The use of PEGylated liposomes to prolong circulation lifetimes of tissue plasminogen activator

Biomaterials

Volumn 30, Issue 29, 2009, Pages 5751-5756

  Kim, Ji Young ^a   Kim, Jin Ki ^a   Park, Jeong Sook ^b   Byun, Youngro ^a   Kim, Chong Kook ^a,c  

^a Seoul National University   (South Korea)

^b Chungnam National University   (South Korea)

^c Inje University   (South Korea)

Author keywords

Fibrinolysis; Half life; Liposomes; PEG; Prolong; Tissue plasminogen activator

Indexed keywords

FIBRINOLYSIS; HALF-LIFE; PEG; PROLONG; TISSUE PLASMINOGEN ACTIVATOR;

CARDIOVASCULAR SYSTEM; CHOLESTEROL; ETHYLENE; ETHYLENE GLYCOL; LIPOSOMES; PARTICLE SIZE; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SODIUM; SODIUM SULFATE; ZETA POTENTIAL;

PHOSPHOLIPIDS;

ALTEPLASE; CHOLESTEROL; CHOLESTEROL SULFATE; LIPOSOME; MACROGOL 2000; PHOSPHATIDYLCHOLINE;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG DOSAGE FORM COMPARISON; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG STABILITY; ENCAPSULATION; FIBRIN CLOT; FIBRINOLYSIS; IN VIVO STUDY; LIPOSOMAL DELIVERY; MALE; MEAN RESIDENCE TIME; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; ZETA POTENTIAL;

ANIMALS; DRUG CARRIERS; LIPOSOMES; MALE; MATERIALS TESTING; METABOLIC CLEARANCE RATE; POLYETHYLENE GLYCOLS; RATS; RATS, SPRAGUE-DAWLEY; TISSUE PLASMINOGEN ACTIVATOR;

EID: 68549092406     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.07.021     Document Type: Article

References (37)

1. Rouf S.A., Moo-Young M., and Chisti Y. Tissue-type plasminogen activator: characteristics, applications and production technology. Biotechnol Adv 14 (1996) 239-266
2. Collen D., and Lijnen H. In: Stamatoyannopoulos G., Nienhuis A.W., Majerus P.W., and Varmus H. (Eds). The molecular basis of blood diseases (1994), W.B. Saunders Co., Philadelphia, PA 725-752
3. Baruah D.B., Dash R.N., Chaudhari M.R., and Kadam S.S. Plasminogen activators: a comparison. Vascul Pharmacol 44 (2006) 1-9
4. Maizel A.S., and Bookstein J.J. Streptokinase, urokinase, and tissue plasminogen activator: pharmacokinetics, relative advantages, and methods for maximizing rates and consistency of lysis. Cardiovasc Intervent Radiol 9 (1986) 234-244
5. Park Y.J., Liang J., Yang Z., and Yang V.C. Controlled release of clot-dissolving tissue-type plasminogen activator from a poly(l-glutamic acid) semi-interpenetrating polymer network hydrogel. J Controlled Release 75 (2001) 37-44
6. Werle M., and Bernkop-Schnürch A. Strategies to improve plasma half life time of peptide and protein drugs. Amino Acids 30 (2006) 351-367
7. Lee K.Y., and Yuk S.H. Polymeric protein delivery systems. Prog Polym Sci 32 (2007) 669-697
8. Lian T., and Ho R.J.Y. Trends and developments in liposome drug delivery systems. J Pharm Sci 90 (2001) 667-680
9. Weiner A.L. Liposomes as carriers for polypeptides. Adv Drug Deliv Rev 3 (1989) 307-341
10. Bergstrand N. Liposomes for drug delivery: from physico-chemical studies to applications. PhD thesis, Uppsala University, Sweden; 2003.
11. Nikolova A.N., and Jones M.N. Effect of grafted PEG-2000 on the size and permeability of vesicles. Biochim Biophys Acta 1304 (1996) 120-128
12. Kim J.K., Choi S.H., Kim C.O., Park J.S., Ahn W.S., and Kim C.K. Enhancement of polyethylene glycol (PEG)-modified cationic liposome-mediated gene deliveries: effects on serum stability and transfection efficiency. J Pharm Pharmacol 55 (2003) 453-460
13. Kim I.S., Choi H.G., Choi H.S., Kim B.K., and Kim C.K. Prolonged systemic delivery of streptokinase using liposome. Arch Pharm Res 21 (1998) 248-252
14. Koppel D.E. Analysis of macromolecular polydispersity in intensity correlation spectroscopy: the method of cumulants. J Chem Phys 57 (1972) 4814-4816
15. Heeremans J.L.M., Mijnheer F.W., Gerritsen H.R., Prevost R., Kluft C., and Crommelin D.J.A. Long-term stability of liposomes containing both tissue-type plasminogen activator and glu-plasminogen. Int J Pharm 129 (1996) 191-202
16. Ntimenou V., Mourtas S., Christodoulakis E.V., Tsilimbaris M., and Antimisiaris S.G. Stability of protein-encapsulating DRV liposomes after freeze-drying: a study with BSA and t-PA. J Liposome Res 16 (2006) 403-416
17. Yang V.C., Naik S.S., Song H., Dombkowski A.A., Crippen G., and Liang J.F. Construction and characterization of a t-PA mutant for use in ATTEMPTS: a drug delivery system for achieving targeted thrombolysis. J Control Release 110 (2005) 164-176
18. Liang J.F., Song H., Li Y.T., and Yang V.C. A novel heparin/protamine-based pro-drug type delivery system for protease drugs. J Pharm Sci 89 (2000) 664-673
19. Berger H., and Pizzo S.V. Preparation of polyethylene glycol-tissue plasminogen activator adducts that retain functional activity: characteristics and behavior in three animal species. Blood 71 (1988) 1641-1647
20. Larsen G.R., Metzger M., Henson K., Blue Y., and Horgan P. Pharmacokinetic and distribution analysis of variant forms of tissue-type plasminogen activator with prolonged clearance in rat. Blood 73 (1989) 1842-1850
21. Heeremans J.L.M., Prevost R., Bekkers M.E., Los P., Emeis J.J., Kluft C., et al. Thrombolytic treatment with tissue-type plasminogen activator (t-PA) containing liposomes in rabbits: a comparison with free t-PA. Thromb Haemost 73 (1995) 488-494
22. Hong M.S., Lim S.J., Oh Y.K., and Kim C.K. pH-sensitive, serum-stable and long-circulating liposomes as a new drug delivery system. J Pharm Pharmacol 54 (2002) 51-58
23. Azonanotechnology article. The use of zeta potential measurements to study sterically stabilized liposomes using Malvern Instruments. http://www.azonano.com/details.asp?ArticleID=1214 [10.02.08].
24. Nicholas A.R., Scott M.J., Kennedy N.I., and Jones M.N. Effect of grafted polyethylene glycol (PEG) on the size, encapsulation efficiency and permeability of vesicles. Biochim Biophys Acta 1463 (2000) 167-178
25. Toongsuwan S., Li L.C., Erickson B.K., and Chang H.C. Formulation and characterization of bupivacaine lipospheres. Int J Pharm 280 (2004) 57-65
26. Wissing S.A., Kayser O., and Muller R.H. Solid lipid nanoparticles for parenteral drug delivery. Adv Drug Deliv Rev 56 (2004) 1257-1272
27. Gupta Y., Jain A., Jain P., and Jain S. Design and development of folate appended liposomes for enhanced delivery of 5-FU to tumor cells. J Drug Target 15 (2007) 231-240
28. Chung T.Z., Wang S.S., and Tsai W.J. Accelerating thrombolysis with chitosan-coated plasminogen activators encapsulated in poly-(lactide-co-glycolide) (PLGA) nanoparticles. Biomaterials 29 (2008) 228-237
29. Crommelin D.J.A., Nassander U.K., Peeters P.A.M., Steerenberg P.A., Dejong W.H., Eling W.M.C., et al. Drug-laden liposome in antitumor therapy and in the treatment of parasitic diseases. J Controlled Release 11 (1990) 233-243
30. Dutta R.C. Drug carriers in pharmaceutical design: promises and progress. Curr Pharm Des 13 (2007) 761-769
31. Gurewich V., Pannell R., Louie S., Kelley P., Suddith R.L., and Greenlee R. Effective and fibrin-specific clot lysis by a zymogen precursor form of urokinase (pro-urokinase). A study in vitro and in two animal species. J Clin Invest 73 (1984) 1731-1739
32. Li Z.L., Zhang N.Z., and Nie Y.H. Accelerated thrombolysis by liposomal-encapsulated urokinase in a model of acute myocardial infarction. Chung Hua I Hseeh Tsa Chih 74 (1994) 338-340
33. Leach J.K., O'Rear E.A., Patterson E., Miao Y., and Johnson A.E. Accelerated thrombolysis in a rabbit model of carotid artery thrombosis with liposome-encapsulated and microencapsulated streptokinase. Thromb Haemost 90 (2003) 64-70
34. Leach J.K., Patterson E., and O'Rear E.A. Distributed intraclot thrombolysis: mechanism of accelerated thrombolysis with encapsulated plasminogen activator. J Thromb Haemost 2 (2004) 1548-1555
35. Tiukinhoy-Laing S.D., Huang S., Klegerman M., Holland C.K., and McPherson D.D. Ultrasound-facilitated thrombolysis using tissue-plasminogen activator-loaded echogenic liposomes. Thromb Res 119 (2007) 777-784
36. Allen T.M., and Hansen C. Pharmacokinetics of stealth versus conventional liposomes: effect of dose. Biochim Biophys Acta 1068 (1991) 133-141
37. Dos Santos N., Allen C., Doppen A.M., Anantha M., Cox K.A.K., Gallagher R.C., et al. Influence of poly(ethylene glycol) grafting density and polymer length on liposomes: relating plasma circulation lifetimes to protein binding. Biochim Biophys Acta 1768 (2007) 1367-1377