Cell type-specific chromatin structure determines the targeting of V(D)J recombinase activity in vitro

Cell

Volumn 85, Issue 6, 1996, Pages 887-897

  Stanhope Baker, Patricia ^a   Hudson, Karen M ^a   Shaffer, Arthur L ^a   Constantinescu, Andrei ^a   Schlissel, Mark S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN; RECOMBINASE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; CHROMATIN STRUCTURE; CONTROLLED STUDY; ENZYME BINDING; ENZYME SPECIFICITY; GENE EXPRESSION REGULATION; GENE REARRANGEMENT; IMMUNOGLOBULIN PRODUCING CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; SIGNAL TRANSDUCTION; T LYMPHOCYTE RECEPTOR GENE;

ANIMALIA;

EID: 0029894165     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81272-6     Document Type: Article

References (45)

1. Alt, F., Yancopoulos, G., Blackwell, T., Wood, C., Thomas, E., Boss, M., Coffman, R., Rosenberg, N., Tonegawa, S., and Baltimore, D. (1984). Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J. 3, 1209-1219.
2. Alt, F., Blackwell, T., and Yancopoulos, G. (1987). Development of the primary antibody repertoire. Science 238, 1079-1087.
3. Ausubel, F., Brent, R., Kingston, R., Moore, D., Seidman, J., Smith, J., and Struhl, K. (1987). Current Protocols in Molecular Biology (New York: Wiley and Sons).
4. Blackwell, T.K., and Alt, F.W. (1989). Mechanism and developmental program of immunoglobulin gene rearrangement in mammals. Annu. Rev. Genet. 23, 605-636.
5. Blackwell, K., Malynn, B., Pollock, R., Ferrier, P., Covey, L., Fulop, G., Phillips, R., Yancopoulos, G., and Alt, F. (1989). Isolation of seid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins. EMBO J. 8, 735-742.
6. Chang, Y., Paige, C.J., and Wu, G.E. (1992). Enumeration and characterization of DJH structures in mouse fetal liver. EMBO J. 11, 1891-1899.
7. Chen, Y.-Y., Wang, L.C., Huang, M.S., and Rosenberg, N. (1994). An active v-abl protein tyrosine kinase blocks immunoglobulin light-chain gene rearrangement. Genes Dev. 8, 688-697.
8. Fernex, C., Capone, M., and Ferrier, P. (1995). The V(D)J recombinational and transcriptional activities of the immunoglobulin heavy-chain intronic enhancer can be mediated through distinct protein-binding sites in a transgenic substrate. Mol. Cell. Biol. 15, 3217-3226.
9. Gay, D., Saunders, T., Camper, S., and Weigert, M. (1993). Receptor editing: an approach by autoreactive B cells to escape tolerance. J. Exp. Med. 177, 999-1008.
10. Hardy, R.R., Carmack, C.E., Shinton, S.A., Kemp, J.D., and Hayakawa, K. (1991). Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173, 1213-1225.
11. Hesse, J., Lieber, M., Gellert, M., and Mizuuchi, K. (1987). Extrachromosomal DNA substrates in pre-B cells undergo inversion or deletion at immunoglobulin V-(D)-J joining signals. Cell 49, 775-783.
12. K joining. Cell 83, 1113-1123.
13. Kitamura, D., and Rajewsky, K. (1992). Targeted disruption of μ chain membrane exon causes loss of heavy-chain allelic exclusion. Nature 356, 154-156.
14. Korsmeyer, S.J. (1992). Chromosomal translocations in lymphoid malignancies reveal novel proto-oncogenes. Annu. Rev. Immunol. 10, 785-807.
15. Krop, I., de Fougerolles, A.R., Hardy, R.R., Allison, M., Schlissel, M. S., and Fearon, D.T. (1996). Self-renewal of B-1 lymphocytes is dependent on CD19. Eur. J. Immunol. 26, 238-242.
16. Lewis, S.M. (1994). The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses. Advances Immunol. 56, 27-150.
17. McBlane, J.F., van Gent, D.C., Ramsden, D.A., Romeo, C., Cuomo, C.A., Gellert, M., and Oettinger, M.A. (1995). Cleavage at a V(D)J recombination signal requires only RAG1 and RAG2 proteins and occurs in two steps. Cell 83, 387-395.
18. Mombaerts, P., lacomini, J., Johnson, R.S., Herrup, K., Tonegawa, S., and Papaioannou, V.E. (1992). RAG-1 deficient mice have no mature B and T lymphocytes. Cell 68, 869-877.
19. Mueller, P.R., and Wold, B. (1989). In vivo footprinting of a muscle specific enhancer by ligation mediated PCR. Science 246, 780-786.
20. Nussenzweig, M.C., Shaw, A.C., Sinn, E., Danner, D.B., Holmes, K.L., Morse, H.C., and Leder, P. (1987). Allelic exclusion in transgenic mice that express the membrane form of immunoglobulin μ. Science 236, 816-819.
21. Oettinger, M.A., Schatz, D.G., Gorka, C., and Baltimore, D. (1990). RAG-1 and RAG-2, adjacent genes that synergisticallyactivate V(D)J recombination. Science 248, 1517-1523.
22. Parker, C.S., and Topol, J. (1984). A Drosophila RNA polymerase II transcription factor contains a promoter-region-specific DNA-binding activity. Cell 36, 357-369.
23. Pernis, B.C., Chiappino, G., Kelus, A.S., and Gell, P.G.H. (1965). Cellular localization of immunoglobulins with different allotype specificities in rabbit lymphoid tissue. J. Exp. Med. 722, 853-875.
24. Ramsden, D.A., and Gellert, M. (1995). Formation and resolution of double-strand break intermediates in V(D)J rearrangement. Genes Dev. 9, 2409-2420.
25. Reth, M.G., Jackson, S., and Alt, F.W. (1986). VHDJH formation and DJH replacement during pre-B differentiation: non-random usage of gene segments. EMBO J. 5, 2131-2138.
26. Reth, M., Petrac, E., Wiese, P., Lobel, L., and Alt, F. (1987). Activation of VK gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains. EMBO J. 6, 3299-3305.
27. Roth, D.B., Nakajima, P., Menetski, J.P., Bosma, M.J., and Gellert, M. (1992a). V(D)J recombination in mouse thymocytes: double-strand breaks near T cell receptor δ rearrangement signals. Cell 69, 41-53.
28. Roth, D.B., Menetski, J.P., Nakajima, P.B., Bosma, M.J., and Gellert, M. (1992b). V(D)J recombination: broken DNA molecules with covalently sealed (hairpin) coding ends in seid mouse thymocytes. Cell 70, 983-991.
29. Roth, D.B., Zhu, C., and Gellert, M. (1993). Characterization of broken DNA molecules associated with V(D)J recombination. Proc. Natl. Acad. Sci. USA 90, 10788-10792.
30. Schatz, D.G., Oettinger, M.A., and Baltimore, D. (1989). The V(D)J recombination activating gene, RAG-1. Cell 59, 1035-1048.
31. Schatz, D.G., Oettinger, M.A., and Schlissel, M.S. (1992). V(D)J recombination: molecular biology and regulation. Annu. Rev. Immunol. 10, 359-383.
32. Schlissel, M., and Baltimore, D. (1989). Activation of immunoglobulin kappa gene rearrangement correlates with induction of germline kappa gene transcription. Cell 58, 1001-1007.
33. Schlissel, M.S., and Morrow, T. (1994). Immunoglobulin heavy-chain protein controls B cell development by regulating germline transcription and retargeting V(D)J recombination. J. Immunol. 153, 1645-1657.
34. Schlissel, M.S., Corcoran, L.M., and Baltimore, D. (1991). Virus-transformed pre-B cells show ordered activation but not inactivation of immunoglobulin gene rearrangement and transcription. J. Exp. Med. 173, 711-720.
35. Schlissel, M.S., Constantinescu, A., Morrow, T., Baxter, M., and Peng, A. (1993). Double-strand signal sequence breaks in V(D)J recombination are blunt, 5′ phosphorylated, RAG-dependent and cell cycle regulated. Genes Dev. 7, 2520-2532.
36. Shinkai, Y., Rathbun, G., Lam, K., Oltz, E., Stewart, V., Mendelsohn, M., Charron, J., Datta, M., Young, F., Stall, A.M., and Alt, F.W. (1992). RAG-2 deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell 68, 855-867.
37. Spanopoulou, E., Roman, C., Corcoran, L.M., Schlissel, M.S., Silver, D. P., Nemazee, D., Nussenzweig, M.C., Shinton, S.A., Hardy, R.R., and Baltimore, D. (1994). Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 8, 1030-1042.
38. Tiegs, S.L., Russell, D.M., and Nemazee, D. (1993). Receptor editing in self-reactive bone marrow B cells. J. Exp. Med. 177, 1009-1020.
39. Tonegawa, S. (1983). Somatic generation of antibody diversity. Nature 302, 575-581.
40. van Gent, D.C., McBlane, J.F., Ramsden, D., Sadofsky, M., Hesse, J., and Gellert, M. (1995). Initiation of V(D)J recombination in a cell-free system. Cell 81, 925-934.
41. Weaver, D., Constantini, F., Imanishi-Kari, T., and Baltimore, D. (1985). A transgenic immunoglobulin μ gene prevents rearrangement of endogenous genes. Cell 42, 117-127.
42. Workman, J.L., and Buchman, A.R. (1993). Multiple functions of nucleosomes and regulatory factors in transcription. Trends Biochem. Sci. 18, 90-95.
43. H gene segments. Cell 40, 271-281.
44. Yancopoulos, G., Blackwell, T., Suh, H., Hood, L., and Alt, F. (1986). Introduced T cell receptor variable region gene segments recombine in pre-B cells: evidence that B and T cells use a common recombinase. Cell 44, 251-259.
45. Young, F., Ardman, B., Shinkai, Y., Lansford, R., Blackwell, T.K., Mendelsohn, M., Rolink, A., Melchers, F., and Alt, F.W. (1994). Influence of immunoglobulin heavy-and light-chain expression on B-cell differentiation. Genes Dev. 8, 1043-1057.