Improvement of in vivo efficacy of recombinant human erythropoietin by encapsulation in PEG-PLA micelle

International Journal of Nanomedicine

Volumn 8, Issue , 2012, Pages 1-11

  Shi, Yanan ^a,b   Huang, Wan ^a   Liang, Rongcai ^a,b,c   Sun, Kaoxiang ^b,c   Zhang, Fangxi ^b,c   Liu, Wanhui ^b,c   Li, Youxin ^a,b,c  

^a JILIN UNIVERSITY   (China)

^b Shandong Luye Pharmaceutical Co Ltd   (China)

^c YANTAI UNIVERSITY   (China)

Author keywords

In vitro; PEG PLA micelle; Pharmacodynamics; Pharmacokinetics; rhEPO

Indexed keywords

HEMOGLOBIN; MACROGOL; PHOSPHATE BUFFERED SALINE; POLYLACTIDE; RECOMBINANT ERYTHROPOIETIN; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG CAPSULE; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG STABILITY; FEMALE; HEMOGLOBIN BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; MICELLE; MOLECULAR SIZE; NONHUMAN; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN AGGREGATION; RAT; TIMED DRUG RELEASE; ZETA POTENTIAL;

IN VITRO; PEG/PLA MICELLE; PHARMACODYNAMICS; PHARMACOKINETICS; RHEPO;

ANALYSIS OF VARIANCE; ANIMALS; AREA UNDER CURVE; DRUG STABILITY; ERYTHROPOIETIN; FEMALE; HEMOGLOBINS; HUMANS; MICELLES; NANOCAPSULES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SODIUM CHLORIDE;

RATTUS;

EID: 84872319982     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S38648     Document Type: Article

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