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Volumn 8, Issue 1, 2008, Pages 9-21

Launching the T-cell-lineage developmental programme

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR; TRANSCRIPTION FACTOR;

EID: 37549010335     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri2232     Document Type: Review
Times cited : (367)

References (134)
  • 1
    • 33846505022 scopus 로고    scopus 로고
    • Key factors in the organized chaos of early T cell development
    • Hayday, A. C. & Pennington, D. J. Key factors in the organized chaos of early T cell development. Nature Immunol. 8, 137-144 (2007).
    • (2007) Nature Immunol , vol.8 , pp. 137-144
    • Hayday, A.C.1    Pennington, D.J.2
  • 2
    • 33645080183 scopus 로고    scopus 로고
    • At the crossroads: Diverse roles of early thymocyte transcriptional regulators
    • Anderson, M. K. At the crossroads: diverse roles of early thymocyte transcriptional regulators. Immunol. Rev. 209, 191-211 (2006).
    • (2006) Immunol. Rev , vol.209 , pp. 191-211
    • Anderson, M.K.1
  • 3
    • 0242636376 scopus 로고    scopus 로고
    • Cell migration and the control of postnatal T-cell lymphopoiesis in the thymus
    • Petrie, H. T. Cell migration and the control of postnatal T-cell lymphopoiesis in the thymus. Nature Rev. Immunol. 3, 859-866 (2003).
    • (2003) Nature Rev. Immunol , vol.3 , pp. 859-866
    • Petrie, H.T.1
  • 4
    • 0033933855 scopus 로고    scopus 로고
    • Stepwise specification of lymphocyte developmental lineages
    • Rothenberg, E. V. Stepwise specification of lymphocyte developmental lineages. Curr. Opin. Genet. Dev. 10, 370-379 (2000).
    • (2000) Curr. Opin. Genet. Dev , vol.10 , pp. 370-379
    • Rothenberg, E.V.1
  • 5
    • 0031726323 scopus 로고    scopus 로고
    • The linkage between T-cell and dendritic cell development in the mouse thymus
    • Shortman, K. et al. The linkage between T-cell and dendritic cell development in the mouse thymus. Immunol. Rev. 165, 39-46 (1998).
    • (1998) Immunol. Rev , vol.165 , pp. 39-46
    • Shortman, K.1
  • 6
    • 0036831290 scopus 로고    scopus 로고
    • Ceredig, R. & Rolink, T. A positive look at doublenegative thymocytes. Nature Rev. Immunol. 2, 888-897 (2002). This review emphasizes the importance of using high KIT expression to define T-cell precursors in the DN1 population and to characterize DN2 cells. DN1 cells defined here largely correspond to the ETP DN1a and DN1b cells confirmed as precursors in references 25 and 131.
    • Ceredig, R. & Rolink, T. A positive look at doublenegative thymocytes. Nature Rev. Immunol. 2, 888-897 (2002). This review emphasizes the importance of using high KIT expression to define T-cell precursors in the DN1 population and to characterize DN2 cells. DN1 cells defined here largely correspond to the ETP DN1a and DN1b cells confirmed as precursors in references 25 and 131.
  • 7
    • 33646203680 scopus 로고    scopus 로고
    • Development of human lymphoid cells
    • Blom, B. & Spits, H. Development of human lymphoid cells. Annu. Rev. Immunol. 24, 287-320 (2006).
    • (2006) Annu. Rev. Immunol , vol.24 , pp. 287-320
    • Blom, B.1    Spits, H.2
  • 8
    • 34247882592 scopus 로고    scopus 로고
    • Zoned out: Functional mapping of stromal signaling microenvironments in the thymus
    • Petrie, H. T. & Zuniga-Pflucker, J. C. Zoned out: functional mapping of stromal signaling microenvironments in the thymus. Annu. Rev. Immunol. 25, 649-679 (2007).
    • (2007) Annu. Rev. Immunol , vol.25 , pp. 649-679
    • Petrie, H.T.1    Zuniga-Pflucker, J.C.2
  • 9
    • 34250212481 scopus 로고    scopus 로고
    • Commitment and developmental potential of extrathymic and intrathymic T cell precursors: Plenty to choose from
    • Bhandoola, A., von Boehmer, H., Petrie, H. T. & Zuniga-Pflucker, J. C. Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. Immunity 26, 678-689 (2007).
    • (2007) Immunity , vol.26 , pp. 678-689
    • Bhandoola, A.1    von Boehmer, H.2    Petrie, H.T.3    Zuniga-Pflucker, J.C.4
  • 10
    • 33644661207 scopus 로고    scopus 로고
    • T lineage progenitors: The earliest steps en route to T lymphocytes
    • Wu, L. T lineage progenitors: the earliest steps en route to T lymphocytes. Curr. Opin. Immunol. 18, 121-126 (2006).
    • (2006) Curr. Opin. Immunol , vol.18 , pp. 121-126
    • Wu, L.1
  • 12
    • 33645876789 scopus 로고    scopus 로고
    • A close developmental relationship between the lymphoid and myeloid lineages
    • Kawamoto, H. A close developmental relationship between the lymphoid and myeloid lineages. Trends Immunol. 27, 169-175 (2006).
    • (2006) Trends Immunol , vol.27 , pp. 169-175
    • Kawamoto, H.1
  • 13
    • 14844288910 scopus 로고    scopus 로고
    • Lymphoid progenitors and primary routes to becoming cells of the immune system
    • Pelayo, R. et al. Lymphoid progenitors and primary routes to becoming cells of the immune system. Curr. Opin. Immunol. 17, 100-107 (2005).
    • (2005) Curr. Opin. Immunol , vol.17 , pp. 100-107
    • Pelayo, R.1
  • 14
    • 33847156724 scopus 로고    scopus 로고
    • TCR and Notch synergize in αβ versus γδ lineage choice
    • Garbe, A. I. & von Boehmer, H. TCR and Notch synergize in αβ versus γδ lineage choice. Trends Immunol. 28, 124-131 (2007).
    • (2007) Trends Immunol , vol.28 , pp. 124-131
    • Garbe, A.I.1    von Boehmer, H.2
  • 15
    • 33748448909 scopus 로고    scopus 로고
    • Thymus-homing precursors and the thymic microenvironment
    • Boehm, T. & Bleul, C. C. Thymus-homing precursors and the thymic microenvironment. Trends Immunol. 27, 477-484 (2006).
    • (2006) Trends Immunol , vol.27 , pp. 477-484
    • Boehm, T.1    Bleul, C.C.2
  • 17
    • 20244387299 scopus 로고    scopus 로고
    • + lymphomyeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment
    • + lymphomyeloid stem cells lacking erythro-megakaryocytic potential: a revised road map for adult blood lineage commitment. Cell 121, 295-306 (2005).
    • (2005) Cell , vol.121 , pp. 295-306
    • Adolfsson, J.1
  • 18
    • 33645109285 scopus 로고    scopus 로고
    • Yoshida, T., Ng, S. Y., Zuniga-Pflucker, J. C. & Georgopoulos, K. Early hematopoietic lineage restrictions directed by Ikaros. Nature Immunol. 7, 382-391 (2006). This paper uses gene expression analysis and in vitro development to establish Ikaros functions in distinct types of multipotent haematopoietic progenitors. It shows that T-cell development qualitatively depends on Ikaros.
    • Yoshida, T., Ng, S. Y., Zuniga-Pflucker, J. C. & Georgopoulos, K. Early hematopoietic lineage restrictions directed by Ikaros. Nature Immunol. 7, 382-391 (2006). This paper uses gene expression analysis and in vitro development to establish Ikaros functions in distinct types of multipotent haematopoietic progenitors. It shows that T-cell development qualitatively depends on Ikaros.
  • 19
    • 33748507998 scopus 로고    scopus 로고
    • Notch1 and IL-7 receptor interplay maintains proliferation of human thymic progenitors while suppressing non-T cell fates
    • Garcia-Peydro, M., de Yebenes, V. G. & Toribio, M. L. Notch1 and IL-7 receptor interplay maintains proliferation of human thymic progenitors while suppressing non-T cell fates. J. Immunol. 177, 3711-3720 (2006).
    • (2006) J. Immunol , vol.177 , pp. 3711-3720
    • Garcia-Peydro, M.1    de Yebenes, V.G.2    Toribio, M.L.3
  • 20
    • 27744509876 scopus 로고    scopus 로고
    • Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment
    • De Smedt, M., Hoebeke, I., Reynvoet, K., Leclercq, G. & Plum, J. Different thresholds of Notch signaling bias human precursor cells toward B-, NK-, monocytic/dendritic-, or T-cell lineage in thymus microenvironment. Blood 106, 3498-3506 (2005).
    • (2005) Blood , vol.106 , pp. 3498-3506
    • De Smedt, M.1    Hoebeke, I.2    Reynvoet, K.3    Leclercq, G.4    Plum, J.5
  • 21
    • 33846216011 scopus 로고    scopus 로고
    • Bone marrow-derived hemopoietic precursors commit to the T cell lineage only after arrival in the thymic microenvironment
    • Heinzel, K., Benz, C., Martins, V. C., Haidl, I. D. & Bleul, C. C. Bone marrow-derived hemopoietic precursors commit to the T cell lineage only after arrival in the thymic microenvironment. J. Immunol. 178, 858-868 (2007).
    • (2007) J. Immunol , vol.178 , pp. 858-868
    • Heinzel, K.1    Benz, C.2    Martins, V.C.3    Haidl, I.D.4    Bleul, C.C.5
  • 22
    • 33846902089 scopus 로고    scopus 로고
    • Selective thymus settling regulated by cytokine and chemokine receptors
    • Schwarz, B. A. et al. Selective thymus settling regulated by cytokine and chemokine receptors. J. Immunol. 178, 2008-2017 (2007).
    • (2007) J. Immunol , vol.178 , pp. 2008-2017
    • Schwarz, B.A.1
  • 23
    • 28644433320 scopus 로고    scopus 로고
    • Prethymic T-cell development defined by the expression of paired immunoglobulinlike receptors
    • Masuda, K. et al. Prethymic T-cell development defined by the expression of paired immunoglobulinlike receptors. EMBO J. 24, 4052-4060 (2005).
    • (2005) EMBO J , vol.24 , pp. 4052-4060
    • Masuda, K.1
  • 24
    • 0141567542 scopus 로고    scopus 로고
    • Unique properties of fetal lymphoid progenitors identified according to RAG1 gene expression
    • Yokota, T. et al. Unique properties of fetal lymphoid progenitors identified according to RAG1 gene expression. Immunity 19, 365-375 (2003).
    • (2003) Immunity , vol.19 , pp. 365-375
    • Yokota, T.1
  • 25
    • 0037320932 scopus 로고    scopus 로고
    • Thymopoiesis independent of common lymphoid progenitors
    • Allman, D. et al. Thymopoiesis independent of common lymphoid progenitors. Nature Immunol. 4, 168-174 (2003).
    • (2003) Nature Immunol , vol.4 , pp. 168-174
    • Allman, D.1
  • 26
    • 0036669273 scopus 로고    scopus 로고
    • Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow
    • Igarashi, H., Gregory, S. C., Yokota, T., Sakaguchi, N. & Kincade, P. W. Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. Immunity 17, 117-130 (2002).
    • (2002) Immunity , vol.17 , pp. 117-130
    • Igarashi, H.1    Gregory, S.C.2    Yokota, T.3    Sakaguchi, N.4    Kincade, P.W.5
  • 27
    • 30444454357 scopus 로고    scopus 로고
    • Developmental and molecular characterization of emerging β- and γδ-selected pre-T cells in the adult mouse thymus
    • Taghon, T., Yui, M. A., Pant, R., Diamond, R. A. & Rothenberg, E. V. Developmental and molecular characterization of emerging β- and γδ-selected pre-T cells in the adult mouse thymus. Immunity 24, 53-64 (2006).
    • (2006) Immunity , vol.24 , pp. 53-64
    • Taghon, T.1    Yui, M.A.2    Pant, R.3    Diamond, R.A.4    Rothenberg, E.V.5
  • 28
    • 21344433039 scopus 로고    scopus 로고
    • Thymus-derived signals regulate early T-cell development
    • Schmitt, T. M. & Zuniga-Pflucker, J. C. Thymus-derived signals regulate early T-cell development. Crit. Rev. Immunol. 25, 141-160 (2005).
    • (2005) Crit. Rev. Immunol , vol.25 , pp. 141-160
    • Schmitt, T.M.1    Zuniga-Pflucker, J.C.2
  • 29
    • 17644382970 scopus 로고    scopus 로고
    • Regulation of lymphoid development, differentiation, and function by the Notch pathway
    • Maillard, I., Fang, T. & Pear, W. S. Regulation of lymphoid development, differentiation, and function by the Notch pathway. Annu. Rev. Immunol. 23, 945-974 (2005).
    • (2005) Annu. Rev. Immunol , vol.23 , pp. 945-974
    • Maillard, I.1    Fang, T.2    Pear, W.S.3
  • 30
    • 0036916440 scopus 로고    scopus 로고
    • Schmitt, T. M. & Zúñiga-Pflücker, J. C. Induction of T cell development from hematopoietic progenitor cells by Delta-like-1 in vitro. Immunity 17, 749-756 (2002). By establishing a highly robust, accessible in vitro culture system for early T-cell development, this paper liberated T-cell development from the 'black box' of the thymic microenvironment and profoundly transformed the field.
    • Schmitt, T. M. & Zúñiga-Pflücker, J. C. Induction of T cell development from hematopoietic progenitor cells by Delta-like-1 in vitro. Immunity 17, 749-756 (2002). By establishing a highly robust, accessible in vitro culture system for early T-cell development, this paper liberated T-cell development from the 'black box' of the thymic microenvironment and profoundly transformed the field.
  • 31
    • 13644251707 scopus 로고    scopus 로고
    • Lymphotoxin-mediated regulation of γδ cell differentiation by αβ T cell progenitors
    • Silva-Santos, B., Pennington, D. J. & Hayday, A. C. Lymphotoxin-mediated regulation of γδ cell differentiation by αβ T cell progenitors. Science 307, 925-928 (2005).
    • (2005) Science , vol.307 , pp. 925-928
    • Silva-Santos, B.1    Pennington, D.J.2    Hayday, A.C.3
  • 32
    • 0036097258 scopus 로고    scopus 로고
    • Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene
    • Gounari, F. et al. Tracing lymphopoiesis with the aid of a pTα-controlled reporter gene. Nature Immunol. 3, 489-496 (2002).
    • (2002) Nature Immunol , vol.3 , pp. 489-496
    • Gounari, F.1
  • 33
    • 35748931463 scopus 로고    scopus 로고
    • Masuda, K. et al. T cell lineage determination precedes the initiation of TCRβ rearrangement. J. Immunol. 179, 3699-3706 (2007). Using a pLCK-GFP transgene to mark a positive switchpoint in T-cell gene expression in living thymocytes, the authors discovered that the DN2 stage is composed of two distinct substages, and that DC developmental potential is lost by the time that the pLCK-GFP transgene is activated.
    • Masuda, K. et al. T cell lineage determination precedes the initiation of TCRβ rearrangement. J. Immunol. 179, 3699-3706 (2007). Using a pLCK-GFP transgene to mark a positive switchpoint in T-cell gene expression in living thymocytes, the authors discovered that the DN2 stage is composed of two distinct substages, and that DC developmental potential is lost by the time that the pLCK-GFP transgene is activated.
  • 34
    • 33645057683 scopus 로고    scopus 로고
    • Progression of regulatory gene expression states in fetal and adult pro-T cell development
    • David-Fung, E. S. et al. Progression of regulatory gene expression states in fetal and adult pro-T cell development. Immunol. Rev. 209, 212-236 (2006).
    • (2006) Immunol. Rev , vol.209 , pp. 212-236
    • David-Fung, E.S.1
  • 35
    • 17444420743 scopus 로고    scopus 로고
    • Taghon, T. N., David, E.-S., Zúñiga-Pflücker, J. C. & Rothenberg, E. V. Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling. Genes Dev. 19, 965-978 (2005). This paper dissects the timing and gene expression signatures that correlate with lineage commitment in vitro in the presence or absence of Notch-DLL signals.
    • Taghon, T. N., David, E.-S., Zúñiga-Pflücker, J. C. & Rothenberg, E. V. Delayed, asynchronous, and reversible T-lineage specification induced by Notch/Delta signaling. Genes Dev. 19, 965-978 (2005). This paper dissects the timing and gene expression signatures that correlate with lineage commitment in vitro in the presence or absence of Notch-DLL signals.
  • 36
    • 14944341196 scopus 로고    scopus 로고
    • Balciunaite, G., Ceredig, R. & Rolink, A. G. The earliest subpopulation of mouse thymocytes contains potent T, significant macrophage, and natural killer cell but no B-lymphocyte potential. Blood 105, 1930-1936 (2005). This study shows that macrophage developmental potential is maintained by ETPs and DN2 thymocytes whereas B-cell potential is not. Macrophages generated from ETP and DN2 cells are phagocytically active and yet may contain limited TCRβ gene rearrangements, confirming their T-cell-lineage origin.
    • Balciunaite, G., Ceredig, R. & Rolink, A. G. The earliest subpopulation of mouse thymocytes contains potent T, significant macrophage, and natural killer cell but no B-lymphocyte potential. Blood 105, 1930-1936 (2005). This study shows that macrophage developmental potential is maintained by ETPs and DN2 thymocytes whereas B-cell potential is not. Macrophages generated from ETP and DN2 cells are phagocytically active and yet may contain limited TCRβ gene rearrangements, confirming their T-cell-lineage origin.
  • 37
    • 3142763848 scopus 로고    scopus 로고
    • Tabrizifard, S. et al. Analysis of transcription factor expression during discrete stages of postnatal thymocyte differentiation. J. Immunol. 173, 1094-1102 (2004). This paper provides an expression analysis of transcription factor genes in murine pro-T cells, based on hybridization to Affymetrix microarrays. Hundreds of regulatory genes are tracked, and genes that are particularly useful for defining specific transitions are described.
    • Tabrizifard, S. et al. Analysis of transcription factor expression during discrete stages of postnatal thymocyte differentiation. J. Immunol. 173, 1094-1102 (2004). This paper provides an expression analysis of transcription factor genes in murine pro-T cells, based on hybridization to Affymetrix microarrays. Hundreds of regulatory genes are tracked, and genes that are particularly useful for defining specific transitions are described.
  • 38
    • 6344272486 scopus 로고    scopus 로고
    • Deranged early T cell development in immunodeficient strains of nonobese diabetic mice
    • Yui, M. A. & Rothenberg, E. V. Deranged early T cell development in immunodeficient strains of nonobese diabetic mice. J. Immunol. 173, 5381-5391 (2004).
    • (2004) J. Immunol , vol.173 , pp. 5381-5391
    • Yui, M.A.1    Rothenberg, E.V.2
  • 39
    • 0035253709 scopus 로고    scopus 로고
    • Differential transcriptional regulation of individual TCR Vβ segments before gene rearrangement
    • Chen, F., Rowen, L., Hood, L. & Rothenberg, E. V. Differential transcriptional regulation of individual TCR Vβ segments before gene rearrangement. J. Immunol. 166, 1771-1780 (2001).
    • (2001) J. Immunol , vol.166 , pp. 1771-1780
    • Chen, F.1    Rowen, L.2    Hood, L.3    Rothenberg, E.V.4
  • 40
    • 0025308679 scopus 로고
    • Interleukin-2 gene inducibility in T cells prior to T-cell receptor expression: Changes in signaling pathways and gene expression requirements during intrathymic maturation
    • Rothenberg, E. V., Diamond, R. A., Pepper, K. A. & Yang, J. A. Interleukin-2 gene inducibility in T cells prior to T-cell receptor expression: changes in signaling pathways and gene expression requirements during intrathymic maturation. J. Immunol. 144, 1614-1624 (1990).
    • (1990) J. Immunol , vol.144 , pp. 1614-1624
    • Rothenberg, E.V.1    Diamond, R.A.2    Pepper, K.A.3    Yang, J.A.4
  • 41
    • 33644961953 scopus 로고    scopus 로고
    • Critical role for c-kit (CD117) in T cell lineage commitment and early thymocyte development in vitro
    • Massa, S., Balciunaite, G., Ceredig, R. & Rolink, A. G. Critical role for c-kit (CD117) in T cell lineage commitment and early thymocyte development in vitro. Eur. J. Immunol. 36, 526-532 (2006).
    • (2006) Eur. J. Immunol , vol.36 , pp. 526-532
    • Massa, S.1    Balciunaite, G.2    Ceredig, R.3    Rolink, A.G.4
  • 42
    • 1542381087 scopus 로고    scopus 로고
    • Cytokine functions in the formative stages of a lymphocyte's life
    • Kang, J. & Der, S. D. Cytokine functions in the formative stages of a lymphocyte's life. Curr. Opin. Immunol. 16, 180-190 (2004).
    • (2004) Curr. Opin. Immunol , vol.16 , pp. 180-190
    • Kang, J.1    Der, S.D.2
  • 43
    • 0037007023 scopus 로고    scopus 로고
    • Lineage infidelity in myeloid cells with TCR gene rearrangement: A latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling
    • King, A. G., Kondo, M., Scherer, D. C. & Weissman, I. L. Lineage infidelity in myeloid cells with TCR gene rearrangement: a latent developmental potential of proT cells revealed by ectopic cytokine receptor signaling. Proc. Natl Acad. Sci. USA 99, 4508-4513 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 4508-4513
    • King, A.G.1    Kondo, M.2    Scherer, D.C.3    Weissman, I.L.4
  • 44
    • 22344450253 scopus 로고    scopus 로고
    • A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision
    • Benz, C. & Bleul, C. C. A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision. J. Exp. Med. 202, 21-31 (2005).
    • (2005) J. Exp. Med , vol.202 , pp. 21-31
    • Benz, C.1    Bleul, C.C.2
  • 45
    • 22144487402 scopus 로고    scopus 로고
    • Notch signaling controls the generation and differentiation of early T lineage progenitors
    • Sambandam, A. et al. Notch signaling controls the generation and differentiation of early T lineage progenitors. Nature Immunol. 6, 663-670 (2005).
    • (2005) Nature Immunol , vol.6 , pp. 663-670
    • Sambandam, A.1
  • 46
    • 27144501454 scopus 로고    scopus 로고
    • Lu, M. et al. The earliest thymic progenitors in adults are restricted to T, NK, and dendritic cell lineage and have a potential to form more diverse TCRβ chains than fetal progenitors. J. Immunol. 175, 5848-5856 (2005).
    • Lu, M. et al. The earliest thymic progenitors in adults are restricted to T, NK, and dendritic cell lineage and have a potential to form more diverse TCRβ chains than fetal progenitors. J. Immunol. 175, 5848-5856 (2005).
  • 47
    • 4344572135 scopus 로고    scopus 로고
    • Maintenance of T cell specification and differentiation requires recurrent Notch receptor-ligand interactions
    • Schmitt, T. M., Ciofani, M., Petrie, H. T. & Zúñiga- Pflücker, J. C. Maintenance of T cell specification and differentiation requires recurrent Notch receptor-ligand interactions. J. Exp. Med. 200, 469-479 (2004).
    • (2004) J. Exp. Med , vol.200 , pp. 469-479
    • Schmitt, T.M.1    Ciofani, M.2    Petrie, H.T.3    Zúñiga- Pflücker, J.C.4
  • 48
    • 0141886221 scopus 로고    scopus 로고
    • T/NK bipotent progenitors in the thymus retain the potential to generate dendritic cells
    • Shen, H. Q. et al. T/NK bipotent progenitors in the thymus retain the potential to generate dendritic cells. J. Immunol. 171, 3401-3406 (2003).
    • (2003) J. Immunol , vol.171 , pp. 3401-3406
    • Shen, H.Q.1
  • 49
    • 0029787979 scopus 로고    scopus 로고
    • Wu, L., Li, C.-L. & Shortman, K. Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny. J. Exp. Med. 184, 903-911 (1996). This paper first showed persistence of a nonlymphoid developmental option into the DN2 stage of thymocyte development, which is shut off in the DN3 stage.
    • Wu, L., Li, C.-L. & Shortman, K. Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny. J. Exp. Med. 184, 903-911 (1996). This paper first showed persistence of a nonlymphoid developmental option into the DN2 stage of thymocyte development, which is shut off in the DN3 stage.
  • 50
    • 34250217913 scopus 로고    scopus 로고
    • Taghon, T., Yui, M. A. & Rothenberg, E. V. Mast cell lineage diversion of T lineage precursors by the essential T-cell transcription factor GATA-3. Nature Immunol. 8, 845-855 (2007). This paper shows that even the essential T-celllineage transcription factor GATA3 can act as a diversionary factor for ETP and DN2 T-cell precursors, if it is expressed at an elevated level. In this case Notch acts as an antagonist of GATA3 instead of a collaborator.
    • Taghon, T., Yui, M. A. & Rothenberg, E. V. Mast cell lineage diversion of T lineage precursors by the essential T-cell transcription factor GATA-3. Nature Immunol. 8, 845-855 (2007). This paper shows that even the essential T-celllineage transcription factor GATA3 can act as a diversionary factor for ETP and DN2 T-cell precursors, if it is expressed at an elevated level. In this case Notch acts as an antagonist of GATA3 instead of a collaborator.
  • 51
    • 34250203551 scopus 로고    scopus 로고
    • Negotiation of the T lineage fate decision by transcription-factor interplay and microenvironmental signals
    • Rothenberg, E. V. Negotiation of the T lineage fate decision by transcription-factor interplay and microenvironmental signals. Immunity 26, 690-702 (2007).
    • (2007) Immunity , vol.26 , pp. 690-702
    • Rothenberg, E.V.1
  • 52
    • 33747045798 scopus 로고    scopus 로고
    • Franco, C. B. et al. Notch/Delta signaling constrains re-engineering of pro-T cells by PU.1. Proc. Natl Acad. Sci. USA 103, 11993-11998 (2006). This paper details the regulatory cascade induced by PU.1 as it diverts thymocytes from the T-cell programme to the myeloid-cell or DC pathway. In DN2 and later thymocytes, Notch-DLL signalling precisely neutralizes a subset of PU.1 effects.
    • Franco, C. B. et al. Notch/Delta signaling constrains re-engineering of pro-T cells by PU.1. Proc. Natl Acad. Sci. USA 103, 11993-11998 (2006). This paper details the regulatory cascade induced by PU.1 as it diverts thymocytes from the T-cell programme to the myeloid-cell or DC pathway. In DN2 and later thymocytes, Notch-DLL signalling precisely neutralizes a subset of PU.1 effects.
  • 53
    • 34249707006 scopus 로고    scopus 로고
    • Tydell, C. C. et al. Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway. J. Immunol. 179, 421-438 (2007). This study reports a panel of transcription factor and signalling genes that are upregulated in early T-cell-lineage development more than in precursors for other lineages. Most of the 'T-cell-lineage' genes are 'legacies' from stem or multipotent progenitors but Bcl11b is uniquely induced during the ETP to DN2 transition in vivo.
    • Tydell, C. C. et al. Molecular dissection of prethymic progenitor entry into the T lymphocyte developmental pathway. J. Immunol. 179, 421-438 (2007). This study reports a panel of transcription factor and signalling genes that are upregulated in early T-cell-lineage development more than in precursors for other lineages. Most of the 'T-cell-lineage' genes are 'legacies' from stem or multipotent progenitors but Bcl11b is uniquely induced during the ETP to DN2 transition in vivo.
  • 54
    • 34247224342 scopus 로고    scopus 로고
    • Regulation of lymphocyte development by Notch signaling
    • Tanigaki, K. & Honjo, T. Regulation of lymphocyte development by Notch signaling. Nature Immunol. 8, 451-456 (2007).
    • (2007) Nature Immunol , vol.8 , pp. 451-456
    • Tanigaki, K.1    Honjo, T.2
  • 55
    • 0036467663 scopus 로고    scopus 로고
    • Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway
    • Reizis, B. & Leder, P. Direct induction of T lymphocyte-specific gene expression by the mammalian Notch signaling pathway. Genes Dev. 16, 295-300 (2002).
    • (2002) Genes Dev , vol.16 , pp. 295-300
    • Reizis, B.1    Leder, P.2
  • 56
    • 0033681301 scopus 로고    scopus 로고
    • Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes
    • Deftos, M. L., Huang, E., Ojala, E. W., Forbush, K. A. & Bevan, M. J. Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes. Immunity 13, 73-84 (2000).
    • (2000) Immunity , vol.13 , pp. 73-84
    • Deftos, M.L.1    Huang, E.2    Ojala, E.W.3    Forbush, K.A.4    Bevan, M.J.5
  • 57
    • 33749327182 scopus 로고    scopus 로고
    • The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor
    • Maillard, I. et al. The requirement for Notch signaling at the β-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. J. Exp. Med. 203, 2239-2245 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 2239-2245
    • Maillard, I.1
  • 58
    • 34249653573 scopus 로고    scopus 로고
    • Regulatory factors for initial T lymphocyte lineage specification
    • Rothenberg, E. V. Regulatory factors for initial T lymphocyte lineage specification. Curr. Opin. Hematol. 14, 322-329 (2007).
    • (2007) Curr. Opin. Hematol , vol.14 , pp. 322-329
    • Rothenberg, E.V.1
  • 59
    • 17444396980 scopus 로고    scopus 로고
    • Molecular genetics of T cell development
    • Rothenberg, E. V. & Taghon, T. Molecular genetics of T cell development. Annu. Rev. Immunol. 23, 601-649 (2005).
    • (2005) Annu. Rev. Immunol , vol.23 , pp. 601-649
    • Rothenberg, E.V.1    Taghon, T.2
  • 61
    • 34249679048 scopus 로고    scopus 로고
    • GATA-3 - not just for Th2 cells anymore
    • Ho, I. C. & Pai, S. Y. GATA-3 - not just for Th2 cells anymore. Cell. Mol. Immunol. 4, 15-29 (2007).
    • (2007) Cell. Mol. Immunol , vol.4 , pp. 15-29
    • Ho, I.C.1    Pai, S.Y.2
  • 62
    • 27544442994 scopus 로고    scopus 로고
    • Helix-loop-helix proteins and lymphocyte development
    • Murre, C. Helix-loop-helix proteins and lymphocyte development. Nature Immunol. 6, 1079-1086 (2005).
    • (2005) Nature Immunol , vol.6 , pp. 1079-1086
    • Murre, C.1
  • 63
    • 0037502235 scopus 로고    scopus 로고
    • Bcl11b is required for differentiation and survival of αβ T lymphocytes
    • Wakabayashi, Y. et al. Bcl11b is required for differentiation and survival of αβ T lymphocytes. Nature Immunol. 4, 533-539 (2003).
    • (2003) Nature Immunol , vol.4 , pp. 533-539
    • Wakabayashi, Y.1
  • 64
    • 33745321679 scopus 로고    scopus 로고
    • The basic helix-loop-helix transcription factor HEBAlt is expressed in pro-T cells and enhances the generation of T cell precursors
    • Wang, D. et al. The basic helix-loop-helix transcription factor HEBAlt is expressed in pro-T cells and enhances the generation of T cell precursors. J. Immunol. 177, 109-119 (2006).
    • (2006) J. Immunol , vol.177 , pp. 109-119
    • Wang, D.1
  • 65
    • 33645095936 scopus 로고    scopus 로고
    • Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus
    • El Andaloussi, A. et al. Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nature Immunol. 7, 418-426 (2006).
    • (2006) Nature Immunol , vol.7 , pp. 418-426
    • El Andaloussi, A.1
  • 66
    • 0033988443 scopus 로고    scopus 로고
    • Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor α2
    • Goetz, T. L., Gu, T. L., Speck, N. A. & Graves, B. J. Auto-inhibition of Ets-1 is counteracted by DNA binding cooperativity with core-binding factor α2. Mol. Cell. Biol. 20, 81-90 (2000).
    • (2000) Mol. Cell. Biol , vol.20 , pp. 81-90
    • Goetz, T.L.1    Gu, T.L.2    Speck, N.A.3    Graves, B.J.4
  • 67
    • 0033988402 scopus 로고    scopus 로고
    • Auto-inhibition and partner proteins, core-binding factor β (CBFβ) and Ets-1, modulate DNA binding by CBFα2 (AML1)
    • Gu, T. L., Goetz, T. L., Graves, B. J. & Speck, N. A. Auto-inhibition and partner proteins, core-binding factor β (CBFβ) and Ets-1, modulate DNA binding by CBFα2 (AML1). Mol. Cell. Biol. 20, 91-103 (2000).
    • (2000) Mol. Cell. Biol , vol.20 , pp. 91-103
    • Gu, T.L.1    Goetz, T.L.2    Graves, B.J.3    Speck, N.A.4
  • 68
    • 33846487941 scopus 로고    scopus 로고
    • Regulation of γδ versus αβ T lymphocyte differentiation by the transcription factor SOX13
    • Melichar, H. J. et al. Regulation of γδ versus αβ T lymphocyte differentiation by the transcription factor SOX13. Science 315, 230-233 (2007).
    • (2007) Science , vol.315 , pp. 230-233
    • Melichar, H.J.1
  • 69
    • 33750323404 scopus 로고    scopus 로고
    • Identification of Notch target genes in uncommitted T-cell progenitors: No direct induction of a T-cell specific gene program
    • Weerkamp, F. et al. Identification of Notch target genes in uncommitted T-cell progenitors: no direct induction of a T-cell specific gene program. Leukemia 20, 1967-1977 (2006).
    • (2006) Leukemia , vol.20 , pp. 1967-1977
    • Weerkamp, F.1
  • 70
    • 4644265888 scopus 로고    scopus 로고
    • Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors
    • Höflinger, S. et al. Analysis of Notch1 function by in vitro T cell differentiation of Pax5 mutant lymphoid progenitors. J. Immunol. 173, 3935-3944 (2004).
    • (2004) J. Immunol , vol.173 , pp. 3935-3944
    • Höflinger, S.1
  • 71
    • 3042627641 scopus 로고    scopus 로고
    • Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro
    • Schmitt, T. M. et al. Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro. Nature Immunol. 5, 410-417 (2004).
    • (2004) Nature Immunol , vol.5 , pp. 410-417
    • Schmitt, T.M.1
  • 72
    • 26844493623 scopus 로고    scopus 로고
    • Propensity of adult lymphoid progenitors to progress to DN2/3 stage thymocytes with Notch receptor ligation
    • Huang, J. et al. Propensity of adult lymphoid progenitors to progress to DN2/3 stage thymocytes with Notch receptor ligation. J. Immunol. 175, 4858-4865 (2005).
    • (2005) J. Immunol , vol.175 , pp. 4858-4865
    • Huang, J.1
  • 73
    • 33746871419 scopus 로고    scopus 로고
    • Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands
    • Krueger, A., Garbe, A. I. & von Boehmer, H. Phenotypic plasticity of T cell progenitors upon exposure to Notch ligands. J. Exp. Med. 203, 1977-1984 (2006).
    • (2006) J. Exp. Med , vol.203 , pp. 1977-1984
    • Krueger, A.1    Garbe, A.I.2    von Boehmer, H.3
  • 74
    • 33751551619 scopus 로고    scopus 로고
    • + cells
    • + cells. Exp. Hematol. 34, 1720-1729 (2006).
    • (2006) Exp. Hematol , vol.34 , pp. 1720-1729
    • Lefort, N.1
  • 75
    • 18644373047 scopus 로고    scopus 로고
    • PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis
    • Dakic, A. et al. PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis. J. Exp. Med. 201, 1487-1502 (2005).
    • (2005) J. Exp. Med , vol.201 , pp. 1487-1502
    • Dakic, A.1
  • 76
    • 23944446085 scopus 로고    scopus 로고
    • Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation
    • Iwasaki, H. et al. Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation. Blood 106, 1590-1600 (2005).
    • (2005) Blood , vol.106 , pp. 1590-1600
    • Iwasaki, H.1
  • 77
    • 33845994697 scopus 로고    scopus 로고
    • T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFβ dosage
    • Talebian, L. et al. T-lymphoid, megakaryocyte, and granulocyte development are sensitive to decreases in CBFβ dosage. Blood 109, 11-21 (2007).
    • (2007) Blood , vol.109 , pp. 11-21
    • Talebian, L.1
  • 78
    • 33646671945 scopus 로고    scopus 로고
    • Ikawa, T., Kawamoto, H., Goldrath, A. W. & Murre, C. E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment. J. Exp. Med. 203, 1329-1342 (2006). The authors use an E2A-knockout haematopoietic progenitor cell line and tamoxifen to identify probable direct targets of E2A in a precursor-cell context. The results show synergistic and combinatorial interaction between Notch and E proteins that activate T-cell-lineage genes.
    • Ikawa, T., Kawamoto, H., Goldrath, A. W. & Murre, C. E proteins and Notch signaling cooperate to promote T cell lineage specification and commitment. J. Exp. Med. 203, 1329-1342 (2006). The authors use an E2A-knockout haematopoietic progenitor cell line and tamoxifen to identify probable direct targets of E2A in a precursor-cell context. The results show synergistic and combinatorial interaction between Notch and E proteins that activate T-cell-lineage genes.
  • 79
    • 34248580502 scopus 로고    scopus 로고
    • Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF
    • Maeda, T. et al. Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF. Science 316, 860-866 (2007).
    • (2007) Science , vol.316 , pp. 860-866
    • Maeda, T.1
  • 80
    • 22144461424 scopus 로고    scopus 로고
    • Requirement for Notch1 signals at sequential early stages of intrathymic T cell development
    • Tan, J. B., Visan, I., Yuan, J. S. & Guidos, C. J. Requirement for Notch1 signals at sequential early stages of intrathymic T cell development. Nature Immunol. 6, 671-679 (2005).
    • (2005) Nature Immunol , vol.6 , pp. 671-679
    • Tan, J.B.1    Visan, I.2    Yuan, J.S.3    Guidos, C.J.4
  • 81
    • 33846240496 scopus 로고    scopus 로고
    • Identification of a T lineage-committed progenitor in adult blood
    • Krueger, A. & von Boehmer, H. Identification of a T lineage-committed progenitor in adult blood. Immunity 26, 105-116 (2007).
    • (2007) Immunity , vol.26 , pp. 105-116
    • Krueger, A.1    von Boehmer, H.2
  • 82
    • 4344717287 scopus 로고    scopus 로고
    • New insights into the proliferation and differentiation of early mouse thymocytes
    • Laurent, J., Bosco, N., Marche, P. N. & Ceredig, R. New insights into the proliferation and differentiation of early mouse thymocytes. Int. Immunol. 16, 1069-1080 (2004).
    • (2004) Int. Immunol , vol.16 , pp. 1069-1080
    • Laurent, J.1    Bosco, N.2    Marche, P.N.3    Ceredig, R.4
  • 83
    • 3242747324 scopus 로고    scopus 로고
    • Regulation of thymus size by competition for stromal niches among early T cell progenitors
    • Prockop, S. E. & Petrie, H. T. Regulation of thymus size by competition for stromal niches among early T cell progenitors. J. Immunol. 173, 1604-1611 (2004).
    • (2004) J. Immunol , vol.173 , pp. 1604-1611
    • Prockop, S.E.1    Petrie, H.T.2
  • 84
    • 17644443312 scopus 로고    scopus 로고
    • The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus
    • Yücel, R., Karsunky, H., Klein-Hitpass, L. & Möröy, T. The transcriptional repressor Gfi1 affects development of early, uncommitted c-Kit+ T cell progenitors and CD4/CD8 lineage decision in the thymus. J. Exp. Med. 197, 831-844 (2003).
    • (2003) J. Exp. Med , vol.197 , pp. 831-844
    • Yücel, R.1    Karsunky, H.2    Klein-Hitpass, L.3    Möröy, T.4
  • 85
    • 0037244284 scopus 로고    scopus 로고
    • Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation
    • Hock, H. et al. Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation. Immunity 18, 109-120 (2003).
    • (2003) Immunity , vol.18 , pp. 109-120
    • Hock, H.1
  • 86
    • 0032532301 scopus 로고    scopus 로고
    • Critical involvement of Tcf-1 in expansion of thymocytes
    • Schilham, M. W. et al. Critical involvement of Tcf-1 in expansion of thymocytes. J. Immunol. 161, 3984-3991 (1998).
    • (1998) J. Immunol , vol.161 , pp. 3984-3991
    • Schilham, M.W.1
  • 87
    • 33644772155 scopus 로고    scopus 로고
    • Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules
    • Weerkamp, F. et al. Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules. Proc. Natl Acad. Sci. USA 103, 3322-3326 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 3322-3326
    • Weerkamp, F.1
  • 88
    • 29444440721 scopus 로고    scopus 로고
    • Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1
    • Rosenbauer, F. et al. Lymphoid cell growth and transformation are suppressed by a key regulatory element of the gene encoding PU.1. Nature Genet. 38, 27-37 (2006).
    • (2006) Nature Genet , vol.38 , pp. 27-37
    • Rosenbauer, F.1
  • 89
    • 0037111391 scopus 로고    scopus 로고
    • Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation
    • Hager-Theodorides, A. L. et al. Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation. J. Immunol. 169, 5496-5504 (2002).
    • (2002) J. Immunol , vol.169 , pp. 5496-5504
    • Hager-Theodorides, A.L.1
  • 90
    • 0345689338 scopus 로고    scopus 로고
    • BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis
    • Tsai, P. T., Lee, R. A. & Wu, H. BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis. Blood 102, 3947-3953 (2003).
    • (2003) Blood , vol.102 , pp. 3947-3953
    • Tsai, P.T.1    Lee, R.A.2    Wu, H.3
  • 91
    • 0037384858 scopus 로고    scopus 로고
    • The role of morphogens in T-cell development
    • Varas, A. et al. The role of morphogens in T-cell development. Trends Immunol. 24, 197-206 (2003).
    • (2003) Trends Immunol , vol.24 , pp. 197-206
    • Varas, A.1
  • 92
    • 33846796314 scopus 로고    scopus 로고
    • Tsuji, M., Shinkura, R., Kuroda, K., Yabe, D. & Honjo, T. Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling. Proc. Natl Acad. Sci. USA 104, 1610-1615 (2007). Deficiency of an inhibitor of Notch-dependent transcription reveals that Notch effects on early T cells depend on feedback negative regulation. The action of MINT and effects on target gene Nrarp distinguish Notch promotion of ETP self renewal from Notch promotion of DN2 cell generation.
    • Tsuji, M., Shinkura, R., Kuroda, K., Yabe, D. & Honjo, T. Msx2-interacting nuclear target protein (Mint) deficiency reveals negative regulation of early thymocyte differentiation by Notch/RBP-J signaling. Proc. Natl Acad. Sci. USA 104, 1610-1615 (2007). Deficiency of an inhibitor of Notch-dependent transcription reveals that Notch effects on early T cells depend on feedback negative regulation. The action of MINT and effects on target gene Nrarp distinguish Notch promotion of ETP self renewal from Notch promotion of DN2 cell generation.
  • 93
    • 0037606092 scopus 로고    scopus 로고
    • Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: Multiple Notch1 signaling pathways involved in T cell development
    • Yun, T. J. & Bevan, M. J. Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development. J. Immunol. 170, 5834-5841 (2003).
    • (2003) J. Immunol , vol.170 , pp. 5834-5841
    • Yun, T.J.1    Bevan, M.J.2
  • 94
    • 33644641356 scopus 로고    scopus 로고
    • Determinants of lymphoid-myeloid lineage diversification
    • Laiosa, C. V., Stadtfeld, M. & Graf, T. Determinants of lymphoid-myeloid lineage diversification. Annu. Rev. Immunol. 24, 705-738 (2006).
    • (2006) Annu. Rev. Immunol , vol.24 , pp. 705-738
    • Laiosa, C.V.1    Stadtfeld, M.2    Graf, T.3
  • 95
    • 33846257739 scopus 로고    scopus 로고
    • + cells by coexpression of NotchIC or GATA3, but not by E2A.
    • + cells by coexpression of NotchIC or GATA3, but not by E2A.
  • 96
    • 18844379144 scopus 로고    scopus 로고
    • Subversion of T lineage commitment by PU.1 in a clonal cell line system
    • Dionne, C. J. et al. Subversion of T lineage commitment by PU.1 in a clonal cell line system. Dev. Biol. 280, 448-466 (2005).
    • (2005) Dev. Biol , vol.280 , pp. 448-466
    • Dionne, C.J.1
  • 97
    • 18644383420 scopus 로고    scopus 로고
    • Enforced expression of Spi-B reverses T lineage commitment and blocks β-selection
    • Lefebvre, J. M. et al. Enforced expression of Spi-B reverses T lineage commitment and blocks β-selection. J. Immunol. 174, 6184-6194 (2005).
    • (2005) J. Immunol , vol.174 , pp. 6184-6194
    • Lefebvre, J.M.1
  • 98
    • 34249014002 scopus 로고    scopus 로고
    • Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity
    • Boos, M. D., Yokota, Y., Eberl, G. & Kee, B. L. Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity. J. Exp. Med. 204, 1119-1130 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 1119-1130
    • Boos, M.D.1    Yokota, Y.2    Eberl, G.3    Kee, B.L.4
  • 99
    • 0035942179 scopus 로고    scopus 로고
    • Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2
    • Ikawa, T., Fujimoto, S., Kawamoto, H., Katsura, Y. & Yokota, Y. Commitment to natural killer cells requires the helix-loop-helix inhibitor Id2. Proc. Natl Acad. Sci. USA 98, 5164-5169 (2001).
    • (2001) Proc. Natl Acad. Sci. USA , vol.98 , pp. 5164-5169
    • Ikawa, T.1    Fujimoto, S.2    Kawamoto, H.3    Katsura, Y.4    Yokota, Y.5
  • 100
    • 0037515610 scopus 로고    scopus 로고
    • Enforced granulocyte/macrophage colony-stimulating factor signals do not support lymphopoiesis, but instruct lymphoid to myelomonocytic lineage conversion
    • Iwasaki-Arai, J., Iwasaki, H., Miyamoto, T., Watanabe, S. & Akashi, K. Enforced granulocyte/macrophage colony-stimulating factor signals do not support lymphopoiesis, but instruct lymphoid to myelomonocytic lineage conversion. J. Exp. Med. 197, 1311-1322 (2003).
    • (2003) J. Exp. Med , vol.197 , pp. 1311-1322
    • Iwasaki-Arai, J.1    Iwasaki, H.2    Miyamoto, T.3    Watanabe, S.4    Akashi, K.5
  • 101
    • 31444431706 scopus 로고    scopus 로고
    • Antagonistic effect of CCAAT enhancer-binding protein-α and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors
    • Hsu, C. L. et al. Antagonistic effect of CCAAT enhancer-binding protein-α and Pax5 in myeloid or lymphoid lineage choice in common lymphoid progenitors. Proc. Natl Acad. Sci. USA 103, 672-677 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 672-677
    • Hsu, C.L.1
  • 102
    • 0034748924 scopus 로고    scopus 로고
    • GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1
    • Shibata, Y. et al. GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity 15, 557-567 (2001).
    • (2001) Immunity , vol.15 , pp. 557-567
    • Shibata, Y.1
  • 103
    • 33845584264 scopus 로고    scopus 로고
    • Transient Notch signaling induces NK cell potential in Pax5-deficient pro-B cells
    • Carotta, S., Brady, J., Wu, L. & Nutt, S. L. Transient Notch signaling induces NK cell potential in Pax5-deficient pro-B cells. Eur. J. Immunol. 36, 3294-3304 (2006).
    • (2006) Eur. J. Immunol , vol.36 , pp. 3294-3304
    • Carotta, S.1    Brady, J.2    Wu, L.3    Nutt, S.L.4
  • 104
    • 33748288072 scopus 로고    scopus 로고
    • The potential involvement of Notch signaling in NK cell development
    • Rolink, A. G., Balciunaite, G., Demoliere, C. & Ceredig, R. The potential involvement of Notch signaling in NK cell development. Immunol. Lett. 107, 50-57 (2006).
    • (2006) Immunol. Lett , vol.107 , pp. 50-57
    • Rolink, A.G.1    Balciunaite, G.2    Demoliere, C.3    Ceredig, R.4
  • 105
    • 0036132393 scopus 로고    scopus 로고
    • Role of Id family proteins in growth control
    • Yokota, Y. & Mori, S. Role of Id family proteins in growth control. J. Cell. Physiol. 190, 21-28 (2002).
    • (2002) J. Cell. Physiol , vol.190 , pp. 21-28
    • Yokota, Y.1    Mori, S.2
  • 106
    • 33751186113 scopus 로고    scopus 로고
    • Low SCL/TAL1 expression reveals its major role in adult hematopoietic myeloid progenitors and stem cells
    • Brunet de la Grange, P. et al. Low SCL/TAL1 expression reveals its major role in adult hematopoietic myeloid progenitors and stem cells. Blood 108, 2998-3004 (2006).
    • (2006) Blood , vol.108 , pp. 2998-3004
    • Brunet de la Grange, P.1
  • 107
    • 1942425445 scopus 로고    scopus 로고
    • SCL is required for normal function of short-term repopulating hematopoietic stem cells
    • Curtis, D. J. et al. SCL is required for normal function of short-term repopulating hematopoietic stem cells. Blood 103, 3342-3348 (2004).
    • (2004) Blood , vol.103 , pp. 3342-3348
    • Curtis, D.J.1
  • 108
    • 0033566720 scopus 로고    scopus 로고
    • A critical role for PU.1 in homing and long-term engraftment by hematopoietic stem cells in the bone marrow
    • Fisher, R. C., Lovelock, J. D. & Scott, E. W. A critical role for PU.1 in homing and long-term engraftment by hematopoietic stem cells in the bone marrow. Blood 94, 1283-1290 (1999).
    • (1999) Blood , vol.94 , pp. 1283-1290
    • Fisher, R.C.1    Lovelock, J.D.2    Scott, E.W.3
  • 109
    • 0032479872 scopus 로고    scopus 로고
    • Transcription factor SCL is required for c-kit expression and c-Kit function in hemopoietic cells
    • Krosl, G. et al. Transcription factor SCL is required for c-kit expression and c-Kit function in hemopoietic cells. J. Exp. Med. 188, 439-450 (1998).
    • (1998) J. Exp. Med , vol.188 , pp. 439-450
    • Krosl, G.1
  • 110
    • 0038375546 scopus 로고    scopus 로고
    • CDK6 blocks differentiation: Coupling cell proliferation to the block to differentiation in leukemic cells
    • Matushansky, I., Radparvar, F. & Skoultchi, A. I. CDK6 blocks differentiation: coupling cell proliferation to the block to differentiation in leukemic cells. Oncogene 22, 4143-4149 (2003).
    • (2003) Oncogene , vol.22 , pp. 4143-4149
    • Matushansky, I.1    Radparvar, F.2    Skoultchi, A.I.3
  • 111
    • 20144367473 scopus 로고    scopus 로고
    • Functional domains of Runx1 are differentially required for CD4 repression, TCRβ expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development
    • Kawazu, M. et al. Functional domains of Runx1 are differentially required for CD4 repression, TCRβ expression, and CD4/8 double-negative to CD4/8 double-positive transition in thymocyte development. J. Immunol. 174, 3526-3533 (2005).
    • (2005) J. Immunol , vol.174 , pp. 3526-3533
    • Kawazu, M.1
  • 113
    • 3242784226 scopus 로고    scopus 로고
    • Critical functions for c-Myb at three checkpoints during thymocyte development
    • Bender, T. P., Kremer, C. S., Kraus, M., Buch, T. & Rajewsky, K. Critical functions for c-Myb at three checkpoints during thymocyte development. Nature Immunol. 5, 721-729 (2004).
    • (2004) Nature Immunol , vol.5 , pp. 721-729
    • Bender, T.P.1    Kremer, C.S.2    Kraus, M.3    Buch, T.4    Rajewsky, K.5
  • 114
    • 0043239343 scopus 로고    scopus 로고
    • Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb
    • Emambokus, N. et al. Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. EMBO J. 22, 4478-4488 (2003).
    • (2003) EMBO J , vol.22 , pp. 4478-4488
    • Emambokus, N.1
  • 115
    • 22144447520 scopus 로고    scopus 로고
    • Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype
    • Growney, J. D. et al. Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype. Blood 106, 494-504 (2005).
    • (2005) Blood , vol.106 , pp. 494-504
    • Growney, J.D.1
  • 116
    • 33646481325 scopus 로고    scopus 로고
    • -/- mice
    • -/- mice. J. Immunol. 176, 5871-5879 (2006).
    • (2006) J. Immunol , vol.176 , pp. 5871-5879
    • Inoue, J.1
  • 117
    • 24944444760 scopus 로고    scopus 로고
    • Notch promotes survival of pre-T cells at the β-selection checkpoint by regulating cellular metabolism
    • Ciofani, M. & Zúñiga-Pflücker, J. C. Notch promotes survival of pre-T cells at the β-selection checkpoint by regulating cellular metabolism. Nature Immunol. 6, 881-888 (2005).
    • (2005) Nature Immunol , vol.6 , pp. 881-888
    • Ciofani, M.1    Zúñiga-Pflücker, J.C.2
  • 118
    • 33746546368 scopus 로고    scopus 로고
    • c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma
    • Weng, A. P. et al. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev. 20, 2096-2109 (2006).
    • (2006) Genes Dev , vol.20 , pp. 2096-2109
    • Weng, A.P.1
  • 119
    • 33845306813 scopus 로고    scopus 로고
    • NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth
    • Palomero, T. et al. NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth. Proc. Natl Acad. Sci. USA 103, 18261-18266 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 18261-18266
    • Palomero, T.1
  • 120
    • 0033811622 scopus 로고    scopus 로고
    • Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB
    • Barndt, R. J., Dai, M. & Zhuang, Y. Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. Mol. Cell. Biol. 20, 6677-6685 (2000).
    • (2000) Mol. Cell. Biol , vol.20 , pp. 6677-6685
    • Barndt, R.J.1    Dai, M.2    Zhuang, Y.3
  • 121
    • 34247627897 scopus 로고    scopus 로고
    • Wojciechowski, J., Lai, A., Kondo, M. & Zhuang, Y. E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. J. Immunol. 178, 5717-5726 (2007). Using a double conditional knockout mouse system, the authors show that cells which reach the DN3 stage before deleting E2A and HEB seem to reverse course after deleting them, and return to extended IL-7-dependent proliferation and a DN2-like phenotype.
    • Wojciechowski, J., Lai, A., Kondo, M. & Zhuang, Y. E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. J. Immunol. 178, 5717-5726 (2007). Using a double conditional knockout mouse system, the authors show that cells which reach the DN3 stage before deleting E2A and HEB seem to reverse course after deleting them, and return to extended IL-7-dependent proliferation and a DN2-like phenotype.
  • 122
    • 33745591644 scopus 로고    scopus 로고
    • Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development
    • Schwartz, R., Engel, I., Fallahi-Sichani, M., Petrie, H. T. & Murre, C. Gene expression patterns define novel roles for E47 in cell cycle progression, cytokine-mediated signaling, and T lineage development. Proc. Natl Acad. Sci. USA 103, 9976-9981 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 9976-9981
    • Schwartz, R.1    Engel, I.2    Fallahi-Sichani, M.3    Petrie, H.T.4    Murre, C.5
  • 123
    • 0842285394 scopus 로고    scopus 로고
    • Engel, I. & Murre, C. E2A proteins enforce a proliferation checkpoint in developing thymocytes. EMBO J. 23, 202-211 (2004).
    • Engel, I. & Murre, C. E2A proteins enforce a proliferation checkpoint in developing thymocytes. EMBO J. 23, 202-211 (2004).
  • 124
    • 33744492040 scopus 로고    scopus 로고
    • Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches
    • Visan, I. et al. Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches. Nature Immunol. 7, 634-643 (2006).
    • (2006) Nature Immunol , vol.7 , pp. 634-643
    • Visan, I.1
  • 125
    • 33847103659 scopus 로고    scopus 로고
    • Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation
    • Besseyrias, V. et al. Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation. J. Exp. Med. 204, 331-343 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 331-343
    • Besseyrias, V.1
  • 126
    • 0035903286 scopus 로고    scopus 로고
    • Early thymocyte development is regulated by modulation of E2A protein activity
    • Engel, I., Johns, C., Bain, G., Rivera, R. R. & Murre, C. Early thymocyte development is regulated by modulation of E2A protein activity. J. Exp. Med. 194, 733-746 (2001).
    • (2001) J. Exp. Med , vol.194 , pp. 733-746
    • Engel, I.1    Johns, C.2    Bain, G.3    Rivera, R.R.4    Murre, C.5
  • 127
    • 0034664769 scopus 로고    scopus 로고
    • Combinatorial roles of the nuclear receptor corepressor in transcription and development
    • Jepsen, K. et al. Combinatorial roles of the nuclear receptor corepressor in transcription and development. Cell 102, 753-763 (2000).
    • (2000) Cell , vol.102 , pp. 753-763
    • Jepsen, K.1
  • 129
    • 2442522357 scopus 로고    scopus 로고
    • Regulation of αβ/γδ T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling
    • Tanigaki, K. et al. Regulation of αβ/γδ T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. Immunity 20, 611-622 (2004).
    • (2004) Immunity , vol.20 , pp. 611-622
    • Tanigaki, K.1
  • 130
    • 5444249783 scopus 로고    scopus 로고
    • GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells
    • Xue, H.-H. et al. GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells. Nature Immunol. 5, 1036-1044 (2004).
    • (2004) Nature Immunol , vol.5 , pp. 1036-1044
    • Xue, H.-H.1
  • 131
    • 2942516896 scopus 로고    scopus 로고
    • Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages
    • Porritt, H. E. et al. Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages. Immunity 20, 735-745 (2004).
    • (2004) Immunity , vol.20 , pp. 735-745
    • Porritt, H.E.1
  • 132
    • 0029924217 scopus 로고    scopus 로고
    • Productive T-cell receptor β-chain gene rearrangement: Coincident regulation of cell cycle and clonality during development in vivo
    • Hoffman, E. S. et al. Productive T-cell receptor β-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo. Genes Dev. 10, 948-962 (1996).
    • (1996) Genes Dev , vol.10 , pp. 948-962
    • Hoffman, E.S.1
  • 133
    • 18344388633 scopus 로고    scopus 로고
    • Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1
    • Izon, D. J. et al. Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. Immunity 16, 231-243 (2002).
    • (2002) Immunity , vol.16 , pp. 231-243
    • Izon, D.J.1
  • 134
    • 0031883962 scopus 로고    scopus 로고
    • Redundant regulation of T cell differentiation and TCRα gene expression by the transcription factors LEF-1 and TCF-1
    • Okamura, R. M. et al. Redundant regulation of T cell differentiation and TCRα gene expression by the transcription factors LEF-1 and TCF-1. Immunity 8, 11-20 (1998).
    • (1998) Immunity , vol.8 , pp. 11-20
    • Okamura, R.M.1


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