Production of solid lipid submicron particles for protein delivery using a novel supercritical gas-assisted melting atomization process

Journal of Pharmaceutical Sciences

Volumn 98, Issue 2, 2009, Pages 640-650

  Salmaso, Stefano ^a   Elvassore, Nicola ^a   Bertucco, Alberto ^a   Caliceti, Paolo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Protein delivery; Solid lipid submicron particles; Supercritical fluids

Indexed keywords

DIMETHYL SULFOXIDE; INSULIN; MACROGOL; PHOSPHATIDYLCHOLINE; POLYSORBATE 80; SOLID LIPID NANOPARTICLE; TRISTEARIN; ANTIDIABETIC AGENT; CARBON DIOXIDE; DOCUSATE SODIUM; DRUG CARRIER; LIPID; MACROGOL DERIVATIVE; POLYSORBATE; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DELIVERY SYSTEM; DRUG FORMULATION; LIGHT SCATTERING; MOUSE; NONHUMAN; PARTICLE SIZE; PROCESS OPTIMIZATION; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; BAGG ALBINO MOUSE; BLOOD; CHEMISTRY; DRUG EFFECT; DRUG STABILITY; EXPERIMENTAL DIABETES MELLITUS; GLUCOSE BLOOD LEVEL; INSTRUMENTATION; KINETICS; MALE; METHODOLOGY; NEBULIZER; PHARMACEUTICS; POWDER; PROTEIN DENATURATION; PROTEIN STABILITY; SOLUBILITY; SUBCUTANEOUS DRUG ADMINISTRATION; SUPERCRITICAL FLUID CHROMATOGRAPHY;

ANIMALS; BLOOD GLUCOSE; CARBON DIOXIDE; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, SUPERCRITICAL FLUID; DIABETES MELLITUS, EXPERIMENTAL; DIMETHYL SULFOXIDE; DIOCTYL SULFOSUCCINIC ACID; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN; KINETICS; LIPIDS; MALE; MICE; MICE, INBRED BALB C; NEBULIZERS AND VAPORIZERS; PARTICLE SIZE; PHOSPHATIDYLCHOLINES; POLYETHYLENE GLYCOLS; POLYSORBATES; POWDERS; PROTEIN DENATURATION; PROTEIN STABILITY; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TRIGLYCERIDES;

EID: 59849090174     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21434     Document Type: Article

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