Protein instability in poly(lactic-co-glycolic acid) microparticles

Pharmaceutical Research

Volumn 17, Issue 10, 2000, Pages 1159-1167

  Van De Weert, M ^a   Hennink, W E ^a   Jiskoot, W ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Controlled release; Microparticles; PLGA; Protein stability; Stabilization

Indexed keywords

POLYGLACTIN;

DRUG DEGRADATION; DRUG RELEASE; DRUG STABILITY; DRUG STORAGE; PRIORITY JOURNAL; PROTEIN STABILITY; PROTEIN STRUCTURE; REVIEW;

EID: 0033635054     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1026498209874     Document Type: Review

References (85)

1. Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: Release kinetics and stability issues
2. Biodegradable polymers for protein and peptide drug delivery
3. Bioerodible polymers for delivery of macromolecules
4. Stable formulations of recombinant human growth hormone and interferon-γ for microencapsulation in biodegradable microspheres
5. Recombinant human growth hormone poly(lactic-co-glycolic acid) (PLGA) microspheres provide a long lasting effect
6. Solvent evaporation processes for the production of controlled release biodegradable microsphere formulations for therapeutics and vaccines
7. The stabilization and encapsulation of human growth hormone into biodegradable microspheres
8. Microencapsulation of human growth hormone within biodegradable polyester microspheres: Protein aggregation, stability and incomplete release mechanism
9. Development and scale-up of a microsphere protein delivery system
10. Use of infrared spectroscopy to assess secondary structure of human growth hormone within biodegradable microspheres
11. Characterization of PLGA microspheres for the controlled delivery of IL1α for tumor immunotherapy
12. Characterization of poly(glycolide-co-D,L-lactide)/poly(D,L-lactide) microspheres for controlled release of GM-CSF
13. Factors affecting the in vitro release of recombinant human interferon-γ (rhIFN-γ) from PLGA microspheres
14. Biodegradable microspheres as controlled-release tetanus toxoid delivery systems
15. Physicochemical and immunological studies on the stability of free and microsphere-encapsulated tetanus toxoid in vitro
16. Physico-chemical and antigenic properties of tetanus and diphtheria toxoids and steps towards improved stability
17. Improving stability and release kinetics of microencapsulated tetanus toxoid by co-encapsulation of additives
18. Diphtheria and tetanus toxoid microencapsulation into conventional and end-group alkylated PLA/PLGAs
19. Formulation strategies for the stabilization of tetanus toxoid in poly(lactide-co-glycolide) microspheres
20. Development of a single-shot subunit vaccine for HIV-1: Part 4. Optimizing microencapsulation and pulsatile release of MN rgp120 from biodegradable microspheres
21. Microencapsulation of hepatitis B core antigen for vaccine preparation
22. The development of stable protein formulations: A close look at protein aggregation, deamidation, and oxidation
23. Protein behavior at the water/methylene chloride interface
24. Protein instability toward organic solvent/water emulsification: Implications for protein microencapsulation into microspheres
25. Preparation and characterization of protein C-loaded PLA nanoparticles
26. Microencapsulation of rh-erythropoietin using biodegradable poly(D,L-lactide-co-glycolide): Protein stability and the effects of stabilizing excipients
27. Selection of the solvent system for the preparation of poly(D,L-lactic-co-glycolic acid) microspheres containing tumor necrosis factor-alpha (TNF-α)
28. Protein release from poly(lactic-co-glycolic acid) microspheres: Protein stability problems
29. The sonochemical hot spot
30. Free radical formation induced by ultrasound and its biological implications
31. Stabilization of proteins against methylene chloride / water interface-induced denaturation and aggregation
32. Adsorption of serum albumin to thin films of poly(lactide-co-glycolide)
33. Formulation of L-asparaginase-loaded poly(lactide-co-glycolide) nanoparticles: Influence of polymer properties on enzyme loading, activity and in vitro release
34. Adsorption of peptides to poly(D,L-lactide-co-glycolide): 1. Effect of physical factors on the adsorption
35. Adsorption of peptides to poly(D,L-lactide-co-glycolide): 2. Effect of solution properties on the adsorption
36. Stability and release of bovine serum albumin encapsulated within poly(D,L-lactide-co-glycolide) microparticles
37. Structure-guided encapsulation of bovine serum albumin in poly(DL-lactic-co-glycolic) acid
38. On protein denaturation in aqueous-organic mixtures but not in pure organic solvents
39. Can conformational changes be responsible for solvent and excipient effects on the catalytic behavior of subtilisin Carlsberg in organic solvents?
40. Structure of lysozyme dissolved in neat organic solvents as assessed by NMR and CD spectroscopies
41. A new preparation method for protein loaded poly(D,L-lactic-co-glycolic acid) microspheres and protein release mechanism study
42. NGF release from poly(D,L-lactide-co-glycolide) microspheres. Effect of some formulation parameters on encapsulated NGF stability
43. Why does PEG 400 co-encapsulation improve NGF stability and release from PLGA biodegradable microspheres
44. A month-long effect from a single injection of microencapsulated human growth hormone
45. Recombinant human erythropoietin (rhEPO) loaded poly(lactide-co-glycolide) microspheres: Influence of the enclapsulation technique and polymer purity on microsphere characteristics
46. Ultrasonic atomization for spray drying: A versatile technique for the preparation of protein loaded biodegradable microspheres
47. Controlled release of ionic compounds from poly (L-lactide) microspheres produced by precipitation with a compressed antisolvent
48. Encapsulation of lysozyme in a biodegradable polymer by precipitation with a vapor-over-liquid antisolvent
49. Rational design of stable lyophilized protein formulations: Some practical advice
50. Erythropoietin loaded microspheres prepared from biodegradable LPLG-PEO-LPLG triblock copolymers: Protein stabilization and in-vitro release properties
51. On the structural preservation of recombinant human growth hormone in a dried film of a synthetic biodegradable polymer
52. FTIR characterization of the secondary structure of proteins encapsulated within PLGA microspheres
53. Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR-techniques
54. A comparison of alternative methods for the determination of the levels of proteins entrapped in poly(lactide-co-glycolide) microparticles
55. A new strategy to determine the actual protein content of poly(lactide-co-glycolide) microspheres
56. Development and characterization of protein-loaded poly(lactide-co-glycolide) nanospheres
57. The distribution of protein associated with poly(DL-lactide-co-glycolide) microparticles and its degradation in simulated body fluids
58. Solid-phase aggregation of proteins under pharmaceutically relevant conditions
59. Solid-state chemical stability of proteins and peptides
60. Chemical interactions between drugs containing reactive amines with hydrolyzable insoluble biopolymers in aqueous solutions
61. Strategies for stabilising tetanus toxoid towards the development of a single-dose tetanus vaccine
62. Porcine insulin biodegradable polyester microspheres: Stability and in vitro release characteristics
63. Influence of formulation variables on the in-vitro release of albumin from biodegradable microparticulate systems
64. Preparation of non-porous microspheres with high entrapment efficiency of proteins by a (water-in-oil)-in-oil emulsion technique
65. Instability, stabilization, and formulation of liquid protein pharmaceuticals
66. Importance of in vitro experimental conditions on protein release kinetics, stability and polymer degradation in protein encapsulated poly(D,L-lactic acid-co-glycolic acid) microspheres
67. The influence of biodegradable microcapsule formulations on the controlled release of a protein
68. Stability of BSA encapsulated into PLGA microspheres using PAGE and capillary electrophoresis
69. Visualization of pH in degrading polymer microspheres
70. pH and osmotic pressure inside biodegradable microspheres during erosion
71. Stabilization of pH-induced degradation of porcine insulin in biodegradable polyester microspheres
72. The acidic microclimate in poly(lactide-co-glycolide) microspheres stabilizes camptothecins
73. Monitoring microviscosity and microacidity of the albumin microenvironment inside degrading microparticles from poly(lactide-co-glycolide) (PLG) or ABA-triblock polymers containing hydrophobic poly(lactide-co-glycolide) A blocks and hydrophilic poly(ethyleneoxide) B blocks
74. The stability of recombinant human growth hormone in poly(lactic-co-glycolic acid) (PLGA) microspheres
75. Polylactide microparticles prepared by double emulsion-evaporation II. Effect of the poly(lactide-co-glycolide) composition on the stability of the primary and secondary emulsions
76. Release fo human serum albumin from poly(lactide-co-glycolide) microspheres
77. Quality improvement of spray-dried protein-loaded D,L-PLA microspheres by appropriate polymer solvent selection
78. Double-walled microparticles for single shot vaccine
79. A novel approach to stabilization of protein drugs in poly(lactic-co-glycolic acid) microspheres using agarose hydrogel
80. New strategies for the microencapsulation of tetanus vaccine
81. Improved immunogenicity of a core-coated tetanus toxoid delivery system
82. Stabilization of proteins encapsulated in injectable poly(lactide-co-glycolide)
83. Influence of basic salts on stability and release of proteins in injectable poly(lactide-co-glycolide) delivery devices
84. Stabilization of bovine serum albumin encapsulated in injectable poly(lactide-co-glycolide) millicylinders
85. Technique to control pH in vicinity of biodegrading PLA-PGA implants