Metabolic sensor AMPK directly phosphorylates RAG1 protein and regulates V(D)J recombination

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 24, 2013, Pages 9873-9878

  Um, Jee Hyun ^a,b   Brown, Alexandra L ^a   Singh, Samarendra K ^c   Chen, Yong ^a   Gucek, Marjan ^a   Lee, Baeck Seung ^d   Luckey, Megan A ^e   Kim, Myung K ^a   Park, Jung Hyun ^e   Sleckman, Barry P ^d   Gellert, Martin ^c   Chung, Jay H ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b Gachon University College of Medicine   (South Korea)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Energy coupling; Immune diversity

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; IMMUNOGLOBULIN; OLIGONUCLEOTIDE; RAG1 PROTEIN; RAG2 PROTEIN; SERINE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; CATALYSIS; CELL ASSAY; COMPLEX FORMATION; CONTROLLED STUDY; DNA CLEAVAGE; DNA RECOMBINATION; EMBRYO; ENZYME ACTIVATION; ENZYME SUBSTRATE; GENETIC VARIABILITY; IMMUNOGLOBULIN STRUCTURE; IN VITRO STUDY; METABOLIC STRESS; MOLECULAR SENSOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE;

ENERGY COUPLING; IMMUNE DIVERSITY;

AMINO ACID SEQUENCE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; CELLS, CULTURED; DNA-BINDING PROTEINS; HEK293 CELLS; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOBLOTTING; MICE; MICE, KNOCKOUT; MUTATION; NUCLEAR PROTEINS; OLIGONUCLEOTIDES; PHOSPHORYLATION; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; SUBSTRATE SPECIFICITY; V(D)J RECOMBINATION;

EUKARYOTA;

EID: 84878996181     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1307928110     Document Type: Article

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