Stabilization of α-chymotrypsin at the CH2Cl2/water interface and upon water-in-oil-in-water encapsulation in PLGA microspheres

Journal of Controlled Release

Volumn 89, Issue 1, 2003, Pages 71-85

  Pérez Rodriguez, Caroline ^a   Montano, Nashbly ^a   Gonzalez, Karilys ^a   Griebenow, Kai ^a  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

Protein aggregation; Protein delivery; Protein stability; Sustained release; Water oil interface

Indexed keywords

ABSORPTION; AGGLOMERATION; ORGANIC SOLVENTS; POLYMERS;

ACTIVITY LOSS;

PROTEINS;

CHYMOTRYPSIN A; EXCIPIENT; LACTULOSE; MACROGOL; MALTOSE; MICROSPHERE; POLYGLACTIN; WATER;

ADSORPTION; AQUEOUS SOLUTION; ARTICLE; DRUG DELIVERY SYSTEM; DRUG RELEASE; ENCAPSULATION; ENZYME ACTIVITY; ENZYME INACTIVATION; FREEZE DRYING; MICROEMULSION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FUNCTION; PROTEIN STABILITY; STRESS; WATER IN OIL IN WATER ENCAPSULATION;

EID: 0037437030     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(03)00074-9     Document Type: Article

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