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Volumn 14, Issue 2, 2014, Pages 69-80

Orchestrating B cell lymphopoiesis through interplay of IL-7 receptor and pre-B cell receptor signalling

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D2; CYCLIN D3; INTERLEUKIN 7 RECEPTOR; JANUS KINASE 3; PRE B CELL RECEPTOR; STAT5 PROTEIN;

EID: 84893685103     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri3570     Document Type: Review
Times cited : (245)

References (153)
  • 1
    • 0242468050 scopus 로고    scopus 로고
    • Regulating antigen-receptor gene assembly
    • Schlissel, M. S. Regulating antigen-receptor gene assembly. Nature Rev. Immunol. 3, 890-899 (2003).
    • (2003) Nature Rev. Immunol. , vol.3 , pp. 890-899
    • Schlissel, M.S.1
  • 2
    • 14544299744 scopus 로고    scopus 로고
    • The pre-B cell receptor in B cell development: Recent advances, persistent questions and conserved mechanisms
    • Clark, M. R., Cooper, A. B., Wang, L. and Aifantis, I. The pre-B cell receptor in B cell development: recent advances, persistent questions and conserved mechanisms. Curr. Top. Microbiol. Immunol. 290, 87-104 (2005).
    • (2005) Curr. Top. Microbiol. Immunol. , vol.290 , pp. 87-104
    • Clark, M.R.1    Cooper, A.B.2    Wang, L.3    Aifantis, I.4
  • 3
    • 61349179407 scopus 로고    scopus 로고
    • Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signaling
    • Herzog, S., Reth, M. and Jumaa, H. Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signaling. Nature Rev. Immunol. 9, 195-205 (2009).
    • (2009) Nature Rev. Immunol. , vol.9 , pp. 195-205
    • Herzog, S.1    Reth, M.2    Jumaa, H.3
  • 4
    • 79951757607 scopus 로고    scopus 로고
    • Coupling of V(D)J recombination to cell cycle suppresses genomic instability and lymphoid tumorigenesis
    • Zhang, L., Reynolds, T. L., Shan, S. and Desiderio, S. Coupling of V(D)J recombination to cell cycle suppresses genomic instability and lymphoid tumorigenesis. Immunity 34, 163-174 (2011).
    • (2011) Immunity , vol.34 , pp. 163-174
    • Zhang, L.1    Reynolds, T.L.2    Shan, S.3    Desiderio, S.4
  • 5
    • 84861190857 scopus 로고    scopus 로고
    • The many roles of IL-7 in B cell development; Mediator of survival, proliferation and differentiation
    • Corfe, S. A. and Paige, C. J. The many roles of IL-7 in B cell development; Mediator of survival, proliferation and differentiation. Semin. Immunol. 24, 198-208 (2012).
    • (2012) Semin. Immunol. , vol.24 , pp. 198-208
    • Corfe, S.A.1    Paige, C.J.2
  • 6
    • 0027988545 scopus 로고
    • Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice
    • Peschon, J. J. et al. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice. J. Exp. Med. 180, 1955-1960 (1994).
    • (1994) J. Exp. Med. , vol.180 , pp. 1955-1960
    • Peschon, J.J.1
  • 7
    • 55249106981 scopus 로고    scopus 로고
    • FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis
    • Jensen, C. T. et al. FLT3 ligand and not TSLP is the key regulator of IL-7-independent B-1 and B-2 B lymphopoiesis. Blood 112, 2297-2304 (2008).
    • (2008) Blood , vol.112 , pp. 2297-2304
    • Jensen, C.T.1
  • 8
    • 79954988554 scopus 로고    scopus 로고
    • Flippin' lipids
    • Clark, M. R. Flippin' lipids. Nature Immunol. 12, 373-375 (2011).
    • (2011) Nature Immunol , vol.12 , pp. 373-375
    • Clark, M.R.1
  • 9
    • 79955004691 scopus 로고    scopus 로고
    • The P4 ATPase ATP11c is essential for B lymphopoiesis in adult bone marrow
    • Siggs, O. M. et al. The P4 ATPase ATP11c is essential for B lymphopoiesis in adult bone marrow. Nature Immunol. 12, 434-440 (2011).
    • (2011) Nature Immunol , vol.12 , pp. 434-440
    • Siggs, O.M.1
  • 10
    • 79954988172 scopus 로고    scopus 로고
    • ATP11c is critical for phosphatidylserine internalization and B lymphocyte differentiation
    • Yabas, M. et al. ATP11c is critical for phosphatidylserine internalization and B lymphocyte differentiation. Nature Immunol. 12, 441-449 (2011).
    • (2011) Nature Immunol , vol.12 , pp. 441-449
    • Yabas, M.1
  • 11
    • 0031740732 scopus 로고    scopus 로고
    • Defective IL7R expression in T-B+ NK+ severe combined immunodeficiency
    • Puel, A., Ziegler, S. F., Buckley, R. H. and Leonard, W. J. Defective IL7R expression in T-B+ NK+ severe combined immunodeficiency. Nature Genet. 20, 394-397 (1998).
    • (1998) Nature Genet , vol.20 , pp. 394-397
    • Puel, A.1    Ziegler, S.F.2    Buckley, R.H.3    Leonard, W.J.4
  • 12
    • 19944433384 scopus 로고    scopus 로고
    • Interleukin-7 receptor α (IL-7Rα) deficiency: Cellular and molecular bases. Analysis of clinical, immunological, and molecular features in 16 novel patients
    • Giliani, S. et al. Interleukin-7 receptor α (IL-7Rα) deficiency: cellular and molecular bases. Analysis of clinical, immunological, and molecular features in 16 novel patients. Immunol. Rev. 203, 110-126 (2005).
    • (2005) Immunol. Rev. , vol.203 , pp. 110-126
    • Giliani, S.1
  • 13
    • 84859972127 scopus 로고    scopus 로고
    • JAK and STAT signaling molecules in immunoregulation and immune-mediated disease
    • O'Shea, J. J. and Plenge, R. M. JAK and STAT signaling molecules in immunoregulation and immune-mediated disease. Immunity 36, 542-550 (2012).
    • (2012) Immunity , vol.36 , pp. 542-550
    • O'Shea, J.J.1    Plenge, R.M.2
  • 14
    • 33751174311 scopus 로고    scopus 로고
    • STAT3 positively regulates an early step in B-cell development
    • Chou, W. C., Levy, D. E. and Lee, C. K. STAT3 positively regulates an early step in B-cell development. Blood 108, 3005-3011 (2006).
    • (2006) Blood , vol.108 , pp. 3005-3011
    • Chou, W.C.1    Levy, D.E.2    Lee, C.K.3
  • 15
    • 32244444750 scopus 로고    scopus 로고
    • Stat5a/b are essential for normal lymphoid development and differentiation
    • Yao, Z. et al. Stat5a/b are essential for normal lymphoid development and differentiation. Proc. Natl Acad. Sci. USA 103, 1000-1005 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 1000-1005
    • Yao, Z.1
  • 16
    • 1842477169 scopus 로고    scopus 로고
    • STAT5 activation underlies IL7 receptor-dependent B cell development
    • Goetz, C. A., Harmon, I. R., O'Neil, J. J., Burchill, M. A. and Farrar, M. A. STAT5 activation underlies IL7 receptor-dependent B cell development. J. Immunol. 172, 4770-4778 (2004).
    • (2004) J. Immunol. , vol.172 , pp. 4770-4778
    • Goetz, C.A.1    Harmon, I.R.2    O'Neil, J.J.3    Burchill, M.A.4    Farrar, M.A.5
  • 17
    • 70349445270 scopus 로고    scopus 로고
    • Ras orchestrates cell cycle exit and light chain recombination during early B cell development
    • Mandal, M. et al. Ras orchestrates cell cycle exit and light chain recombination during early B cell development. Nature Immunol. 10, 1110-1117 (2009).
    • (2009) Nature Immunol , vol.10 , pp. 1110-1117
    • Mandal, M.1
  • 18
    • 28244453738 scopus 로고    scopus 로고
    • Murine and human IL-7 activate STAT5 and induce proliferation of normal human pro-B cells
    • Johnson, S. E., Shah, N., Panoskaltsis-Mortari, A. and LeBien, T. W. Murine and human IL-7 activate STAT5 and induce proliferation of normal human pro-B cells. J. Immunol. 175, 7325-7331 (2005).
    • (2005) J. Immunol. , vol.175 , pp. 7325-7331
    • Johnson, S.E.1    Shah, N.2    Panoskaltsis-Mortari, A.3    Lebien, T.W.4
  • 19
    • 33645964321 scopus 로고    scopus 로고
    • A unique function for cyclin D3 in early B cell development
    • Cooper, A. B. et al. A unique function for cyclin D3 in early B cell development. Nature Immunol. 7, 489-497 (2006).
    • (2006) Nature Immunol. , vol.7 , pp. 489-497
    • Cooper, A.B.1
  • 20
    • 0033564697 scopus 로고    scopus 로고
    • CDK inhibitors: Positive and negative regulators of G1-phase progression
    • Sherr, C. J. and Roberts, J. CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev. 13, 1501-1512 (1999).
    • (1999) Genes Dev , vol.13 , pp. 1501-1512
    • Sherr, C.J.1    Roberts, J.2
  • 21
    • 18344381110 scopus 로고    scopus 로고
    • Cell cycle in mouse development
    • Ciemerych, M. A. and Sicinski, P. Cell cycle in mouse development. Oncogene 24, 2877-2898 (2005).
    • (2005) Oncogene , vol.24 , pp. 2877-2898
    • Ciemerych, M.A.1    Sicinski, P.2
  • 22
    • 4444307411 scopus 로고    scopus 로고
    • Mouse development and cell proliferation in the absence of D-cyclins
    • Kozar, K. et al. Mouse development and cell proliferation in the absence of D-cyclins. Cell 118, 477-491 (2004).
    • (2004) Cell , vol.118 , pp. 477-491
    • Kozar, K.1
  • 23
    • 4444247138 scopus 로고    scopus 로고
    • Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
    • Malumbres, M. et al. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Cell 118, 493-504 (2004).
    • (2004) Cell , vol.118 , pp. 493-504
    • Malumbres, M.1
  • 24
    • 84871869185 scopus 로고    scopus 로고
    • Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression
    • Powers, S. E. et al. Subnuclear cyclin D3 compartments and the coordinated regulation of proliferation and immunoglobulin variable gene repression. J. Exp. Med. 209, 2199-2213 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 2199-2213
    • Powers, S.E.1
  • 25
    • 9144229104 scopus 로고    scopus 로고
    • Requirement for cyclin D3 in lymphocyte development and T cell leukemias
    • Sicinska, E. et al. Requirement for cyclin D3 in lymphocyte development and T cell leukemias. Cancer Cell 4, 451-461 (2003).
    • (2003) Cancer Cell , vol.4 , pp. 451-461
    • Sicinska, E.1
  • 26
    • 77953291378 scopus 로고    scopus 로고
    • Requirement for cyclin D3 in germinal center formation and function
    • Peled, J. U. et al. Requirement for cyclin D3 in germinal center formation and function. Cell Res. 20, 631-646 (2010).
    • (2010) Cell Res , vol.20 , pp. 631-646
    • Peled, J.U.1
  • 27
    • 0034603064 scopus 로고    scopus 로고
    • Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40
    • Lam, E. W. et al. Cyclin D3 compensates for loss of cyclin D2 in mouse B-lymphocytes activated via the antigen receptor and CD40. J. Biol. Chem. 275, 3479-3484 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 3479-3484
    • Lam, E.W.1
  • 28
    • 17544395426 scopus 로고    scopus 로고
    • Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development
    • Solvason, N. et al. Cyclin D2 is essential for BCR-mediated proliferation and CD5 B cell development. Int. Immunol. 12, 631-638 (2000).
    • (2000) Int. Immunol. , vol.12 , pp. 631-638
    • Solvason, N.1
  • 29
    • 40249112989 scopus 로고    scopus 로고
    • Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling
    • Johnson, K. et al. Regulation of immunoglobulin light-chain recombination by the transcription factor IRF-4 and the attenuation of interleukin-7 signaling. Immunity 28, 335-345 (2008).
    • (2008) Immunity , vol.28 , pp. 335-345
    • Johnson, K.1
  • 30
    • 77956630164 scopus 로고    scopus 로고
    • Ikaros and Aiolos inhibit pre-B cell proliferation by directly suppressing c-Myc expression
    • Ma, S. et al. Ikaros and Aiolos inhibit pre-B cell proliferation by directly suppressing c-Myc expression. Mol. Cell. Biol. 30, 4149-4158 (2010).
    • (2010) Mol. Cell. Biol. , vol.30 , pp. 4149-4158
    • Ma, S.1
  • 31
    • 0030010591 scopus 로고    scopus 로고
    • Mice lacking p27kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia and pituitary tumors
    • Nakayama, K. et al. Mice lacking p27kip1 display increased body size, multiple organ hyperplasia, retinal dysplasia and pituitary tumors. Cell 85, 707-720 (1996).
    • (1996) Cell , vol.85 , pp. 707-720
    • Nakayama, K.1
  • 32
    • 75649093758 scopus 로고    scopus 로고
    • Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development
    • Malin, S. et al. Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell development. Nature Immunol. 11, 171-179 (2010).
    • (2010) Nature Immunol , vol.11 , pp. 171-179
    • Malin, S.1
  • 33
    • 3042716781 scopus 로고    scopus 로고
    • Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members
    • Jiang, Q. et al. Distinct regions of the interleukin-7 receptor regulate different Bcl2 family members. Mol. Cell. Biol. 24, 6501-6513 (2004).
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 6501-6513
    • Jiang, Q.1
  • 34
    • 84856812404 scopus 로고    scopus 로고
    • RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation
    • Bednarski, J. J. et al. RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation. J. Exp. Med. 209, 11-17 (2011).
    • (2011) J. Exp. Med. , vol.209 , pp. 11-17
    • Bednarski, J.J.1
  • 35
    • 32544448486 scopus 로고    scopus 로고
    • IL-7: A key regulator of B lymphopoiesis
    • Milne, C. D. and Paige, C. J. IL-7: a key regulator of B lymphopoiesis. Semin. Immunol. 18, 20-30 (2006).
    • (2006) Semin. Immunol. , vol.18 , pp. 20-30
    • Milne, C.D.1    Paige, C.J.2
  • 36
    • 84857195761 scopus 로고    scopus 로고
    • A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation
    • Ochiai, K. et al. A self-reinforcing regulatory network triggered by limiting IL-7 activates pre-BCR signaling and differentiation. Nature Immunol. 13, 300-307 (2012).
    • (2012) Nature Immunol. , vol.13 , pp. 300-307
    • Ochiai, K.1
  • 37
    • 0029983731 scopus 로고    scopus 로고
    • The interleukin-7 receptor α chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis
    • Corcoran, A. E. et al. The interleukin-7 receptor α chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. EMBO J. 15, 1924-1932 (1996).
    • (1996) EMBO J , vol.15 , pp. 1924-1932
    • Corcoran, A.E.1
  • 38
    • 77956636063 scopus 로고    scopus 로고
    • The PI3K isoforms p110α and p110δ are essential for pre-B cell receptor signaling and B cell development
    • Ramadani, F. et al. The PI3K isoforms p110α and p110δ are essential for pre-B cell receptor signaling and B cell development. Sci. Signal. 3, ra60 (2010).
    • (2010) Sci. Signal. , vol.3
    • Ramadani, F.1
  • 39
    • 0033556333 scopus 로고    scopus 로고
    • Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α
    • Fruman, D. A. et al. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α. Science 283, 393-397 (1999).
    • (1999) Science , vol.283 , pp. 393-397
    • Fruman, D.A.1
  • 40
    • 0033555829 scopus 로고    scopus 로고
    • Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3- kinase
    • Suzuki, H. et al. Xid-like immunodeficiency in mice with disruption of the p85α subunit of phosphoinositide 3- kinase. Science. 283, 390-392 (1999).
    • (1999) Science , vol.283 , pp. 390-392
    • Suzuki, H.1
  • 41
    • 0037119630 scopus 로고    scopus 로고
    • A crucial role for the p110δ subunit of phosphatidylinositol 3-kinase in B cell development and activation
    • Clayton, E. et al. A crucial role for the p110δ subunit of phosphatidylinositol 3-kinase in B cell development and activation. J. Exp. Med. 196, 753-763 (2002).
    • (2002) J. Exp. Med. , vol.196 , pp. 753-763
    • Clayton, E.1
  • 42
    • 0037695593 scopus 로고    scopus 로고
    • Essential nonredundant role of the phosphoinositide 3-kinase p110δ in signaling by the b-cell receptor complex
    • Jou, S.-T. et al. Essential, nonredundant role of the phosphoinositide 3-kinase p110δ in signaling by the B-cell receptor complex. Mol. Cell. Biol. 22, 8580-8591 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 8580-8591
    • Jou, S.-T.1
  • 43
    • 0037047590 scopus 로고    scopus 로고
    • Impaired B and T cell antigen receptor signaling in p110δ
    • Okkenhaug, K. et al. Impaired B and T cell antigen receptor signaling in p110δ PI 3-kinase mutant mice. Science 297, 1031-1034 (2002).
    • (2002) PI 3-kinase Mutant Mice. Science , vol.297 , pp. 1031-1034
    • Okkenhaug, K.1
  • 44
    • 66249096306 scopus 로고    scopus 로고
    • Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7
    • Huntington, N. D. et al. Loss of the pro-apoptotic BH3-only Bcl-2 family member Bim sustains B lymphopoiesis in the absence of IL-7. Int. Immunol. 21, 715-725 (2009).
    • (2009) Int. Immunol. , vol.21 , pp. 715-725
    • Huntington, N.D.1
  • 45
    • 68949094024 scopus 로고    scopus 로고
    • MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation
    • Kruse, E. A. et al. MEK/ERK-mediated phosphorylation of Bim is required to ensure survival of T and B lymphocytes during mitogenic stimulation. J. Immunol. 183, 261-269 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 261-269
    • Kruse, E.A.1
  • 46
    • 0842281645 scopus 로고    scopus 로고
    • Cell death: Critical control points
    • Danial, N. N. and Korsmeyer, S. J. Cell death: critical control points. Cell 116, 205-219 (2004).
    • (2004) Cell , vol.116 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 47
    • 17444405985 scopus 로고    scopus 로고
    • Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells
    • Essafi, A. et al. Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. Oncogene 24, 2317-2329 (2005).
    • (2005) Oncogene , vol.24 , pp. 2317-2329
    • Essafi, A.1
  • 48
    • 79960055459 scopus 로고    scopus 로고
    • RAS interaction with PI3K: More than just another effector pathway
    • Castellano, E. and Downward, J. RAS interaction with PI3K: more than just another effector pathway. Genes Cancer 2, 261-274 (2011).
    • (2011) Genes Cancer , vol.2 , pp. 261-274
    • Castellano, E.1    Downward, J.2
  • 49
    • 0029045161 scopus 로고
    • Failure of B-cell differentiation in mice lacking the transcription factor EBF
    • Lin, H. and Grosschedl, R. Failure of B-cell differentiation in mice lacking the transcription factor EBF. Nature 376, 263-267 (1995).
    • (1995) Nature , vol.376 , pp. 263-267
    • Lin, H.1    Grosschedl, R.2
  • 50
    • 5044249424 scopus 로고    scopus 로고
    • Assembling a gene regulatory network for specification of the B cell fate
    • Medina, K. L. et al. Assembling a gene regulatory network for specification of the B cell fate. Dev. Cell 7, 607-617 (2004).
    • (2004) Dev. Cell , vol.7 , pp. 607-617
    • Medina, K.L.1
  • 51
    • 38449102306 scopus 로고    scopus 로고
    • Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5
    • Pongubala, J. M. et al. Transcription factor EBF restricts alternative lineage options and promotes B cell fate commitment independently of Pax5. Nature Immunol. 9, 203-215 (2008).
    • (2008) Nature Immunol. , vol.9 , pp. 203-215
    • Pongubala, J.M.1
  • 52
    • 17044440153 scopus 로고    scopus 로고
    • Contigent gene regulatory networks and B cell fate specification
    • Singh, H., Medina, K. L. and Pongubala, M. R. Contigent gene regulatory networks and B cell fate specification. Proc. Natl Acad. Sci. USA 102, 4949-4953 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 4949-4953
    • Singh, H.1    Medina, K.L.2    Pongubala, M.R.3
  • 53
    • 34250212629 scopus 로고    scopus 로고
    • The transcriptional regulation of B cell lineage commitment
    • Nutt, S. L. and Kee, B. L. The transcriptional regulation of B cell lineage commitment. Immunity 26, 715-725 (2007).
    • (2007) Immunity , vol.26 , pp. 715-725
    • Nutt, S.L.1    Kee, B.L.2
  • 54
    • 84859297104 scopus 로고    scopus 로고
    • Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells
    • Gyory, I. et al. Transcription factor Ebf1 regulates differentiation stage-specific signaling, proliferation, and survival of B cells. Genes Dev. 26, 668-682 (2012).
    • (2012) Genes Dev , vol.26 , pp. 668-682
    • Gyory, I.1
  • 55
    • 56349127778 scopus 로고    scopus 로고
    • Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation
    • Dengler, H. S. et al. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nature Immunol. 12, 1388-1398 (2008).
    • (2008) Nature Immunol , vol.12 , pp. 1388-1398
    • Dengler, H.S.1
  • 56
    • 0028105980 scopus 로고
    • Stem cell factor and interleukin-7 synergize to enhance early myelopoiesis in vitro
    • Fahlman, C., Blomhoff, H. K., Veiby, O. P., McNiece, I. K. and Jacobsen, S. E. Stem cell factor and interleukin-7 synergize to enhance early myelopoiesis in vitro. Blood 84, 1450-1456 (1994).
    • (1994) Blood , vol.84 , pp. 1450-1456
    • Fahlman, C.1    Blomhoff, H.K.2    Veiby, O.P.3    McNiece, I.K.4    Jacobsen, S.E.5
  • 57
    • 77950989198 scopus 로고    scopus 로고
    • C-Myb is required for pro-B cell differentiation
    • Fahl, S. P., Crittenden, R. B., Allman, D. and Bender, T. P. c-Myb is required for pro-B cell differentiation. J. Immunol. 183, 5582-5592 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 5582-5592
    • Fahl, S.P.1    Crittenden, R.B.2    Allman, D.3    Bender, T.P.4
  • 58
    • 78650170140 scopus 로고    scopus 로고
    • Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation
    • Kosan, C. et al. Transcription factor miz-1 is required to regulate interleukin-7 receptor signaling at early commitment stages of B cell differentiation. Immunity 33, 917-928 (2010).
    • (2010) Immunity , vol.33 , pp. 917-928
    • Kosan, C.1
  • 59
    • 0029125871 scopus 로고
    • Bone marrow B lymphocyte development in c-abl-deficient mice
    • Hardin, J. D. et al. Bone marrow B lymphocyte development in c-abl-deficient mice. Cell. Immunol. 165, 44-54 (1995).
    • (1995) Cell. Immunol. , vol.165 , pp. 44-54
    • Hardin, J.D.1
  • 60
    • 0025923088 scopus 로고
    • Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations
    • Schwartzberg, P. L. et al. Mice homozygous for the ablm1 mutation show poor viability and depletion of selected B and T cell populations. Cell 65, 1165-1175 (1991).
    • (1991) Cell , vol.65 , pp. 1165-1175
    • Schwartzberg, P.L.1
  • 61
    • 0025780879 scopus 로고
    • Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-Abl proto-oncogene
    • Tybulewicz, V. L., Crawford, C. E., Jackson, P. K., Bronson, R. T. and Mulligan, R. C. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-Abl proto-oncogene. Cell 65, 1153-1164 (1991).
    • (1991) Cell , vol.65 , pp. 1153-1164
    • Tybulewicz, V.L.1    Crawford, C.E.2    Jackson, P.K.3    Bronson, R.T.4    Mulligan, R.C.5
  • 62
    • 65549142721 scopus 로고    scopus 로고
    • The effects of c-Abl mutation on developing B cell differentiation and survival
    • Brightbill, H. and Schlissel, M. S. The effects of c-Abl mutation on developing B cell differentiation and survival. Int. Immunol. 21, 575-585 (2009).
    • (2009) Int. Immunol. , vol.21 , pp. 575-585
    • Brightbill, H.1    Schlissel, M.S.2
  • 63
    • 33847345575 scopus 로고    scopus 로고
    • Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice
    • Lam, Q. L. et al. Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice. Int. Immunol. 19, 267-276 (2007).
    • (2007) Int. Immunol. , vol.19 , pp. 267-276
    • Lam, Q.L.1
  • 64
    • 38849103061 scopus 로고    scopus 로고
    • Defective T cell development and function in the absence of Abelson kinases
    • Gu, J. J., Zhang, N., He, Y. W., Koleske, A. J. and Pendergast, A. M. Defective T cell development and function in the absence of Abelson kinases. J. Immunol. 179, 7334-7344 (2007).
    • (2007) J. Immunol. , vol.179 , pp. 7334-7344
    • Gu, J.J.1    Zhang, N.2    He, Y.W.3    Koleske, A.J.4    Pendergast, A.M.5
  • 65
    • 0034671627 scopus 로고    scopus 로고
    • The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19
    • Zipfel, P. A. et al. The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. J. Immunol. 165, 6872-6881 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 6872-6881
    • Zipfel, P.A.1
  • 66
    • 2342475200 scopus 로고    scopus 로고
    • T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression
    • Roose, J. P. et al. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol. 1, E53 (2003).
    • (2003) PLoS Biol. , vol.1
    • Roose, J.P.1
  • 67
    • 0029098225 scopus 로고    scopus 로고
    • Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents
    • Kharbanda, S. et al. Activation of the c-Abl tyrosine kinase in the stress response to DMA-damaging agents. Nature 376, 785-788 (2002).
    • (2002) Nature , vol.376 , pp. 785-788
    • Kharbanda, S.1
  • 68
    • 0030787787 scopus 로고    scopus 로고
    • Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common γ chain-deficient mice
    • Kondo, M., Akashi, K., Domen, J., Sugamura, K. and Weissman, I. L. Bcl-2 rescues T lymphopoiesis, but not B or NK cell development, in common γ chain-deficient mice. Immunity 7, 155-162 (1997).
    • (1997) Immunity , vol.7 , pp. 155-162
    • Kondo, M.1    Akashi, K.2    Domen, J.3    Sugamura, K.4    Weissman, I.L.5
  • 69
    • 33846141460 scopus 로고    scopus 로고
    • Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5
    • Roessler, S. et al. Distinct promoters mediate the regulation of Ebf1 gene expression by interleukin-7 and Pax5. Mol. Cell. Biol. 27, 579-594 (2007).
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 579-594
    • Roessler, S.1
  • 70
    • 48749094942 scopus 로고    scopus 로고
    • E2A proteins promote development of lymphoid-primed multipotent progenitors
    • Dias, S., Mansson, R., Gurbuxani, S., Sigvardsson, M. and Kee, B. L. E2A proteins promote development of lymphoid-primed multipotent progenitors. Immunity 29, 217-227 (2005).
    • (2005) Immunity , vol.29 , pp. 217-227
    • Dias, S.1    Mansson, R.2    Gurbuxani, S.3    Sigvardsson, M.4    Kee, B.L.5
  • 71
    • 18244386710 scopus 로고    scopus 로고
    • IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF
    • Kikuchi, K., Lai, A. Y., Hsu, C. L. and Kondo, M. IL-7 receptor signaling is necessary for stage transition in adult B cell development through up-regulation of EBF. J. Exp. Med. 201, 1197-1203 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 1197-1203
    • Kikuchi, K.1    Lai, A.Y.2    Hsu, C.L.3    Kondo, M.4
  • 72
    • 37549010335 scopus 로고    scopus 로고
    • Launching the T-cell-lineage developmental programme
    • Rothenberg, E. V., Moore, J. E. and Yui, M. A. Launching the T-cell-lineage developmental programme. Nature Rev. Immunol. 8, 9-21 (2008).
    • (2008) Nature Rev. Immunol. , vol.8 , pp. 9-21
    • Rothenberg, E.V.1    Moore, J.E.2    Yui, M.A.3
  • 73
    • 44049101651 scopus 로고    scopus 로고
    • SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3) K-PKB-Foxo pathway
    • Herzog, S. et al. SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3) K-PKB-Foxo pathway. Nature Immunol. 9, 623-631 (2008).
    • (2008) Nature Immunol , vol.9 , pp. 623-631
    • Herzog, S.1
  • 74
    • 44049091757 scopus 로고    scopus 로고
    • Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
    • Amin, R. H. and Schlissel, M. S. Foxo1 directly regulates the transcription of recombination-activating genes during B cell development. Nature Immunol. 9, 613-622 (2008).
    • (2008) Nature Immunol. , vol.9 , pp. 613-622
    • Amin, R.H.1    Schlissel, M.S.2
  • 75
    • 0033427205 scopus 로고    scopus 로고
    • Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair
    • Lee, J. and Desiderio, S. Cyclin A/CDK2 regulates V(D)J recombination by coordinating RAG-2 accumulation and DNA repair. Immunity 11, 771-781 (1999).
    • (1999) Immunity , vol.11 , pp. 771-781
    • Lee, J.1    Desiderio, S.2
  • 76
    • 0030498092 scopus 로고    scopus 로고
    • A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D). J recombination to the cell cycle
    • Li, Z., Dordai, D. I., Lee, J. and Desiderio, S. A conserved degradation signal regulates RAG-2 accumulation during cell division and links V(D)J recombination to the cell cycle. Immunity 5, 575-589 (1996).
    • (1996) Immunity , vol.5 , pp. 575-589
    • Li, Z.1    Dordai, D.I.2    Lee, J.3    Desiderio, S.4
  • 77
    • 20444403003 scopus 로고    scopus 로고
    • Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle
    • Jiang, H. et al. Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle. Mol. Cell 18, 699-709 (2005).
    • (2005) Mol. Cell , vol.18 , pp. 699-709
    • Jiang, H.1
  • 78
    • 84862634384 scopus 로고    scopus 로고
    • IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle
    • Johnson, K. et al. IL-7 functionally segregates the pro-B cell stage by regulating transcription of recombination mediators across cell cycle. J. Immunol. 188, 6084-6092 (2012).
    • (2012) J. Immunol. , vol.188 , pp. 6084-6092
    • Johnson, K.1
  • 79
    • 47849118209 scopus 로고    scopus 로고
    • Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros
    • Reynaud, D. et al. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nature Immunol. 9, 927-936 (2008).
    • (2008) Nature Immunol. , vol.9 , pp. 927-936
    • Reynaud, D.1
  • 80
    • 84856927632 scopus 로고    scopus 로고
    • FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination
    • Alkhatib, A. et al. FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination. J. Exp. Med. 209, 395-406 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 395-406
    • Alkhatib, A.1
  • 81
    • 23944495647 scopus 로고    scopus 로고
    • Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5
    • Bertolino, E. et al. Regulation of interleukin 7-dependent immunoglobulin heavy-chain variable gene rearrangements by transcription factor STAT5. Nature Immunol. 6, 836-843 (2005).
    • (2005) Nature Immunol , vol.6 , pp. 836-843
    • Bertolino, E.1
  • 82
    • 0025852445 scopus 로고
    • B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene
    • Kitamura, D., Roes, J., Kuhn, R. and Rajewsky, K. A. B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350, 423-426 (1991).
    • (1991) Nature , vol.350 , pp. 423-426
    • Kitamura, D.1    Roes, J.2    Kuhn, R.3    Rajewsky, K.A.4
  • 83
    • 0037097681 scopus 로고    scopus 로고
    • VpreB1/VpreB2/λ5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus
    • Shimizu, T., Mundt, C., Licence, S., Melchers, F. and Martensson, I. VpreB1/VpreB2/λ5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locus. J. Immunol. 168, 6286-6293 (2002).
    • (2002) J. Immunol. , vol.168 , pp. 6286-6293
    • Shimizu, T.1    Mundt, C.2    Licence, S.3    Melchers, F.4    Martensson, I.5
  • 84
    • 0037100435 scopus 로고    scopus 로고
    • B cell progenitors are arrested in maturation but have intact V(D). J recombination in the absence of Ig-α and Ig-β
    • Pelanda, R., Braun, U., Hobeika, E., Nussenzweig, M. C. and Reth, M. B cell progenitors are arrested in maturation but have intact V(D)J recombination in the absence of Ig-α and Ig-β. J. Immunol. 169, 865-872 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 865-872
    • Pelanda, R.1    Braun, U.2    Hobeika, E.3    Nussenzweig, M.C.4    Reth, M.5
  • 85
    • 0029913115 scopus 로고    scopus 로고
    • Regulation of an early developmental checkpoint in the B cell pathway by Ig-β
    • Gong, S. and Nussenzweig, M. C. Regulation of an early developmental checkpoint in the B cell pathway by Ig-β. Science 272, 411-414 (1996).
    • (1996) Science , vol.272 , pp. 411-414
    • Gong, S.1    Nussenzweig, M.C.2
  • 86
    • 33947183940 scopus 로고    scopus 로고
    • Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor
    • Meixlsperger, S. et al. Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor. Immunity 26, 323-333 (2007).
    • (2007) Immunity , vol.26 , pp. 323-333
    • Meixlsperger, S.1
  • 87
    • 0041732283 scopus 로고    scopus 로고
    • The nonimmunoglobulin portion of λ5 mediates cell-auttonomous pre-B cell receptor signaling
    • Ohnishi, K. and Melchers, F. The nonimmunoglobulin portion of λ5 mediates cell-auttonomous pre-B cell receptor signaling. Nature Immunol. 4, 849-856 (2003).
    • (2003) Nature Immunol , vol.4 , pp. 849-856
    • Ohnishi, K.1    Melchers, F.2
  • 88
    • 34247354176 scopus 로고    scopus 로고
    • Structural insight into pre-B cell receptor function
    • Bankovich, A. J. et al. Structural insight into pre-B cell receptor function. Science 316, 291-294 (2007).
    • (2007) Science , vol.316 , pp. 291-294
    • Bankovich, A.J.1
  • 89
    • 51549120217 scopus 로고    scopus 로고
    • A unique role for the lambda5 non-immunoglobulin tail in early B lymphocyte development
    • Vettermann, C. et al. A unique role for the lambda5 non-immunoglobulin tail in early B lymphocyte development. J. Immunol. 181, 3232-3242 (2008).
    • (2008) J. Immunol. , vol.181 , pp. 3232-3242
    • Vettermann, C.1
  • 90
    • 57449084323 scopus 로고    scopus 로고
    • Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells
    • Kohler, F. et al. Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells. Immunity 29, 912-921 (2008).
    • (2008) Immunity , vol.29 , pp. 912-921
    • Kohler, F.1
  • 91
    • 0042430496 scopus 로고    scopus 로고
    • Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of lambda 5 and stroma cell-associated heparan sulfate
    • Bradl, H., Wittmann, J., Milius, D., Vettermann, C. and Jack, H. M. Interaction of murine precursor B cell receptor with stroma cells is controlled by the unique tail of lambda 5 and stroma cell-associated heparan sulfate. J. Immunol. 171, 2338-2348 (2003).
    • (2003) J. Immunol. , vol.171 , pp. 2338-2348
    • Bradl, H.1    Wittmann, J.2    Milius, D.3    Vettermann, C.4    Jack, H.M.5
  • 92
    • 0036790940 scopus 로고    scopus 로고
    • Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering
    • Gauthier, L., Rossi, B., Roux, F., Termine, E. and Schiff, C. Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering. Proc. Natl Acad. Sci. USA 99, 13014-13019 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 13014-13019
    • Gauthier, L.1    Rossi, B.2    Roux, F.3    Termine, E.4    Schiff, C.5
  • 93
    • 67651102911 scopus 로고    scopus 로고
    • Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions
    • Espeli, M., Mancini, S. J. C., Breton, C., Poirier, F. and Schiff, C. Impaired B-cell development at the pre-BII-cell stage in galectin-1-deficient mice due to inefficient pre-BII/stromal cell interactions. Blood 113, 5878-5886 (2009).
    • (2009) Blood , vol.113 , pp. 5878-5886
    • Espeli, M.1    Mancini, S.J.C.2    Breton, C.3    Poirier, F.4    Schiff, C.5
  • 94
    • 79959208871 scopus 로고    scopus 로고
    • Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow
    • Mourcin, F. et al. Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow. Blood 117, 6552-6561 (2011).
    • (2011) Blood , vol.117 , pp. 6552-6561
    • Mourcin, F.1
  • 95
    • 48749111345 scopus 로고    scopus 로고
    • Censoring of autoreactive B cell development by the pre-B cell receptor
    • Keenan, R. A. et al. Censoring of autoreactive B cell development by the pre-B cell receptor. Science 321, 696-699 (2008).
    • (2008) Science , vol.321 , pp. 696-699
    • Keenan, R.A.1
  • 96
    • 79960707615 scopus 로고    scopus 로고
    • Efficient generation of B lymphocytes by recognition of self-antigens
    • Eschbach, C. et al. Efficient generation of B lymphocytes by recognition of self-antigens. Eur. J. Immunol. 41, 2397-2403 (2011).
    • (2011) Eur. J. Immunol. , vol.41 , pp. 2397-2403
    • Eschbach, C.1
  • 97
    • 33744462050 scopus 로고    scopus 로고
    • Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: Role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth
    • Doughty, C. A. et al. Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth. Blood 107, 4458-4465 (2006).
    • (2006) Blood , vol.107 , pp. 4458-4465
    • Doughty, C.A.1
  • 99
    • 77955488179 scopus 로고    scopus 로고
    • Sin1-mTORC2 suppresses rag and Il7r gene expression through Akt2 in B cells
    • Lazorchak, A. S. et al. Sin1-mTORC2 suppresses rag and Il7r gene expression through Akt2 in B cells. Mol. Cell 39, 433-443 (2010).
    • (2010) Mol. Cell , vol.39 , pp. 433-443
    • Lazorchak, A.S.1
  • 100
    • 0141863388 scopus 로고    scopus 로고
    • Akt-directed glucose matabolism can prevent Bax conformation change and promote growth factor-independent survival
    • Rathmell, J. C. et al. Akt-directed glucose matabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol. Cell. Biol. 23, 7315-7328 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 7315-7328
    • Rathmell, J.C.1
  • 101
    • 0034983918 scopus 로고    scopus 로고
    • Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
    • Gottlob, K. et al. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev. 15, 1406-1418 (2001).
    • (2001) Genes Dev , vol.15 , pp. 1406-1418
    • Gottlob, K.1
  • 102
    • 84858414020 scopus 로고    scopus 로고
    • Cellular metabolism and disease: What do metabolic outliers teach us?
    • DeBerardinis, R. J. and Thompson, C. B. Cellular metabolism and disease: what do metabolic outliers teach us? Cell 148, 1132-1144 (2012).
    • (2012) Cell , vol.148 , pp. 1132-1144
    • Deberardinis, R.J.1    Thompson, C.B.2
  • 103
    • 77957054466 scopus 로고    scopus 로고
    • The mammalian target of rapamycin: Linking T cell differentiation, function, and metabolism
    • Powell, D. J. and Delgoffe, G. M. The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity 33, 301-311 (2010).
    • (2010) Immunity , vol.33 , pp. 301-311
    • Powell, D.J.1    Delgoffe, G.M.2
  • 104
    • 0033539555 scopus 로고    scopus 로고
    • C-Myc enhances protein synthesis and cell size during B lymphocyte development
    • Iritani, B. M. and Eisenman, R. N. c-Myc enhances protein synthesis and cell size during B lymphocyte development. Proc. Natl Acad. Sci, USA 1999, 13180-13185 (1999).
    • (1999) Proc. Natl Acad. Sci, USA , vol.1999 , pp. 13180-13185
    • Iritani, B.M.1    Eisenman, R.N.2
  • 105
    • 0036928333 scopus 로고    scopus 로고
    • B cell growth is controlled by phosphatidylinosotol 3-kinase-dependent induction of Rel/NF-κB regulated c-myc transcription
    • Grumont, R. J., Strasser, A. and Gerondakis, S. B cell growth is controlled by phosphatidylinosotol 3-kinase-dependent induction of Rel/NF-κB regulated c-myc transcription. Mol. Cell 10, 1283-1294 (2002).
    • (2002) Mol. Cell , vol.10 , pp. 1283-1294
    • Grumont, R.J.1    Strasser, A.2    Gerondakis, S.3
  • 106
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • Dang, C. V. MYC on the path to cancer. Cell 149, 22-35 (2012).
    • (2012) Cell , vol.149 , pp. 22-35
    • Dang, C.V.1
  • 107
    • 39749163245 scopus 로고    scopus 로고
    • Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes
    • Xiao, C. et al. Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes. Nature Immunol. 9, 405-414 (2008).
    • (2008) Nature Immunol. , vol.9 , pp. 405-414
    • Xiao, C.1
  • 108
    • 84874895696 scopus 로고    scopus 로고
    • Cutting edge: Cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells
    • Sandoval, G. J. et al. Cutting edge: cell-autonomous control of IL-7 response revealed in a novel stage of precursor B cells. J. Immunol. 190, 2485-2489 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 2485-2489
    • Sandoval, G.J.1
  • 109
    • 41549103208 scopus 로고    scopus 로고
    • Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion
    • Yasuda, T. et al. Erk kinases link pre-B cell receptor signaling to transcriptional events required for early B cell expansion. Immunity 28, 499-508 (2008).
    • (2008) Immunity , vol.28 , pp. 499-508
    • Yasuda, T.1
  • 110
    • 0034598353 scopus 로고    scopus 로고
    • Precursor B cell receptor-dependent B cell proliferation and differentiation does not require the bone marrow or fetal liver environment
    • Rolink, A., Winkler, T., Melchers, F. and Andersson, J. Precursor B cell receptor-dependent B cell proliferation and differentiation does not require the bone marrow or fetal liver environment. J. Exp. Med. 191, 23-31 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 23-31
    • Rolink, A.1    Winkler, T.2    Melchers, F.3    Andersson, J.4
  • 111
    • 27844560104 scopus 로고    scopus 로고
    • The pre-B-cell receptor induces silencing of VpreB and λ5 transcription
    • Parker, M. J. et al. The pre-B-cell receptor induces silencing of VpreB and λ5 transcription. EMBO J. 24, 3895-3905 (2005).
    • (2005) EMBO J , vol.24 , pp. 3895-3905
    • Parker, M.J.1
  • 112
    • 21844445331 scopus 로고    scopus 로고
    • The pre-B-cell receptor: Selector of fitting immunoglobulin heavy chains for the B-cell repertoire
    • Melchers, F. The pre-B-cell receptor: selector of fitting immunoglobulin heavy chains for the B-cell repertoire. Nature Rev. Immunol. 5, 578-584 (2005).
    • (2005) Nature Rev. Immunol. , vol.5 , pp. 578-584
    • Melchers, F.1
  • 113
    • 0033948368 scopus 로고    scopus 로고
    • Repertoire selection by pre-B-cell receptors and B-cell receptors, and genetic control of B-cell development from immature to mature B cells
    • Melchers, F. et al. Repertoire selection by pre-B-cell receptors and B-cell receptors, and genetic control of B-cell development from immature to mature B cells. Immunol. Rev. 175, 33-46 (2000).
    • (2000) Immunol. Rev. , vol.175 , pp. 33-46
    • Melchers, F.1
  • 114
    • 34548666994 scopus 로고    scopus 로고
    • Surrogate-light-chain silencing is not critical for the limitation of pre-B cell expansion but is for the termination of constitutive signaling
    • van Loo, P. F., Dingjan, G. M., Maas, A. and Hendriks, R. W. Surrogate-light-chain silencing is not critical for the limitation of pre-B cell expansion but is for the termination of constitutive signaling. Immunity 27, 1-13 (2007).
    • (2007) Immunity , vol.27 , pp. 1-13
    • Van Loo, P.F.1    Dingjan, G.M.2    Maas, A.3    Hendriks, R.W.4
  • 115
    • 0033229798 scopus 로고    scopus 로고
    • Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65
    • Jumaa, H. et al. Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity 11, 547-554 (1999).
    • (1999) Immunity , vol.11 , pp. 547-554
    • Jumaa, H.1
  • 116
    • 34147188126 scopus 로고    scopus 로고
    • Combined deficiencies in Bruton tyrosine kinase and phospholipase Cγ2 arrest B-cell development at a pre-BCR+ stage
    • Xu, S., Lee, K. G., Huo, J., Kurosaki, T. and Lam, K. P. Combined deficiencies in Bruton tyrosine kinase and phospholipase Cγ2 arrest B-cell development at a pre-BCR+ stage. Blood 109, 3377-3384 (2007).
    • (2007) Blood , vol.109 , pp. 3377-3384
    • Xu, S.1    Lee, K.G.2    Huo, J.3    Kurosaki, T.4    Lam, K.P.5
  • 117
    • 34548203816 scopus 로고    scopus 로고
    • Phospholipase Cγ2 contributes to light-chain gene activation and receptor editing
    • Bai, L. et al. Phospholipase Cγ2 contributes to light-chain gene activation and receptor editing. Mol. Cell. Biol. 27, 5957-5967 (2007).
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 5957-5967
    • Bai, L.1
  • 118
    • 33947153094 scopus 로고    scopus 로고
    • Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits
    • Thompson, E. C. et al. Ikaros DNA-binding proteins as integral components of B cell developmental-stage-specific regulatory circuits. Immunity 26, 335-344 (2007).
    • (2007) Immunity , vol.26 , pp. 335-344
    • Thompson, E.C.1
  • 119
    • 52649097448 scopus 로고    scopus 로고
    • The Immunological Genome Project: Networks of gene expression in immune cells
    • Heng, T. S., Painter, M. W. and Consortium, I. G. P. The Immunological Genome Project: networks of gene expression in immune cells. Nature Immunol. 9, 1091-1094 (2008).
    • (2008) Nature Immunol , vol.9 , pp. 1091-1094
    • Heng, T.S.1    Painter, M.W.2    Consortium, I.G.P.3
  • 120
    • 0030664126 scopus 로고    scopus 로고
    • Control of B cell development by Ras-mediated activation of Raf
    • Iritani, B. M., Forbush, K. A., Farrar, M. A. and Perlmutter, R. M. Control of B cell development by Ras-mediated activation of Raf. EMBO J. 16, 7019-7031 (1997).
    • (1997) EMBO J. , vol.16 , pp. 7019-7031
    • Iritani, B.M.1    Forbush, K.A.2    Farrar, M.A.3    Perlmutter, R.M.4
  • 121
    • 58549090499 scopus 로고    scopus 로고
    • Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid
    • Mandal, M. et al. Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid. Proc. Natl Acad. Sci. USA 105, 20840-20845 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 20840-20845
    • Mandal, M.1
  • 122
    • 0038482050 scopus 로고    scopus 로고
    • Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
    • Ley, R., Balmanno, K., Hadfield, K., Weston, C. and Cook, S. J. Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim. J. Biol. Chem. 278, 18811-18816 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 18811-18816
    • Ley, R.1    Balmanno, K.2    Hadfield, K.3    Weston, C.4    Cook, S.J.5
  • 123
    • 84878996181 scopus 로고    scopus 로고
    • Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination
    • Um, J. H. et al. Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination. Proc. Natl Acad. Sci. USA 110, 9873-9878 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 9873-9878
    • Um, J.H.1
  • 124
    • 84861455990 scopus 로고    scopus 로고
    • Disruption of Fnip1 reveals a metabolic checkpoint controlling B lymphocyte development
    • Park, H. et al. Disruption of Fnip1 reveals a metabolic checkpoint controlling B lymphocyte development. Immunity 36, 1-13 (2012).
    • (2012) Immunity , vol.36 , pp. 1-13
    • Park, H.1
  • 125
    • 0029894165 scopus 로고    scopus 로고
    • Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro
    • Stanhope-Baker, P., Hudson, K., Shaffer, A. L., Constantinescu, A. and Schlissel, M. Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro. Cell 85, 887-897 (1996).
    • (1996) Cell , vol.85 , pp. 887-897
    • Stanhope-Baker, P.1    Hudson, K.2    Shaffer, A.L.3    Constantinescu, A.4    Schlissel, M.5
  • 126
    • 0028347698 scopus 로고
    • Influnence of immunoglobulin heavy-and light-chain expression on B-cell differentation
    • Young, F. et al. Influnence of immunoglobulin heavy-and light-chain expression on B-cell differentation. Genes Dev. 8, 1043-1057 (1994).
    • (1994) Genes Dev , vol.8 , pp. 1043-1057
    • Young, F.1
  • 127
    • 0037234971 scopus 로고    scopus 로고
    • The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion
    • Flemming, A., Brummer, T., Reth, M. and Jumaa, H. The adaptor protein SLP-65 acts as a tumor suppressor that limits pre-B cell expansion. Nature Immunol. 4, 38-43 (2003).
    • (2003) Nature Immunol , vol.4 , pp. 38-43
    • Flemming, A.1    Brummer, T.2    Reth, M.3    Jumaa, H.4
  • 128
    • 0033521687 scopus 로고    scopus 로고
    • Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes
    • Shaw, A. C., Swat, W., Ferrini, R., Davidson, L. and Alt, F. W. Activated Ras signals developmental progression of recombinase-activating gene (RAG)-deficient pro-B lymphocytes. J. Exp. Med. 189, 123-129 (1999).
    • (1999) J. Exp. Med. , vol.189 , pp. 123-129
    • Shaw, A.C.1    Swat, W.2    Ferrini, R.3    Davidson, L.4    Alt, F.W.5
  • 129
    • 0033515093 scopus 로고    scopus 로고
    • Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras
    • Shaw, A. C., Swat, W., Davidson, L. and Alt, F. W. Induction of Ig light chain gene rearrangement in heavy chain-deficient B cells by activated Ras. Proc. Natl Acad. Sci. USA 96, 2239-2243 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 2239-2243
    • Shaw, A.C.1    Swat, W.2    Davidson, L.3    Alt, F.W.4
  • 130
    • 0033946934 scopus 로고    scopus 로고
    • E2A proteins: Essential regulators at multiple stages of B-cell development
    • Kee, B. L., Quong, M. W. and Murre, C. E2A proteins: essential regulators at multiple stages of B-cell development. Immunol. Rev. 175, 138-149 (2000).
    • (2000) Immunol. Rev. , vol.175 , pp. 138-149
    • Kee, B.L.1    Quong, M.W.2    Murre, C.3
  • 131
    • 8644262467 scopus 로고    scopus 로고
    • Important roles for e protein binding sites within the immunoglobulin k chain intronic enhance in avtivating V-κJ-κ rearrangement
    • Inlay, M. A., Tian, H., Lin, T. and Xu, Y. Important roles for E protein binding sites within the immunoglobulin k chain intronic enhance in avtivating V-κJ-κ rearrangement. J. Exp. Med. 200, 1205-1211 (2004).
    • (2004) J. Exp. Med. , vol.200 , pp. 1205-1211
    • Inlay, M.A.1    Tian, H.2    Lin, T.3    Xu, Y.4
  • 132
    • 0033871151 scopus 로고    scopus 로고
    • E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells
    • Ronanow, W. J. et al. E2A and EBF act in synergy with the V(D)J recombinase to generate a diverse immunoglobulin repertoire in nonlymphoid cells. Mol. Cell 5, 215-223 (2000).
    • (2000) Mol. Cell , vol.5 , pp. 215-223
    • Ronanow, W.J.1
  • 133
    • 19544365049 scopus 로고    scopus 로고
    • New insights into E-protein function in lymphocyte development
    • Lazorchak, A., Jones, M. E. and Zhuang, Y. New insights into E-protein function in lymphocyte development. Trends Immunol. 26, 334-338 (2005).
    • (2005) Trends Immunol , vol.26 , pp. 334-338
    • Lazorchak, A.1    Jones, M.E.2    Zhuang, Y.3
  • 134
    • 31344465701 scopus 로고    scopus 로고
    • E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin κ locus in pre-B cells
    • Lazorchak, A. S., Schlissel, M. S. and Zhuang, Y. E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin κ locus in pre-B cells. Mol. Cell. Biol. 26, 810-821 (2006).
    • (2006) Mol. Cell. Biol. , vol.26 , pp. 810-821
    • Lazorchak, A.S.1    Schlissel, M.S.2    Zhuang, Y.3
  • 135
    • 3242886298 scopus 로고    scopus 로고
    • Regulation of activation and recombination of the murine Igκ locus
    • Schlissel, M. S. Regulation of activation and recombination of the murine Igκ locus. Immunol. Rev. 200, 215-223 (2004).
    • (2004) Immunol. Rev. , vol.200 , pp. 215-223
    • Schlissel, M.S.1
  • 136
    • 70350462285 scopus 로고    scopus 로고
    • Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci
    • Beck, K., Peak, M. M., Ota, T., Nemazee, D. and Murre, C. Distinct roles for E12 and E47 in B cell specification and the sequential rearrangement of immunoglobulin light chain loci. J. Exp. Med. 206, 2271-2284 (2009).
    • (2009) J. Exp. Med. , vol.206 , pp. 2271-2284
    • Beck, K.1    Peak, M.M.2    Ota, T.3    Nemazee, D.4    Murre, C.5
  • 137
    • 84862102070 scopus 로고    scopus 로고
    • E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin κ locus
    • Sakamoto, S. et al. E2A and CBP/p300 act in synergy to promote chromatin accessibility of the immunoglobulin κ locus. J. Immunol. 188, 5547-5560 (2012).
    • (2012) J. Immunol. , vol.188 , pp. 5547-5560
    • Sakamoto, S.1
  • 138
    • 0038506030 scopus 로고    scopus 로고
    • IRF-4,8 orchestrate the pre-B to B transition in lymphocyte development
    • Lu, R., Kay, L., Lancki, D. W. and Singh, H. IRF-4,8 orchestrate the pre-B to B transition in lymphocyte development. Genes Dev. 17, 1703-1708 (2003).
    • (2003) Genes Dev , vol.17 , pp. 1703-1708
    • Lu, R.1    Kay, L.2    Lancki, D.W.3    Singh, H.4
  • 139
    • 38949178110 scopus 로고    scopus 로고
    • Interferon regulatory factors 7 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre-B cell receptor and promote cell-cycle withdrawal in pre-B cell development
    • Ma, S., Pathak, S., Trinh, L. and Lu, R. Interferon regulatory factors 7 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre-B cell receptor and promote cell-cycle withdrawal in pre-B cell development. Blood 111, 1396-1403 (2008).
    • (2008) Blood , vol.111 , pp. 1396-1403
    • Ma, S.1    Pathak, S.2    Trinh, L.3    Lu, R.4
  • 140
    • 81255154496 scopus 로고    scopus 로고
    • Epigenetic repression of the Ig-κ locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2
    • Mandal, M. et al. Epigenetic repression of the Ig-κ locus by STAT5-mediated recruitment of the histone methyltransferase Ezh2. Nature Immunol. 12, 1212-1220 (2011).
    • (2011) Nature Immunol , vol.12 , pp. 1212-1220
    • Mandal, M.1
  • 141
    • 63149116657 scopus 로고    scopus 로고
    • The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling
    • Xu, C.-R. and Feeney, A. J. The epigenetic profile of Ig genes is dynamically regulated during B cell differentiation and is modulated by pre-B cell receptor signaling. J. Immunol. 182, 1362-1369 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 1362-1369
    • Xu, C.-R.1    Feeney, A.J.2
  • 142
    • 38949164409 scopus 로고    scopus 로고
    • Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase
    • Aiba, Y., Kameyama, M., Yamazaki, T., Tedder, T. F. and Kurosaki, T. Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase. Blood 111, 1497-1503 (2008).
    • (2008) Blood , vol.111 , pp. 1497-1503
    • Aiba, Y.1    Kameyama, M.2    Yamazaki, T.3    Tedder, T.F.4    Kurosaki, T.5
  • 143
    • 2942523585 scopus 로고    scopus 로고
    • Cellular niches controlling B lymphocyte behavior within bone marrow during development
    • Tokoyoda, K., Egawa, T., Sugiyama, T., Choi, B. I. and Nagasawa, T. Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity 20, 335-344 (2004).
    • (2004) Immunity , vol.20 , pp. 335-344
    • Tokoyoda, K.1    Egawa, T.2    Sugiyama, T.3    Choi, B.I.4    Nagasawa, T.5
  • 144
    • 84872727730 scopus 로고    scopus 로고
    • Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments
    • Park, S. Y. et al. Focal adhesion kinase regulates the localization and retention of pro-B cells in bone marrow microenvironments. J. Immunol. 190, 1094-1102 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 1094-1102
    • Park, S.Y.1
  • 145
    • 0034748389 scopus 로고    scopus 로고
    • Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway
    • Fleming, H. E. and Paige, C. J. Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway. Immunity 15, 521-531 (2001).
    • (2001) Immunity , vol.15 , pp. 521-531
    • Fleming, H.E.1    Paige, C.J.2
  • 146
    • 3342934648 scopus 로고    scopus 로고
    • Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment
    • Vosshenrich, C. A., Cumano, A., Muller, W., Di Santo, J. P. and Vieira, P. Pre-B cell receptor expression is necessary for thymic stromal lymphopoietin responsiveness in the bone marrow but not in the liver environment. Proc. Natl Acad. Sci. USA 101, 11070-11075 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 11070-11075
    • Vosshenrich, C.A.1    Cumano, A.2    Muller, W.3    Di Santo, J.P.4    Vieira, P.5
  • 147
    • 33846895443 scopus 로고    scopus 로고
    • The PI3K p110δ is required for down-regulation of RAG expression in immature B cells
    • Llorian, M., Stamataki, Z., Hill, S., Turner, M. S. and Martensson, I. L. The PI3K p110δ is required for down-regulation of RAG expression in immature B cells. J. Immunol. 178, 1981-1985 (2007).
    • (2007) J. Immunol. , vol.178 , pp. 1981-1985
    • Llorian, M.1    Stamataki, Z.2    Hill, S.3    Turner, M.S.4    Martensson, I.L.5
  • 148
    • 44449095675 scopus 로고    scopus 로고
    • B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements
    • Schram, B. R. et al. B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements. J. Immunol. 180, 4728-4741 (2008).
    • (2008) J. Immunol. , vol.180 , pp. 4728-4741
    • Schram, B.R.1
  • 149
    • 20944435721 scopus 로고    scopus 로고
    • Basal immunoglobulin signaling actively maintains developmental stage in immature B cells
    • Tze, L. E. et al. Basal immunoglobulin signaling actively maintains developmental stage in immature B cells. PLoS Biol. 3, e82 (2005).
    • (2005) PLoS Biol , vol.3
    • Tze, L.E.1
  • 150
    • 0034608364 scopus 로고    scopus 로고
    • Revising B cell receptors
    • Nemazee, D. and Weigert, M. Revising B cell receptors. J. Exp. Med. 191, 1813-1817 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 1813-1817
    • Nemazee, D.1    Weigert, M.2
  • 151
    • 0035936833 scopus 로고    scopus 로고
    • Contribution of receptor editing to the antibody repertoire
    • Casellas, R. et al. Contribution of receptor editing to the antibody repertoire. Science 291, 1541-1544 (2001).
    • (2001) Science , vol.291 , pp. 1541-1544
    • Casellas, R.1
  • 152
    • 33846438984 scopus 로고    scopus 로고
    • Igκ allelic inclusion is a consequence of receptor editing
    • Casellas, R. et al. Igκ allelic inclusion is a consequence of receptor editing. J. Exp. Med. 204, 153-160 (2007).
    • (2007) J. Exp. Med. , vol.204 , pp. 153-160
    • Casellas, R.1
  • 153
    • 2542461255 scopus 로고    scopus 로고
    • Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution
    • Buckley, R. H. Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution. Annu. Rev. Immunol. 22, 625-655 (2004).
    • (2004) Annu. Rev. Immunol. , vol.22 , pp. 625-655
    • Buckley, R.H.1


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