Autophagy and metastasis: Another double-edged sword

Current Opinion in Cell Biology

Volumn 22, Issue 2, 2010, Pages 241-245

  Kenific, Candia M ^a   Thorburn, Andrew ^b   Debnath, Jayanta ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANOIKIS; ANTINEOPLASTIC ACTIVITY; AUTOPHAGY; CELL DEATH; CELL STRESS; CELL SURVIVAL; DISEASE COURSE; DORMANCY; EXTRACELLULAR MATRIX; INFLAMMATION; MACROMETASTASIS; METASTASIS; METASTASIS INHIBITION; MICROENVIRONMENT; NONHUMAN; PRIORITY JOURNAL; REVIEW; TUMOR CELL;

ANIMALS; ANOIKIS; AUTOPHAGY; CELL CYCLE; HUMANS; INFLAMMATION; NECROSIS; NEOPLASM METASTASIS;

EID: 77951212660     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2009.10.008     Document Type: Review

References (34)

1. Chambers A.F., Groom A.C., MacDonald I.C. Metastasis: dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002, 2:563-572.
2. Lock R., Debnath J. Extracellular matrix regulation of autophagy. Curr Opin Cell Biol 2008, 20:583-588.
3. Mathew R., Karantza-Wadsworth V., White E. Role of autophagy in cancer. Nat Rev Cancer 2007, 7:961-967.
4. Hippert M.M., O'Toole P.S., Thorburn A. Autophagy in cancer: good, bad, or both?. Cancer Res 2006, 66:9349-9351.
5. Tlsty T.D., Coussens L.M. Tumor stroma and regulation of cancer development. Annu Rev Pathol: Mech Dis 2006, 1:119-150.
6. DeNardo D., Johansson M., Coussens L. Immune cells as mediators of solid tumor metastasis. Cancer Metastasis Rev 2008, 27:11-18.
7. DeNardo D.G., Barreto J.B., Andreu P., Vasquez L., Tawfik D., Kolhatkar N., Coussens L.M. CD4+ T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages. Cancer Cell 2009, 16:91-102.
8. Bingle L., Brown N.J., Lewis C.E. The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J Pathol 2002, 196:254-265.
9. Degenhardt K., Mathew R., Beaudoin B., Bray K., Anderson D., Chen G., Mukherjee C., Shi Y., Gélinas C., Fan Y., et al. Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis. Cancer Cell 2006, 10:51-64.
10. Lin E.Y., Nguyen A.V., Russell R.G., Pollard J.W. Colony-stimulating Factor 1 promotes progression of mammary tumors to malignancy. J Exp Med 2001, 193:727-740.
11. Apetoh L., Ghiringhelli F., Tesniere A., Obeid M., Ortiz C., Criollo A., Mignot G., Maiuri M.C., Ullrich E., Saulnier P., et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nat Med 2007, 13:1050-1059.
12. Thorburn J., Horita H., Redzic J., Hansen K., Frankel A.E., Thorburn A. Autophagy regulates selective HMGB1 release in tumor cells that are destined to die. Cell Death Differ 2008, 16:175-183.
13. Shin M.S., Kim H.S., Lee S.H., Park W.S., Kim S.Y., Park J.Y., Lee J.H., Lee S.K., Lee S.N., Jung S.S., et al. Mutations of tumor necrosis factor-related apoptosis-inducing ligand Receptor 1 (TRAIL-R1) and Receptor 2 (TRAIL-R2) genes in metastatic breast cancers. Cancer Res 2001, 61:4942-4946.
14. Han J., Hou W., Goldstein L.A., Lu C., Stolz D.B., Yin X.-M., Rabinowich H. Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells. J Biol Chem 2008, 283:19665-19677.
15. Herrero-Martin G., Hoyer-Hansen M., Garcia-Garcia C., Fumarola C., Farkas T., Lopez-Rivas A., Jaattela M. TAK1 activates AMPK-dependent cytoprotective autophagy in TRAIL-treated epithelial cells. EMBO J 2009, 28:677-685.
16. Nguyen D.X., Bos P.D., Massague J. Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 2009, 9:274-284.
17. Chiarugi P., Giannoni E. Anoikis: a necessary death program for anchorage-dependent cells. Biochem Pharmacol 2008, 76:1352-1364.
18. Frisch S., Francis H. Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994, 124:619-626.
19. Mailleux A.A., Overholtzer M., Schmelzle T., Bouillet P., Strasser A., Brugge J.S. BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanisms. Dev Cell 2007, 12:221-234.
20. Yawata A., Adachi M., Okuda H., Naishiro Y., Takamura T., Hareyama M., Takayama S., Reed J.C., Imai K. Prolonged cell survival enhances peritoneal dissemination of gastric cancer cells. Oncogene 1998, 16:2681-2686.
21. Douma S., van Laar T., Zevenhoven J., Meuwissen R., van Garderen E., Peeper D.S. Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature 2004, 430:1034-1039.
22. Fung C., Lock R., Gao S., Salas E., Debnath J. Induction of autophagy during extracellular matrix detachment promotes cell survival. Mol Biol Cell 2008, 19:797-806.
23. Debnath J., Mills K.R., Collins N.L., Reginato M.J., Muthuswamy S.K., Brugge J.S. The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini. Cell 2002, 111:29-40.
24. Miranti C.K., Brugge J.S. Sensing the environment: a historical perspective on integrin signal transduction. Nat Cell Biol 2002, 4:E83-E90.
25. Edinger A.L., Thompson C.B. Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol Biol Cell 2002, 13:2276-2288.
26. Schafer Z.T., Grassian A.R., Song L., Jiang Z., Gerhart-Hines Z., Irie H.Y., Gao S., Puigserver P., Brugge J.S. Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment. Nature 2009, 461:109-113.
27. Mori S., Chang J.T., Andrechek E.R., Matsumura N., Baba T., Yao G., Kim J.W., Gatza M., Murphy S., Nevins J.R. Anchorage-independent cell growth signature identifies tumors with metastatic potential. Oncogene 2009, 28:2796-2805.
28. Aguirre-Ghiso J.A. Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer 2007, 7:834-846.
29. White D.E., Kurpios N.A., Zuo D., Hassell J.A., Blaess S., Mueller U., Muller W.J. Targeted disruption of [beta]1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction. Cancer Cell 2004, 6:159-170.
30. Zhang X.H.F., Wang Q., Gerald W., Hudis C.A., Norton L., Smid M., Foekens J.A., Massagué J. Latent bone metastasis in breast cancer tied to Src-dependent survival signals. Cancer Cell 2009, 16:67-78.
31. Melendez A., Talloczy Z., Seaman M., Eskelinen E.-L., Hall D.H., Levine B. Autophagy genes are essential for Dauer development and life-span extension in C. elegans. Science 2003, 301:1387-1391.
32. Liang J., Shao S.H., Xu Z.-X., Hennessy B., Ding Z., Larrea M., Kondo S., Dumont D.J., Gutterman J.U., Walker C.L., et al. The energy sensing LKB1-AMPK pathway regulates p27kip1 phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 2007, 9:218-224.
33. Barkan D., Kleinman H., Simmons J.L., Asmussen H., Kamaraju A.K., Hoenorhoff M.J., Liu Z.-y., Costes S.V., Cho E.H., Lockett S., et al. Inhibition of metastatic outgrowth from single dormant tumor cells by targeting the cytoskeleton. Cancer Res 2008, 68:6241-6250.
34. Lu Z., Luo R.Z., Lu Y., Zhang X., Yu Q., Khare S., Kondo S., Kondo Y., Yu Y., Mills G.B., et al. The tumor suppressor gene ARHI regulates autophagy and tumor dormancy in human ovarian cancer cells. J Clin Invest 2008, 118:3917-3929.