-
2
-
-
80053575783
-
The multifaceted roles of autophagy in tumors-implications for breast cancer
-
Debnath J. The multifaceted roles of autophagy in tumors-implications for breast cancer. J Mammary Gland Biol Neoplasia 2011; 16: 73-187.
-
(2011)
J Mammary Gland Biol Neoplasia
, vol.16
, pp. 73-187
-
-
Debnath, J.1
-
3
-
-
72549095406
-
Regulation mechanisms and signaling pathways of autophagy
-
He C and Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet 2009; 43: 67-93.
-
(2009)
Annu Rev Genet
, vol.43
, pp. 67-93
-
-
He, C.1
Klionsky, D.J.2
-
4
-
-
35448981935
-
Autophagy: from phenomenology to molecular understanding in less than a decade
-
Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007; 8: 931-937.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 931-937
-
-
Klionsky, D.J.1
-
6
-
-
77951221542
-
The role of the Atg1/ULK1 complex in autophagy regulation
-
Mizushima N. The role of the Atg1/ULK1 complex in autophagy regulation. Curr Opin Cell Biol 2010; 22: 132-139.
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 132-139
-
-
Mizushima, N.1
-
7
-
-
65249176304
-
ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery
-
Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J, Kundu M and Kim DH. ULK-Atg13-FIP200 complexes mediate mTOR signaling to the autophagy machinery. Mol Biol Cell 2009; 20: 1992-2003.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1992-2003
-
-
Jung, C.H.1
Jun, C.B.2
Ro, S.H.3
Kim, Y.M.4
Otto, N.M.5
Cao, J.6
Kundu, M.7
Kim, D.H.8
-
8
-
-
65249119430
-
Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy
-
Hosokawa N, Hara T, Kaizuka T, Kishi C, Takamura A, Miura Y, Iemura S, Natsume T, Takehana K, Yamada N, Guan JL, Oshiro N and Mizushima N. Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy. Mol Biol Cell 2009; 20: 1981-1991.
-
(2009)
Mol Biol Cell
, vol.20
, pp. 1981-1991
-
-
Hosokawa, N.1
Hara, T.2
Kaizuka, T.3
Kishi, C.4
Takamura, A.5
Miura, Y.6
Iemura, S.7
Natsume, T.8
Takehana, K.9
Yamada, N.10
Guan, J.L.11
Oshiro, N.12
Mizushima, N.13
-
9
-
-
59249089394
-
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
-
Itakura E, Kishi C, Inoue K and Mizushima N. Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol Biol Cell 2008; 19: 5360-5372.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 5360-5372
-
-
Itakura, E.1
Kishi, C.2
Inoue, K.3
Mizushima, N.4
-
10
-
-
27944504351
-
p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
-
Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H and Johansen T. p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 2005; 171: 603-614.
-
(2005)
J Cell Biol
, vol.171
, pp. 603-614
-
-
Bjorkoy, G.1
Lamark, T.2
Brech, A.3
Outzen, H.4
Perander, M.5
Overvatn, A.6
Stenmark, H.7
Johansen, T.8
-
11
-
-
84869210001
-
Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation
-
Romanov J, Walczak M, Ibiricu I, Schuchner S, Ogris E, Kraft C and Martens S. Mechanism and functions of membrane binding by the Atg5-Atg12/Atg16 complex during autophagosome formation. EMBO J 2012; 31: 4304-4317.
-
(2012)
EMBO J
, vol.31
, pp. 4304-4317
-
-
Romanov, J.1
Walczak, M.2
Ibiricu, I.3
Schuchner, S.4
Ogris, E.5
Kraft, C.6
Martens, S.7
-
12
-
-
38049098543
-
The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy
-
Hanada T, Noda NN, Satomi Y, Ichimura Y, Fujioka Y, Takao T, Inagaki F and Ohsumi Y. The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy. J Biol Chem 2007; 282: 37298-37302.
-
(2007)
J Biol Chem
, vol.282
, pp. 37298-37302
-
-
Hanada, T.1
Noda, N.N.2
Satomi, Y.3
Ichimura, Y.4
Fujioka, Y.5
Takao, T.6
Inagaki, F.7
Ohsumi, Y.8
-
13
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y and Yoshimori T. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 2000; 19: 5720-5728.
-
(2000)
EMBO J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
Yamamoto, A.4
Kirisako, T.5
Noda, T.6
Kominami, E.7
Ohsumi, Y.8
Yoshimori, T.9
-
14
-
-
79959761278
-
Regulation of autophagy by kinases
-
Sridharan S, Jain K and Basu A. Regulation of autophagy by kinases. Cancers 2011; 3: 2630-2654.
-
(2011)
Cancers
, vol.3
, pp. 2630-2654
-
-
Sridharan, S.1
Jain, K.2
Basu, A.3
-
15
-
-
66449083078
-
ULK1 ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy.
-
Ganley IG, Lam du H, Wang J, Ding X, Chen S and Jiang X. ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy. J Biol Chem 2009; 284: 12297-12305.
-
(2009)
J Biol Chem
, vol.284
, pp. 12297-12305
-
-
Ganley, I.G.1
Lam du, H.2
Wang, J.3
Ding, X.4
Chen, S.5
Jiang, X.6
-
16
-
-
78650510609
-
mTOR: from growth signal integration to cancer, diabetes and ageing
-
Zoncu R, Efeyan A and Sabatini DM. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12: 21-35.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
17
-
-
80052188788
-
Spatial regulation of the mTORC1 system in amino acids sensing pathway
-
Suzuki T and Inoki K. Spatial regulation of the mTORC1 system in amino acids sensing pathway. Acta Biochim Biophys Sin (Shanghai) 2011; 43: 671-679.
-
(2011)
Acta Biochim Biophys Sin (Shanghai)
, vol.43
, pp. 671-679
-
-
Suzuki, T.1
Inoki, K.2
-
18
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
Kim J, Kundu M, Viollet B and Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011; 13: 132-141.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
19
-
-
81155123729
-
The serine/threonine kinase ULK1 is a target of multiple phosphorylation events
-
Bach M, Larance M, James DE and Ramm G. The serine/threonine kinase ULK1 is a target of multiple phosphorylation events. Biochem J 2011; 440: 283-291.
-
(2011)
Biochem J
, vol.440
, pp. 283-291
-
-
Bach, M.1
Larance, M.2
James, D.E.3
Ramm, G.4
-
20
-
-
79953211917
-
Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK
-
Shang L, Chen S, Du F, Li S, Zhao L and Wang X. Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK. Proc Natl Acad Sci U S A 2011; 108: 4788-4793.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 4788-4793
-
-
Shang, L.1
Chen, S.2
Du, F.3
Li, S.4
Zhao, L.5
Wang, X.6
-
21
-
-
63849149937
-
LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
-
Shaw RJ. LKB1 and AMP-activated protein kinase control of mTOR signalling and growth. Acta Physiol (Oxf) 2009; 196: 65-80.
-
(2009)
Acta Physiol (Oxf)
, vol.196
, pp. 65-80
-
-
Shaw, R.J.1
-
22
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
-
Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N, Packer M, Schneider MD and Levine B. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 2005; 122: 927-939.
-
(2005)
Cell
, vol.122
, pp. 927-939
-
-
Pattingre, S.1
Tassa, A.2
Qu, X.3
Garuti, R.4
Liang, X.H.5
Mizushima, N.6
Packer, M.7
Schneider, M.D.8
Levine, B.9
-
23
-
-
34248998801
-
Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1
-
Maiuri MC, Le Toumelin G, Criollo A, Rain JC, Gautier F, Juin P, Tasdemir E, Pierron G, Troulinaki K, Tavernarakis N, Hickman JA, Geneste O and Kroemer G. Functional and physical interaction between Bcl-X(L) and a BH3-like domain in Beclin-1. EMBO J 2007; 26: 2527-2539.
-
(2007)
EMBO J
, vol.26
, pp. 2527-2539
-
-
Maiuri, M.C.1
Le Toumelin, G.2
Criollo, A.3
Rain, J.C.4
Gautier, F.5
Juin, P.6
Tasdemir, E.7
Pierron, G.8
Troulinaki, K.9
Tavernarakis, N.10
Hickman, J.A.11
Geneste, O.12
Kroemer, G.13
-
24
-
-
84983718691
-
Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells
-
Tai WT, Shiau CW, Chen HL, Liu CY, Lin CS, Cheng AL, Chen PJ and Chen KF. Mcl-1-dependent activation of Beclin 1 mediates autophagic cell death induced by sorafenib and SC-59 in hepatocellular carcinoma cells. Cell Death Dis 2013; 4: e485.
-
(2013)
Cell Death Dis
, vol.4
-
-
Tai, W.T.1
Shiau, C.W.2
Chen, H.L.3
Liu, C.Y.4
Lin, C.S.5
Cheng, A.L.6
Chen, P.J.7
Chen, K.F.8
-
25
-
-
84877628647
-
Autophagy in human health and disease
-
Choi AM, Ryter SW and Levine B. Autophagy in human health and disease. N Engl J Med 2013; 368: 651-662.
-
(2013)
N Engl J Med
, vol.368
, pp. 651-662
-
-
Choi, A.M.1
Ryter, S.W.2
Levine, B.3
-
26
-
-
84864960912
-
Autophagy, stress, and cancer metabolism: what doesn't kill you makes you stronger
-
Mathew R and White E. Autophagy, stress, and cancer metabolism: what doesn't kill you makes you stronger. Cold Spring Harb Symp Quant Biol 2011; 76: 389-396.
-
(2011)
Cold Spring Harb Symp Quant Biol
, vol.76
, pp. 389-396
-
-
Mathew, R.1
White, E.2
-
27
-
-
84872733519
-
Autophagy controls p38 activation to promote cell survival under genotoxic stress
-
Qiang L, Wu C, Ming M, Viollet B and He YY. Autophagy controls p38 activation to promote cell survival under genotoxic stress. J Biol Chem 2013; 288: 1603-1611.
-
(2013)
J Biol Chem
, vol.288
, pp. 1603-1611
-
-
Qiang, L.1
Wu, C.2
Ming, M.3
Viollet, B.4
He, Y.Y.5
-
29
-
-
11144242211
-
Timeline: Chemotherapy and the war on cancer
-
Chabner BA and Roberts TG Jr. Timeline: Chemotherapy and the war on cancer. Nat Rev Cancer 2005; 5: 65-72.
-
(2005)
Nat Rev Cancer
, vol.5
, pp. 65-72
-
-
Chabner, B.A.1
Roberts, T.G.2
-
31
-
-
84867182336
-
Autophagy and ionizing radiation in tumors: the "survive or not survive" dilemma
-
Palumbo S and Comincini S. Autophagy and ionizing radiation in tumors: the "survive or not survive" dilemma. J Cell Physiol 2013; 228: 1-8.
-
(2013)
J Cell Physiol
, vol.228
, pp. 1-8
-
-
Palumbo, S.1
Comincini, S.2
-
32
-
-
84868197448
-
Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis
-
Ouyang L, Shi Z, Zhao S, Wang FT, Zhou TT, Liu B and Bao JK. Programmed cell death pathways in cancer: a review of apoptosis, autophagy and programmed necrosis. Cell Prolif 2012; 45: 487-498.
-
(2012)
Cell Prolif
, vol.45
, pp. 487-498
-
-
Ouyang, L.1
Shi, Z.2
Zhao, S.3
Wang, F.T.4
Zhou, T.T.5
Liu, B.6
Bao, J.K.7
-
33
-
-
0034012322
-
Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments
-
Bursch W, Hochegger K, Torok L, Marian B, Ellinger A and Hermann RS. Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J Cell Sci 2000; 113: 1189-1198.
-
(2000)
J Cell Sci
, vol.113
, pp. 1189-1198
-
-
Bursch, W.1
Hochegger, K.2
Torok, L.3
Marian, B.4
Ellinger, A.5
Hermann, R.S.6
-
35
-
-
84874865711
-
Attacking breast cancer at the preinvasion stage by targeting autophagy
-
(Lond Engl)
-
Espina V, Wysolmerski J, Edmiston K and Liotta LA. Attacking breast cancer at the preinvasion stage by targeting autophagy. Womens Health (Lond Engl) 2013; 9: 157-170.
-
(2013)
Womens Health
, vol.9
, pp. 157-170
-
-
Espina, V.1
Wysolmerski, J.2
Edmiston, K.3
Liotta, L.A.4
-
36
-
-
78649663247
-
Triple-negative breast cancer: disease entity or title of convenience?
-
Carey L, Winer E, Viale G, Cameron D and Gianni L. Triple-negative breast cancer: disease entity or title of convenience? Nat Rev Clin Oncol 2010; 7: 683-692.
-
(2010)
Nat Rev Clin Oncol
, vol.7
, pp. 683-692
-
-
Carey, L.1
Winer, E.2
Viale, G.3
Cameron, D.4
Gianni, L.5
-
38
-
-
0344142468
-
Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21
-
Aita VM, Liang XH, Murty VV, Pincus DL, Yu W, Cayanis E, Kalachikov S, Gilliam TC and Levine B. Cloning and genomic organization of beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics 1999; 59: 59-65.
-
(1999)
Genomics
, vol.59
, pp. 59-65
-
-
Aita, V.M.1
Liang, X.H.2
Murty, V.V.3
Pincus, D.L.4
Yu, W.5
Cayanis, E.6
Kalachikov, S.7
Gilliam, T.C.8
Levine, B.9
-
39
-
-
0032575551
-
Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae
-
Kametaka S, Okano T, Ohsumi M and Ohsumi Y. Apg14p and Apg6/Vps30p form a protein complex essential for autophagy in the yeast, Saccharomyces cerevisiae. J Biol Chem 1998; 273: 22284-22291.
-
(1998)
J Biol Chem
, vol.273
, pp. 22284-22291
-
-
Kametaka, S.1
Okano, T.2
Ohsumi, M.3
Ohsumi, Y.4
-
40
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
Yue Z, Jin S, Yang C, Levine AJ and Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci U S A 2003; 100: 15077-15082.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
Levine, A.J.4
Heintz, N.5
-
41
-
-
9144240441
-
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
-
Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A, Rosen J, Eskelinen EL, Mizushima N, Ohsumi Y, Cattoretti G and Levine B. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112: 1809-1820.
-
(2003)
J Clin Invest
, vol.112
, pp. 1809-1820
-
-
Qu, X.1
Yu, J.2
Bhagat, G.3
Furuya, N.4
Hibshoosh, H.5
Troxel, A.6
Rosen, J.7
Eskelinen, E.L.8
Mizushima, N.9
Ohsumi, Y.10
Cattoretti, G.11
Levine, B.12
-
42
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H and Levine B. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402: 672-676.
-
(1999)
Nature
, vol.402
, pp. 672-676
-
-
Liang, X.H.1
Jackson, S.2
Seaman, M.3
Brown, K.4
Kempkes, B.5
Hibshoosh, H.6
Levine, B.7
-
43
-
-
79953306808
-
Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival
-
Elgendy M, Sheridan C, Brumatti G and Martin SJ. Oncogenic Ras-induced expression of Noxa and Beclin-1 promotes autophagic cell death and limits clonogenic survival. Mol Cell 2011; 42: 23-35.
-
(2011)
Mol Cell
, vol.42
, pp. 23-35
-
-
Elgendy, M.1
Sheridan, C.2
Brumatti, G.3
Martin, S.J.4
-
44
-
-
0035870257
-
Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function
-
Liang XH, Yu J, Brown K and Levine B. Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. Cancer Res 2001; 61: 3443-3449.
-
(2001)
Cancer Res
, vol.61
, pp. 3443-3449
-
-
Liang, X.H.1
Yu, J.2
Brown, K.3
Levine, B.4
-
45
-
-
77951237303
-
The Beclin 1 interactome
-
He C and Levine B. The Beclin 1 interactome. Curr Opin Cell Biol 2010; 22: 140-149.
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 140-149
-
-
He, C.1
Levine, B.2
-
46
-
-
84861526009
-
Deconvoluting the context-dependent role for autophagy in cancer
-
White E. Deconvoluting the context-dependent role for autophagy in cancer. Nat Rev Cancer 2012; 12: 401-410.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 401-410
-
-
White, E.1
-
47
-
-
7744235672
-
Death by design: apoptosis, necrosis and autophagy
-
Edinger AL and Thompson CB. Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol 2004; 16: 663-669.
-
(2004)
Curr Opin Cell Biol
, vol.16
, pp. 663-669
-
-
Edinger, A.L.1
Thompson, C.B.2
-
48
-
-
79955377420
-
Autophagy-deficient mice develop multiple liver tumors
-
Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S, Eishi Y, Hino O, Tanaka K and Mizushima N. Autophagy-deficient mice develop multiple liver tumors. Genes Dev 2011; 25: 795-800.
-
(2011)
Genes Dev
, vol.25
, pp. 795-800
-
-
Takamura, A.1
Komatsu, M.2
Hara, T.3
Sakamoto, A.4
Kishi, C.5
Waguri, S.6
Eishi, Y.7
Hino, O.8
Tanaka, K.9
Mizushima, N.10
-
49
-
-
38049058666
-
To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation
-
Kang C and Avery L. To be or not to be, the level of autophagy is the question: dual roles of autophagy in the survival response to starvation. Autophagy 2008; 4: 82-84.
-
(2008)
Autophagy
, vol.4
, pp. 82-84
-
-
Kang, C.1
Avery, L.2
-
50
-
-
79952228407
-
Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis
-
Guo JY, Chen HY, Mathew R, Fan J, Strohecker AM, Karsli-Uzunbas G, Kamphorst JJ, Chen G, Lemons JM, Karantza V, Coller HA, Dipaola RS, Gelinas C, Rabinowitz JD and White E. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev 2011; 25: 460-470.
-
(2011)
Genes Dev
, vol.25
, pp. 460-470
-
-
Guo, J.Y.1
Chen, H.Y.2
Mathew, R.3
Fan, J.4
Strohecker, A.M.5
Karsli-Uzunbas, G.6
Kamphorst, J.J.7
Chen, G.8
Lemons, J.M.9
Karantza, V.10
Coller, H.A.11
Dipaola, R.S.12
Gelinas, C.13
Rabinowitz, J.D.14
White, E.15
-
51
-
-
79952229430
-
Pancreatic cancers require autophagy for tumor growth
-
Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N and Kimmelman AC. Pancreatic cancers require autophagy for tumor growth. Genes Dev 2011; 25: 717-729.
-
(2011)
Genes Dev
, vol.25
, pp. 717-729
-
-
Yang, S.1
Wang, X.2
Contino, G.3
Liesa, M.4
Sahin, E.5
Ying, H.6
Bause, A.7
Li, Y.8
Stommel, J.M.9
Dell'antonio, G.10
Mautner, J.11
Tonon, G.12
Haigis, M.13
Shirihai, O.S.14
Doglioni, C.15
Bardeesy, N.16
Kimmelman, A.C.17
-
52
-
-
3042742432
-
Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis
-
Eckert LB, Repasky GA, Ulku AS, McFall A, Zhou H, Sartor CI and Der CJ. Involvement of Ras activation in human breast cancer cell signaling, invasion, and anoikis. Cancer Res 2004; 64: 4585-4592.
-
(2004)
Cancer Res
, vol.64
, pp. 4585-4592
-
-
Eckert, L.B.1
Repasky, G.A.2
Ulku, A.S.3
McFall, A.4
Zhou, H.5
Sartor, C.I.6
Der, C.J.7
-
53
-
-
61849098916
-
A reason why the ERBB2 gene is amplified and not mutated in breast cancer
-
Birnbaum D, Sircoulomb F and Imbert J. A reason why the ERBB2 gene is amplified and not mutated in breast cancer. Cancer Cell Int 2009; 9: 5.
-
(2009)
Cancer Cell Int
, vol.9
, pp. 5
-
-
Birnbaum, D.1
Sircoulomb, F.2
Imbert, J.3
-
54
-
-
79952066460
-
p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target?
-
Arias-Romero LE and Chernoff J. p21-activated kinases in Erbb2-positive breast cancer: A new therapeutic target?. Small GTPases 2010; 1: 124-128.
-
(2010)
Small GTPases
, vol.1
, pp. 124-128
-
-
Arias-Romero, L.E.1
Chernoff, J.2
-
55
-
-
78751511180
-
Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation
-
Lock R, Roy S, Kenific CM, Su JS, Salas E, Ronen SM and Debnath J. Autophagy facilitates glycolysis during Ras-mediated oncogenic transformation. Mol Biol Cell 2011; 22: 165-178.
-
(2011)
Mol Biol Cell
, vol.22
, pp. 165-178
-
-
Lock, R.1
Roy, S.2
Kenific, C.M.3
Su, J.S.4
Salas, E.5
Ronen, S.M.6
Debnath, J.7
-
56
-
-
79953856887
-
Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation
-
Kim MJ, Woo SJ, Yoon CH, Lee JS, An S, Choi YH, Hwang SG, Yoon G and Lee SJ. Involvement of autophagy in oncogenic K-Ras-induced malignant cell transformation. J Biol Chem 2011; 286: 12924-12932.
-
(2011)
J Biol Chem
, vol.286
, pp. 12924-12932
-
-
Kim, M.J.1
Woo, S.J.2
Yoon, C.H.3
Lee, J.S.4
An, S.5
Choi, Y.H.6
Hwang, S.G.7
Yoon, G.8
Lee, S.J.9
-
57
-
-
79960401862
-
Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis
-
Wei H, Wei S, Gan B, Peng X, Zou W and Guan JL. Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis. Genes Dev 2011; 25: 1510-1527.
-
(2011)
Genes Dev
, vol.25
, pp. 1510-1527
-
-
Wei, H.1
Wei, S.2
Gan, B.3
Peng, X.4
Zou, W.5
Guan, J.L.6
-
58
-
-
24744441497
-
Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation
-
Onodera J and Ohsumi Y. Autophagy is required for maintenance of amino acid levels and protein synthesis under nitrogen starvation. J Biol Chem 2005; 280: 31582-31586.
-
(2005)
J Biol Chem
, vol.280
, pp. 31582-31586
-
-
Onodera, J.1
Ohsumi, Y.2
-
59
-
-
11144245626
-
The role of autophagy during the early neonatal starvation period
-
Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T and Mizushima N. The role of autophagy during the early neonatal starvation period. Nature 2004; 432: 1032-1036.
-
(2004)
Nature
, vol.432
, pp. 1032-1036
-
-
Kuma, A.1
Hatano, M.2
Matsui, M.3
Yamamoto, A.4
Nakaya, H.5
Yoshimori, T.6
Ohsumi, Y.7
Tokuhisa, T.8
Mizushima, N.9
-
60
-
-
33646831810
-
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
-
Lavieu G, Scarlatti F, Sala G, Carpentier S, Levade T, Ghidoni R, Botti J and Codogno P. Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation. J Biol Chem 2006; 281: 8518-8527.
-
(2006)
J Biol Chem
, vol.281
, pp. 8518-8527
-
-
Lavieu, G.1
Scarlatti, F.2
Sala, G.3
Carpentier, S.4
Levade, T.5
Ghidoni, R.6
Botti, J.7
Codogno, P.8
-
61
-
-
79551631199
-
Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells
-
Santi SA and Lee H. Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70S6K, and the deregulation of mitochondria in MDA-MB231 cells. PloS One 2011; 6: e14614.
-
(2011)
PloS One
, vol.6
-
-
Santi, S.A.1
Lee, H.2
-
62
-
-
77952040472
-
LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas
-
Sivridis E, Koukourakis MI, Zois CE, Ledaki I, Ferguson DJ, Harris AL, Gatter KC and Giatromanolaki A. LC3A-positive light microscopy detected patterns of autophagy and prognosis in operable breast carcinomas. Am J Pathol 2010; 176: 2477-2489.
-
(2010)
Am J Pathol
, vol.176
, pp. 2477-2489
-
-
Sivridis, E.1
Koukourakis, M.I.2
Zois, C.E.3
Ledaki, I.4
Ferguson, D.J.5
Harris, A.L.6
Gatter, K.C.7
Giatromanolaki, A.8
-
64
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, Lim M, Hilton DA, Zagzag D, Buechler P, Isaacs WB, Semenza GL and Simons JW. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res 1999; 59: 5830-5835.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
Lim, M.4
Hilton, D.A.5
Zagzag, D.6
Buechler, P.7
Isaacs, W.B.8
Semenza, G.L.9
Simons, J.W.10
-
65
-
-
66349121718
-
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
-
Bellot G, Garcia-Medina R, Gounon P, Chiche J, Roux D, Pouyssegur J and Mazure NM. Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains. Mol Cell Biol 2009; 29: 2570-2581.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 2570-2581
-
-
Bellot, G.1
Garcia-Medina, R.2
Gounon, P.3
Chiche, J.4
Roux, D.5
Pouyssegur, J.6
Mazure, N.M.7
-
66
-
-
34548235820
-
BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy
-
Tracy K, Dibling BC, Spike BT, Knabb JR, Schumacker P and Macleod KF. BNIP3 is an RB/E2F target gene required for hypoxia-induced autophagy. Mol Cell Biol 2007; 27: 6229-6242.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 6229-6242
-
-
Tracy, K.1
Dibling, B.C.2
Spike, B.T.3
Knabb, J.R.4
Schumacker, P.5
Macleod, K.F.6
-
67
-
-
43649104579
-
Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
-
Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, Gonzalez FJ and Semenza GL. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem 2008; 283: 10892-10903.
-
(2008)
J Biol Chem
, vol.283
, pp. 10892-10903
-
-
Zhang, H.1
Bosch-Marce, M.2
Shimoda, L.A.3
Tan, Y.S.4
Baek, J.H.5
Wesley, J.B.6
Gonzalez, F.J.7
Semenza, G.L.8
-
68
-
-
84872379495
-
Hypoxia inducible factor-1 alpha and carbonic anhydrase IX overexpression are associated with poor survival in breast cancer patients
-
Kaya AO, Gunel N, Benekli M, Akyurek N, Buyukberber S, Tatli H, Coskun U, Yildiz R, Yaman E and Ozturk B. Hypoxia inducible factor-1 alpha and carbonic anhydrase IX overexpression are associated with poor survival in breast cancer patients. J BUON 2012; 17: 663-668.
-
(2012)
J BUON
, vol.17
, pp. 663-668
-
-
Kaya, A.O.1
Gunel, N.2
Benekli, M.3
Akyurek, N.4
Buyukberber, S.5
Tatli, H.6
Coskun, U.7
Yildiz, R.8
Yaman, E.9
Ozturk, B.10
-
69
-
-
77954564670
-
Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1alpha, GLUT1, and CAIX
-
Chen CL, Chu JS, Su WC, Huang SC and Lee WY. Hypoxia and metabolic phenotypes during breast carcinogenesis: expression of HIF-1alpha, GLUT1, and CAIX. Virchows Arch 2010; 457: 53-61.
-
(2010)
Virchows Arch
, vol.457
, pp. 53-61
-
-
Chen, C.L.1
Chu, J.S.2
Su, W.C.3
Huang, S.C.4
Lee, W.Y.5
-
70
-
-
84872346471
-
VEGF, HIF-1alpha expression and MVD as an angiogenic network in familial breast cancer
-
Saponaro C, Malfettone A, Ranieri G, Danza K, Simone G, Paradiso A and Mangia A. VEGF, HIF-1alpha expression and MVD as an angiogenic network in familial breast cancer. PloS One 2013; 8: e53070.
-
(2013)
PloS One
, vol.8
-
-
Saponaro, C.1
Malfettone, A.2
Ranieri, G.3
Danza, K.4
Simone, G.5
Paradiso, A.6
Mangia, A.7
-
71
-
-
84870608916
-
Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression
-
Luo W, Chang R, Zhong J, Pandey A and Semenza GL. Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proc Natl Acad Sci U S A 2012; 109: E3367-3376.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
-
-
Luo, W.1
Chang, R.2
Zhong, J.3
Pandey, A.4
Semenza, G.L.5
-
72
-
-
70349298359
-
PPARgamma activation induces autophagy in breast cancer cells
-
Zhou J, Zhang W, Liang B, Casimiro MC, Whitaker-Menezes D, Wang M, Lisanti MP, Lanza-Jacoby S, Pestell RG and Wang C. PPARgamma activation induces autophagy in breast cancer cells. Int J Biochem Cell Biol 2009; 41: 2334-2342.
-
(2009)
Int J Biochem Cell Biol
, vol.41
, pp. 2334-2342
-
-
Zhou, J.1
Zhang, W.2
Liang, B.3
Casimiro, M.C.4
Whitaker-Menezes, D.5
Wang, M.6
Lisanti, M.P.7
Lanza-Jacoby, S.8
Pestell, R.G.9
Wang, C.10
-
73
-
-
77955467319
-
Regulation of autophagy by ATF4 in response to severe hypoxia
-
Rzymski T, Milani M, Pike L, Buffa F, Mellor HR, Winchester L, Pires I, Hammond E, Ragoussis I and Harris AL. Regulation of autophagy by ATF4 in response to severe hypoxia. Oncogene 2010; 29: 4424-4435.
-
(2010)
Oncogene
, vol.29
, pp. 4424-4435
-
-
Rzymski, T.1
Milani, M.2
Pike, L.3
Buffa, F.4
Mellor, H.R.5
Winchester, L.6
Pires, I.7
Hammond, E.8
Ragoussis, I.9
Harris, A.L.10
-
74
-
-
52149101812
-
Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L
-
Papandreou I, Lim AL, Laderoute K and Denko NC. Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L. Cell Death Differ 2008; 15: 1572-1581.
-
(2008)
Cell Death Differ
, vol.15
, pp. 1572-1581
-
-
Papandreou, I.1
Lim, A.L.2
Laderoute, K.3
Denko, N.C.4
-
75
-
-
74949118681
-
The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5
-
Rouschop KM, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K, Keulers T, Mujcic H, Landuyt W, Voncken JW, Lambin P, van der Kogel AJ, Koritzinsky M and Wouters BG. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J Clin Invest 2010; 120: 127-141.
-
(2010)
J Clin Invest
, vol.120
, pp. 127-141
-
-
Rouschop, K.M.1
van den Beucken, T.2
Dubois, L.3
Niessen, H.4
Bussink, J.5
Savelkouls, K.6
Keulers, T.7
Mujcic, H.8
Landuyt, W.9
Voncken, J.W.10
Lambin, P.11
van der Kogel, A.J.12
Koritzinsky, M.13
Wouters, B.G.14
-
76
-
-
84856551514
-
InterfERing with endoplasmic reticulum stress
-
Kraskiewicz H and FitzGerald U. InterfERing with endoplasmic reticulum stress. Trends Pharmacol Sci 2012; 33: 53-63.
-
(2012)
Trends Pharmacol Sci
, vol.33
, pp. 53-63
-
-
Kraskiewicz, H.1
FitzGerald, U.2
-
77
-
-
0037096823
-
Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation
-
Kouroku Y, Fujita E, Jimbo A, Kikuchi T, Yamagata T, Momoi MY, Kominami E, Kuida K, Sakamaki K, Yonehara S and Momoi T. Polyglutamine aggregates stimulate ER stress signals and caspase-12 activation. Hum Mol Genet 2002; 11: 1505-1515.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 1505-1515
-
-
Kouroku, Y.1
Fujita, E.2
Jimbo, A.3
Kikuchi, T.4
Yamagata, T.5
Momoi, M.Y.6
Kominami, E.7
Kuida, K.8
Sakamaki, K.9
Yonehara, S.10
Momoi, T.11
-
78
-
-
77953232252
-
Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2alpha in caspase-3/7-deficient cells
-
Kim KW, Moretti L, Mitchell LR, Jung DK and Lu B. Endoplasmic reticulum stress mediates radiation-induced autophagy by perk-eIF2alpha in caspase-3/7-deficient cells. Oncogene 2010; 29: 3241-3251.
-
(2010)
Oncogene
, vol.29
, pp. 3241-3251
-
-
Kim, K.W.1
Moretti, L.2
Mitchell, L.R.3
Jung, D.K.4
Lu, B.5
-
79
-
-
33845459165
-
Autophagy is activated for cell survival after endoplasmic reticulum stress
-
Ogata M, Hino S, Saito A, Morikawa K, Kondo S, Kanemoto S, Murakami T, Taniguchi M, Tanii I, Yoshinaga K, Shiosaka S, Hammarback JA, Urano F and Imaizumi K. Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol 2006; 26: 9220-9231.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 9220-9231
-
-
Ogata, M.1
Hino, S.2
Saito, A.3
Morikawa, K.4
Kondo, S.5
Kanemoto, S.6
Murakami, T.7
Taniguchi, M.8
Tanii, I.9
Yoshinaga, K.10
Shiosaka, S.11
Hammarback, J.A.12
Urano, F.13
Imaizumi, K.14
-
80
-
-
33947386684
-
Endoplasmic reticulum stress: a new pathway to induce autophagy
-
Yorimitsu T and Klionsky DJ. Endoplasmic reticulum stress: a new pathway to induce autophagy. Autophagy 2007; 3: 160-162.
-
(2007)
Autophagy
, vol.3
, pp. 160-162
-
-
Yorimitsu, T.1
Klionsky, D.J.2
-
81
-
-
77953763757
-
Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen-activated protein kinases and retards cell death by suppressing endoplasmic reticulum stress-mediated apoptosis
-
Choi CH, Jung YK and Oh SH. Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen-activated protein kinases and retards cell death by suppressing endoplasmic reticulum stress-mediated apoptosis. Mol Pharmacol 2010; 78: 114-125.
-
(2010)
Mol Pharmacol
, vol.78
, pp. 114-125
-
-
Choi, C.H.1
Jung, Y.K.2
Oh, S.H.3
-
82
-
-
66249085237
-
The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib
-
Milani M, Rzymski T, Mellor HR, Pike L, Bottini A, Generali D and Harris AL. The role of ATF4 stabilization and autophagy in resistance of breast cancer cells treated with Bortezomib. Cancer Res 2009; 69: 4415-4423.
-
(2009)
Cancer Res
, vol.69
, pp. 4415-4423
-
-
Milani, M.1
Rzymski, T.2
Mellor, H.R.3
Pike, L.4
Bottini, A.5
Generali, D.6
Harris, A.L.7
-
83
-
-
38049123578
-
Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress
-
Ullman E, Fan Y, Stawowczyk M, Chen HM, Yue Z and Zong WX. Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress. Cell Death Differ 2008; 15: 422-425.
-
(2008)
Cell Death Differ
, vol.15
, pp. 422-425
-
-
Ullman, E.1
Fan, Y.2
Stawowczyk, M.3
Chen, H.M.4
Yue, Z.5
Zong, W.X.6
-
84
-
-
38949119423
-
Hypoxia induces autophagic cell death in apoptosiscompetent cells through a mechanism involving BNIP3
-
Azad MB, Chen Y, Henson ES, Cizeau J, McMillan-Ward E, Israels SJ and Gibson SB. Hypoxia induces autophagic cell death in apoptosiscompetent cells through a mechanism involving BNIP3. Autophagy 2008; 4: 195-204.
-
(2008)
Autophagy
, vol.4
, pp. 195-204
-
-
Azad, M.B.1
Chen, Y.2
Henson, E.S.3
Cizeau, J.4
McMillan-Ward, E.5
Israels, S.J.6
Gibson, S.B.7
-
85
-
-
8144228952
-
Friends or foes -bipolar effects of the tumour stroma in cancer
-
Mueller MM and Fusenig NE. Friends or foes -bipolar effects of the tumour stroma in cancer. Nat Rev Cancer 2004; 4: 839-849.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 839-849
-
-
Mueller, M.M.1
Fusenig, N.E.2
-
86
-
-
84865846037
-
Targeting the tumor stroma as a novel treatment strategy for breast cancer: shifting from the neoplastic cell-centric to a stroma-centric paradigm
-
Tchou J and Conejo-Garcia J. Targeting the tumor stroma as a novel treatment strategy for breast cancer: shifting from the neoplastic cell-centric to a stroma-centric paradigm. Adv Pharmacol 2012; 65: 45-61.
-
(2012)
Adv Pharmacol
, vol.65
, pp. 45-61
-
-
Tchou, J.1
Conejo-Garcia, J.2
-
87
-
-
77957138161
-
Understanding the "lethal" drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/ mitophagy in the tumor micro-environment
-
Lisanti MP, Martinez-Outschoorn UE, Chiavarina B, Pavlides S, Whitaker-Menezes D, Tsirigos A, Witkiewicz A, Lin Z, Balliet R, Howell A and Sotgia F. Understanding the "lethal" drivers of tumor-stroma co-evolution: emerging role(s) for hypoxia, oxidative stress and autophagy/ mitophagy in the tumor micro-environment. Cancer Biol Ther 2010; 10: 537-542.
-
(2010)
Cancer Biol Ther
, vol.10
, pp. 537-542
-
-
Lisanti, M.P.1
Martinez-Outschoorn, U.E.2
Chiavarina, B.3
Pavlides, S.4
Whitaker-Menezes, D.5
Tsirigos, A.6
Witkiewicz, A.7
Lin, Z.8
Balliet, R.9
Howell, A.10
Sotgia, F.11
-
88
-
-
84872683287
-
Fibroblast-dependent regulation of the stem cell properties of cancer cells
-
Weiland A, Roswall P, Hatzihristidis TC, Pietras K, Ostman A and Strell C. Fibroblast-dependent regulation of the stem cell properties of cancer cells. Neoplasma 2012; 59: 719-727.
-
(2012)
Neoplasma
, vol.59
, pp. 719-727
-
-
Weiland, A.1
Roswall, P.2
Hatzihristidis, T.C.3
Pietras, K.4
Ostman, A.5
Strell, C.6
-
89
-
-
77954162846
-
Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
-
Martinez-Outschoorn UE, Balliet RM, Rivadeneira DB, Chiavarina B, Pavlides S, Wang C, Whitaker-Menezes D, Daumer KM, Lin Z, Witkiewicz AK, Flomenberg N, Howell A, Pestell RG, Knudsen ES, Sotgia F and Lisanti MP. Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell cycle 2010; 9: 3256-3276.
-
(2010)
Cell cycle
, vol.9
, pp. 3256-3276
-
-
Martinez-Outschoorn, U.E.1
Balliet, R.M.2
Rivadeneira, D.B.3
Chiavarina, B.4
Pavlides, S.5
Wang, C.6
Whitaker-Menezes, D.7
Daumer, K.M.8
Lin, Z.9
Witkiewicz, A.K.10
Flomenberg, N.11
Howell, A.12
Pestell, R.G.13
Knudsen, E.S.14
Sotgia, F.15
Lisanti, M.P.16
-
90
-
-
77956400210
-
Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFkappaB activation in the tumor stromal microenvironment
-
Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, Wang C, Pavlides S, Martinez-Cantarin MP, Capozza F, Witkiewicz AK, Flomenberg N, Howell A, Pestell RG, Caro J, Lisanti MP and Sotgia F. Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFkappaB activation in the tumor stromal microenvironment. Cell cycle 2010; 9: 3515-3533.
-
(2010)
Cell cycle
, vol.9
, pp. 3515-3533
-
-
Martinez-Outschoorn, U.E.1
Trimmer, C.2
Lin, Z.3
Whitaker-Menezes, D.4
Chiavarina, B.5
Zhou, J.6
Wang, C.7
Pavlides, S.8
Martinez-Cantarin, M.P.9
Capozza, F.10
Witkiewicz, A.K.11
Flomenberg, N.12
Howell, A.13
Pestell, R.G.14
Caro, J.15
Lisanti, M.P.16
Sotgia, F.17
-
91
-
-
78349266054
-
The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox
-
Martinez-Outschoorn UE, Whitaker-Menezes D, Pavlides S, Chiavarina B, Bonuccelli G, Casey T, Tsirigos A, Migneco G, Witkiewicz A, Balliet R, Mercier I, Wang C, Flomenberg N, Howell A, Lin Z, Caro J, Pestell RG, Sotgia F and Lisanti MP. The autophagic tumor stroma model of cancer or "battery-operated tumor growth": A simple solution to the autophagy paradox. Cell cycle 2010; 9: 4297-4306.
-
(2010)
Cell cycle
, vol.9
, pp. 4297-4306
-
-
Martinez-Outschoorn, U.E.1
Whitaker-Menezes, D.2
Pavlides, S.3
Chiavarina, B.4
Bonuccelli, G.5
Casey, T.6
Tsirigos, A.7
Migneco, G.8
Witkiewicz, A.9
Balliet, R.10
Mercier, I.11
Wang, C.12
Flomenberg, N.13
Howell, A.14
Lin, Z.15
Caro, J.16
Pestell, R.G.17
Sotgia, F.18
Lisanti, M.P.19
-
92
-
-
77953560003
-
Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation
-
Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, Wang C, Fortina P, Addya S, Pestell RG, Martinez-Outschoorn UE, Sotgia F and Lisanti MP. Loss of stromal caveolin-1 leads to oxidative stress, mimics hypoxia and drives inflammation in the tumor microenvironment, conferring the "reverse Warburg effect": a transcriptional informatics analysis with validation. Cell cycle 2010; 9: 2201-2219.
-
(2010)
Cell cycle
, vol.9
, pp. 2201-2219
-
-
Pavlides, S.1
Tsirigos, A.2
Vera, I.3
Flomenberg, N.4
Frank, P.G.5
Casimiro, M.C.6
Wang, C.7
Fortina, P.8
Addya, S.9
Pestell, R.G.10
Martinez-Outschoorn, U.E.11
Sotgia, F.12
Lisanti, M.P.13
-
93
-
-
84869467226
-
Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells
-
Martinez-Outschoorn UE, Lin Z, Whitaker-Menezes D, Howell A, Lisanti MP and Sotgia F. Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells. Cell cycle 2012; 11: 3956-3963.
-
(2012)
Cell cycle
, vol.11
, pp. 3956-3963
-
-
Martinez-Outschoorn, U.E.1
Lin, Z.2
Whitaker-Menezes, D.3
Howell, A.4
Lisanti, M.P.5
Sotgia, F.6
-
94
-
-
84869436102
-
Ketone body utilization drives tumor growth and metastasis
-
Martinez-Outschoorn UE, Lin Z, Whitaker-Menezes D, Howell A, Sotgia F and Lisanti MP. Ketone body utilization drives tumor growth and metastasis. Cell cycle 2012; 11: 3964-3971.
-
(2012)
Cell cycle
, vol.11
, pp. 3964-3971
-
-
Martinez-Outschoorn, U.E.1
Lin, Z.2
Whitaker-Menezes, D.3
Howell, A.4
Sotgia, F.5
Lisanti, M.P.6
-
95
-
-
84055193571
-
Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance
-
Ko YH, Lin Z, Flomenberg N, Pestell RG, Howell A, Sotgia F, Lisanti MP and Martinez-Outschoorn UE. Glutamine fuels a vicious cycle of autophagy in the tumor stroma and oxidative mitochondrial metabolism in epithelial cancer cells: implications for preventing chemotherapy resistance. Cancer Biol Ther 2011; 12: 1085-1097.
-
(2011)
Cancer Biol Ther
, vol.12
, pp. 1085-1097
-
-
Ko, Y.H.1
Lin, Z.2
Flomenberg, N.3
Pestell, R.G.4
Howell, A.5
Sotgia, F.6
Lisanti, M.P.7
Martinez-Outschoorn, U.E.8
-
96
-
-
77956419439
-
Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism
-
Bonuccelli G, Tsirigos A, Whitaker-Menezes D, Pavlides S, Pestell RG, Chiavarina B, Frank PG, Flomenberg N, Howell A, Martinez-Outschoorn UE, Sotgia F and Lisanti MP. Ketones and lactate "fuel" tumor growth and metastasis: Evidence that epithelial cancer cells use oxidative mitochondrial metabolism. Cell cycle 2010; 9: 3506-3514.
-
(2010)
Cell cycle
, vol.9
, pp. 3506-3514
-
-
Bonuccelli, G.1
Tsirigos, A.2
Whitaker-Menezes, D.3
Pavlides, S.4
Pestell, R.G.5
Chiavarina, B.6
Frank, P.G.7
Flomenberg, N.8
Howell, A.9
Martinez-Outschoorn, U.E.10
Sotgia, F.11
Lisanti, M.P.12
-
97
-
-
77954155633
-
Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling"
-
Pavlides S, Tsirigos A, Vera I, Flomenberg N, Frank PG, Casimiro MC, Wang C, Pestell RG, Martinez-Outschoorn UE, Howell A, Sotgia F and Lisanti MP. Transcriptional evidence for the "Reverse Warburg Effect" in human breast cancer tumor stroma and metastasis: similarities with oxidative stress, inflammation, Alzheimer's disease, and "Neuron-Glia Metabolic Coupling". Aging (Albany NY) 2010; 2: 185-199.
-
(2010)
Aging (Albany NY)
, vol.2
, pp. 185-199
-
-
Pavlides, S.1
Tsirigos, A.2
Vera, I.3
Flomenberg, N.4
Frank, P.G.5
Casimiro, M.C.6
Wang, C.7
Pestell, R.G.8
Martinez-Outschoorn, U.E.9
Howell, A.10
Sotgia, F.11
Lisanti, M.P.12
-
98
-
-
0030034772
-
Identification, sequence, and expression of caveolin-2 defines a caveolin gene family
-
U S A
-
Scherer PE, Okamoto T, Chun M, Nishimoto I, Lodish HF and Lisanti MP. Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. Proc Natl Acad Sci U S A 1996; 93: 131-135.
-
(1996)
Proc Natl Acad Sci
, vol.93
, pp. 131-135
-
-
Scherer, P.E.1
Okamoto, T.2
Chun, M.3
Nishimoto, I.4
Lodish, H.F.5
Lisanti, M.P.6
-
99
-
-
0034741834
-
Caveolin-1, a putative tumour suppressor gene
-
Razani B, Schlegel A, Liu J and Lisanti MP. Caveolin-1, a putative tumour suppressor gene. Biochem Soc Trans 2001; 29: 494-499.
-
(2001)
Biochem Soc Trans
, vol.29
, pp. 494-499
-
-
Razani, B.1
Schlegel, A.2
Liu, J.3
Lisanti, M.P.4
-
100
-
-
66549114050
-
An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers
-
Witkiewicz AK, Dasgupta A, Sotgia F, Mercier I, Pestell RG, Sabel M, Kleer CG, Brody JR and Lisanti MP. An absence of stromal caveolin-1 expression predicts early tumor recurrence and poor clinical outcome in human breast cancers. Am J Pathol 2009; 174: 2023-2034.
-
(2009)
Am J Pathol
, vol.174
, pp. 2023-2034
-
-
Witkiewicz, A.K.1
Dasgupta, A.2
Sotgia, F.3
Mercier, I.4
Pestell, R.G.5
Sabel, M.6
Kleer, C.G.7
Brody, J.R.8
Lisanti, M.P.9
-
101
-
-
77955443486
-
Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers
-
Witkiewicz AK, Dasgupta A, Sammons S, Er O, Potoczek MB, Guiles F, Sotgia F, Brody JR, Mitchell EP and Lisanti MP. Loss of stromal caveolin-1 expression predicts poor clinical outcome in triple negative and basal-like breast cancers. Cancer Biol Ther 2010; 10: 135-143.
-
(2010)
Cancer Biol Ther
, vol.10
, pp. 135-143
-
-
Witkiewicz, A.K.1
Dasgupta, A.2
Sammons, S.3
Er, O.4
Potoczek, M.B.5
Guiles, F.6
Sotgia, F.7
Brody, J.R.8
Mitchell, E.P.9
Lisanti, M.P.10
-
102
-
-
84860317909
-
Stromal caveolin-1 expression in breast carcinoma Correlation with early tumor recurrence and clinical outcome
-
El-Gendi SM, Mostafa MF and El-Gendi AM. Stromal caveolin-1 expression in breast carcinoma. Correlation with early tumor recurrence and clinical outcome. Pathol Oncol Res 2012; 18: 459-469.
-
(2012)
Pathol Oncol Res
, vol.18
, pp. 459-469
-
-
El-Gendi, S.M.1
Mostafa, M.F.2
El-Gendi, A.M.3
-
103
-
-
74849092905
-
Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance
-
Thomas NB, Hutcheson IR, Campbell L, Gee J, Taylor KM, Nicholson RI and Gumbleton M. Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat 2010; 119: 575-591.
-
(2010)
Breast Cancer Res Treat
, vol.119
, pp. 575-591
-
-
Thomas, N.B.1
Hutcheson, I.R.2
Campbell, L.3
Gee, J.4
Taylor, K.M.5
Nicholson, R.I.6
Gumbleton, M.7
-
104
-
-
0037388204
-
Prospective identification of tumorigenic breast cancer cells
-
U S A
-
Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ and Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A 2003; 100: 3983-3988.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 3983-3988
-
-
Al-Hajj, M.1
Wicha, M.S.2
Benito-Hernandez, A.3
Morrison, S.J.4
Clarke, M.F.5
-
105
-
-
48949119473
-
Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy
-
Fillmore CM and Kuperwasser C. Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res 2008; 10: R25.
-
(2008)
Breast Cancer Res
, vol.10
-
-
Fillmore, C.M.1
Kuperwasser, C.2
-
106
-
-
84863736653
-
Review of stem cell deregulation and breast cancer: an emerging hypothesis
-
Kumar DH and Kutty MK. Review of stem cell deregulation and breast cancer: an emerging hypothesis. Indian J Pathol Microbiol 2012; 55: 147-153.
-
(2012)
Indian J Pathol Microbiol
, vol.55
, pp. 147-153
-
-
Kumar, D.H.1
Kutty, M.K.2
-
107
-
-
80655140436
-
Autophagy positively regulates the CD44(+) CD24(-/low) breast cancer stem-like phenotype
-
Cufi S, Vazquez-Martin A, Oliveras-Ferraros C, Martin-Castillo B, Vellon L and Menendez JA. Autophagy positively regulates the CD44(+) CD24(-/low) breast cancer stem-like phenotype. Cell cycle 2011; 10: 3871-3885.
-
(2011)
Cell cycle
, vol.10
, pp. 3871-3885
-
-
Cufi, S.1
Vazquez-Martin, A.2
Oliveras-Ferraros, C.3
Martin-Castillo, B.4
Vellon, L.5
Menendez, J.A.6
-
108
-
-
79960046702
-
Activation of autophagy in mesenchymal stem cells provides tumor stromal support
-
Sanchez CG, Penfornis P, Oskowitz AZ, Boonjindasup AG, Cai DZ, Dhule SS, Rowan BG, Kelekar A, Krause DS and Pochampally RR. Activation of autophagy in mesenchymal stem cells provides tumor stromal support. Carcinogenesis 2011; 32: 964-972.
-
(2011)
Carcinogenesis
, vol.32
, pp. 964-972
-
-
Sanchez, C.G.1
Penfornis, P.2
Oskowitz, A.Z.3
Boonjindasup, A.G.4
Cai, D.Z.5
Dhule, S.S.6
Rowan, B.G.7
Kelekar, A.8
Krause, D.S.9
Pochampally, R.R.10
-
109
-
-
0037264812
-
Metastasis suppressors alter the signal transduction of cancer cells
-
Steeg PS. Metastasis suppressors alter the signal transduction of cancer cells. Nat Rev Cancer 2003; 3: 55-63.
-
(2003)
Nat Rev Cancer
, vol.3
, pp. 55-63
-
-
Steeg, P.S.1
-
110
-
-
41449114759
-
Detachment-induced autophagy during anoikis and lumen formation in epithelial acini
-
Debnath J. Detachment-induced autophagy during anoikis and lumen formation in epithelial acini. Autophagy 2008; 4: 351-353.
-
(2008)
Autophagy
, vol.4
, pp. 351-353
-
-
Debnath, J.1
-
111
-
-
59249105413
-
Detachment-induced autophagy in three-dimensional epithelial cell cultures
-
Debnath J. Detachment-induced autophagy in three-dimensional epithelial cell cultures. Methods Enzymol 2009; 452: 423-439.
-
(2009)
Methods Enzymol
, vol.452
, pp. 423-439
-
-
Debnath, J.1
-
113
-
-
41449109334
-
Induction of autophagy during extracellular matrix detachment promotes cell survival
-
Fung C, Lock R, Gao S, Salas E and Debnath J. Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol Biol Cell 2008; 19: 797-806.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 797-806
-
-
Fung, C.1
Lock, R.2
Gao, S.3
Salas, E.4
Debnath, J.5
-
114
-
-
1542513774
-
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro
-
Mills KR, Reginato M, Debnath J, Queenan B and Brugge JS. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc Natl Acad Sci U S A 2004; 101: 3438-3443.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 3438-3443
-
-
Mills, K.R.1
Reginato, M.2
Debnath, J.3
Queenan, B.4
Brugge, J.S.5
-
115
-
-
78649369742
-
The epithelial-mesenchymal transition (EMT) phenomenon
-
Savagner P. The epithelial-mesenchymal transition (EMT) phenomenon. Ann Oncol 2010; 21 Suppl 7: vii89-92.
-
(2010)
Ann Oncol
, vol.21
, Issue.SUPPL. 7
-
-
Savagner, P.1
-
116
-
-
84863578884
-
DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer
-
Lv Q, Wang W, Xue J, Hua F, Mu R, Lin H, Yan J, Lv X, Chen X and Hu ZW. DEDD interacts with PI3KC3 to activate autophagy and attenuate epithelial-mesenchymal transition in human breast cancer. Cancer Res 2012; 72: 3238-3250.
-
(2012)
Cancer Res
, vol.72
, pp. 3238-3250
-
-
Lv, Q.1
Wang, W.2
Xue, J.3
Hua, F.4
Mu, R.5
Lin, H.6
Yan, J.7
Lv, X.8
Chen, X.9
Hu, Z.W.10
-
117
-
-
84870816403
-
Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1
-
Ocana OH, Corcoles R, Fabra A, Moreno-Bueno G, Acloque H, Vega S, Barrallo-Gimeno A, Cano A and Nieto MA. Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer cell 2012; 22: 709-724.
-
(2012)
Cancer cell
, vol.22
, pp. 709-724
-
-
Ocana, O.H.1
Corcoles, R.2
Fabra, A.3
Moreno-Bueno, G.4
Acloque, H.5
Vega, S.6
Barrallo-Gimeno, A.7
Cano, A.8
Nieto, M.A.9
-
118
-
-
84871830508
-
Metastasis: Epithelial to mesenchymal and back again
-
Alderton GK. Metastasis: Epithelial to mesenchymal and back again. Nat Rev Cancer 2013; 13: 3.
-
(2013)
Nat Rev Cancer
, vol.13
, pp. 3
-
-
Alderton, G.K.1
-
119
-
-
78649467513
-
Does tumour dormancy offer a therapeutic target?
-
Goss PE and Chambers AF. Does tumour dormancy offer a therapeutic target?. Nat Rev Cancer 2010; 10: 871-877.
-
(2010)
Nat Rev Cancer
, vol.10
, pp. 871-877
-
-
Goss, P.E.1
Chambers, A.F.2
-
120
-
-
57449121645
-
The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells
-
Lu Z, Luo RZ, Lu Y, Zhang X, Yu Q, Khare S, Kondo S, Kondo Y, Yu Y, Mills GB, Liao WS and Bast RC Jr. The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. J Clin Invest 2008; 118: 3917-3929.
-
(2008)
J Clin Invest
, vol.118
, pp. 3917-3929
-
-
Lu, Z.1
Luo, R.Z.2
Lu, Y.3
Zhang, X.4
Yu, Q.5
Khare, S.6
Kondo, S.7
Kondo, Y.8
Yu, Y.9
Mills, G.B.10
Liao, W.S.11
Bast, R.C.12
-
121
-
-
5144235557
-
Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction
-
White DE, Kurpios NA, Zuo D, Hassell JA, Blaess S, Mueller U and Muller WJ. Targeted disruption of beta1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer cell 2004; 6: 159-170.
-
(2004)
Cancer cell
, vol.6
, pp. 159-170
-
-
White, D.E.1
Kurpios, N.A.2
Zuo, D.3
Hassell, J.A.4
Blaess, S.5
Mueller, U.6
Muller, W.J.7
-
123
-
-
50349098812
-
Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells
-
Han J, Hou W, Goldstein LA, Lu C, Stolz DB, Yin XM and Rabinowich H. Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells. J Biol Chem 2008; 283: 19665-19677.
-
(2008)
J Biol Chem
, vol.283
, pp. 19665-19677
-
-
Han, J.1
Hou, W.2
Goldstein, L.A.3
Lu, C.4
Stolz, D.B.5
Yin, X.M.6
Rabinowich, H.7
-
124
-
-
67649311599
-
Latent bone metastasis in breast cancer tied to Srcdependent survival signals
-
Zhang XH, Wang Q, Gerald W, Hudis CA, Norton L, Smid M, Foekens JA and Massague J. Latent bone metastasis in breast cancer tied to Srcdependent survival signals. Cancer cell 2009; 16: 67-78.
-
(2009)
Cancer cell
, vol.16
, pp. 67-78
-
-
Zhang, X.H.1
Wang, Q.2
Gerald, W.3
Hudis, C.A.4
Norton, L.5
Smid, M.6
Foekens, J.A.7
Massague, J.8
-
125
-
-
66949165559
-
Autophagy in disease: a double-edged sword with therapeutic potential
-
Martinet W, Agostinis P, Vanhoecke B, Dewaele M and De Meyer GR. Autophagy in disease: a double-edged sword with therapeutic potential. Clin Sci (Lond) 2009; 116: 697-712.
-
(2009)
Clin Sci (Lond)
, vol.116
, pp. 697-712
-
-
Martinet, W.1
Agostinis, P.2
Vanhoecke, B.3
Dewaele, M.4
De Meyer, G.R.5
-
126
-
-
84863661689
-
Therapeutic targets in cancer cell metabolism and autophagy
-
Cheong H, Lu C, Lindsten T and Thompson CB. Therapeutic targets in cancer cell metabolism and autophagy. Nat Biotechnol 2012; 30: 671-678.
-
(2012)
Nat Biotechnol
, vol.30
, pp. 671-678
-
-
Cheong, H.1
Lu, C.2
Lindsten, T.3
Thompson, C.B.4
-
127
-
-
84864385373
-
Autophagy: friend or foe in breast cancer development, progression, and treatment
-
Berardi DE, Campodonico PB, Diaz Bessone MI, Urtreger AJ and Todaro LB. Autophagy: friend or foe in breast cancer development, progression, and treatment. Int J Breast Cancer 2011; 2011: 595092.
-
(2011)
Int J Breast Cancer
, vol.2011
, pp. 595092
-
-
Berardi, D.E.1
Campodonico, P.B.2
Diaz Bessone, M.I.3
Urtreger, A.J.4
Todaro, L.B.5
-
128
-
-
79960917666
-
Autophagy as a mediator of chemotherapy-induced cell death in cancer
-
Notte A, Leclere L and Michiels C. Autophagy as a mediator of chemotherapy-induced cell death in cancer. Biochem Pharmacol 2011; 82: 427-434.
-
(2011)
Biochem Pharmacol
, vol.82
, pp. 427-434
-
-
Notte, A.1
Leclere, L.2
Michiels, C.3
-
129
-
-
65349114832
-
Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia
-
Crazzolara R, Cisterne A, Thien M, Hewson J, Baraz R, Bradstock KF and Bendall LJ. Potentiating effects of RAD001 (Everolimus) on vincristine therapy in childhood acute lymphoblastic leukemia. Blood 2009; 113: 3297-3306.
-
(2009)
Blood
, vol.113
, pp. 3297-3306
-
-
Crazzolara, R.1
Cisterne, A.2
Thien, M.3
Hewson, J.4
Baraz, R.5
Bradstock, K.F.6
Bendall, L.J.7
-
130
-
-
17144427728
-
Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors
-
Takeuchi H, Kondo Y, Fujiwara K, Kanzawa T, Aoki H, Mills GB and Kondo S. Synergistic augmentation of rapamycin-induced autophagy in malignant glioma cells by phosphatidylinositol 3-kinase/protein kinase B inhibitors. Cancer Res 2005; 65: 3336-3346.
-
(2005)
Cancer Res
, vol.65
, pp. 3336-3346
-
-
Takeuchi, H.1
Kondo, Y.2
Fujiwara, K.3
Kanzawa, T.4
Aoki, H.5
Mills, G.B.6
Kondo, S.7
-
131
-
-
77957875453
-
Rhabdastrellic acid-A induced autophagy-associated cell death through blocking Akt pathway in human cancer cells
-
Li DD, Guo JF, Huang JJ, Wang LL, Deng R, Liu JN, Feng GK, Xiao DJ, Deng SZ, Zhang XS and Zhu XF. Rhabdastrellic acid-A induced autophagy-associated cell death through blocking Akt pathway in human cancer cells. PloS One 2010; 5: e12176.
-
(2010)
PloS One
, vol.5
-
-
Li, D.D.1
Guo, J.F.2
Huang, J.J.3
Wang, L.L.4
Deng, R.5
Liu, J.N.6
Feng, G.K.7
Xiao, D.J.8
Deng, S.Z.9
Zhang, X.S.10
Zhu, X.F.11
-
132
-
-
84859360525
-
Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy
-
Shi WY, Xiao D, Wang L, Dong LH, Yan ZX, Shen ZX, Chen SJ, Chen Y and Zhao WL. Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy. Cell Death Dis 2012; 3: e275.
-
(2012)
Cell Death Dis
, vol.3
-
-
Shi, W.Y.1
Xiao, D.2
Wang, L.3
Dong, L.H.4
Yan, Z.X.5
Shen, Z.X.6
Chen, S.J.7
Chen, Y.8
Zhao, W.L.9
-
133
-
-
65949086045
-
Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells
-
Bommareddy A, Hahm ER, Xiao D, Powolny AA, Fisher AL, Jiang Y and Singh SV. Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells. Cancer Res 2009; 69: 3704-3712.
-
(2009)
Cancer Res
, vol.69
, pp. 3704-3712
-
-
Bommareddy, A.1
Hahm, E.R.2
Xiao, D.3
Powolny, A.A.4
Fisher, A.L.5
Jiang, Y.6
Singh, S.V.7
-
134
-
-
2642553881
-
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
-
Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, Baehrecke EH and Lenardo MJ. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004; 304: 1500-1502.
-
(2004)
Science
, vol.304
, pp. 1500-1502
-
-
Yu, L.1
Alva, A.2
Su, H.3
Dutt, P.4
Freundt, E.5
Welsh, S.6
Baehrecke, E.H.7
Lenardo, M.J.8
-
135
-
-
84873709314
-
Identification of a candidate therapeutic autophagy-inducing peptide
-
Shoji-Kawata S, Sumpter R, Leveno M, Campbell GR, Zou Z, Kinch L, Wilkins AD, Sun Q, Pallauf K, MacDuff D, Huerta C, Virgin HW, Helms JB, Eerland R, Tooze SA, Xavier R, Lenschow DJ, Yamamoto A, King D, Lichtarge O, Grishin NV, Spector SA, Kaloyanova DV and Levine B. Identification of a candidate therapeutic autophagy-inducing peptide. Nature 2013; 494: 201-206.
-
(2013)
Nature
, vol.494
, pp. 201-206
-
-
Shoji-Kawata, S.1
Sumpter, R.2
Leveno, M.3
Campbell, G.R.4
Zou, Z.5
Kinch, L.6
Wilkins, A.D.7
Sun, Q.8
Pallauf, K.9
MacDuff, D.10
Huerta, C.11
Virgin, H.W.12
Helms, J.B.13
Eerland, R.14
Tooze, S.A.15
Xavier, R.16
Lenschow, D.J.17
Yamamoto, A.18
King, D.19
Lichtarge, O.20
Grishin, N.V.21
Spector, S.A.22
Kaloyanova, D.V.23
Levine, B.24
more..
-
136
-
-
40449086885
-
Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy
-
Apel A, Herr I, Schwarz H, Rodemann HP and Mayer A. Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res 2008; 68: 1485-1494.
-
(2008)
Cancer Res
, vol.68
, pp. 1485-1494
-
-
Apel, A.1
Herr, I.2
Schwarz, H.3
Rodemann, H.P.4
Mayer, A.5
-
137
-
-
56549116658
-
Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization
-
Qadir MA, Kwok B, Dragowska WH, To KH, Le D, Bally MB and Gorski SM. Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization. Breast Cancer Res Treat 2008; 112: 389-403.
-
(2008)
Breast Cancer Res Treat
, vol.112
, pp. 389-403
-
-
Qadir, M.A.1
Kwok, B.2
Dragowska, W.H.3
To, K.H.4
Le, D.5
Bally, M.B.6
Gorski, S.M.7
-
138
-
-
67650885510
-
Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab
-
Vazquez-Martin A, Oliveras-Ferraros C and Menendez JA. Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab. PloS One 2009; 4: e6251.
-
(2009)
PloS One
, vol.4
-
-
Vazquez-Martin, A.1
Oliveras-Ferraros, C.2
Menendez, J.A.3
-
139
-
-
80655125020
-
Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator
-
Lee KH, Hsu EC, Guh JH, Yang HC, Wang D, Kulp SK, Shapiro CL and Chen CS. Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator. J Biol Chem 2011; 286: 39247-39258.
-
(2011)
J Biol Chem
, vol.286
, pp. 39247-39258
-
-
Lee, K.H.1
Hsu, E.C.2
Guh, J.H.3
Yang, H.C.4
Wang, D.5
Kulp, S.K.6
Shapiro, C.L.7
Chen, C.S.8
-
140
-
-
84861961464
-
Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells
-
Rao R, Balusu R, Fiskus W, Mudunuru U, Venkannagari S, Chauhan L, Smith JE, Hembruff SL, Ha K, Atadja P and Bhalla KN. Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells. Mol Cancer Ther 2012; 11: 973-983.
-
(2012)
Mol Cancer Ther
, vol.11
, pp. 973-983
-
-
Rao, R.1
Balusu, R.2
Fiskus, W.3
Mudunuru, U.4
Venkannagari, S.5
Chauhan, L.6
Smith, J.E.7
Hembruff, S.L.8
Ha, K.9
Atadja, P.10
Bhalla, K.N.11
-
141
-
-
84865300412
-
Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors
-
Thomas S, Sharma N, Golden EB, Cho H, Agarwal P, Gaffney KJ, Petasis NA, Chen TC, Hofman FM, Louie SG and Schonthal AH. Preferential killing of triple-negative breast cancer cells in vitro and in vivo when pharmacological aggravators of endoplasmic reticulum stress are combined with autophagy inhibitors. Cancer Lett 2012; 325: 63-71.
-
(2012)
Cancer Lett
, vol.325
, pp. 63-71
-
-
Thomas, S.1
Sharma, N.2
Golden, E.B.3
Cho, H.4
Agarwal, P.5
Gaffney, K.J.6
Petasis, N.A.7
Chen, T.C.8
Hofman, F.M.9
Louie, S.G.10
Schonthal, A.H.11
-
142
-
-
79960356284
-
Autophagy contributes to resistance of tumor cells to ionizing radiation
-
Chaachouay H, Ohneseit P, Toulany M, Kehlbach R, Multhoff G and Rodemann HP. Autophagy contributes to resistance of tumor cells to ionizing radiation. Radiother Oncol 2011; 99: 287-292.
-
(2011)
Radiother Oncol
, vol.99
, pp. 287-292
-
-
Chaachouay, H.1
Ohneseit, P.2
Toulany, M.3
Kehlbach, R.4
Multhoff, G.5
Rodemann, H.P.6
-
143
-
-
84862603409
-
Dual functions of autophagy in the response of breast tumor cells to radiation: cytoprotective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D3
-
Bristol ML, Di X, Beckman MJ, Wilson EN, Henderson SC, Maiti A, Fan Z and Gewirtz DA. Dual functions of autophagy in the response of breast tumor cells to radiation: cytoprotective autophagy with radiation alone and cytotoxic autophagy in radiosensitization by vitamin D3. Autophagy 2012; 8: 739-753.
-
(2012)
Autophagy
, vol.8
, pp. 739-753
-
-
Bristol, M.L.1
Di, X.2
Beckman, M.J.3
Wilson, E.N.4
Henderson, S.C.5
Maiti, A.6
Fan, Z.7
Gewirtz, D.A.8
-
144
-
-
84875364684
-
3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy
-
Sheng Y, Sun B, Guo WT, Zhang YH, Liu X, Xing Y and Dong DL. 3-Methyladenine induces cell death and its interaction with chemotherapeutic drugs is independent of autophagy. Biochem Biophys Res Commun 2013; 432: 5-9.
-
(2013)
Biochem Biophys Res Commun
, vol.432
, pp. 5-9
-
-
Sheng, Y.1
Sun, B.2
Guo, W.T.3
Zhang, Y.H.4
Liu, X.5
Xing, Y.6
Dong, D.L.7
-
145
-
-
71749096160
-
Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies
-
Solomon VR and Lee H. Chloroquine and its analogs: a new promise of an old drug for effective and safe cancer therapies. Eur J Pharmacol 2009; 625: 220-233.
-
(2009)
Eur J Pharmacol
, vol.625
, pp. 220-233
-
-
Solomon, V.R.1
Lee, H.2
-
146
-
-
84857267849
-
Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy
-
Maycotte P, Aryal S, Cummings CT, Thorburn J, Morgan MJ and Thorburn A. Chloroquine sensitizes breast cancer cells to chemotherapy independent of autophagy. Autophagy 2012; 8: 200-212.
-
(2012)
Autophagy
, vol.8
, pp. 200-212
-
-
Maycotte, P.1
Aryal, S.2
Cummings, C.T.3
Thorburn, J.4
Morgan, M.J.5
Thorburn, A.6
-
147
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine B and Kroemer G. Autophagy in the pathogenesis of disease. Cell 2008; 132: 27-42.
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
148
-
-
60549093730
-
Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates
-
Korolchuk VI, Mansilla A, Menzies FM and Rubinsztein DC. Autophagy inhibition compromises degradation of ubiquitin-proteasome pathway substrates. Mol Cell 2009; 33: 517-527.
-
(2009)
Mol Cell
, vol.33
, pp. 517-527
-
-
Korolchuk, V.I.1
Mansilla, A.2
Menzies, F.M.3
Rubinsztein, D.C.4
|