    • Fernandes, A.I.1    Gregoriadis, G.2
  • 42
    • 0037757532 scopus 로고    scopus 로고
    • Polysialylated insulin: Synthesis, characterization and biological activity in vivo
    • Jain S, Hreczuk-Hirst DH, Mccormack B et al. Polysialylated insulin: synthesis, characterization and biological activity in vivo. Biochim. Biophys. Acta 1622(1), 42-49 (2003).
    • (2003) Biochim. Biophys. Acta , vol.1622 , Issue.1 , pp. 42-49
    • Jain, S.1    Hreczuk-Hirst, D.H.2    McCormack, B.3
  • 44
    • 39149098790 scopus 로고    scopus 로고
    • Novel long-lasting interferon a derivatives designed by glycoengineering
    • Ceaglio N, Etcheverrigaray M, Kratje R, Oggero M. Novel long-lasting interferon a derivatives designed by glycoengineering. Biochimie 90(3), 437-449 (2008).
    • (2008) Biochimie , vol.90 , Issue.3 , pp. 437-449
    • Ceaglio, N.1    Etcheverrigaray, M.2    Kratje, R.3    Oggero, M.4
  • 45
    • 77954657941 scopus 로고    scopus 로고
    • Influence of carbohydrates on the stability and structure of a hyperglycosylated human interferon a mutein
    • Ceaglio N, Etcheverrigaray M, Kratje R, Oggero M. Influence of carbohydrates on the stability and structure of a hyperglycosylated human interferon a mutein. Biochimie 92(8), 971-978 (2010).
    • (2010) Biochimie 92 , Issue.8 , pp. 971-978
    • Ceaglio, N.1    Etcheverrigaray, M.2    Kratje, R.3    Oggero, M.4
  • 46
    • 73349085222 scopus 로고    scopus 로고
    • Role of glycosylation in conformational stability, activity, macromolecular interaction and immunogenicity of recombinant human factor VIII
    • Kosloski MP, Miclea RD, Balu-Iyer SV. Role of glycosylation in conformational stability, activity, macromolecular interaction and immunogenicity of recombinant human factor VIII. AAPS J. 11(3), 424-431 (2009).
    • (2009) AAPS J. , vol.11 , Issue.3 , pp. 424-431
    • Kosloski, M.P.1    Miclea, R.D.2    Balu-Iyer, S.V.3
  • 48
    • 85157104412 scopus 로고    scopus 로고
    • Lipoxen PLC. www.bionity.com/en/companies/12278/lipoxen-plc.html
    • Plc, L.1
  • 51
    • 0027102397 scopus 로고
    • Therapeutic effects of superoxide dismutase derivatives modified with mono-or polysaccharides on hepatic injury induced by ischemia/reperfusion
    • Fujita T, Furitsu H, Nishikawa M, Takakura Y, Sezaki H, Hashida M. Therapeutic effects of superoxide dismutase derivatives modified with mono-or polysaccharides on hepatic injury induced by ischemia/reperfusion. Biochem. Biophysical Res. Comm. 189(1), 191-196 (1992).
    • (1992) Biochem. Biophysical Res. Comm. , vol.189 , Issue.1 , pp. 191-196
    • Fujita, T.1    Furitsu, H.2    Nishikawa, M.3    Takakura, Y.4    Sezaki, H.5    Hashida, M.6
  • 52
    • 33847010300 scopus 로고    scopus 로고
    • Soluble mannosylated myelin peptide inhibits the encephalitogenicity of autoreactive T cells during experimental autoimmune encephalomyelitis
    • Kel J, Oldenampsen J, Luca M, Drijfhout JW, Koning F, Nagelkerken L. Soluble mannosylated myelin peptide inhibits the encephalitogenicity of autoreactive T cells during experimental autoimmune encephalomyelitis. Am. J. Path. 170(1), 272-280 (2007).
    • (2007) Am. J. Path. , vol.170 , Issue.1 , pp. 272-280
    • Kel, J.1    Oldenampsen, J.2    Luca, M.3    Drijfhout, J.W.4    Koning, F.5    Nagelkerken, L.6
  • 53
    • 72749093756 scopus 로고    scopus 로고
    • Recent developments in liposomes, microparticles and nanoparticles for protein and peptide drug delivery
    • Tan ML, Choong PF, Dass CR. Recent developments in liposomes, microparticles and nanoparticles for protein and peptide drug delivery. Peptides 31(1), 184-193 (2010).
    • (2010) Peptides , vol.31 , Issue.1 , pp. 184-193
    • Tan, M.L.1    Choong, P.F.2    Dass, C.R.3
  • 54
    • 84876743815 scopus 로고    scopus 로고
    • Colloidal drug delivery systems in vaccine delivery
    • Beg S, Samad A, Nazish I et al. Colloidal drug delivery systems in vaccine delivery. Curr. Drug Targets 14(1), 123-137 (2013).
    • (2013) Curr. Drug Targets , vol.14 , Issue.1 , pp. 123-137
    • Beg, S.1    Samad, A.2    Nazish, I.3
  • 55
    • 77955418929 scopus 로고    scopus 로고
    • Issues in long-term protein delivery using biodegradable microparticles
    • Ye M, Kim S, Park K. Issues in long-term protein delivery using biodegradable microparticles. J. Control. Release 146(2), 241-260 (2010).
    • (2010) J. Control. Release 146 , Issue.2 , pp. 241-260
    • Ye, M.1    Kim, S.2    Park, K.3
  • 56
    • 0038445582 scopus 로고    scopus 로고
    • Biodegradable microspheres for protein delivery
    • Sinha VR, Trehan A. Biodegradable microspheres for protein delivery. J. Control. Release 90(3), 261-280 (2003).
    • (2003) J. Control. Release , vol.90 , Issue.3 , pp. 261-280
    • Sinha, V.R.1    Trehan, A.2
  • 57
    • 0033635054 scopus 로고    scopus 로고
    • Protein instability in poly(lactic-co-glycolic acid) microparticles
    • Van De Weert M, Hennink WE, Jiskoot W. Protein instability in poly(lactic-co-glycolic acid) microparticles. Pharm. Res. 17(10), 1159-1167 (2000).
    • (2000) Pharm. Res. , vol.17 , Issue.10 , pp. 1159-1167
    • Van De Weert, M.1    Hennink, W.E.2    Jiskoot, W.3
  • 58
    • 28244434064 scopus 로고    scopus 로고
    • Current advances in sustained-release systems for parenteral drug delivery
    • Shi Y, Li LC. Current advances in sustained-release systems for parenteral drug delivery. Expert Opin. Drug Deliv. 2(6), 1039-1058 (2005).
    • (2005) Expert Opin. Drug Deliv. , vol.2 , Issue.6 , pp. 1039-1058
    • Shi, Y.1    Li, L.C.2
  • 60
    • 1842850706 scopus 로고    scopus 로고
    • Biodegradable PLGA microparticles for sustained release of a new GnRH antagonist: Part II
    • Schwach G, Oudry N, Giliberto JP et al. Biodegradable PLGA microparticles for sustained release of a new GnRH antagonist: part II. In vivo performance. Eur. J. Pharm. Biopharm. 57(3), 441-446 (2004).
    • (2004) Vivo Performance. Eur. J. Pharm. Biopharm. , vol.57 , Issue.3 , pp. 441-446
    • Schwach, G.1    Oudry, N.2    Giliberto, J.P.3
  • 61
    • 79955581199 scopus 로고    scopus 로고
    • Development of interferon a-2b microspheres with constant release
    • Li Z, Li L, Liu Y et al. Development of interferon a-2b microspheres with constant release. Int. J. Pharm. 410(1-2), 48-53 (2011).
    • (2011) Int. J. Pharm. , vol.410 , Issue.1-2 , pp. 48-53
    • Li, Z.1    Li, L.2    Liu, Y.3
  • 63
    • 34147126384 scopus 로고    scopus 로고
    • Recent advances in protein and peptide drug delivery systems
    • Malik DK, Baboota S, Ahuja A, Hasan S, Ali J. Recent advances in protein and peptide drug delivery systems. Curr. Drug Deliv. 4(2), 141-151 (2007).
    • (2007) Curr. Drug Deliv. , vol.4 , Issue.2 , pp. 141-151
    • Malik, D.K.1    Baboota, S.2    Ahuja, A.3    Hasan, S.4    Ali, J.5
  • 64
    • 77952031302 scopus 로고    scopus 로고
    • Benchmarking drug delivery-defining product benefit and value
    • Bossart J. Benchmarking drug delivery-defining product benefit and value. Drug Deliv. Technol. 5(2), 22 (2005).
    • (2005) Drug Deliv. Technol. , vol.5 , Issue.2 , pp. 22
    • Bossart, J.1
  • 65
    • 50149086491 scopus 로고    scopus 로고
    • Reversible protein precipitation to ensure stability during encapsulation within PLGA microspheres
    • Giteau A, Venier-Julienne MC, Marchal S et al. Reversible protein precipitation to ensure stability during encapsulation within PLGA microspheres. Eur. J. Pharm. Biopharm. 70(1), 127-136 (2008).
    • (2008) Eur. J. Pharm. Biopharm. , vol.70 , Issue.1 , pp. 127-136
    • Giteau, A.1    Venier-Julienne, M.C.2    Marchal, S.3
  • 66
    • 84862901722 scopus 로고    scopus 로고
    • Improved enzyme activity and stability in polymer microspheres by encapsulation of protein nanospheres
    • Montalvo-Ortiz BL, Sosa B, Griebenow K. Improved enzyme activity and stability in polymer microspheres by encapsulation of protein nanospheres. AAPS PharmSciTech 13(2), 632-636 (2012).
    • (2012) AAPS PharmSciTech , vol.13 , Issue.2 , pp. 632-636
    • Montalvo-Ortiz, B.L.1    Sosa, B.2    Griebenow, K.3
  • 67
    • 79951948157 scopus 로고    scopus 로고
    • PEGylated TNF-related apoptosis-inducing ligand (TRAIL)-loaded sustained release PLGA microspheres for enhanced stability and antitumor activity
    • Kim TH, Jiang HH, Park CW et al. PEGylated TNF-related apoptosis-inducing ligand (TRAIL)-loaded sustained release PLGA microspheres for enhanced stability and antitumor activity. J. Control. Release 150(1), 63-69 (2011).
    • (2011) J. Control. Release , vol.150 , Issue.1 , pp. 63-69
    • Kim, T.H.1    Jiang, H.H.2    Park, C.W.3
  • 69
    • 48149090216 scopus 로고    scopus 로고
    • Sustained release of bioactive glycosylated glial cell-line derived neurotrophic factor from biodegradable polymeric microspheres
    • Garbayo E, Ansorena E, Lanciego JL, Aymerich MS, Blanco-Prieto MJ. Sustained release of bioactive glycosylated glial cell-line derived neurotrophic factor from biodegradable polymeric microspheres. Eur. J. Pharm. Biopharm. 69(3), 844-851 (2008).
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , Issue.3 , pp. 844-851
    • Garbayo, E.1    Ansorena, E.2    Lanciego, J.L.3    Aymerich, M.S.4    Blanco-Prieto, M.J.5
  • 70
    • 77955610669 scopus 로고    scopus 로고
    • Studies on MEP421 PLGA microspheres: Preparation and drug release
    • Ji Y, Dong W, Wanga X et al. Studies on MEP421 PLGA microspheres: preparation and drug release. Asian J. Pharm. Sci. 3(5), 211-216 (2008).
    • (2008) Asian J. Pharm. Sci. , vol.3 , Issue.5 , pp. 211-216
    • Ji, Y.1    Dong, W.2    Wanga, X.3
  • 71
    • 34548279009 scopus 로고    scopus 로고
    • In vitro release study of mono-PEGylated growth hormone-releasing peptide-6 from PLGA microspheres
    • Park EJ, Na DH, Lee KC. In vitro release study of mono-PEGylated growth hormone-releasing peptide-6 from PLGA microspheres. Int. J. Pharm. 343(1-2), 281-283 (2007).
    • (2007) Int. J. Pharm. , vol.343 , Issue.1-2 , pp. 281-283
    • Park, E.J.1    Na, D.H.2    Lee, K.C.3
  • 72
    • 78649447564 scopus 로고    scopus 로고
    • Chitosan-polycaprolactone copolymer microspheres for transforming growth factor-b1 delivery
    • Wu H, Wang S, Fang H, Zan X, Zhang J, Wan Y. Chitosan-polycaprolactone copolymer microspheres for transforming growth factor-b1 delivery. Colloids Surf. B Biointerfaces 82(2), 602-608 (2011).
    • (2011) Colloids Surf. B Biointerfaces , vol.82 , Issue.2 , pp. 602-608
    • Wu, H.1    Wang, S.2    Fang, H.3    Zan, X.4    Zhang, J.5    Wan, Y.6
  • 73
    • 38849117218 scopus 로고    scopus 로고
    • Preparation of glucagon-like peptide-1 loaded PLGA microspheres: Characterizations, release studies and bioactivities in vitro/in vivo
    • Yin D, Lu Y, Zhang H et al. Preparation of glucagon-like peptide-1 loaded PLGA microspheres: characterizations, release studies and bioactivities in vitro/in vivo. Chem. Pharm. Bull. 56(2), 156-161 (2008).
    • (2008) Chem. Pharm. Bull. , vol.56 , Issue.2 , pp. 156-161
    • Yin, D.1    Lu, Y.2    Zhang, H.3
  • 74
    • 84866881663 scopus 로고    scopus 로고
    • Multi-arm histidine copolymer for controlled release of insulin from poly(lactide-co-glycolide) microsphere
    • Park W, Kim D, Kang HC, Bae YH, Na K. Multi-arm histidine copolymer for controlled release of insulin from poly(lactide-co-glycolide) microsphere. Biomaterials 33(34), 8848-8857 (2012).
    • (2012) Biomaterials , vol.33 , Issue.34 , pp. 8848-8857
    • Park, W.1    Kim, D.2    Kang, H.C.3    Bae, Y.H.4    Na, K.5
  • 75
    • 70349633416 scopus 로고    scopus 로고
    • Evaluation of polyanhydride microspheres for basal insulin delivery: Effect of copolymer composition and zinc salt on encapsulation, in vitro release, stability, in vivo absorption and bioactivity in diabetic rats
    • Manoharan C, Singh J. Evaluation of polyanhydride microspheres for basal insulin delivery: effect of copolymer composition and zinc salt on encapsulation, in vitro release, stability, in vivo absorption and bioactivity in diabetic rats. J. Pharm. Sci. 98(11), 4237-4250 (2009).
    • (2009) J. Pharm. Sci. , vol.98 , Issue.11 , pp. 4237-4250
    • Manoharan, C.1    Singh, J.2
  • 76
    • 78049461216 scopus 로고    scopus 로고
    • Preparation, characterization, and pharmacodynamics of exenatide-loaded poly(DL-lactic-co-glycolic acid) microspheres
    • Liu B, Dong Q, Wang M et al. Preparation, characterization, and pharmacodynamics of exenatide-loaded poly(DL-lactic-co-glycolic acid) microspheres. Chem. Pharm. Bull. 58(11), 1474-1479 (2010).
    • (2010) Chem. Pharm. Bull. , vol.58 , Issue.11 , pp. 1474-1479
    • Liu, B.1    Dong, Q.2    Wang, M.3
  • 77
    • 84888106647 scopus 로고    scopus 로고
    • Controlled delivery of fibroblast growth factor-1 and neuregulin-1 from biodegradable microparticles promotes cardiac repair in a rat myocardial infarction model through activation of endogenous regeneration
    • Formiga FR, Pelacho B, Garbayo E et al. Controlled delivery of fibroblast growth factor-1 and neuregulin-1 from biodegradable microparticles promotes cardiac repair in a rat myocardial infarction model through activation of endogenous regeneration. J. Control. Release 173, 132-139 (2014).
    • (2014) J. Control. Release , vol.173 , pp. 132-139
    • Formiga, F.R.1    Pelacho, B.2    Garbayo, E.3
  • 78
    • 33646802288 scopus 로고    scopus 로고
    • Intratracheal and subcutaneous liposomal VIP normalizes arterial pressure in spontaneously hypertensive hamsters
    • Rubinstein I, Ikezaki H, Onyuksel H. Intratracheal and subcutaneous liposomal VIP normalizes arterial pressure in spontaneously hypertensive hamsters. Int. J. Pharm. 316(1-2), 144-147 (2006).
    • (2006) Int. J. Pharm. , vol.316 , Issue.1-2 , pp. 144-147
    • Rubinstein, I.1    Ikezaki, H.2    Onyuksel, H.3
  • 79
    • 79960201227 scopus 로고    scopus 로고
    • Encapsulation enhancement and stabilization of insulin in cationic liposomes
    • Park SJ, Choi SG, Davaa E, Park JS. Encapsulation enhancement and stabilization of insulin in cationic liposomes. Int. J. Pharm. 415(1-2), 267-272 (2011).
    • (2011) Int. J. Pharm. , vol.415 , Issue.1-2 , pp. 267-272
    • Park, S.J.1    Choi, S.G.2    Davaa, E.3    Park, J.S.4
  • 80
    • 84860390401 scopus 로고    scopus 로고
    • Antigen in chitosan coated liposomes enhances immune responses through parenteral immunization
    • Behera T, Swain P, Sahoo SK. Antigen in chitosan coated liposomes enhances immune responses through parenteral immunization. Int. Immunopharmacol. 11(8), 907-914 (2011).
    • (2011) Int. Immunopharmacol. , vol.11 , Issue.8 , pp. 907-914
    • Behera, T.1    Swain, P.2    Sahoo, S.K.3
  • 81
    • 79960236174 scopus 로고    scopus 로고
    • Encapsulation, pharmacokinetics and tissue distribution of interferon a-2b liposomes after intramuscular injection to rats
    • Li H, Yang L, Cheng G, Wei HY, Zeng Q. Encapsulation, pharmacokinetics and tissue distribution of interferon a-2b liposomes after intramuscular injection to rats. Arch. Pharm. Res. 34(6), 941-948 (2011).
    • (2011) Arch. Pharm. Res. , vol.34 , Issue.6 , pp. 941-948
    • Li, H.1    Yang, L.2    Cheng, G.3    Wei, H.Y.4    Zeng, Q.5
  • 82
    • 79958051531 scopus 로고    scopus 로고
    • Multivesicular liposome (MVL) sustained delivery of a novel synthetic cationic GnRH antagonist for prostate cancer treatment
    • Wang T, Gao L, Quan D. Multivesicular liposome (MVL) sustained delivery of a novel synthetic cationic GnRH antagonist for prostate cancer treatment. J. Pharm. Pharmacol. 63(7), 904-910 (2011).
    • (2011) J. Pharm. Pharmacol. , vol.63 , Issue.7 , pp. 904-910
    • Wang, T.1    Gao, L.2    Quan, D.3
  • 83
    • 43449100313 scopus 로고    scopus 로고
    • Increase of the pharmacological and pharmacokinetic efficacy of negatively charged polypeptide recombinant hirudin in rats via parenteral route by association with cationic liposomes
    • Meng M, Liu Y, Wang YB et al. Increase of the pharmacological and pharmacokinetic efficacy of negatively charged polypeptide recombinant hirudin in rats via parenteral route by association with cationic liposomes. J. Control. Release 128(2), 113-119 (2008).
    • (2008) J. Control. Release , vol.128 , Issue.2 , pp. 113-119
    • Meng, M.1    Liu, Y.2    Wang, Y.B.3
  • 84
    • 84873929926 scopus 로고    scopus 로고
    • In vivo evaluation of a conjugated poly(lactide-ethylene glycol) nanoparticle depot formulation for prolonged insulin delivery in the diabetic rabbit model
    • Tomar L, Tyagi C, Kumar M et al. In vivo evaluation of a conjugated poly(lactide-ethylene glycol) nanoparticle depot formulation for prolonged insulin delivery in the diabetic rabbit model. Int. J. Nanomed. 8, 505-520 (2013).
    • (2013) Int. J. Nanomed. , vol.8 , pp. 505-520
    • Tomar, L.1    Tyagi, C.2    Kumar, M.3
  • 85
    • 84855678453 scopus 로고    scopus 로고
    • Formulation of PEG-ylated L-asparaginase loaded poly (lactide-co- glycolide) nanoparticles: Influence of PEGylation on enzyme loading, activity and in vitro release
    • Vasudev SS, Ahmad S, Parveen R et al. Formulation of PEG-ylated L-asparaginase loaded poly (lactide-co-glycolide) nanoparticles: influence of PEGylation on enzyme loading, activity and in vitro release. Die Pharmazie 66(12), 956-960 (2011).
    • (2011) Die Pharmazie , vol.66 , Issue.12 , pp. 956-960
    • Vasudev, S.S.1    Ahmad, S.2    Parveen, R.3
  • 86
    • 79960785994 scopus 로고    scopus 로고
    • Preparation and characterization of catalase-loaded solid lipid nanoparticles protecting enzyme against proteolysis
    • Qi C, Chen Y, Jing QZ, Wang XG. Preparation and characterization of catalase-loaded solid lipid nanoparticles protecting enzyme against proteolysis. Int. J. Mol. Sci. 12(7), 4282-4293 (2011).
    • (2011) Int. J. Mol. Sci. , vol.12 , Issue.7 , pp. 4282-4293
    • Qi, C.1    Chen, Y.2    Jing, Q.Z.3    Wang, X.G.4
  • 87
    • 84856681528 scopus 로고    scopus 로고
    • Preparation and characterization of catalase-loaded solid lipid nanoparticles based on soybean phosphatidylcholine
    • Qi C, Chen Y, Huang JH, Jin QZ, Wang XG. Preparation and characterization of catalase-loaded solid lipid nanoparticles based on soybean phosphatidylcholine. J. Sci. Food Agric. 92(4), 787-793 (2012).
    • (2012) J. Sci. Food Agric. , vol.92 , Issue.4 , pp. 787-793
    • Qi, C.1    Chen, Y.2    Huang, J.H.3    Jin, Q.Z.4    Wang, X.G.5
  • 92
    • 84896785856 scopus 로고    scopus 로고
    • Application of nanotechnology in ocular drug delivery
    • Mitra AK (Ed.) Bentham Science Publishers, Sharjah, United Arab Emirates
    • Yang X, Patel A, Vadlapudi AD, Mitra AK. Application of Nanotechnology in Ocular Drug De l iver y. In: Treatise on Ocular Drug Delivery. Mitra AK (Ed.). Bentham Science Publishers, Sharjah, United Arab Emirates, 253-284 (2013).
    • (2013) Treatise on Ocular Drug Delivery , pp. 253-284
    • Yang, X.1    Patel, A.2    Vadlapudi, A.D.3    Mitra, A.K.4
  • 93
    • 78650524261 scopus 로고    scopus 로고
    • Development of peptide and protein nanotherapeutics by nanoencapsulation and nanobioconjugation
    • Yadav SC, Kumari A, Yadav R. Development of peptide and protein nanotherapeutics by nanoencapsulation and nanobioconjugation. Peptides 32(1), 173-187 (2011).
    • (2011) Peptides , vol.32 , Issue.1 , pp. 173-187
    • Yadav, S.C.1    Kumari, A.2    Yadav, R.3
  • 95
    • 75449117868 scopus 로고    scopus 로고
    • Preparation and in vitro-in vivo evaluation of salmon calcitonin-loaded polymeric nanoparticles
    • Glowka E, Sapin-Minet A, Leroy P, Lulek J, Maincent P. Preparation and in vitro-in vivo evaluation of salmon calcitonin-loaded polymeric nanoparticles. J. Microencapsul. 27(1), 25-36 (2010).
    • (2010) J. Microencapsul. , vol.27 , Issue.1 , pp. 25-36
    • Glowka, E.1    Sapin-Minet, A.2    Leroy, P.3    Lulek, J.4    Maincent, P.5
  • 96
    • 36248994764 scopus 로고    scopus 로고
    • Novel approach for delivery of insulin loaded poly(lactide-co-glycolide) nanoparticles using a combination of stabilizers
    • Kumar PS, Saini TR, Chandrasekar D, Yellepeddi VK, Ramakrishna S, Diwan PV. Novel approach for delivery of insulin loaded poly(lactide-co-glycolide) nanoparticles using a combination of stabilizers. Drug Deliv. 14(8), 517-523 (2007).
    • (2007) Drug Deliv. , vol.14 , Issue.8 , pp. 517-523
    • Kumar, P.S.1    Saini, T.R.2    Chandrasekar, D.3    Yellepeddi, V.K.4    Ramakrishna, S.5    Diwan, P.V.6
  • 97
    • 84892478123 scopus 로고    scopus 로고
    • Encapsulation of protein-polysaccharide HIP complex in polymeric nanoparticles
    • Gaudana R, Khurana V, Parenky A, Mitra AK. Encapsulation of protein-polysaccharide HIP complex in polymeric nanoparticles. J. Drug Deliv. 2011, 458128 (2011).
    • (2011) J. Drug Deliv. , vol.2011 , pp. 458128
    • Gaudana, R.1    Khurana, V.2    Parenky, A.3    Mitra, A.K.4
  • 98
    • 61449246499 scopus 로고    scopus 로고
    • Investigation of drug loading and in vitro release mechanisms of insulin-lauryl sulfate complex loaded PLGA nanoparticles
    • Shi K, Cui F, Yamamoto H, Kawashima Y. Investigation of drug loading and in vitro release mechanisms of insulin-lauryl sulfate complex loaded PLGA nanoparticles. Die Pharmazie 63(12), 866-871 (2008).
    • (2008) Die Pharmazie , vol.63 , Issue.12 , pp. 866-871
    • Shi, K.1    Cui, F.2    Yamamoto, H.3    Kawashima, Y.4
  • 99
    • 70350672531 scopus 로고    scopus 로고
    • Design of high payload PLGA nanoparticles containing melittin/sodium dodecyl sulfate complex by the hydrophobic ion-pairing technique
    • Yang L, Cui F, Shi K, Cun D, Wang R. Design of high payload PLGA nanoparticles containing melittin/sodium dodecyl sulfate complex by the hydrophobic ion-pairing technique. Drug Dev. Ind. Pharm. 35(8), 959-968 (2009).
    • (2009) Drug Dev. Ind. Pharm. , vol.35 , Issue.8 , pp. 959-968
    • Yang, L.1    Cui, F.2    Shi, K.3    Cun, D.4    Wang, R.5
  • 100
    • 0034255054 scopus 로고    scopus 로고
    • Hydrophobic ion pair formation between leuprolide and sodium oleate for sustained release from biodegradable polymeric microspheres
    • Choi SH, Park TG. Hydrophobic ion pair formation between leuprolide and sodium oleate for sustained release from biodegradable polymeric microspheres. Int. J. Pharm. 203(1-2), 193-202 (2000).
    • (2000) Int. J. Pharm. , vol.203 , Issue.1-2 , pp. 193-202
    • Choi, S.H.1    Park, T.G.2
  • 101
    • 84891655460 scopus 로고    scopus 로고
    • Design and evaluation of a novel nanoparticulate-based formulation encapsulating a HIP complex of lysozyme
    • Gaudana R, Gokulgandhi M, Khurana V, Kwatra D, Mitra AK. Design and evaluation of a novel nanoparticulate-based formulation encapsulating a HIP complex of lysozyme. Pharm. Dev. Technol. 18(3), 752-759 (2013).
    • (2013) Pharm. Dev. Technol. , vol.18 , Issue.3 , pp. 752-759
    • Gaudana, R.1    Gokulgandhi, M.2    Khurana, V.3    Kwatra, D.4    Mitra, A.K.5
  • 102
    • 83355162688 scopus 로고    scopus 로고
    • A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles
    • Peng Q, Zhang ZR, Gong T, Chen GQ, Sun X. A rapid-acting, long-acting insulin formulation based on a phospholipid complex loaded PHBHHx nanoparticles. Biomaterials 33(5), 1583-1588 (2012).
    • (2012) Biomaterials , vol.33 , Issue.5 , pp. 1583-1588
    • Peng, Q.1    Zhang, Z.R.2    Gong, T.3    Chen, G.Q.4    Sun, X.5
  • 103
    • 0038032150 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery a review of the state of the art
    • Muller RH, Mader K, Gohla S. Solid lipid nanoparticles (SLN) for controlled drug delivery-a review of the state of the art. Eur. J. Pharm. Biopharm. 50(1), 161-177 (2000).
    • (2000) Eur. J. Pharm. Biopharm. , vol.50 , Issue.1 , pp. 161-177
    • Muller, R.H.1    Mader, K.2    Gohla, S.3
  • 104
    • 0035946615 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: Production, characterization and applications
    • Mehnert W, Mader K. Solid lipid nanoparticles: production, characterization and applications. Adv. Drug Deliv. Rev. 47(2-3), 165-196 (2001).
    • (2001) Adv. Drug Deliv. Rev. , vol.47 , Issue.2-3 , pp. 165-196
    • Mehnert, W.1    Mader, K.2
  • 105
    • 34547899919 scopus 로고    scopus 로고
    • Solid lipid nanoparticles as a drug delivery system for peptides and proteins
    • Almeida AJ, Souto E. Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv. Drug Deliv. Rev. 59(6), 478-490 (2007).
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , Issue.6 , pp. 478-490
    • Almeida, A.J.1    Souto, E.2
  • 106
    • 84896779744 scopus 로고    scopus 로고
    • Strategies of drug targeting
    • Mitra A, Lee CH, Cheng K (Eds) John-Wiley and Sons, Inc., Hoboken, NJ, USA
    • Ravi S, Shukla ZC, Kun Cheng. Strategies of Drug Targeting. In: Advanced Drug Delivery. Mitra A, Lee CH, Cheng K (Eds). John Wiley and Sons, Inc., Hoboken, NJ, USA, 105-120 (2013).
    • (2013) Advanced Drug Delivery , pp. 105-120
    • Ravi, S.1    Shukla, Z.C.2    Kun, C.3
  • 107
    • 59849090174 scopus 로고    scopus 로고
    • Production of solid lipid submicron particles for protein delivery using a novel supercritical gas-assisted melting atomization process
    • Salmaso S, Elvassore N, Bertucco A, Caliceti P. Production of solid lipid submicron particles for protein delivery using a novel supercritical gas-assisted melting atomization process. J. Pharm. Sci. 98(2), 640-650 (2009).
    • (2009) J. Pharm. Sci. , vol.98 , Issue.2 , pp. 640-650
    • Salmaso, S.1    Elvassore, N.2    Bertucco, A.3    Caliceti, P.4
  • 108
    • 84880773008 scopus 로고    scopus 로고
    • Hybrid melittin cytolytic peptide-driven ultrasmall lipid nanoparticles block melanoma growth in vivo
    • Huang C, Jin H, Qian Y et al. Hybrid melittin cytolytic peptide-driven ultrasmall lipid nanoparticles block melanoma growth in vivo. ACS Nano 7(7), 5791-5800 (2013).
    • (2013) ACS Nano , vol.7 , Issue.7 , pp. 5791-5800
    • Huang, C.1    Jin, H.2    Qian, Y.3
  • 109
    • 84873624680 scopus 로고    scopus 로고
    • Preparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles
    • Zhang L, Zhao ZL, Wei XH, Liu JH. Preparation and in vitro and in vivo characterization of cyclosporin A-loaded, PEGylated chitosan-modified, lipid-based nanoparticles. Int. J. Nanomed. 8, 601-610 (2013).
    • (2013) Int. J. Nanomed. , vol.8 , pp. 601-610
    • Zhang, L.1    Zhao, Z.L.2    Wei, X.H.3    Liu, J.H.4
  • 110
    • 79955000174 scopus 로고    scopus 로고
    • Peptide-loaded solid lipid nanoparticles prepared through coacervation technique
    • Gallarate M, Battaglia L, Peira E, Trotta M. Peptide-loaded solid lipid nanoparticles prepared through coacervation technique. Int. J. Chem. Eng. 2011, 132435 (2011).
    • (2011) Int. J. Chem. Eng. , pp. 132435
    • Gallarate, M.1    Battaglia, L.2    Peira, E.3    Trotta, M.4
  • 111
    • 77956314276 scopus 로고    scopus 로고
    • Preparation of gel-core-solid lipid nanoparticle: A novel way to improve the encapsulation of protein and peptide
    • Yang R, Gao RC, Cai CF et al. Preparation of gel-core-solid lipid nanoparticle: a novel way to improve the encapsulation of protein and peptide. Chem. Pharm. Bull. 58(9), 1195-1202 (2010).
    • (2010) Chem. Pharm. Bull. , vol.58 , Issue.9 , pp. 1195-1202
    • Yang, R.1    Gao, R.C.2    Cai, C.F.3
  • 112
    • 41849105252 scopus 로고    scopus 로고
    • Lipid-based colloidal carriers for peptide and protein delivery-liposomes versus lipid nanoparticles
    • Martins S, Sarmento B, Ferreira DC, Souto EB. Lipid-based colloidal carriers for peptide and protein delivery-liposomes versus lipid nanoparticles. Int. J. Nanomed. 2(4), 595-607 (2007).
    • (2007) Int. J. Nanomed. , vol.2 , Issue.4 , pp. 595-607
    • Martins, S.1    Sarmento, B.2    Ferreira, D.C.3    Souto, E.B.4
  • 113
    • 0034826741 scopus 로고    scopus 로고
    • Enzymes inside lipid vesicles: Preparation, reactivity and applications
    • Walde P, Ichikawa S. Enzymes inside lipid vesicles: preparation, reactivity and applications. Biomol. Eng. 18(4), 143-177 (2001).
    • (2001) Biomol. Eng. , vol.18 , Issue.4 , pp. 143-177
    • Walde, P.1    Ichikawa, S.2
  • 114
    • 84869773544 scopus 로고    scopus 로고
    • Liposomal delivery of proteins and peptides
    • Swaminathan J, Ehrhardt C. Liposomal delivery of proteins and peptides. Expert Opin. Drug Deliv. 9(12), 1489-1503 (2012).
    • (2012) Expert Opin. Drug Deliv. , vol.9 , Issue.12 , pp. 1489-1503
    • Swaminathan, J.1    Ehrhardt, C.2
  • 115
    • 0020070164 scopus 로고
    • Prolonged hypoglycemic effect in diabetic dogs due to subcutaneous administration of insulin in liposomes
    • Stevenson RW, Patel HM, Parsons JA, Ryman BE. Prolonged hypoglycemic effect in diabetic dogs due to subcutaneous administration of insulin in liposomes. Diabetes 31(6 Pt 1), 506-511 (1982).
    • (1982) Diabetes , vol.31 , Issue.6 PART 1 , pp. 506-511
    • Stevenson, R.W.1    Patel, H.M.2    Parsons, J.A.3    Ryman, B.E.4
  • 116
    • 0344629794 scopus 로고    scopus 로고
    • Continuous release of interleukin-2 from liposomal IL-2 (mixture of interleukin-2 and liposomes) after subcutaneous administration to mice
    • Kanaoka E, Takahashi K, Yoshikawa T, Jizomoto H, Nishihara Y, Hirano K. Continuous release of interleukin-2 from liposomal IL-2 (mixture of interleukin-2 and liposomes) after subcutaneous administration to mice. Drug Dev. Ind. Pharm. 29 (10), 1149-1153 (2003).
    • (2003) Drug Dev. Ind. Pharm. , vol.29 , Issue.10 , pp. 1149-1153
    • Kanaoka, E.1    Takahashi, K.2    Yoshikawa, T.3    Jizomoto, H.4    Nishihara, Y.5    Hirano, K.6
  • 117
    • 0025636148 scopus 로고
    • Factors influencing the enhanced hypocalcemic action of liposome-entrapped calcitonin
    • Fukunaga M, Miller MM, Deftos LJ. Factors influencing the enhanced hypocalcemic action of liposome-entrapped calcitonin. Calcif. Tissue Int. 47(6), 373-377 (1990).
    • (1990) Calcif. Tissue Int. , vol.47 , Issue.6 , pp. 373-377
    • Fukunaga, M.1    Miller, M.M.2    Deftos, L.J.3
  • 118
    • 0036018133 scopus 로고    scopus 로고
    • A lipid based depot (DepoFoam technology) for sustained release drug delivery
    • Mantripragada S. A lipid based depot (DepoFoam technology) for sustained release drug delivery. Prog. Lipid. Res. 41(5), 392-406 (2002).
    • (2002) Prog. Lipid. Res. , vol.41 , Issue.5 , pp. 392-406
    • Mantripragada, S.1
  • 119
    • 33746810003 scopus 로고    scopus 로고
    • PEGylated protein encapsulated multivesicular liposomes: A novel approach for sustained release of interferon a
    • Vyas SP, Rawat M, Rawat A, Mahor S, Gupta PN. PEGylated protein encapsulated multivesicular liposomes: a novel approach for sustained release of interferon a. Drug Dev. Ind. Pharm. 32(6), 699-707 (2006).
    • (2006) Drug Dev. Ind. Pharm. , vol.32 , Issue.6 , pp. 699-707
    • Vyas, S.P.1    Rawat, M.2    Rawat, A.3    Mahor, S.4    Gupta, P.N.5
  • 120
    • 0037133030 scopus 로고    scopus 로고
    • Sustained-delivery of an apolipoprotein E-peptidomimetic using multivesicular liposomes lowers serum cholesterol levels
    • Ramprasad MP, Anantharamaiah GM, Garber DW, Katre NV. Sustained-delivery of an apolipoprotein E-peptidomimetic using multivesicular liposomes lowers serum cholesterol levels. J. Control. Release 79(1-3), 207-218 (2002).
    • (2002) J. Control. Release , vol.79 , Issue.1-3 , pp. 207-218
    • Ramprasad, M.P.1    Anantharamaiah, G.M.2    Garber, D.W.3    Katre, N.V.4
  • 121
    • 0031793433 scopus 로고    scopus 로고
    • Multivesicular liposome (DepoFoam) technology for the sustained delivery of insulin-like growth factor-I (IGF-I)
    • Katre NV, Asherman J, Schaefer H, Hora M. Multivesicular liposome (DepoFoam) technology for the sustained delivery of insulin-like growth factor-I (IGF-I). J. Pharm. Sci. 87(11), 1341-1346 (1998).
    • (1998) J. Pharm. Sci. , vol.87 , Issue.11 , pp. 1341-1346
    • Katre, N.V.1    Asherman, J.2    Schaefer, H.3    Hora, M.4
  • 122
    • 0043028158 scopus 로고    scopus 로고
    • The sustained granulopoietic effect of progenipoietin encapsulated in multivesicular liposomes
    • Ramprasad MP, Amini A, Kararli T, Katre N V. The sustained granulopoietic effect of progenipoietin encapsulated in multivesicular liposomes. Int. J. Pharm. 261(1-2), 93-103 (2003).
    • (2003) Int. J. Pharm. , vol.261 , Issue.1-2 , pp. 93-103
    • Ramprasad, M.P.1    Amini, A.2    Kararli, T.3    Katre, N.V.4
  • 123
    • 0037437076 scopus 로고    scopus 로고
    • Modulation of the sustained delivery of myelopoietin (Leridistim) encapsulated in multivesicular liposomes (DepoFoam)
    • Langston MV, Ramprasad MP, Kararli TT, Galluppi GR, Katre NV. Modulation of the sustained delivery of myelopoietin (Leridistim) encapsulated in multivesicular liposomes (DepoFoam). J. Control. Release 9(1), 87-99 (2003).
    • (2003) J. Control. Release , vol.9 , Issue.1 , pp. 87-99
    • Langston, M.V.1    Ramprasad, M.P.2    Kararli, T.T.3    Galluppi, G.R.4    Katre, N.V.5
  • 124
    • 27744532479 scopus 로고    scopus 로고
    • Multivesicular liposome formulations for the sustained delivery of interferon a-2b
    • Qiu J, Wei XH, Geng F, Liu R, Zhang JW, Xu YH. Multivesicular liposome formulations for the sustained delivery of interferon a-2b. Acta Pharmacol. Sinica 26(11), 1395-1401 (2005).
    • (2005) Acta Pharmacol. Sinica , vol.26 , Issue.11 , pp. 1395-1401
    • Qiu, J.1    Wei, X.H.2    Geng, F.3    Liu, R.4    Zhang, J.W.5    Xu, Y.H.6
  • 125
    • 0033621759 scopus 로고    scopus 로고
    • DepoFoam technology: A vehicle for controlled delivery of protein and peptide drugs
    • Ye Q, Asherman J, Stevenson M, Brownson E, Katre N V. DepoFoam technology: a vehicle for controlled delivery of protein and peptide drugs. J. Control. Release 64(1-3), 155-166 (2000).
    • (2000) J. Control. Release , vol.64 , Issue.1-3 , pp. 155-166
    • Ye, Q.1    Asherman, J.2    Stevenson, M.3    Brownson, E.4    Katre, N.V.5
  • 126
    • 0035715353 scopus 로고    scopus 로고
    • Clinical applications of a novel sustained-release injectable drug delivery system: DepoFoam technology
    • Howell SB. Clinical applications of a novel sustained-release injectable drug delivery system: DepoFoam technology. Cancer J. 7(3), 219-227 (2001).
    • (2001) Cancer J. , vol.7 , Issue.3 , pp. 219-227
    • Howell, S.B.1
  • 127
    • 68549092406 scopus 로고    scopus 로고
    • The use of PEGylated liposomes to prolong circulation lifetimes of tissue plasminogen activator
    • Kim JY, Kim JK, Park JS, Byun Y, Kim CK. The use of PEGylated liposomes to prolong circulation lifetimes of tissue plasminogen activator. Biomaterials 30(29), 5751-5756 (2009).
    • (2009) Biomaterials , vol.30 , Issue.29 , pp. 5751-5756
    • Kim, J.Y.1    Kim, J.K.2    Park, J.S.3    Byun, Y.4    Kim, C.K.5
  • 128
    • 76149134362 scopus 로고    scopus 로고
    • Enhancement of the efficacy of therapeutic proteins by formulation with PEGylated liposomes; A case of FVIII
    • Yatuv R, Robinson M, Dayan I, Baru M. Enhancement of the efficacy of therapeutic proteins by formulation with PEGylated liposomes; a case of FVIII, FVIIa and G-CSF. Expert Opin. Drug Deliv. 7(2), 187-201 (2010).
    • (2010) FVIIa and G-CSF. Expert Opin. Drug Deliv. , vol.7 , Issue.2 , pp. 187-201
    • Yatuv, R.1    Robinson, M.2    Dayan, I.3    Baru, M.4
  • 129
    • 79952115967 scopus 로고    scopus 로고
    • The use of PEGylated liposomes in the development of drug delivery applications for the treatment of hemophilia
    • Yatuv R, Robinson M, Dayan-Tarshish I, Baru M. The use of PEGylated liposomes in the development of drug delivery applications for the treatment of hemophilia. Int. J. Nanomed. 5, 581-591 (2010).
    • (2010) Int. J. Nanomed. , vol.5 , pp. 581-591
    • Yatuv, R.1    Robinson, M.2    Dayan-Tarshish, I.3    Baru, M.4
  • 130
    • 79960799372 scopus 로고    scopus 로고
    • Carbon nanotubes as carriers for delivery of bioactive and therapeutic agents: An overview
    • Mali N, Jadhav S, Karpe M, Kadam V. Carbon nanotubes as carriers for delivery of bioactive and therapeutic agents: an overview. Int. J. Pharm. Sci. 3(3), 45-52 (2011).
    • (2011) Int. J. Pharm. Sci. , vol.3 , Issue.3 , pp. 45-52
    • Mali, N.1    Jadhav, S.2    Karpe, M.3    Kadam, V.4
  • 131
    • 84896785303 scopus 로고    scopus 로고
    • Functionalized CNTs for delivery of therapeutics
    • Garmaroudi FS, Vahdati RAR. Functionalized CNTs for delivery of therapeutics. Int. J. Nano Dim. 1(2), 89-102 (2010).
    • (2010) Int. J. Nano Dim. , vol.1 , Issue.2 , pp. 89-102
    • Garmaroudi, F.S.1    Rar, V.2
  • 133
    • 3042818668 scopus 로고    scopus 로고
    • Nanotube molecular transporters: Internalization of carbon nanotube-protein conjugates into mammalian cells
    • Shi Kam NW, Jessop TC, Wender PA, Dai H. Nanotube molecular transporters: internalization of carbon nanotube-protein conjugates into mammalian cells. J. Am. Chem. Soc. 126(22), 6850-6851 (2004).
    • (2004) J. Am. Chem. Soc. , vol.126 , Issue.22 , pp. 6850-6851
    • Shi Kam, N.W.1    Jessop, T.C.2    Wender, P.A.3    Dai, H.4
  • 134
    • 17744390893 scopus 로고    scopus 로고
    • Carbon nanotubes as intracellular protein transporters: Generality and biological functionality
    • Kam NW, Dai H. Carbon nanotubes as intracellular protein transporters: generality and biological functionality. J. Am. Chem. Soc. 127(16), 6021-6026 (2005).
    • (2005) J. Am. Chem. Soc. , vol.127 , Issue.16 , pp. 6021-6026
    • Kam, N.W.1    Dai, H.2
  • 135
    • 70349315071 scopus 로고    scopus 로고
    • Carbon nanotubes as a protein toxin transporter for selective HER2-positive breast cancer cell destruction
    • Weng X, Wang M, Ge J et al. Carbon nanotubes as a protein toxin transporter for selective HER2-positive breast cancer cell destruction. Mol. Biosyst. 5(10), 1224-1231 (2009).
    • (2009) Mol. Biosyst. , vol.5 , Issue.10 , pp. 1224-1231
    • Weng, X.1    Wang, M.2    Ge, J.3
  • 136
    • 27744504244 scopus 로고    scopus 로고
    • Applications of carbon nanotubes in drug delivery
    • Bianco A, Kostarelos K, Prato M. Applications of carbon nanotubes in drug delivery. Curr. Opin. Chem. Biol. 9(6), 674-679 (2005).
    • (2005) Curr. Opin. Chem. Biol. , vol.9 , Issue.6 , pp. 674-679
    • Bianco, A.1    Kostarelos, K.2    Prato, M.3
  • 137
    • 0142229613 scopus 로고    scopus 로고
    • Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses
    • Pantarotto D, Partidos CD, Hoebeke J et al. Immunization with peptide-functionalized carbon nanotubes enhances virus-specific neutralizing antibody responses. Chem. Biol. 10(10), 961-966 (2003).
    • (2003) Chem. Biol. , vol.10 , Issue.10 , pp. 961-966
    • Pantarotto, D.1    Partidos, C.D.2    Hoebeke, J.3
  • 138
    • 52649154711 scopus 로고    scopus 로고
    • Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy
    • Meng J, Meng J, Duan J et al. Carbon nanotubes conjugated to tumor lysate protein enhance the efficacy of an antitumor immunotherapy. Small 4(9), 1364-1370 (2008).
    • (2008) Small , vol.4 , Issue.9 , pp. 1364-1370
    • Meng, J.1    Meng, J.2    Duan, J.3
  • 139
    • 53449093079 scopus 로고    scopus 로고
    • Immunological profile of a Plasmodium vivax AMA-1 N-terminus peptide-carbon nanotube conjugate in an infected Plasmodium berghei mouse model
    • Yandar N, Pastorin G, Prato M, Bianco A, Patarroyo ME, Lozano JM. Immunological profile of a Plasmodium vivax AMA-1 N-terminus peptide-carbon nanotube conjugate in an infected Plasmodium berghei mouse model. Vaccine 26(46), 5864-5873 (2008).
    • (2008) Vaccine , vol.26 , Issue.46 , pp. 5864-5873
    • Yandar, N.1    Pastorin, G.2    Prato, M.3    Bianco, A.4    Patarroyo, M.E.5    Lozano, J.M.6
  • 140
    • 79961033075 scopus 로고    scopus 로고
    • Single-walled carbon nanotubes deliver peptide antigen into dendritic cells and enhance IgG responses to tumor-associated antigens
    • Villa CH, Dao T, Ahearn I et al. Single-walled carbon nanotubes deliver peptide antigen into dendritic cells and enhance IgG responses to tumor-associated antigens. ACS Nano 5(7), 5300-5311 (2011).
    • (2011) ACS Nano , vol.5 , Issue.7 , pp. 5300-5311
    • Villa, C.H.1    Dao, T.2    Ahearn, I.3
  • 141
    • 84871552617 scopus 로고    scopus 로고
    • Novel nanomicellar formulation approaches for anterior and posterior segment ocular drug delivery
    • Cholkar K, Patel A, Vadlapudi AD, Mitra AK. Novel nanomicellar formulation approaches for anterior and posterior segment ocular drug delivery. Recent Patents Nanomed. 2(2), 82-95 (2012).
    • (2012) Recent Patents Nanomed. , vol.2 , Issue.2 , pp. 82-95
    • Cholkar, K.1    Patel, A.2    Vadlapudi, A.D.3    Mitra, A.K.4
  • 142
    • 84872319982 scopus 로고    scopus 로고
    • Improvement of in vivo efficacy of recombinant human erythropoietin by encapsulation in PEG-PLA micelle
    • Shi Y, Huang W, Liang R et al. Improvement of in vivo efficacy of recombinant human erythropoietin by encapsulation in PEG-PLA micelle. Int. J. Nanomed. 8, 1-11 (2013).
    • (2013) Int. J. Nanomed. , vol.8 , pp. 1-11
    • Shi, Y.1    Huang, W.2    Liang, R.3
  • 143
    • 42649125562 scopus 로고    scopus 로고
    • Freeze drying of peptide drugs self-associated with long-circulating, biocompatible and biodegradable sterically stabilized phospholipid nanomicelles
    • Lim SB, Rubinstein I, Onyuksel H. Freeze drying of peptide drugs self-associated with long-circulating, biocompatible and biodegradable sterically stabilized phospholipid nanomicelles. Int. J. Pharm. 356(1-2), 345-350 (2008).
    • (2008) Int. J. Pharm. , vol.356 , Issue.1-2 , pp. 345-350
    • Lim, S.B.1    Rubinstein, I.2    Onyuksel, H.3
  • 144
    • 70349213715 scopus 로고    scopus 로고
    • Disulfide-crosslinked polyion micelles for delivery of protein therapeutics
    • Heffernan MJ, Murthy N. Disulfide-crosslinked polyion micelles for delivery of protein therapeutics. Ann. Biomed. Eng. 37(10), 1993-2002 (2009).
    • (2009) Ann. Biomed. Eng. , vol.37 , Issue.10 , pp. 1993-2002
    • Heffernan, M.J.1    Murthy, N.2
  • 145
    • 84892369730 scopus 로고    scopus 로고
    • Optimization of landscape phage fusion protein-modified polymeric PEG-PE micelles for improved breast cancer cell targeting
    • Wang T, Petrenko VA, Torchilin VP. Optimization of landscape phage fusion protein-modified polymeric PEG-PE micelles for improved breast cancer cell targeting. Nanomed. Nanotechnol. 1-7 (2012).
    • (2012) Nanomed. Nanotechnol. , vol.1-7
    • Wang, T.1    Petrenko, V.A.2    Torchilin, V.P.3
  • 146
    • 63249104815 scopus 로고    scopus 로고
    • Micelles formed by self-assembly of hyperbranched poly[(amine-ester)-co- (D, L-lactide)] (HPAE-co-PLA) copolymers for protein drug delivery
    • Jiang M, Wu Y, Yong H, Jun N. Micelles formed by self-assembly of hyperbranched poly[(amine-ester)-co-(D, L-lactide)] (HPAE-co-PLA) copolymers for protein drug delivery. Polymer Int. 58(1), 31-39 (2009).
    • (2009) Polymer Int. , vol.58 , Issue.1 , pp. 31-39
    • Jiang, M.1    Wu, Y.2    Yong, H.3    Jun, N.4
  • 147
    • 84862639203 scopus 로고    scopus 로고
    • Human pancreatic polypeptide in a phospholipid-based micellar formulation
    • Banerjee A, Onyuksel H. Human pancreatic polypeptide in a phospholipid-based micellar formulation. Pharm. Res. 29(6), 1698-1711 (2012).
    • (2012) Pharm. Res. , vol.29 , Issue.6 , pp. 1698-1711
    • Banerjee, A.1    Onyuksel, H.2
  • 148
    • 79960703248 scopus 로고    scopus 로고
    • Micellar nanomedicine of human neuropeptide y
    • Kuzmis A, Lim SB, Desai E et al. Micellar nanomedicine of human neuropeptide Y. Nanomedicine 7(4), 464-471 (2011).
    • (2011) Nanomedicine , vol.7 , Issue.4 , pp. 464-471
    • Kuzmis, A.1    Lim, S.B.2    Desai, E.3
  • 149
    • 79952487368 scopus 로고    scopus 로고
    • A novel peptide nanomedicine against acute lung injury: GLP-1 in phospholipid micelles
    • Lim SB, Rubinstein I, Sadikot RT, Artwohl JE, Onyuksel H. A novel peptide nanomedicine against acute lung injury: GLP-1 in phospholipid micelles. Pharm. Res. 28(3), 662-672 (2011).
    • (2011) Pharm. Res. , vol.28 , Issue.3 , pp. 662-672
    • Lim, S.B.1    Rubinstein, I.2    Sadikot, R.T.3    Artwohl, J.E.4    Onyuksel, H.5
  • 150
    • 77953235585 scopus 로고    scopus 로고
    • Nanoscaled polyion complex micelles for targeted delivery of recombinant hirudin to platelets based on cationic copolymer
    • Wang F, Li X, Zhou Y et al. Nanoscaled polyion complex micelles for targeted delivery of recombinant hirudin to platelets based on cationic copolymer. Mol. Pharm. 7(3), 718-726 (2010).
    • (2010) Mol. Pharm. , vol.7 , Issue.3 , pp. 718-726
    • Wang, F.1    Li, X.2    Zhou, Y.3
  • 151
  • 152
    • 34848910216 scopus 로고    scopus 로고
    • Smart polymer based delivery systems for peptides and proteins
    • Al-Tahami K, Singh J. Smart polymer based delivery systems for peptides and proteins. Recent Pat. Drug Deliv. Formul. 1(1), 65-71 (2007).
    • (2007) Recent Pat. Drug Deliv. Formul. , vol.1 , Issue.1 , pp. 65-71
    • Al-Tahami, K.1    Singh, J.2
  • 153
    • 39649106936 scopus 로고    scopus 로고
    • Controlled release of growth hormone from thermosensitive triblock copolymer systems: In vitro and in vivo evaluation
    • Chen S, Singh J. Controlled release of growth hormone from thermosensitive triblock copolymer systems: in vitro and in vivo evaluation. Int. J. Pharm. 352(1-2), 58-65 (2008).
    • (2008) Int. J. Pharm. , vol.352 , Issue.1-2 , pp. 58-65
    • Chen, S.1    Singh, J.2
  • 154
    • 33846818951 scopus 로고    scopus 로고
    • Controlled delivery of recombinant hirudin based on thermo-sensitive Pluronic F127 hydrogel for subcutaneous administration: In vitro and in vivo characterization
    • Liu Y, Lu WL, Wang JC et al. Controlled delivery of recombinant hirudin based on thermo-sensitive Pluronic F127 hydrogel for subcutaneous administration: in vitro and in vivo characterization. J. Control. Release 117(3), 387-395 (2007).
    • (2007) J. Control. Release , vol.117 , Issue.3 , pp. 387-395
    • Liu, Y.1    Lu, W.L.2    Wang, J.C.3
  • 156
    • 84897979761 scopus 로고    scopus 로고
    • Assessment of release kinetics, stability and polymer interaction of poloxamer 407-based thermosensitive gel of interleukin-1 receptor antagonist
    • Akash MS, Rehman K, Sun H, Chen S. Assessment of release kinetics, stability and polymer interaction of poloxamer 407-based thermosensitive gel of interleukin-1 receptor antagonist. Pharm. Dev. Technol. 19(3), 278-284 (2013).
    • (2013) Pharm. Dev. Technol. , vol.19 , Issue.3 , pp. 278-284
    • Akash, M.S.1    Rehman, K.2    Sun, H.3    Chen, S.4
  • 157
    • 84873668406 scopus 로고    scopus 로고
    • Sustained delivery of IL-1Ra from PF127-gel reduces hyperglycemia in diabetic GK-rats
    • Akash MS, Rehman K, Sun H, Chen S. Sustained delivery of IL-1Ra from PF127-gel reduces hyperglycemia in diabetic GK-rats. PloS ONE 8(2), e55925 (2013).
    • (2013) PloS ONE , vol.8 , Issue.2
    • Akash, M.S.1    Rehman, K.2    Sun, H.3    Chen, S.4
  • 158
    • 84872064405 scopus 로고    scopus 로고
    • Sustained delivery of IL-1Ra from pluronic F127-based thermosensitive gel prolongs its therapeutic potentials
    • Akash MS, Rehman K, Li N, Gao JQ, Sun H, Chen S. Sustained delivery of IL-1Ra from pluronic F127-based thermosensitive gel prolongs its therapeutic potentials. Pharm. Res. 29(12), 3475-3485 (2012).
    • (2012) Pharm. Res. , vol.29 , Issue.12 , pp. 3475-3485
    • Akash, M.S.1    Rehman, K.2    Li, N.3    Gao, J.Q.4    Sun, H.5    Chen, S.6
  • 159
    • 78049477102 scopus 로고    scopus 로고
    • Sustained delivery of human growth hormone using a polyelectrolyte complex-loaded thermosensitive polyphosphazene hydrogel
    • Park MR, Chun C, Ahn SW, Ki MH, Cho CS, Song SC. Sustained delivery of human growth hormone using a polyelectrolyte complex-loaded thermosensitive polyphosphazene hydrogel. J. Control. Release 147(3), 359-367 (2010).
    • (2010) J. Control. Release , vol.147 , Issue.3 , pp. 359-367
    • Park, M.R.1    Chun, C.2    Ahn, S.W.3    Ki, M.H.4    Cho, C.S.5    Song, S.C.6
  • 160
    • 84869886684 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of an in situ gel forming system for the delivery of PEGylated octreotide
    • Jabarian EL, Rouini MR, Atyabi F, Foroumadi A, Nassiri SM, Dinarvand R. In vitro and in vivo evaluation of an in situ gel forming system for the delivery of PEGylated octreotide. Eur. J. Pharm. Sci. 48(1-2), 87-96 (2013).
    • (2013) Eur. J. Pharm. Sci. , vol.48 , Issue.1-2 , pp. 87-96
    • Jabarian, E.L.1    Rouini, M.R.2    Atyabi, F.3    Foroumadi, A.4    Nassiri, S.M.5    Dinarvand, R.6
  • 161
    • 80052719146 scopus 로고    scopus 로고
    • In vitro release of lysozyme from gelatin microspheres: Effect of cross-linking agents and thermoreversible gel as suspending medium
    • Hiwale P, Lampis S, Conti G et al. In vitro release of lysozyme from gelatin microspheres: effect of cross-linking agents and thermoreversible gel as suspending medium. Biomacromolecules 12(9), 3186-3193 (2011).
    • (2011) Biomacromolecules , vol.12 , Issue.9 , pp. 3186-3193
    • Hiwale, P.1    Lampis, S.2    Conti, G.3
  • 162
    • 80053247704 scopus 로고    scopus 로고
    • Basal level insulin delivery: In vitro release, stability, biocompatibility, and in vivo absorption from thermosensitive triblock copolymers
    • Al-Tahami K, Oak M, Mandke R, Singh J. Basal level insulin delivery: in vitro release, stability, biocompatibility, and in vivo absorption from thermosensitive triblock copolymers. J. Pharm. Sci. 100(11), 4790-4803 (2011).
    • (2011) J. Pharm. Sci. , vol.100 , Issue.11 , pp. 4790-4803
    • Al-Tahami, K.1    Oak, M.2    Mandke, R.3    Singh, J.4
  • 164
    • 79954541186 scopus 로고    scopus 로고
    • Controlled delivery of basal insulin from phase-sensitive polymeric systems after subcutaneous administration: In vitro release, stability, biocompatibility, in vivo absorption, and bioactivity of insulin
    • Al-Tahami K, Oak M, Singh J. Controlled delivery of basal insulin from phase-sensitive polymeric systems after subcutaneous administration: in vitro release, stability, biocompatibility, in vivo absorption, and bioactivity of insulin. J. Pharm. Sci. 100(6), 2161-2171 (2011).
    • (2011) J. Pharm. Sci. , vol.100 , Issue.6 , pp. 2161-2171
    • Al-Tahami, K.1    Oak, M.2    Singh, J.3
  • 165
    • 80155192341 scopus 로고    scopus 로고
    • A novel vaccine delivery system: Biodegradable nanoparticles in thermosensitive hydrogel
    • Wu Q J, Zhu XC, Xiao X et al. A novel vaccine delivery system: biodegradable nanoparticles in thermosensitive hydrogel. Growth Factors 29(6), 290-297 (2011).
    • (2011) Growth Factors , vol.29 , Issue.6 , pp. 290-297
    • Wu, Q.J.1    Zhu, X.C.2    Xiao, X.3
  • 166
    • 70450207980 scopus 로고    scopus 로고
    • Biodegradable thermosensitive injectable PEG-PCL-PEG hydrogel for bFGF antigen delivery to improve humoral immunity
    • Gong CY, Shi S, Peng XY et al. Biodegradable thermosensitive injectable PEG-PCL-PEG hydrogel for bFGF antigen delivery to improve humoral immunity. Growth Factors 27(6), 377-383 (2009).
    • (2009) Growth Factors , vol.27 , Issue.6 , pp. 377-383
    • Gong, C.Y.1    Shi, S.2    Peng, X.Y.3
  • 167
    • 77949270236 scopus 로고    scopus 로고
    • Thermosensitive drug delivery system of salmon calcitonin: In vitro release, in vivo absorption, bioactivity and therapeutic efficacies
    • Tang Y, Singh J. Thermosensitive drug delivery system of salmon calcitonin: in vitro release, in vivo absorption, bioactivity and therapeutic efficacies. Pharm. Res. 27(2), 272-284 (2010).
    • (2010) Pharm. Res. , vol.27 , Issue.2 , pp. 272-284
    • Tang, Y.1    Singh, J.2
  • 168
    • 72149088227 scopus 로고    scopus 로고
    • Cationic and thermosensitive protamine conjugated gels for enhancing sustained human growth hormone delivery
    • Park MR, Chun C, Ahn SW, Ki MH, Cho CS, Song SC. Cationic and thermosensitive protamine conjugated gels for enhancing sustained human growth hormone delivery. Biomaterials 31(6), 1349-1359 (2010).
    • (2010) Biomaterials , vol.31 , Issue.6 , pp. 1349-1359
    • Park, M.R.1    Chun, C.2    Ahn, S.W.3    Ki, M.H.4    Cho, C.S.5    Song, S.C.6
  • 169
    • 80052365356 scopus 로고    scopus 로고
    • The biological efficiency and bioavailability of human growth hormone delivered using injectable, ionic, thermosensitive poly(organophosphazene)- polyethylenimine conjugate hydrogels
    • Seo BB, Park MR, Chun C, Lee JY, Song SC. The biological efficiency and bioavailability of human growth hormone delivered using injectable, ionic, thermosensitive poly(organophosphazene)-polyethylenimine conjugate hydrogels. Biomaterials 32(32), 8271-8280 (2011).
    • (2011) Biomaterials , vol.32 , Issue.32 , pp. 8271-8280
    • Seo, B.B.1    Park, M.R.2    Chun, C.3    Lee, J.Y.4    Song, S.C.5
  • 170
    • 84855883888 scopus 로고    scopus 로고
    • Controlled delivery of basal level of insulin from chitosan-zinc-insulin- complex-loaded thermosensitive copolymer
    • Oak M, Singh J. Controlled delivery of basal level of insulin from chitosan-zinc-insulin-complex-loaded thermosensitive copolymer. J. Pharm. Sci. 101(3), 1079-1096 (2012).
    • (2012) J. Pharm. Sci. , vol.101 , Issue.3 , pp. 1079-1096
    • Oak, M.1    Singh, J.2
  • 171
    • 84870365758 scopus 로고    scopus 로고
    • Dual ionic interaction system based on polyelectrolyte complex and ionic, injectable, and thermosensitive hydrogel for sustained release of human growth hormone
    • Park MR, Seo BB, Song SC. Dual ionic interaction system based on polyelectrolyte complex and ionic, injectable, and thermosensitive hydrogel for sustained release of human growth hormone. Biomaterials 34(4), 1327-1336 (2013).
    • (2013) Biomaterials , vol.34 , Issue.4 , pp. 1327-1336
    • Park, M.R.1    Seo, B.B.2    Song, S.C.3
  • 172
    • 33645343012 scopus 로고    scopus 로고
    • Sustained release of bee venom peptide from biodegradable thermosensitive PLGA-PEG-PLGA triblock copolymer-based hydrogels in vitro
    • Qiao M, Chen D, Ma X, Hu H. Sustained release of bee venom peptide from biodegradable thermosensitive PLGA-PEG-PLGA triblock copolymer-based hydrogels in vitro. Die Pharm. 61(3), 199-202 (2006)
    • (2006) Die Pharm. , vol.61 , Issue.3 , pp. 199-202
    • Qiao, M.1    Chen, D.2    Ma, X.3    Hu, H.4
  • 173
    • 85157255611 scopus 로고    scopus 로고
    • US FDA regulatory information
    • US FDA regulatory information. www.fda.gov/regulatoryinformation/ legislation/default.htm
  • 174
    • 85157279071 scopus 로고    scopus 로고
    • US FDA guidance compliance
    • US FDA guidance compliance. www.fda.gov/downloads/drugs/ guidancecomplianceregulatoryinformation/duidances/ucm338856.pdf
  • 175
    • 85157059277 scopus 로고    scopus 로고
    • US FDA regulatory information
    • US FDA regulatory information www.fda.dov/downloads/ regulatoryinformation/guidances/uc m129171.pdf


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.