-
1
-
-
2942635256
-
Paul Ehrlich: In search of the magic bullet
-
Winau F, Westphal O, Winau R. Paul Ehrlich: in search of the magic bullet. Microbes Infect 2004; 6: 786-9
-
(2004)
Microbes Infect
, vol.6
, pp. 786-789
-
-
Winau, F.1
Westphal, O.2
Winau, R.3
-
2
-
-
33748929541
-
Applications of nanomedicine
-
Sahoo SK. Applications of nanomedicine. Asia Pacific Biotech News 2005; 9: 1048-50
-
(2005)
Asia Pacific Biotech News
, vol.9
, pp. 1048-1050
-
-
Sahoo, S.K.1
-
3
-
-
0038387390
-
The dawning era of polymer therapeutics
-
Duncan R. The dawning era of polymer therapeutics. Nat Rev Drug Discov 2003; 2: 347-60
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 347-360
-
-
Duncan, R.1
-
4
-
-
0036781811
-
Ligand-targeted therapeutics in anticancer therapy
-
Allen TM. Ligand-targeted therapeutics in anticancer therapy. Nat Rev Cancer 2002; 2: 750-63
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 750-763
-
-
Allen, T.M.1
-
5
-
-
14144250911
-
Recent advances with liposomes as pharmaceutical carriers
-
Torchilin VP. Recent advances with liposomes as pharmaceutical carriers. Nat Rev Drug Discov 2005; 4: 145-60
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 145-160
-
-
Torchilin, V.P.1
-
6
-
-
29144530123
-
Nanomedicine transforms drug delivery
-
Shaffer C. Nanomedicine transforms drug delivery. Drug Discov Today 2005; 10: 1581-2
-
(2005)
Drug Discov Today
, vol.10
, pp. 1581-1582
-
-
Shaffer, C.1
-
7
-
-
32944456781
-
What is nanomedicine?
-
Freitas Jr RA. What is nanomedicine? Dis Mon 2005; 51: 325-41
-
(2005)
Dis Mon
, vol.51
, pp. 325-341
-
-
Freitas Jr., R.A.1
-
8
-
-
14644396096
-
Nanomedicine: Current status and future prospects
-
Moghimi SM, Hunter AC, Murray JC. Nanomedicine: current status and future prospects. FASEB J 2005; 19: 311-30
-
(2005)
FASEB J
, vol.19
, pp. 311-330
-
-
Moghimi, S.M.1
Hunter, A.C.2
Murray, J.C.3
-
9
-
-
0041664881
-
Polymer-protein and polymer-drug conjugates in cancer therapy
-
Thanou M, Duncan R. Polymer-protein and polymer-drug conjugates in cancer therapy. Curr Opin Investig Drugs 2003; 4: 701-9
-
(2003)
Curr Opin Investig Drugs
, vol.4
, pp. 701-709
-
-
Thanou, M.1
Duncan, R.2
-
10
-
-
13844297094
-
The impact of nanobiotechnology on the development of new drug delivery systems
-
Kayser O, Lemke A, Hernandez-Trejo N. The impact of nanobiotechnology on the development of new drug delivery systems. Curr Pharm Biotechnol 2005; 6: 3-5
-
(2005)
Curr Pharm Biotechnol
, vol.6
, pp. 3-5
-
-
Kayser, O.1
Lemke, A.2
Hernandez-Trejo, N.3
-
11
-
-
3042685415
-
Drug delivery systems: Past, present, and future
-
Mainardes RM, Silva LP. Drug delivery systems: past, present, and future. Curr Drug Targets 2004; 5: 449-55
-
(2004)
Curr Drug Targets
, vol.5
, pp. 449-455
-
-
Mainardes, R.M.1
Silva, L.P.2
-
12
-
-
22244488749
-
Oral delivery of peptide drugs: Barriers and developments
-
Hamman JH, Enslin GM, Kotze AF. Oral delivery of peptide drugs: barriers and developments. BioDrugs 2005; 19: 165-77
-
(2005)
BioDrugs
, vol.19
, pp. 165-177
-
-
Hamman, J.H.1
Enslin, G.M.2
Kotze, A.F.3
-
13
-
-
3442879344
-
Protein and peptide parenteral controlled delivery
-
Pawar R, Ben-Ari A, Domb AJ. Protein and peptide parenteral controlled delivery. Expert Opin Biol Ther 2004; 4: 1203-12
-
(2004)
Expert Opin Biol Ther
, vol.4
, pp. 1203-1212
-
-
Pawar, R.1
Ben-Ari, A.2
Domb, A.J.3
-
15
-
-
12344281758
-
Commercial challenges of protein drug delivery
-
Brown LR. Commercial challenges of protein drug delivery. Expert Opin Drug Deliv 2005; 2: 29-42
-
(2005)
Expert Opin Drug Deliv
, vol.2
, pp. 29-42
-
-
Brown, L.R.1
-
16
-
-
0030580944
-
Importance of receptor-mediated endocytosis in peptide delivery and targeting: Kinetic aspects
-
Sato H, Sugiyama Y, Tsuji A, et al. Importance of receptor-mediated endocytosis in peptide delivery and targeting: kinetic aspects. Adv Drug Deliv Rev 1996; 19: 445-67
-
(1996)
Adv Drug Deliv Rev
, vol.19
, pp. 445-467
-
-
Sato, H.1
Sugiyama, Y.2
Tsuji, A.3
-
17
-
-
0035915017
-
Cell-specific delivery of genes with glycosylated carriers
-
Hashida M, Nishikawa M, Yamashita F, et al. Cell-specific delivery of genes with glycosylated carriers. Adv Drug Deliv Rev 2001; 52: 187-96
-
(2001)
Adv Drug Deliv Rev
, vol.52
, pp. 187-196
-
-
Hashida, M.1
Nishikawa, M.2
Yamashita, F.3
-
18
-
-
0033799839
-
Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs
-
Krishna R, Mayer LD. Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur J Pharm Sci 2000; 11: 265-83
-
(2000)
Eur J Pharm Sci
, vol.11
, pp. 265-283
-
-
Krishna, R.1
Mayer, L.D.2
-
19
-
-
85012557924
-
Clinical relevance of the molecular mechanisms of resistance to anti-cancer drugs
-
Links M, Brown R. Clinical relevance of the molecular mechanisms of resistance to anti-cancer drugs. Expert Rev Mol Med 1999; 1999: 1-21
-
(1999)
Expert Rev Mol Med
, vol.1999
, pp. 1-21
-
-
Links, M.1
Brown, R.2
-
20
-
-
0017388651
-
Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase
-
Abuchowski A, McCoy JR, Palczuk NC, et al. Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase. J Biol Chem 1977; 252: 3582-6
-
(1977)
J Biol Chem
, vol.252
, pp. 3582-3586
-
-
Abuchowski, A.1
McCoy, J.R.2
Palczuk, N.C.3
-
22
-
-
32244443852
-
Polymer architecture and drug delivery
-
Qiu LY, Bae YH. Polymer architecture and drug delivery. Pharm Res 2006; 23: 1-30
-
(2006)
Pharm Res
, vol.23
, pp. 1-30
-
-
Qiu, L.Y.1
Bae, Y.H.2
-
23
-
-
0035126943
-
Polymeric controlled drug-delivery systems: Perspective issues and opportunities
-
Kumar MN, Kumar N. Polymeric controlled drug-delivery systems: perspective issues and opportunities. Drug Dev Ind Pharm 2001; 27: 1-30
-
(2001)
Drug Dev Ind Pharm
, vol.27
, pp. 1-30
-
-
Kumar, M.N.1
Kumar, N.2
-
24
-
-
14744279591
-
Modeling of drug release from polymeric delivery systems: A review
-
Kanjickal DG, Lopina ST. Modeling of drug release from polymeric delivery systems: a review. Crit Rev Ther Drug Carrier Syst 2004; 21: 345-86
-
(2004)
Crit Rev Ther Drug Carrier Syst
, vol.21
, pp. 345-386
-
-
Kanjickal, D.G.1
Lopina, S.T.2
-
25
-
-
0029360322
-
Which polymers can make nanoparticulate drug carriers long-circulating?
-
Torchilin VP, Trubetskoy VS. Which polymers can make nanoparticulate drug carriers long-circulating? Adv Drug Deliv Rev 1995; 16: 141-55
-
(1995)
Adv Drug Deliv Rev
, vol.16
, pp. 141-155
-
-
Torchilin, V.P.1
Trubetskoy, V.S.2
-
26
-
-
0031962780
-
Polymer-coated long-circulating microparticulate pharmaceuticals
-
Torchilin VP. Polymer-coated long-circulating microparticulate pharmaceuticals. J Microencapsul 1998; 15: 1-19
-
(1998)
J Microencapsul
, vol.15
, pp. 1-19
-
-
Torchilin, V.P.1
-
28
-
-
23444444512
-
Biodegradable long-circulating polymeric nanospheres
-
Gref R, Minamitake Y, Peracchia MT, et al. Biodegradable long-circulating polymeric nanospheres. Science 1994; 263: 1600-3
-
(1994)
Science
, vol.263
, pp. 1600-1603
-
-
Gref, R.1
Minamitake, Y.2
Peracchia, M.T.3
-
29
-
-
17844380498
-
Pegylation: A novel process for modifying pharmacokinetics
-
Harris JM, Martin NE, Modi M. Pegylation: a novel process for modifying pharmacokinetics. Clin Pharmacokinet 2001; 40: 539-51
-
(2001)
Clin Pharmacokinet
, vol.40
, pp. 539-551
-
-
Harris, J.M.1
Martin, N.E.2
Modi, M.3
-
31
-
-
0017701219
-
Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol
-
Abuchowski A, van Es T, Palczuk NC, et al. Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol. J Biol Chem 1977; 252: 3578-81
-
(1977)
J Biol Chem
, vol.252
, pp. 3578-3581
-
-
Abuchowski, A.1
Van Es, T.2
Palczuk, N.C.3
-
32
-
-
0036083609
-
Pegylation: Engineering improved pharmaceuticals for enhanced therapy
-
Molineux G. Pegylation: engineering improved pharmaceuticals for enhanced therapy. Cancer Treat Rev 2002; 28 Suppl. A: 13-6
-
(2002)
Cancer Treat Rev
, vol.28
, Issue.SUPPL. A
, pp. 13-16
-
-
Molineux, G.1
-
33
-
-
0036087485
-
Novel effects with polyethylene glycol modified pharmaceuticals
-
Yowell SL, Blackwell S. Novel effects with polyethylene glycol modified pharmaceuticals. Cancer Treat Rev 2002; 28 Suppl. A: 3-6
-
(2002)
Cancer Treat Rev
, vol.28
, Issue.SUPPL. A
, pp. 3-6
-
-
Yowell, S.L.1
Blackwell, S.2
-
34
-
-
0035291191
-
SMANCS and polymer-conjugated macromolecular drugs: Advantages in cancer chemotherapy
-
Maeda H. SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy. Adv Drug Deliv Rev 2001; 46: 169-85
-
(2001)
Adv Drug Deliv Rev
, vol.46
, pp. 169-185
-
-
Maeda, H.1
-
35
-
-
0032959549
-
Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl) methacrylamide copolymer doxorubicin]: First member of a new class of chemotherapeutic agents-drug-polymer conjugates
-
Cancer Research Campaign Phase I/II Committee
-
Vasey PA, Kaye SB, Morrison R, et al. Phase I clinical and pharmacokinetic study of PK1 [N-(2-hydroxypropyl) methacrylamide copolymer doxorubicin]: first member of a new class of chemotherapeutic agents-drug-polymer conjugates. Cancer Research Campaign Phase I/II Committee. Clin Cancer Res 1999; 5: 83-94
-
(1999)
Clin Cancer Res
, vol.5
, pp. 83-94
-
-
Vasey, P.A.1
Kaye, S.B.2
Morrison, R.3
-
36
-
-
0035253404
-
Drug-targeting strategies in cancer therapy
-
Huang PS, Oliff A. Drug-targeting strategies in cancer therapy. Curr Opin Genet Dev 2001; 11: 104-10
-
(2001)
Curr Opin Genet Dev
, vol.11
, pp. 104-110
-
-
Huang, P.S.1
Oliff, A.2
-
37
-
-
0037087719
-
Hepatic drug targeting: Phase I evaluation of polymer-bound doxorubicin
-
Seymour LW, Ferry DR, Anderson D, et al. Hepatic drug targeting: phase I evaluation of polymer-bound doxorubicin. J Clin Oncol 2002; 20: 1668-76
-
(2002)
J Clin Oncol
, vol.20
, pp. 1668-1676
-
-
Seymour, L.W.1
Ferry, D.R.2
Anderson, D.3
-
38
-
-
0022635574
-
Fate of N-(2-hydroxypropyl)methacrylamide copolymers with pendent galactosamine residues after intravenous administration to rats
-
Duncan R, Seymour LC, Scarlett L, et al. Fate of N-(2-hydroxypropyl) methacrylamide copolymers with pendent galactosamine residues after intravenous administration to rats. Biochim Biophys Acta 1986; 880: 62-71
-
(1986)
Biochim Biophys Acta
, vol.880
, pp. 62-71
-
-
Duncan, R.1
Seymour, L.C.2
Scarlett, L.3
-
39
-
-
0035012701
-
Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel
-
Meerum Terwogt JM, ten Bokkel Huinink WW, Schellens JH, et al. Phase I clinical and pharmacokinetic study of PNU166945, a novel water-soluble polymer-conjugated prodrug of paclitaxel. Anticancer Drugs 2001; 12: 315-23
-
(2001)
Anticancer Drugs
, vol.12
, pp. 315-323
-
-
Meerum Terwogt, J.M.1
Ten Bokkel Huinink, W.W.2
Schellens, J.H.3
-
40
-
-
3943108941
-
AP-5346 polymer-delivered platinum complex
-
Rice JR, Howell SB. AP-5346 polymer-delivered platinum complex. Drugs Future 2004; 29: 561-5
-
(2004)
Drugs Future
, vol.29
, pp. 561-565
-
-
Rice, J.R.1
Howell, S.B.2
-
41
-
-
0036875839
-
HPMA copolymers platinates containing dicarboxylato ligands: Preparation, characterisation and in vitro and in vivo evaluation
-
Gianasi E, Buckley RG, Latigo J, et al. HPMA copolymers platinates containing dicarboxylato ligands: preparation, characterisation and in vitro and in vivo evaluation. J Drug Target 2002; 10: 549-56
-
(2002)
J Drug Target
, vol.10
, pp. 549-556
-
-
Gianasi, E.1
Buckley, R.G.2
Latigo, J.3
-
42
-
-
0033152928
-
HPMA copolymer platinates as novel antitumour agents: In vitro properties, pharmacokinetics and antitumour activity in vivo
-
Gianasi E, Wasil M, Evagorou EG, et al. HPMA copolymer platinates as novel antitumour agents: in vitro properties, pharmacokinetics and antitumour activity in vivo. Eur J Cancer 1999; 35: 994-1002
-
(1999)
Eur J Cancer
, vol.35
, pp. 994-1002
-
-
Gianasi, E.1
Wasil, M.2
Evagorou, E.G.3
-
43
-
-
18544376660
-
A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin
-
Schoemaker NE, van Kesteren C, Rosing H, et al. A phase I and pharmacokinetic study of MAG-CPT, a water-soluble polymer conjugate of camptothecin. Br J Cancer 2002; 87: 608-14
-
(2002)
Br J Cancer
, vol.87
, pp. 608-614
-
-
Schoemaker, N.E.1
Van Kesteren, C.2
Rosing, H.3
-
44
-
-
0035322799
-
New form of paclitaxel shows promise
-
Garfield D. New form of paclitaxel shows promise. Lancet Oncol 2001; 2: 192
-
(2001)
Lancet Oncol
, vol.2
, pp. 192
-
-
Garfield, D.1
-
45
-
-
0032101105
-
Complete regression of well-established tumors using a novel water-soluble poly(L-glutamic acid)-paclitaxel conjugate
-
Li C, Yu DF, Newman RA, et al. Complete regression of well-established tumors using a novel water-soluble poly(L-glutamic acid)-paclitaxel conjugate. Cancer Res 1998; 58: 2404-9
-
(1998)
Cancer Res
, vol.58
, pp. 2404-2409
-
-
Li, C.1
Yu, D.F.2
Newman, R.A.3
-
46
-
-
29944433355
-
Phase I study of CT-2103, a polymer-conjugated paclitaxel, and carboplatin in patients with advanced solid tumors
-
Nemunaitis J, Cunningham C, Senzer N, et al. Phase I study of CT-2103, a polymer-conjugated paclitaxel, and carboplatin in patients with advanced solid tumors. Cancer Invest 2005; 23: 671-6
-
(2005)
Cancer Invest
, vol.23
, pp. 671-676
-
-
Nemunaitis, J.1
Cunningham, C.2
Senzer, N.3
-
47
-
-
0037362655
-
Effect of pegylation on pharmaceuticals
-
Harris JM, Chess RB. Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov 2003; 2: 214-21
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 214-221
-
-
Harris, J.M.1
Chess, R.B.2
-
48
-
-
0033654389
-
Modulation of the pharmacokinetics and pharmacodynamics of proteins by polyethylene glycol conjugation
-
Mehvar R. Modulation of the pharmacokinetics and pharmacodynamics of proteins by polyethylene glycol conjugation. J Pharm Pharm Sci 2000; 3: 125-36
-
(2000)
J Pharm Pharm Sci
, vol.3
, pp. 125-136
-
-
Mehvar, R.1
-
49
-
-
0037124473
-
Introduction and overview of peptide and protein pegylation
-
Veronese FM, Harris JM. Introduction and overview of peptide and protein pegylation. Adv Drug Deliv Rev 2002; 54: 453-6
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 453-456
-
-
Veronese, F.M.1
Harris, J.M.2
-
51
-
-
0028337034
-
Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice
-
Yamaoka T, Tabata Y, Ikada Y. Distribution and tissue uptake of poly(ethylene glycol) with different molecular weights after intravenous administration to mice. J Pharm Sci 1994; 83: 601-6
-
(1994)
J Pharm Sci
, vol.83
, pp. 601-606
-
-
Yamaoka, T.1
Tabata, Y.2
Ikada, Y.3
-
52
-
-
0028913713
-
Fate of water-soluble polymers administered via different routes
-
Yamaoka T, Tabata Y, Ikada Y. Fate of water-soluble polymers administered via different routes. J Pharm Sci 1995; 84: 349-54
-
(1995)
J Pharm Sci
, vol.84
, pp. 349-354
-
-
Yamaoka, T.1
Tabata, Y.2
Ikada, Y.3
-
53
-
-
0027473377
-
Hepatic excretion and metabolism of polyethylene glycols and mannitol in the cat
-
Friman S, Egestad B, Sjovall J, et al. Hepatic excretion and metabolism of polyethylene glycols and mannitol in the cat. J Hepatol 1993; 17: 48-55
-
(1993)
J Hepatol
, vol.17
, pp. 48-55
-
-
Friman, S.1
Egestad, B.2
Sjovall, J.3
-
54
-
-
0036169032
-
Microbial degradation of polyethers
-
Kawai F. Microbial degradation of polyethers. Appl Microbiol Biotechnol 2002; 58: 30-8
-
(2002)
Appl Microbiol Biotechnol
, vol.58
, pp. 30-38
-
-
Kawai, F.1
-
55
-
-
0018801628
-
Some properties of polyethylene glycol: Phenylalanine ammonia-lyase adducts
-
Wieder KJ, Palczuk NC, van Es T, et al. Some properties of polyethylene glycol: phenylalanine ammonia-lyase adducts. J Biol Chem 1979; 254: 12579-87
-
(1979)
J Biol Chem
, vol.254
, pp. 12579-12587
-
-
Wieder, K.J.1
Palczuk, N.C.2
Van Es, T.3
-
56
-
-
0037124466
-
PEGylated antibodies and antibody fragments for improved therapy: A review
-
Chapman AP. PEGylated antibodies and antibody fragments for improved therapy: a review. Adv Drug Deliv Rev 2002; 54: 531-45
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 531-545
-
-
Chapman, A.P.1
-
57
-
-
0020053016
-
Pharmacokinetic properties of polyethylene glycol derivatized superoxide dismutase
-
Boccu E, Velo GP, Veronese FM. Pharmacokinetic properties of polyethylene glycol derivatized superoxide dismutase. Pharmacol Res Commun 1982; 14: 113-20
-
(1982)
Pharmacol Res Commun
, vol.14
, pp. 113-120
-
-
Boccu, E.1
Velo, G.P.2
Veronese, F.M.3
-
58
-
-
0020607315
-
A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and alpha 2-macroglobulin
-
Beauchamp CO, Gonias SL, Menapace DP, et al. A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and alpha 2-macroglobulin. Anal Biochem 1983; 131: 25-33
-
(1983)
Anal Biochem
, vol.131
, pp. 25-33
-
-
Beauchamp, C.O.1
Gonias, S.L.2
Menapace, D.P.3
-
59
-
-
0344420226
-
Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates
-
Caliceti P, Veronese FM. Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates. Adv Drug Deliv Rev 2003; 55: 1261-77
-
(2003)
Adv Drug Deliv Rev
, vol.55
, pp. 1261-1277
-
-
Caliceti, P.1
Veronese, F.M.2
-
60
-
-
0029265458
-
Functionalized poly(ethylene glycol) for preparation of biologically relevant conjugates
-
Zalipsky S. Functionalized poly(ethylene glycol) for preparation of biologically relevant conjugates. Bioconjug Chem 1995; 6: 150-65
-
(1995)
Bioconjug Chem
, vol.6
, pp. 150-165
-
-
Zalipsky, S.1
-
61
-
-
0032126845
-
PEGylation of cytokines and other therapeutic proteins and peptides: The importance of biological optimisation of coupling techniques
-
Francis GE, Fisher D, Delgado C, et al. PEGylation of cytokines and other therapeutic proteins and peptides: the importance of biological optimisation of coupling techniques. Int J Hematol 1998; 68: 1-18
-
(1998)
Int J Hematol
, vol.68
, pp. 1-18
-
-
Francis, G.E.1
Fisher, D.2
Delgado, C.3
-
62
-
-
0026687890
-
Biological activities of polyethylene-glycol immunoglobulin conjugates: Resistance to enzymatic degradation
-
Cunningham-Rundles C, Zhuo Z, Griffith B, et al. Biological activities of polyethylene-glycol immunoglobulin conjugates: resistance to enzymatic degradation. J Immunol Methods 1992; 152: 177-90
-
(1992)
J Immunol Methods
, vol.152
, pp. 177-190
-
-
Cunningham-Rundles, C.1
Zhuo, Z.2
Griffith, B.3
-
63
-
-
0034000453
-
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: A review
-
Maeda H, Wu J, Sawa T, et al. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release 2000; 65: 271-84
-
(2000)
J Control Release
, vol.65
, pp. 271-284
-
-
Maeda, H.1
Wu, J.2
Sawa, T.3
-
64
-
-
0022858683
-
A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
-
Matsumura Y, Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986; 46: 6387-92
-
(1986)
Cancer Res
, vol.46
, pp. 6387-6392
-
-
Matsumura, Y.1
Maeda, H.2
-
65
-
-
0023146216
-
Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase
-
Hershfield MS, Buckley RH, Greenberg ML, et al. Treatment of adenosine deaminase deficiency with polyethylene glycol-modified adenosine deaminase. N Engl J Med 1987; 316: 589-96
-
(1987)
N Engl J Med
, vol.316
, pp. 589-596
-
-
Hershfield, M.S.1
Buckley, R.H.2
Greenberg, M.L.3
-
66
-
-
0022922655
-
Clinical pharmacology of polyethylene glycol-L-asparaginase
-
Ho DH, Brown NS, Yen A, et al. Clinical pharmacology of polyethylene glycol-L-asparaginase. Drug Metab Dispos 1986; 14: 349-52
-
(1986)
Drug Metab Dispos
, vol.14
, pp. 349-352
-
-
Ho, D.H.1
Brown, N.S.2
Yen, A.3
-
67
-
-
0025233873
-
A phase II trial of PEG-L-asparaginase in the treatment of non-Hodgkins lymphoma
-
Muss HB, Spell N, Scudiery D, et al. A phase II trial of PEG-L-asparaginase in the treatment of non-Hodgkins lymphoma. Invest New Drugs 1990; 8: 125-30
-
(1990)
Invest New Drugs
, vol.8
, pp. 125-130
-
-
Muss, H.B.1
Spell, N.2
Scudiery, D.3
-
68
-
-
0034619980
-
Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis
-
Heathcote EJ, Shiffman ML, Cooksley WG, et al. Peginterferon alfa-2a in patients with chronic hepatitis C and cirrhosis. N Engl J Med 2000; 343: 1673-80
-
(2000)
N Engl J Med
, vol.343
, pp. 1673-1680
-
-
Heathcote, E.J.1
Shiffman, M.L.2
Cooksley, W.G.3
-
69
-
-
0034324083
-
Pegylated interferon-alpha2b: Pharmacokinetics, pharmacodynamics, safety, and preliminary efficacy data
-
Hepatitis C Intervention Therapy Group
-
Glue P, Fang JW, Rouzier-Panis R, et al. Pegylated interferon-alpha2b: pharmacokinetics, pharmacodynamics, safety, and preliminary efficacy data. Hepatitis C Intervention Therapy Group. Clin Pharmacol Ther 2000; 68: 556-67
-
(2000)
Clin Pharmacol Ther
, vol.68
, pp. 556-567
-
-
Glue, P.1
Fang, J.W.2
Rouzier-Panis, R.3
-
70
-
-
0025125916
-
Biochemical and biopharmaceutical properties of macromolecular conjugates of uricase with dextran and polyethylene glycol
-
Tokyo
-
Yasuda Y, Fujita T, Takakura Y, et al. Biochemical and biopharmaceutical properties of macromolecular conjugates of uricase with dextran and polyethylene glycol. Chem Pharm Bull (Tokyo) 1990; 38: 2053-6
-
(1990)
Chem Pharm Bull
, vol.38
, pp. 2053-2056
-
-
Yasuda, Y.1
Fujita, T.2
Takakura, Y.3
-
72
-
-
0038180346
-
Counterintuitive red blood cell substitute: Polyethylene glycol-modified human hemoglobin
-
Kramer GC. Counterintuitive red blood cell substitute: polyethylene glycol-modified human hemoglobin. Crit Care Med 2003; 31: 1882-4
-
(2003)
Crit Care Med
, vol.31
, pp. 1882-1884
-
-
Kramer, G.C.1
-
73
-
-
0036215202
-
Activation-induced cell death: The controversial role of Fas and Fas ligand in immune privilege and tumour counterattack
-
Maher S, Toomey D, Condron C, et al. Activation-induced cell death: the controversial role of Fas and Fas ligand in immune privilege and tumour counterattack. Immunol Cell Biol 2002; 80: 131-7
-
(2002)
Immunol Cell Biol
, vol.80
, pp. 131-137
-
-
Maher, S.1
Toomey, D.2
Condron, C.3
-
74
-
-
0030892234
-
Apoptosis by death factor
-
Nagata S. Apoptosis by death factor. Cell 1997; 88: 355-65
-
(1997)
Cell
, vol.88
, pp. 355-365
-
-
Nagata, S.1
-
75
-
-
0031756579
-
Dendritic cells prevent CD95 mediated T lymphocyte death through costimulatory signals
-
Daniel PT, Scholz C, Westermann J, et al. Dendritic cells prevent CD95 mediated T lymphocyte death through costimulatory signals. Adv Exp Med Biol 1998; 451: 173-7
-
(1998)
Adv Exp Med Biol
, vol.451
, pp. 173-177
-
-
Daniel, P.T.1
Scholz, C.2
Westermann, J.3
-
76
-
-
0034080750
-
Not so Fas: Re-evaluating the mechanisms of immune privilege and tumor escape
-
Restifo NP. Not so Fas: re-evaluating the mechanisms of immune privilege and tumor escape. Nat Med 2000; 6: 493-5
-
(2000)
Nat Med
, vol.6
, pp. 493-495
-
-
Restifo, N.P.1
-
77
-
-
0031570098
-
Role of Fas ligand (CD95L) in immune escape: The tumor cell strikes back
-
Walker PR, Saas P, Dietrich PY. Role of Fas ligand (CD95L) in immune escape: the tumor cell strikes back. J Immunol 1997; 158: 4521-4
-
(1997)
J Immunol
, vol.158
, pp. 4521-4524
-
-
Walker, P.R.1
Saas, P.2
Dietrich, P.Y.3
-
78
-
-
0032893304
-
Pancreatic cancer cells can evade immune surveillance via nonfunctional Fas (APO-1/CD95) receptors and aberrant expression of functional Fas ligand
-
von Bernstorff W, Spanjaard RA, Chan AK, et al. Pancreatic cancer cells can evade immune surveillance via nonfunctional Fas (APO-1/CD95) receptors and aberrant expression of functional Fas ligand. Surgery 1999; 125: 73-84
-
(1999)
Surgery
, vol.125
, pp. 73-84
-
-
Von Bernstorff, W.1
Spanjaard, R.A.2
Chan, A.K.3
-
79
-
-
16144363507
-
Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells: A mechanism of immune evasion?
-
Strand S, Hofmann WJ, Hug H, et al. Lymphocyte apoptosis induced by CD95 (APO-1/Fas) ligand-expressing tumor cells: a mechanism of immune evasion? Nat Med 1996; 2: 1361-6
-
(1996)
Nat Med
, vol.2
, pp. 1361-1366
-
-
Strand, S.1
Hofmann, W.J.2
Hug, H.3
-
80
-
-
0029808372
-
The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand
-
O'Connell J, O'Sullivan GC, Collins JK, et al. The Fas counterattack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand. J Exp Med 1996; 184: 1075-82
-
(1996)
J Exp Med
, vol.184
, pp. 1075-1082
-
-
O'Connell, J.1
O'Sullivan, G.C.2
Collins, J.K.3
-
82
-
-
10544232277
-
Melanoma cell expression of Fas(Apo-1/CD95) ligand: Implications for tumor immune escape
-
Hahne M, Rimoldi D, Schroter M, et al. Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape. Science 1996; 274: 1363-6
-
(1996)
Science
, vol.274
, pp. 1363-1366
-
-
Hahne, M.1
Rimoldi, D.2
Schroter, M.3
-
83
-
-
0032742205
-
Cytotoxic drugs and the CD95 pathway
-
Friesen C, Fulda S, Debatin KM. Cytotoxic drugs and the CD95 pathway. Leukemia 1999; 13: 1854-8
-
(1999)
Leukemia
, vol.13
, pp. 1854-1858
-
-
Friesen, C.1
Fulda, S.2
Debatin, K.M.3
-
84
-
-
2142809327
-
Immunoprotective therapy with targeted anticancer drugs
-
Rihova B, Strohalm J, Hoste K, et al. Immunoprotective therapy with targeted anticancer drugs. Macromol Symp 2001; 172: 21-8
-
(2001)
Macromol Symp
, vol.172
, pp. 21-28
-
-
Rihova, B.1
Strohalm, J.2
Hoste, K.3
-
85
-
-
0016622773
-
Structure and properties of pharmacologically active polymers
-
Ringsdorf H. Structure and properties of pharmacologically active polymers. J Polym Sci Symp 1975; 51: 135-53
-
(1975)
J Polym Sci Symp
, vol.51
, pp. 135-153
-
-
Ringsdorf, H.1
-
86
-
-
0026757191
-
Drug-polymer conjugates: Potential for improved chemotherapy
-
Duncan R. Drug-polymer conjugates: potential for improved chemotherapy. Anticancer Drugs 1992; 3: 175-210
-
(1992)
Anticancer Drugs
, vol.3
, pp. 175-210
-
-
Duncan, R.1
-
87
-
-
0031747280
-
The next frontier of molecular medicine: Delivery of therapeutics
-
Jain RK. The next frontier of molecular medicine: delivery of therapeutics. Nat Med 1998; 4: 655-7
-
(1998)
Nat Med
, vol.4
, pp. 655-657
-
-
Jain, R.K.1
-
88
-
-
29144519267
-
Essential properties of drug-targeting delivery systems
-
Petrak K. Essential properties of drug-targeting delivery systems. Drug Discov Today 2005; 10: 1667-73
-
(2005)
Drug Discov Today
, vol.10
, pp. 1667-1673
-
-
Petrak, K.1
-
89
-
-
0002079949
-
Disposition and tumor localization of mitomycin C-dextran conjugates in mice
-
Takakura Y, Takagi A, Hashida M, et al. Disposition and tumor localization of mitomycin C-dextran conjugates in mice. Pharm Res 1987; 4: 293-300
-
(1987)
Pharm Res
, vol.4
, pp. 293-300
-
-
Takakura, Y.1
Takagi, A.2
Hashida, M.3
-
90
-
-
0032870935
-
Bioconjugation in pharmaceutical chemistry
-
Veronese FM, Morpurgo M. Bioconjugation in pharmaceutical chemistry. Farmaco 1999; 54: 497-516
-
(1999)
Farmaco
, vol.54
, pp. 497-516
-
-
Veronese, F.M.1
Morpurgo, M.2
-
91
-
-
0028949238
-
Stability, specific binding activity, and plasma concentration in mice of an oligodeoxynucleotide modified at 5′-terminal with poly(ethylene glycol)
-
Kawaguchi T, Asakawa H, Tashiro Y, et al. Stability, specific binding activity, and plasma concentration in mice of an oligodeoxynucleotide modified at 5′-terminal with poly(ethylene glycol). Biol Pharm Bull 1995; 18: 474-6
-
(1995)
Biol Pharm Bull
, vol.18
, pp. 474-476
-
-
Kawaguchi, T.1
Asakawa, H.2
Tashiro, Y.3
-
92
-
-
0029007384
-
Poly (ethylene glycol) with reactive endgroups: I - Modification of proteins
-
Herman S, Hooftman G, Schacht E. Poly (ethylene glycol) with reactive endgroups: I - modification of proteins. J Bioact Compat Polym 1995; 10: 145-87
-
(1995)
J Bioact Compat Polym
, vol.10
, pp. 145-187
-
-
Herman, S.1
Hooftman, G.2
Schacht, E.3
-
93
-
-
0035284411
-
Peptide and protein PEGylation: A review of problems and solutions
-
Veronese FM. Peptide and protein PEGylation: a review of problems and solutions. Biomaterials 2001; 22: 405-17
-
(2001)
Biomaterials
, vol.22
, pp. 405-417
-
-
Veronese, F.M.1
-
94
-
-
0037124507
-
Enzymatic procedure for site-specific pegylation of proteins
-
Sato H. Enzymatic procedure for site-specific pegylation of proteins. Adv Drug Deliv Rev 2002; 54: 487-504
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 487-504
-
-
Sato, H.1
-
95
-
-
0027998163
-
Synthesis and properties of oligodeoxyribonucleotide-polyethylene glycol conjugates
-
Jaschke A, Furste JP, Nordhoff E, et al. Synthesis and properties of oligodeoxyribonucleotide-polyethylene glycol conjugates. Nucleic Acids Res 1994; 22: 4810-7
-
(1994)
Nucleic Acids Res
, vol.22
, pp. 4810-4817
-
-
Jaschke, A.1
Furste, J.P.2
Nordhoff, E.3
-
96
-
-
0031056605
-
Characterization of oligodeoxyribonucleotide-polyethylene glycol conjugates by electrospray mass spectrometry
-
Tarasow TM, Tinnermeier D, Zyzniewski C. Characterization of oligodeoxyribonucleotide-polyethylene glycol conjugates by electrospray mass spectrometry. Bioconjug Chem 1997; 8: 89-93
-
(1997)
Bioconjug Chem
, vol.8
, pp. 89-93
-
-
Tarasow, T.M.1
Tinnermeier, D.2
Zyzniewski, C.3
-
97
-
-
0242288519
-
Macromolecular therapeutics: Advantages and prospects with special emphasis on solid tumour targeting
-
Greish K, Fang J, Inutsuka T, et al. Macromolecular therapeutics: advantages and prospects with special emphasis on solid tumour targeting. Clin Pharmacokinet 2003; 42: 1089-105
-
(2003)
Clin Pharmacokinet
, vol.42
, pp. 1089-1105
-
-
Greish, K.1
Fang, J.2
Inutsuka, T.3
-
98
-
-
0027235785
-
Preparation and properties of monomethoxy poly(ethylene glycol) doxorubicin conjugates linked by an amino acid or a peptide as spacer
-
Caliceti P, Monfardini C, Sartore L, et al. Preparation and properties of monomethoxy poly(ethylene glycol) doxorubicin conjugates linked by an amino acid or a peptide as spacer. Farmaco 1993; 48: 919-32
-
(1993)
Farmaco
, vol.48
, pp. 919-932
-
-
Caliceti, P.1
Monfardini, C.2
Sartore, L.3
-
99
-
-
0023813205
-
Adenosine deaminase deficiency with late onset of recurrent infections: Response to treatment with polyethylene glycol-modified adenosine deaminase
-
Levy Y, Hershfield MS, Fernandez-Mejia C, et al. Adenosine deaminase deficiency with late onset of recurrent infections: response to treatment with polyethylene glycol-modified adenosine deaminase. J Pediatr 1988; 113: 312-7
-
(1988)
J Pediatr
, vol.113
, pp. 312-317
-
-
Levy, Y.1
Hershfield, M.S.2
Fernandez-Mejia, C.3
-
100
-
-
0042999388
-
Pegaspargase: A review of clinical studies
-
Graham ML. Pegaspargase: a review of clinical studies. Adv Drug Deliv Rev 2003; 55: 1293-302
-
(2003)
Adv Drug Deliv Rev
, vol.55
, pp. 1293-1302
-
-
Graham, M.L.1
-
101
-
-
0037124508
-
Use of peginterferon a-2a (40 KD) (Pegasys®) for the treatment of hepatitis C
-
Reddy KR, Modi MW, Pedder S. Use of peginterferon a-2a (40 KD) (Pegasys®) for the treatment of hepatitis C. Adv Drug Deliv Rev 2002; 54: 571-86
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 571-586
-
-
Reddy, K.R.1
Modi, M.W.2
Pedder, S.3
-
102
-
-
0037124398
-
Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications
-
Wang YS, Youngster S, Grace M, et al. Structural and biological characterization of pegylated recombinant interferon alpha-2b and its therapeutic implications. Adv Drug Deliv Rev 2002; 54: 547-70
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 547-570
-
-
Wang, Y.S.1
Youngster, S.2
Grace, M.3
-
103
-
-
0037106366
-
Pegylated interferon alfa-2b treatment for patients with solid tumors: A phase I/II study
-
Bukowski R, Ernstoff MS, Gore ME, et al. Pegylated interferon alfa-2b treatment for patients with solid tumors: a phase I/II study. J Clin Oncol 2002; 20: 3841-9
-
(2002)
J Clin Oncol
, vol.20
, pp. 3841-3849
-
-
Bukowski, R.1
Ernstoff, M.S.2
Gore, M.E.3
-
104
-
-
6844251615
-
A randomized, double-blind, placebo-controlled, phase III study of filgrastim in remission induction and consolidation therapy for adults with de novo acute myeloid leukemia
-
The International Acute Myeloid Leukemia Study Group
-
Heil G, Hoelzer D, Sanz MA, et al. A randomized, double-blind, placebo-controlled, phase III study of filgrastim in remission induction and consolidation therapy for adults with de novo acute myeloid leukemia. The International Acute Myeloid Leukemia Study Group. Blood 1997; 90: 4710-8
-
(1997)
Blood
, vol.90
, pp. 4710-4718
-
-
Heil, G.1
Hoelzer, D.2
Sanz, M.A.3
-
105
-
-
0035990090
-
Comparable efficacy and safety profiles of once-per-cycle pegfilgrastim and daily injection filgrastim in chemotherapy-induced neutropenia: A multicenter dose-finding study in women with breast cancer
-
Holmes FA, Jones SE, O'Shaughnessy J, et al. Comparable efficacy and safety profiles of once-per-cycle pegfilgrastim and daily injection filgrastim in chemotherapy-induced neutropenia: a multicenter dose-finding study in women with breast cancer. Ann Oncol 2002; 13: 903-9
-
(2002)
Ann Oncol
, vol.13
, pp. 903-909
-
-
Holmes, F.A.1
Jones, S.E.2
O'Shaughnessy, J.3
-
106
-
-
0037124498
-
Mono-N-terminal poly(ethylene glycol)-protein conjugates
-
Kinstler O, Molineux G, Treuheit M, et al. Mono-N-terminal poly(ethylene glycol)-protein conjugates. Adv Drug Deliv Rev 2002; 54: 477-85
-
(2002)
Adv Drug Deliv Rev
, vol.54
, pp. 477-485
-
-
Kinstler, O.1
Molineux, G.2
Treuheit, M.3
-
107
-
-
0041931084
-
The enzyme as drug: Application of enzymes as pharmaceuticals
-
Vellard M. The enzyme as drug: application of enzymes as pharmaceuticals. Curr Opin Biotechnol 2003; 14: 1-7
-
(2003)
Curr Opin Biotechnol
, vol.14
, pp. 1-7
-
-
Vellard, M.1
-
108
-
-
29544448116
-
Polymer conjugates: Nanosized medicines for treating cancer
-
Vicent MJ, Duncan R. Polymer conjugates: nanosized medicines for treating cancer. Trends Biotechnol 2006; 24: 39-47
-
(2006)
Trends Biotechnol
, vol.24
, pp. 39-47
-
-
Vicent, M.J.1
Duncan, R.2
-
109
-
-
9544220647
-
Long-acting growth hormones produced by conjugation with polyethylene glycol
-
Clark R, Olson K, Fuh G, et al. Long-acting growth hormones produced by conjugation with polyethylene glycol. J Biol Chem 1996; 271: 21969-77
-
(1996)
J Biol Chem
, vol.271
, pp. 21969-21977
-
-
Clark, R.1
Olson, K.2
Fuh, G.3
-
110
-
-
0344876665
-
Clinical use of pegvisomant for the treatment of acromegaly
-
Drake WM, Trainer PJ. Clinical use of pegvisomant for the treatment of acromegaly. Treat Endocrinol 2003; 2: 369-74
-
(2003)
Treat Endocrinol
, vol.2
, pp. 369-374
-
-
Drake, W.M.1
Trainer, P.J.2
-
111
-
-
24144483087
-
A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease
-
Schreiber S, Rutgeerts P, Fedorak RN, et al. A randomized, placebo-controlled trial of certolizumab pegol (CDP870) for treatment of Crohn's disease. Gastroenterology 2005; 129: 807-18
-
(2005)
Gastroenterology
, vol.129
, pp. 807-818
-
-
Schreiber, S.1
Rutgeerts, P.2
Fedorak, R.N.3
-
112
-
-
0032868653
-
Therapeutic antibody fragments with prolonged in vivo half-lives
-
Chapman AP, Antoniw P, Spitali M, et al. Therapeutic antibody fragments with prolonged in vivo half-lives. Nat Biotechnol 1999; 17: 780-3
-
(1999)
Nat Biotechnol
, vol.17
, pp. 780-783
-
-
Chapman, A.P.1
Antoniw, P.2
Spitali, M.3
-
113
-
-
0030747017
-
Effect of polyethylene glycol conjugated bovine hemoglobin in both top-load and exchange transfusion rat models
-
Conover CD, Linberg R, Gilbert CW, et al. Effect of polyethylene glycol conjugated bovine hemoglobin in both top-load and exchange transfusion rat models. Artif Organs 1997; 21: 1066-75
-
(1997)
Artif Organs
, vol.21
, pp. 1066-1075
-
-
Conover, C.D.1
Linberg, R.2
Gilbert, C.W.3
-
114
-
-
0036735357
-
Uricase formulated with polyethylene glycol (uricase-PEG 20): Biochemical rationale and preclinical studies
-
Bomalaski JS, Holtsberg FW, Ensor CM, et al. Uricase formulated with polyethylene glycol (uricase-PEG 20): biochemical rationale and preclinical studies. J Rheumatol 2002; 29: 1942-9
-
(2002)
J Rheumatol
, vol.29
, pp. 1942-1949
-
-
Bomalaski, J.S.1
Holtsberg, F.W.2
Ensor, C.M.3
-
115
-
-
0037428969
-
Effective drug delivery by PEGylated drug conjugates
-
Greenwald RB, Choe YH, McGuire J, et al. Effective drug delivery by PEGylated drug conjugates. Adv Drug Deliv Rev 2003; 55: 217-50
-
(2003)
Adv Drug Deliv Rev
, vol.55
, pp. 217-250
-
-
Greenwald, R.B.1
Choe, Y.H.2
McGuire, J.3
-
116
-
-
0030071043
-
Drug delivery systems: Water soluble taxol 2′-poly(ethylene glycol) ester prodrugs-design and in vivo effectiveness
-
Greenwald RB, Gilbert CW, Pendri A, et al. Drug delivery systems: water soluble taxol 2′-poly(ethylene glycol) ester prodrugs-design and in vivo effectiveness. J Med Chem 1996; 39: 424-31
-
(1996)
J Med Chem
, vol.39
, pp. 424-431
-
-
Greenwald, R.B.1
Gilbert, C.W.2
Pendri, A.3
-
117
-
-
0036959644
-
Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration
-
Eyetech Study Group. Preclinical and phase 1A clinical evaluation of an anti-VEGF pegylated aptamer (EYE001) for the treatment of exudative age-related macular degeneration. Retina 2002; 22: 143-52
-
(2002)
Retina
, vol.22
, pp. 143-152
-
-
-
118
-
-
33748936390
-
Shellac to pegylation: 2500 years of polymers in controlled release drug delivery
-
Filbey JA, Charles SA. Shellac to pegylation: 2500 years of polymers in controlled release drug delivery. Drug Delivery Technology 2005; 5: 65-9
-
(2005)
Drug Delivery Technology
, vol.5
, pp. 65-69
-
-
Filbey, J.A.1
Charles, S.A.2
-
119
-
-
33644874163
-
The Food and Drug Administration's Office of Orphan Products Development: Incentives, grants, and special designations speed therapies for orphan diseases
-
Haffner ME. The Food and Drug Administration's Office of Orphan Products Development: incentives, grants, and special designations speed therapies for orphan diseases. Retina 2005; 25: S89-90
-
(2005)
Retina
, vol.25
-
-
Haffner, M.E.1
-
120
-
-
50549191387
-
Tumor inhibitory effect of L-asparaginase from escherichia coli
-
Mashburn LT, Wriston Jr JC. Tumor inhibitory effect of L-asparaginase from escherichia coli. Arch Biochem Biophys 1964; 105: 450-2
-
(1964)
Arch Biochem Biophys
, vol.105
, pp. 450-452
-
-
Mashburn, L.T.1
Wriston Jr., J.C.2
-
121
-
-
0037177490
-
Effects of polyethylene glycol attachment on physicochemical and biological stability of E. coli L-asparaginase
-
Soares AL, Guimaraes GM, Polakiewicz B, et al. Effects of polyethylene glycol attachment on physicochemical and biological stability of E. coli L-asparaginase. Int J Pharm 2002; 237: 163-70
-
(2002)
Int J Pharm
, vol.237
, pp. 163-170
-
-
Soares, A.L.1
Guimaraes, G.M.2
Polakiewicz, B.3
-
122
-
-
0242319356
-
Water-soluble polymer therapeutics with a special emphasis on cancer chemotherapy
-
Arshady R, editor. London: Citus Books
-
Sawa T, Sahoo SK, Maeda H. Water-soluble polymer therapeutics with a special emphasis on cancer chemotherapy. In: Arshady R, editor. Polymeric biomaterials, the PBM series, volume 1: introduction to polymeric biomaterials. London: Citus Books, 2003: 233-61
-
(2003)
Polymeric Biomaterials, the PBM Series, Volume 1: Introduction to Polymeric Biomaterials
, vol.1
, pp. 233-261
-
-
Sawa, T.1
Sahoo, S.K.2
Maeda, H.3
-
123
-
-
0033844251
-
A dose-ranging study of pegylated interferon alfa-2b and ribavirin in chronic hepatitis C
-
The Hepatitis C Intervention Therapy Group
-
Glue P, Rouzier-Panis R, Raffanel C, et al. A dose-ranging study of pegylated interferon alfa-2b and ribavirin in chronic hepatitis C. The Hepatitis C Intervention Therapy Group. Hepatology 2000; 32: 647-53
-
(2000)
Hepatology
, vol.32
, pp. 647-653
-
-
Glue, P.1
Rouzier-Panis, R.2
Raffanel, C.3
-
124
-
-
0033045004
-
Relationship between molecular mass and duration of activity of polyethylene glycol conjugated granulocyte colony-timulating factor mutein
-
Bowen S, Tare N, Inoue T, et al. Relationship between molecular mass and duration of activity of polyethylene glycol conjugated granulocyte colony-timulating factor mutein. Exp Hematol 1999; 27: 425-32
-
(1999)
Exp Hematol
, vol.27
, pp. 425-432
-
-
Bowen, S.1
Tare, N.2
Inoue, T.3
-
125
-
-
0026715826
-
Chemical modification of recombinant human granulocyte colony-stimulating factor by polyethylene glycol increases its biological activity in vivo
-
Satake-Ishikawa R, Ishikawa M, Okada Y, et al. Chemical modification of recombinant human granulocyte colony-stimulating factor by polyethylene glycol increases its biological activity in vivo. Cell Struct Funct 1992; 17: 157-60
-
(1992)
Cell Struct Funct
, vol.17
, pp. 157-160
-
-
Satake-Ishikawa, R.1
Ishikawa, M.2
Okada, Y.3
-
126
-
-
29344445267
-
Treatment of pituitary tumors: Pegvisomant
-
Paisley AN, Drake WM. Treatment of pituitary tumors: pegvisomant. Endocrine 2005; 28: 111-4
-
(2005)
Endocrine
, vol.28
, pp. 111-114
-
-
Paisley, A.N.1
Drake, W.M.2
-
127
-
-
0022991475
-
Immunogenicity of polyethylene glycol-modified superoxide dismutase and catalase
-
Nucci ML, Olejarczyk J, Abuchowski A. Immunogenicity of polyethylene glycol-modified superoxide dismutase and catalase. J Free Radic Biol Med 1986; 2: 321-5
-
(1986)
J Free Radic Biol Med
, vol.2
, pp. 321-325
-
-
Nucci, M.L.1
Olejarczyk, J.2
Abuchowski, A.3
-
128
-
-
0018894595
-
Preparation of a polyethylene glycol: Superoxide dismutase adduct, and an examination of its blood circulation life and anti-inflammatory activity
-
Pyatak PS, Abuchowski A, Davis FF. Preparation of a polyethylene glycol: superoxide dismutase adduct, and an examination of its blood circulation life and anti-inflammatory activity. Res Commun Chem Pathol Pharmacol 1980; 29: 113-27
-
(1980)
Res Commun Chem Pathol Pharmacol
, vol.29
, pp. 113-127
-
-
Pyatak, P.S.1
Abuchowski, A.2
Davis, F.F.3
-
129
-
-
0028612041
-
Clinical trials with Dismutec (pegorgotein; polyethylene glycol-conjugated superoxide dismutase; PEG-SOD) in the treatment of severe closed head injury
-
Muizelaar JP. Clinical trials with Dismutec (pegorgotein; polyethylene glycol-conjugated superoxide dismutase; PEG-SOD) in the treatment of severe closed head injury. Adv Exp Med Biol 1994; 366: 389-400
-
(1994)
Adv Exp Med Biol
, vol.366
, pp. 389-400
-
-
Muizelaar, J.P.1
-
130
-
-
0027414276
-
Improving the outcome of severe head injury with the oxygen radical scavenger polyethylene glycol-conjugated superoxide dismutase: A phase II trial
-
Muizelaar JP, Marmarou A, Young HF, et al. Improving the outcome of severe head injury with the oxygen radical scavenger polyethylene glycol-conjugated superoxide dismutase: a phase II trial. J Neurosurg 1993; 78: 375-82
-
(1993)
J Neurosurg
, vol.78
, pp. 375-382
-
-
Muizelaar, J.P.1
Marmarou, A.2
Young, H.F.3
-
131
-
-
0036160864
-
Discovery of TNF-alpha as a therapeutic target in rheumatoid arthritis: Preclinical and clinical studies
-
Feldmann M, Maini RN. Discovery of TNF-alpha as a therapeutic target in rheumatoid arthritis: preclinical and clinical studies. Joint Bone Spine 2002; 69: 12-8
-
(2002)
Joint Bone Spine
, vol.69
, pp. 12-18
-
-
Feldmann, M.1
Maini, R.N.2
-
132
-
-
0037630208
-
Strategies for targeting tumour necrosis factor in IBD
-
Sandborn WJ. Strategies for targeting tumour necrosis factor in IBD. Best Pract Res Clin Gastroenterol 2003; 17: 105-17
-
(2003)
Best Pract Res Clin Gastroenterol
, vol.17
, pp. 105-117
-
-
Sandborn, W.J.1
-
133
-
-
0029848854
-
Glucocerebrosidase (Gaucher disease)
-
Beutler E, Gelbart T. Glucocerebrosidase (Gaucher disease). Hum Mutat 1996; 8: 207-13
-
(1996)
Hum Mutat
, vol.8
, pp. 207-213
-
-
Beutler, E.1
Gelbart, T.2
-
134
-
-
0031806430
-
Increased tissue oxygenation and enhanced radiation sensitivity of solid tumors in rodents following polyethylene glycol conjugated bovine hemoglobin administration
-
Linberg R, Conover CD, Shum KL, et al. Increased tissue oxygenation and enhanced radiation sensitivity of solid tumors in rodents following polyethylene glycol conjugated bovine hemoglobin administration. In Vivo 1998; 12: 167-73
-
(1998)
In Vivo
, vol.12
, pp. 167-173
-
-
Linberg, R.1
Conover, C.D.2
Shum, K.L.3
-
135
-
-
0019415611
-
Hypouricaemic effect of polyethyleneglycol modified urate oxidase
-
Davis S, Park YK, Abuchowski A, et al. Hypouricaemic effect of polyethyleneglycol modified urate oxidase. Lancet 1981; II: 281-3
-
(1981)
Lancet
, vol.2
, pp. 281-283
-
-
Davis, S.1
Park, Y.K.2
Abuchowski, A.3
-
136
-
-
0032863833
-
Camptothecin antitumor agents
-
Lerchen HG. Camptothecin antitumor agents. IDrugs 1999; 2: 896-906
-
(1999)
IDrugs
, vol.2
, pp. 896-906
-
-
Lerchen, H.G.1
-
137
-
-
0026349087
-
The anti-gene strategy: Control of gene expression by triplex-forming-oligonucleotides
-
Helene C. The anti-gene strategy: control of gene expression by triplex-forming-oligonucleotides. Anticancer Drug Des 1991; 6: 569-84
-
(1991)
Anticancer Drug des
, vol.6
, pp. 569-584
-
-
Helene, C.1
-
138
-
-
0029031094
-
Oligonucleotides as research, diagnostic, and therapeutic agents
-
Gold L. Oligonucleotides as research, diagnostic, and therapeutic agents. J Biol Chem 1995; 270: 13581-4
-
(1995)
J Biol Chem
, vol.270
, pp. 13581-13584
-
-
Gold, L.1
-
139
-
-
12744269417
-
CT-2103: A novel macromolecular taxane with potential advantages compared with conventional taxanes
-
Langer CJ. CT-2103: a novel macromolecular taxane with potential advantages compared with conventional taxanes. Clin Lung Cancer 2004; 6 Suppl. 2: S85-8
-
(2004)
Clin Lung Cancer
, vol.6
, Issue.2 SUPPL.
-
-
Langer, C.J.1
-
140
-
-
23744463076
-
Pegaptanib: In exudative age-related macular degeneration
-
Siddiqui MA, Keating GM. Pegaptanib: in exudative age-related macular degeneration. Drugs 2005; 65: 1571-7
-
(2005)
Drugs
, vol.65
, pp. 1571-1577
-
-
Siddiqui, M.A.1
Keating, G.M.2
-
141
-
-
30444431604
-
Pegaptanib for wet macular degeneration
-
Barc
-
Fraunfelder FW. Pegaptanib for wet macular degeneration. Drugs Today (Barc) 2005; 41: 703-9
-
(2005)
Drugs Today
, vol.41
, pp. 703-709
-
-
Fraunfelder, F.W.1
-
143
-
-
23744471772
-
Drug targeting with nano-sized carrier systems
-
Yokoyama M. Drug targeting with nano-sized carrier systems. J Artif Organs 2005; 8: 77-84
-
(2005)
J Artif Organs
, vol.8
, pp. 77-84
-
-
Yokoyama, M.1
-
144
-
-
0026926609
-
Conjugates of anticancer agents and polymers: Advantages of macromolecular therapeutics in vivo
-
Maeda H, Seymour LW, Miyamoto Y. Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo. Bioconjug Chem 1992; 3: 351-62
-
(1992)
Bioconjug Chem
, vol.3
, pp. 351-362
-
-
Maeda, H.1
Seymour, L.W.2
Miyamoto, Y.3
-
145
-
-
0033800221
-
Drug targeting
-
Torchilin VP. Drug targeting. Eur J Pharm Sci 2000; 11 Suppl. 2: S81-91
-
(2000)
Eur J Pharm Sci
, vol.11
, Issue.2 SUPPL.
-
-
Torchilin, V.P.1
-
146
-
-
0035816178
-
Determinants of drug delivery and transport to solid tumors
-
Au JL, Jang SH, Zheng J, et al. Determinants of drug delivery and transport to solid tumors. J Control Release 2001; 74: 31-46
-
(2001)
J Control Release
, vol.74
, pp. 31-46
-
-
Au, J.L.1
Jang, S.H.2
Zheng, J.3
-
147
-
-
0032580354
-
Drug delivery and targeting
-
Langer R. Drug delivery and targeting. Nature 1998; 392: 5-10
-
(1998)
Nature
, vol.392
, pp. 5-10
-
-
Langer, R.1
-
148
-
-
33748922307
-
Polymer-drug conjugates: Recent development for anticancer drugs
-
Modi S, Jain JP, Kumar N. Polymer-drug conjugates: recent development for anticancer drugs. CRIPS 2004; 5 (2): 2-8
-
(2004)
CRIPS
, vol.5
, Issue.2
, pp. 2-8
-
-
Modi, S.1
Jain, J.P.2
Kumar, N.3
-
149
-
-
0033567094
-
Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor
-
Monsky WL, Fukumura D, Gohongi T, et al. Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. Cancer Res 1999; 59: 4129-35
-
(1999)
Cancer Res
, vol.59
, pp. 4129-4135
-
-
Monsky, W.L.1
Fukumura, D.2
Gohongi, T.3
-
150
-
-
0032516078
-
Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment
-
Hobbs SK, Monsky WL, Yuan F, et al. Regulation of transport pathways in tumor vessels: role of tumor type and microenvironment. Proc Natl Acad Sci U S A 1998; 95: 4607-12
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 4607-4612
-
-
Hobbs, S.K.1
Monsky, W.L.2
Yuan, F.3
-
151
-
-
0028025011
-
Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows
-
Yuan F, Salehi HA, Boucher Y, et al. Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows. Cancer Res 1994; 54: 4564-8
-
(1994)
Cancer Res
, vol.54
, pp. 4564-4568
-
-
Yuan, F.1
Salehi, H.A.2
Boucher, Y.3
-
152
-
-
0029900738
-
Quantitation and physiological characterization of angiogenic vessels in mice: Effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment
-
Dellian M, Witwer BP, Salehi HA, et al. Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment. Am J Pathol 1996; 149: 59-71
-
(1996)
Am J Pathol
, vol.149
, pp. 59-71
-
-
Dellian, M.1
Witwer, B.P.2
Salehi, H.A.3
-
153
-
-
0037334516
-
Vascular permeability enhancement in solid tumor: Various factors, mechanisms involved and its implications
-
Maeda H, Fang J, Inutsuka T, et al. Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications. Int Immunopharmacol 2003; 3: 319-28
-
(2003)
Int Immunopharmacol
, vol.3
, pp. 319-328
-
-
Maeda, H.1
Fang, J.2
Inutsuka, T.3
-
154
-
-
0032900507
-
Doxorubicin-polymer conjugates: Further demonstration of the concept of enhanced permeability and retention
-
Muggia FM. Doxorubicin-polymer conjugates: further demonstration of the concept of enhanced permeability and retention. Clin Cancer Res 1999; 5: 7-8
-
(1999)
Clin Cancer Res
, vol.5
, pp. 7-8
-
-
Muggia, F.M.1
-
155
-
-
0033231137
-
Polymer conjugates for tumour targeting and intra-cytoplasmic delivery. The EPR effect as a common gateway?
-
Duncan R. Polymer conjugates for tumour targeting and intra-cytoplasmic delivery. The EPR effect as a common gateway? Pharm Sci Technol Today 1999; 2: 441-9
-
(1999)
Pharm Sci Technol Today
, vol.2
, pp. 441-449
-
-
Duncan, R.1
-
156
-
-
0037508920
-
Factors and mechanism of 'EPR' effect and the enhanced antitumor effects of macromolecular drugs including SMANCS
-
Fang J, Sawa T, Maeda H. Factors and mechanism of 'EPR' effect and the enhanced antitumor effects of macromolecular drugs including SMANCS. Adv Exp Med Biol 2003; 519: 29-49
-
(2003)
Adv Exp Med Biol
, vol.519
, pp. 29-49
-
-
Fang, J.1
Sawa, T.2
Maeda, H.3
-
157
-
-
0029896601
-
Ability of serum prostate-specific antigen levels to predict normal bone scans in patients with newly diagnosed prostate cancer
-
Gleave ME, Coupland D, Drachenberg D, et al. Ability of serum prostate-specific antigen levels to predict normal bone scans in patients with newly diagnosed prostate cancer. Urology 1996; 47: 708-12
-
(1996)
Urology
, vol.47
, pp. 708-712
-
-
Gleave, M.E.1
Coupland, D.2
Drachenberg, D.3
-
158
-
-
0141787063
-
Predictive modeling for the presence of prostate carcinoma using clinical, laboratory, and ultrasound parameters in patients with prostate specific antigen levels < or = 10 ng/mL
-
Garzotto M, Hudson RG, Peters L, et al. Predictive modeling for the presence of prostate carcinoma using clinical, laboratory, and ultrasound parameters in patients with prostate specific antigen levels < or = 10 ng/mL. Cancer 2003; 98: 1417-22
-
(2003)
Cancer
, vol.98
, pp. 1417-1422
-
-
Garzotto, M.1
Hudson, R.G.2
Peters, L.3
-
159
-
-
0012579234
-
Prostate-specific antigen and the early diagnosis of prostate cancer
-
Caplan A, Kratz A. Prostate-specific antigen and the early diagnosis of prostate cancer. Am J Clin Pathol 2002; 117 Suppl.: S104-8
-
(2002)
Am J Clin Pathol
, vol.117
, Issue.SUPPL.
-
-
Caplan, A.1
Kratz, A.2
-
160
-
-
24144490885
-
Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention
-
Sahoo SK, Labhasetwar V. Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention. Mol Pharm 2005; 2: 373-83
-
(2005)
Mol Pharm
, vol.2
, pp. 373-383
-
-
Sahoo, S.K.1
Labhasetwar, V.2
-
161
-
-
4544358907
-
Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancer
-
Sahoo SK, Ma W, Labhasetwar V. Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancer. Int J Cancer 2004; 112: 335-40
-
(2004)
Int J Cancer
, vol.112
, pp. 335-340
-
-
Sahoo, S.K.1
Ma, W.2
Labhasetwar, V.3
-
162
-
-
0034756945
-
Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease
-
Lamprecht A, Ubrich N, Yamamoto H, et al. Biodegradable nanoparticles for targeted drug delivery in treatment of inflammatory bowel disease. J Pharmacol Exp Ther 2001; 299: 775-81
-
(2001)
J Pharmacol Exp Ther
, vol.299
, pp. 775-781
-
-
Lamprecht, A.1
Ubrich, N.2
Yamamoto, H.3
-
163
-
-
85047695405
-
Magnetofection: Enhancing and targeting gene delivery by magnetic force in vitro and in vivo
-
Scherer F, Anton M, Schillinger U, et al. Magnetofection: enhancing and targeting gene delivery by magnetic force in vitro and in vivo. Gene Ther 2002; 9: 102-9
-
(2002)
Gene Ther
, vol.9
, pp. 102-109
-
-
Scherer, F.1
Anton, M.2
Schillinger, U.3
-
164
-
-
0842311621
-
Vascular targeting agents as cancer therapeutics
-
Thorpe PE. Vascular targeting agents as cancer therapeutics. Clin Cancer Res 2004; 10: 415-27
-
(2004)
Clin Cancer Res
, vol.10
, pp. 415-427
-
-
Thorpe, P.E.1
-
165
-
-
0037404842
-
Endoglin (CD105): A target for anti-angiogenetic cancer therapy
-
Fonsatti E, Altomonte M, Arslan P, et al. Endoglin (CD105): a target for anti-angiogenetic cancer therapy. Curr Drug Targets 2003; 4: 291-6
-
(2003)
Curr Drug Targets
, vol.4
, pp. 291-296
-
-
Fonsatti, E.1
Altomonte, M.2
Arslan, P.3
-
166
-
-
0032525740
-
Tumor vasculature targeted therapies: Getting the players organized
-
Molema G, Meijer DK, de Leij LF. Tumor vasculature targeted therapies: getting the players organized. Biochem Pharmacol 1998; 55: 1939-45
-
(1998)
Biochem Pharmacol
, vol.55
, pp. 1939-1945
-
-
Molema, G.1
Meijer, D.K.2
De Leij, L.F.3
-
167
-
-
0036631492
-
Identification of tumour-associated T-cell epitopes for vaccine development
-
Stevanovic S. Identification of tumour-associated T-cell epitopes for vaccine development. Nat Rev Cancer 2002; 2: 514-20
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 514-520
-
-
Stevanovic, S.1
-
168
-
-
0037320594
-
Cancer/testis tumour-associated antigens: Immunohistochemical detection with monoclonal antibodies
-
Juretic A, Spagnoli GC, Schultz-Thater E, et al. Cancer/testis tumour-associated antigens: immunohistochemical detection with monoclonal antibodies. Lancet Oncol 2003; 4: 104-9
-
(2003)
Lancet Oncol
, vol.4
, pp. 104-109
-
-
Juretic, A.1
Spagnoli, G.C.2
Schultz-Thater, E.3
-
170
-
-
4444274816
-
Chemotherapy targeted to cancers through tumoral hormone receptors
-
Schally AV, Nagy A. Chemotherapy targeted to cancers through tumoral hormone receptors. Trends Endocrinol Metab 2004; 15: 300-10
-
(2004)
Trends Endocrinol Metab
, vol.15
, pp. 300-310
-
-
Schally, A.V.1
Nagy, A.2
-
171
-
-
33644819090
-
Fully human therapeutic monoclonal antibodies
-
Weiner LM. Fully human therapeutic monoclonal antibodies. J Immunother 2006; 29: 1-9
-
(2006)
J Immunother
, vol.29
, pp. 1-9
-
-
Weiner, L.M.1
-
172
-
-
0027218284
-
Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates
-
Trail PA, Willner D, Lasch SJ, et al. Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates. Science 1993; 261: 212-5
-
(1993)
Science
, vol.261
, pp. 212-215
-
-
Trail, P.A.1
Willner, D.2
Lasch, S.J.3
-
173
-
-
0032498324
-
Targeted chemotherapy in mice with peritoneally disseminated gastric cancer using monoclonal antibody-drug conjugate
-
Okamoto K, Yamaguchi T, Otsuji E, et al. Targeted chemotherapy in mice with peritoneally disseminated gastric cancer using monoclonal antibody-drug conjugate. Cancer Lett 1998; 122: 231-6
-
(1998)
Cancer Lett
, vol.122
, pp. 231-236
-
-
Okamoto, K.1
Yamaguchi, T.2
Otsuji, E.3
-
174
-
-
0034059501
-
Enhanced delivery improves the efficacy of a tumor-specific doxorubicin immunoconjugate in a human brain tumor xenograft model
-
Remsen LG, Trail PA, Hellstrom I, et al. Enhanced delivery improves the efficacy of a tumor-specific doxorubicin immunoconjugate in a human brain tumor xenograft model. Neurosurgery 2000; 46: 704-9
-
(2000)
Neurosurgery
, vol.46
, pp. 704-709
-
-
Remsen, L.G.1
Trail, P.A.2
Hellstrom, I.3
-
175
-
-
0034523979
-
Effective cancer targeting using an anti-tumor tissue vascular endothelium-specific monoclonal antibody (TES-23)
-
Wakai Y, Matsui J, Koizumi K, et al. Effective cancer targeting using an anti-tumor tissue vascular endothelium-specific monoclonal antibody (TES-23). Jpn J Cancer Res 2000; 91: 1319-25
-
(2000)
Jpn J Cancer Res
, vol.91
, pp. 1319-1325
-
-
Wakai, Y.1
Matsui, J.2
Koizumi, K.3
-
176
-
-
0026286167
-
Accurate evaluation method of the polymer content in monomethoxy(polyethylene glycol) modified proteins based on amino acid analysis
-
Sartore L, Caliceti P, Schiavon O, et al. Accurate evaluation method of the polymer content in monomethoxy(polyethylene glycol) modified proteins based on amino acid analysis. Appl Biochem Biotechnol 1991; 31: 213-22
-
(1991)
Appl Biochem Biotechnol
, vol.31
, pp. 213-222
-
-
Sartore, L.1
Caliceti, P.2
Schiavon, O.3
-
177
-
-
0016636179
-
An improved 2,4,6-trinitrobenzene-sulfonic acid method for the determination of amines
-
Snyder SL, Sobocinski PZ. An improved 2,4,6-trinitrobenzene-sulfonic acid method for the determination of amines. Anal Biochem 1975; 64: 284-8
-
(1975)
Anal Biochem
, vol.64
, pp. 284-288
-
-
Snyder, S.L.1
Sobocinski, P.Z.2
-
178
-
-
0013889689
-
Determination of free amino groups in proteins by trinitrobenzenesulfonic acid
-
Habeeb AF. Determination of free amino groups in proteins by trinitrobenzenesulfonic acid. Anal Biochem 1966; 14: 328-36
-
(1966)
Anal Biochem
, vol.14
, pp. 328-336
-
-
Habeeb, A.F.1
-
179
-
-
0037133086
-
Anticancer drug delivery systems: Multi-loaded N4-acyl poly(ethylene glycol) prodrugs of ara-C: II. Efficacy in ascites and solid tumors
-
Choe YH, Conover CD, Wu D, et al. Anticancer drug delivery systems: multi-loaded N4-acyl poly(ethylene glycol) prodrugs of ara-C: II. efficacy in ascites and solid tumors. J Control Release 2002; 79: 55-70
-
(2002)
J Control Release
, vol.79
, pp. 55-70
-
-
Choe, Y.H.1
Conover, C.D.2
Wu, D.3
-
180
-
-
0029167706
-
A branched monomethoxypoly(ethylene glycol) for protein modification
-
Monfardini C, Schiavon O, Caliceti P, et al. A branched monomethoxypoly(ethylene glycol) for protein modification. Bioconjug Chem 1995; 6: 62-9
-
(1995)
Bioconjug Chem
, vol.6
, pp. 62-69
-
-
Monfardini, C.1
Schiavon, O.2
Caliceti, P.3
-
181
-
-
0025931920
-
Selective synthesis of 2,4-bis(O-methoxypolyethylene glycol)-6-chloro-s- triazine as a protein modifier
-
Ono K, Kai Y, Maeda H, et al. Selective synthesis of 2,4-bis(O- methoxypolyethylene glycol)-6-chloro-s-triazine as a protein modifier. J Biomater Sci Polym Ed 1991; 2: 61-5
-
(1991)
J Biomater Sci Polym Ed
, vol.2
, pp. 61-65
-
-
Ono, K.1
Kai, Y.2
Maeda, H.3
|