Sustained delivery of human growth hormone using a polyelectrolyte complex-loaded thermosensitive polyphosphazene hydrogel

Journal of Controlled Release

Volumn 147, Issue 3, 2010, Pages 359-367

  Park, Mi Ran ^a,c   Chun, ChangJu ^a   Ahn, Sung Won ^b   Ki, Min Hyo ^b   Cho, Chong Su ^c,d   Song, Soo Chang ^a  

^a Korea Institute of Science and Technology   (South Korea)

^b Chong Kun Dang Research Institute   (South Korea)

^c Seoul National University   (South Korea)

^d Seoul National University   (South Korea)

Author keywords

Human growth hormone (hGH); Polycation; Polyelectrolyte complex (PEC); Sustained protein delivery; Thermosensitive hydrogel

Indexed keywords

HUMAN GROWTH HORMONE; POLYCATIONS; POLYELECTROLYTE COMPLEX (PEC); SUSTAINED PROTEIN DELIVERY; THERMO-SENSITIVE HYDROGEL;

AMINO ACIDS; POLYELECTROLYTES; ZINC;

HYDROGELS;

ALPHA AMINO OMEGA METHOXY POLY(ETHYLENE GLYCOL); ETHYL 2 (O GLYCYL)LACTATE; HUMAN GROWTH HORMONE; ISOLEUCINE ETHYL ESTER; POLYARGININE; POLYELECTROLYTE; POLYLYSINE; POLYMER; POLYORGANOPHOSPHAZENE DERIVATIVE; UNCLASSIFIED DRUG; ZINC;

ANIMAL EXPERIMENT; ARTICLE; DRUG DELIVERY SYSTEM; DRUG RELEASE; DRUG STABILITY; HYDROGEL; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; TEMPERATURE SENSITIVITY; ZETA POTENTIAL;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; EXCIPIENTS; HUMAN GROWTH HORMONE; HUMANS; HYDROGELS; INJECTIONS, SUBCUTANEOUS; ISOLEUCINE; KINETICS; MALE; ORGANOPHOSPHORUS COMPOUNDS; PARTICLE SIZE; PEPTIDES; POLYAMINES; POLYETHYLENE GLYCOLS; POLYMERS; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; ZINC ACETATE;

EID: 78049477102     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.07.126     Document Type: Article

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