Role of glycosylation in conformational stability, activity, macromolecular interaction and immunogenicity of recombinant human factor VIII

AAPS Journal

Volumn 11, Issue 3, 2009, Pages 424-431

  Kosloski, Matthew P ^a   Miclea, Razvan D ^b   Balu Iyer, Sathy V ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b AMGEN INC   (United States)

Author keywords

Factor VIII; Glycosylation; Hemophilia A; Immunogenicity; Inhibitor development

Indexed keywords

RECOMBINANT BLOOD CLOTTING FACTOR 8;

ARTICLE; BLOOD CLOTTING; CONFORMATIONAL TRANSITION; DEGLYCOSYLATION; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG STABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL PERMEATION CHROMATOGRAPHY; GENE DELETION; GLYCOSYLATION; HEMOPHILIA A; IMMUNOGENICITY; MACROMOLECULE; PROTEIN CLEAVAGE; PROTEIN LIPID INTERACTION;

ANIMALS; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FACTOR VIII; GLYCOSYLATION; HUMANS; MICE; MODELS, MOLECULAR; PROTEIN CONFORMATION; RECOMBINANT PROTEINS;

EID: 73349085222     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-009-9119-y     Document Type: Article

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