Combination of pan-histone deacetylase inhibitor and autophagy inhibitor exerts superior efficacy against triple-negative human breast cancer cells

Molecular Cancer Therapeutics

Volumn 11, Issue 4, 2012, Pages 973-983

  Rao, Rekha ^a   Balusu, Ramesh ^a   Fiskus, Warren ^a   Mudunuru, Uma ^a   Venkannagari, Sreedhar ^a   Chauhan, Lata ^a   Smith, Jacqueline E ^a   Hembruff, Stacey L ^a   Ha, Kyungsoo ^a   Atadja, Peter ^b   Bhalla, Kapil N ^a  

^a UNIVERSITY OF KANSAS CANCER CENTER   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; HEAT SHOCK PROTEIN 90; HEAT SHOCK TRANSCRIPTION FACTOR 1; HISTONE DEACETYLASE 6; PANOBINOSTAT; PROTEIN; PROTEIN LC3B II; PROTEIN P62; PROTEIN P97; UBIQUITINATED PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL; CANCER SURVIVAL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; DRUG EFFICACY; DRUG POTENTIATION; ENDOPLASMIC RETICULUM STRESS; HEAT SHOCK; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TRIPLE NEGATIVE BREAST CANCER; TUMOR VOLUME; TUMOR XENOGRAFT; UPREGULATION;

ANIMALS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; APOPTOSIS; AUTOPHAGY; BREAST NEOPLASMS; CELL LINE, TUMOR; CHLOROQUINE; DRUG SYNERGISM; FEMALE; HISTONE DEACETYLASE INHIBITORS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYDROXAMIC ACIDS; MICE; MICE, INBRED NOD; MICE, SCID; MICROSCOPY, CONFOCAL; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84861961464     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-11-0979     Document Type: Article

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