Preparation of glucagon-like peptide-1 loaded PLGA microspheres: Characterizations, release studies and bioactivities in vitro/in vivo

Chemical and Pharmaceutical Bulletin

Volumn 56, Issue 2, 2008, Pages 156-161

  Yin, Dongfeng ^a   Lu, Ying ^a   Zhang, He ^a   Zhang, Guoqing ^b   Zou, Hao ^a   Sun, Duxin ^c   Zhong, Yanqiang ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b Key Laboratory of Arrhythmias of Ministry of Education   (China)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Bioactivity in vitro; Bioactivity in vivo; Drug release; Glucagon like peptide 1; Poly(D,L lactic co glycolic acid) microsphere

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; GLUCOSE; MICROSPHERE; POLYGLACTIN; RESOMER; WATER; ZINC CARBONATE; ZINC COMPLEX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPLEX FORMATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG SOLUBILITY; DRUG STABILITY; ENCAPSULATION; EXPERIMENTAL MOUSE; GLUCOSE BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHARMACEUTICAL ENGINEERING; RAT; SCANNING ELECTRON MICROSCOPY; STREPTOZOCIN DIABETES; SURFACE PROPERTY;

ANIMALS; BLOOD GLUCOSE; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DIABETES MELLITUS, EXPERIMENTAL; EMULSIONS; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE TOLERANCE TEST; LACTIC ACID; MALE; MICE; MICE, INBRED ICR; MICROSCOPY, ELECTRON, SCANNING; MICROSPHERES; PARTICLE SIZE; PHARMACEUTIC AIDS; POLYGLYCOLIC ACID; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SOLVENTS; ZINC ACETATE;

EID: 38849117218     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.56.156     Document Type: Article

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