Site-specific pegylation of human thyroid stimulating hormone to prolong duration of action

Bioconjugate Chemistry

Volumn 24, Issue 3, 2013, Pages 408-418

  Qiu, Huawei ^a   Boudanova, Ekaterina ^a   Park, Anna ^a   Bird, Julie J ^a   Honey, Denise M ^a   Zarazinski, Christine ^a   Greene, Ben ^a   Kingsbury, Jonathan S ^a   Boucher, Susan ^a   Pollock, Julie ^a   McPherson, John M ^a   Pan, Clark Q ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

CANCER DIAGNOSTICS; DOSING FREQUENCY; HALF LIVES; HUMAN THYROID; PEGYLATION; REACTION YIELDS; RECEPTOR BINDING; SITE-SPECIFIC; THYROID CANCERS; THYROID STIMULATING HORMONES;

AMINO ACIDS;

CYSTEINE; LYSINE; RECOMBINANT THYROTROPIN; THYROTROPIN RECEPTOR;

ALPHA CHAIN; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BETA CHAIN; CANCER DIAGNOSIS; CANCER THERAPY; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG CONJUGATION; DRUG HALF LIFE; DRUG RECEPTOR BINDING; IC 50; MUTANT; NONHUMAN; OLIGOMERIZATION; PHARMACODYNAMICS; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN FOLDING; REDUCTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SCALE UP; STABLE EXPRESSION; THYROID CANCER; TRANSIENT EXPRESSION; WESTERN BLOTTING;

RATTUS;

EID: 84875428215     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc300519h     Document Type: Article

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