Ablation of Akt2 induces autophagy through cell cycle arrest, the downregulation of p70s6k, and the deregulation of mitochondria in MDA-MB231 cells

PLoS ONE

Volumn 6, Issue 1, 2011, Pages

  Santi, Stacey A ^a,b   Lee, Hoyun ^a,b,c  

^a SUDBURY REGIONAL HOSPITAL   (Canada)

^b UNIVERSITY OF OTTAWA   (Canada)

^c NORTHERN ONTARIO SCHOOL OF MEDICINE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLATE KINASE; CYCLIN A; CYCLIN D; CYCLIN DEPENDENT KINASE 2; CYCLIN E; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN KINASE B; PROTEIN KINASE B BETA; PROTEIN P27; S PHASE KINASE ASSOCIATED PROTEIN; S PHASE KINASE ASSOCIATED PROTEIN 2; S6 KINASE; SMALL INTERFERING RNA; THREONINE; AKT2 PROTEIN, HUMAN; CELL CYCLE PROTEIN; ISOPROTEIN;

ARTICLE; AUTOPHAGY; BIOGENESIS; BREAST CANCER; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL DEATH; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA REPLICATION; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; BREAST TUMOR; CELL CYCLE; DRUG DELIVERY SYSTEM; DRUG EFFECT; FEMALE; GENETICS; METHODOLOGY; PATHOLOGY; TUMOR CELL LINE;

AUTOPHAGY; BREAST NEOPLASMS; CELL CYCLE; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DOWN-REGULATION; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; MITOCHONDRIA; PROTEIN ISOFORMS; PROTO-ONCOGENE PROTEINS C-AKT; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; RNA, SMALL INTERFERING;

EID: 79551631199     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014614     Document Type: Article

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