Nanoscaled polyion complex micelles for targeted delivery of recombinant hirudin to platelets based on cationic copolymer

Molecular Pharmaceutics

Volumn 7, Issue 3, 2010, Pages 718-726

  Wang, Fei ^a,b   Li, Xinru ^a,b   Zhou, Yanxia ^a   Zhang, Yanhui ^a   Chen, Xingwei ^a   Yang, Jingxiong ^a   Huang, Yanqing ^b   Liu, Yan ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Anticoagulant activity; Inhibition of platelet aggregation; Platelet targeted; Poly(ethylene glycol) grafted chitosan; Polyion complex micelles; Recombinant hirudin

Indexed keywords

CHITOSAN; COPOLYMER; MACROGOL; RECOMBINANT HIRUDIN;

ANIMAL EXPERIMENT; ANTICOAGULATION; AREA UNDER THE CURVE; ARTICLE; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG INHIBITION; DRUG STRUCTURE; DRUG TARGETING; ENCAPSULATION; MALE; MICELLE; NANOANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; THROMBOCYTE; THROMBOCYTE AGGREGATION;

ANIMALS; ANTICOAGULANTS; BLOOD PLATELETS; CATIONS; CHITOSAN; HIRUDIN THERAPY; HIRUDINS; MALE; MICELLES; MICROSCOPY, CONFOCAL; MOLECULAR STRUCTURE; OLIGOPEPTIDES; PLATELET AGGREGATION; POLYETHYLENE GLYCOLS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS;

EID: 77953235585     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp900271r     Document Type: Article

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