RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation

Journal of Experimental Medicine

Volumn 209, Issue 1, 2012, Pages 11-17

  Bednarski, Jeffrey J ^a   Nickless, Andrew ^a   Bhattacharya, Deepta ^a   Amin, Rupesh H ^b   Schlissel, Mark S ^c   Sleckman, Barry P ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c University of California Berkeley   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; INTERLEUKIN 17; PROTEIN BAD; PROTEIN BAX; PROTEIN KINASE; PROTEIN KINASE PIM 1; PROTEIN KINASE PIM 2; RAG1 PROTEIN; RAG2 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA STRAND BREAKAGE; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANIMALS; BCL-ASSOCIATED DEATH PROTEIN; CELL CYCLE CHECKPOINTS; CELL PROLIFERATION; CELL SURVIVAL; DNA BREAKS, DOUBLE-STRANDED; DNA DAMAGE; GENES, RAG-1; INTERLEUKIN-7; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PRECURSOR CELLS, B-LYMPHOID; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSPOSASES;

EID: 84856812404     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20112078     Document Type: Article

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