PEGylation enhancement of pH stability of uricase via inhibitive tetramer dissociation

Journal of Pharmacy and Pharmacology

Volumn 65, Issue 1, 2013, Pages 53-63

  Tian, Hong ^a   Guo, Yuan ^a   Gao, Xiangdong ^a   Yao, Wenbing ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

PEGylation; tetramer dissociation; uricase; wrapping effect

Indexed keywords

PEGLOTICASE;

ARTICLE; CHEMICAL MODIFICATION; CIRCULAR DICHROISM; CONTROLLED STUDY; DISSOCIATION; DRUG DESIGN; DRUG PURIFICATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME MODIFICATION; ENZYME SPECIFICITY; ENZYME STABILITY; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INHIBITION KINETICS; LIGHT SCATTERING; LIVER; MOLECULAR WEIGHT; PEGYLATION; PH; PROTEIN CONTENT; ULTRAFILTRATION;

CANDIDA; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; DIFFUSION; DRUG STABILITY; ENZYME STABILITY; ENZYMES, IMMOBILIZED; FUNGAL PROTEINS; GOUT SUPPRESSANTS; HOT TEMPERATURE; HYDROGEN-ION CONCENTRATION; KINETICS; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SOLUBILITY; ULTRAFILTRATION; URATE OXIDASE;

EID: 84870918540     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2012.01575.x     Document Type: Article

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