Review of stem cell deregulation and breast cancer: An emerging hypothesis

Indian Journal of Pathology and Microbiology

Volumn 55, Issue 2, 2012, Pages 147-153

  Kumar, Darnal ^b   Kutty, Methil ^a  

^a UNIVERSITI SAINS ISLAM MALAYSIA   (Malaysia)

^b MONASH UNIVERSITY MALAYSIA   (Malaysia)

Author keywords

Cancer; molecular pathways; progenitor cell; stem cell; targeted therapy

Indexed keywords

ANTIESTROGEN; GAMMA SECRETASE INHIBITOR; LETROZOLE; STEROID HORMONE; TAMOXIFEN;

BREAST CANCER; BREAST CANCER STEM CELL; BREAST EPITHELIUM; CANCER PREVENTION; CANCER STEM CELL; CANCER THERAPY; CELL DIFFERENTIATION; CELL FUNCTION; DRUG MECHANISM; GENE DOSAGE; GENE EXPRESSION; HUMAN; NONHUMAN; NOTCH GENE; ONCOGENE; ONCOGENE C MYC; REVIEW; WNT GENE;

BREAST NEOPLASMS; CELL PROLIFERATION; FEMALE; HUMANS; MODELS, BIOLOGICAL; NEOPLASTIC STEM CELLS; STEM CELLS;

EID: 84863736653     PISSN: 03774929     EISSN: 09745130     Source Type: Journal    
DOI: 10.4103/0377-4929.97842     Document Type: Review

References (64)

1. Dantu G, Al-Hajj M, Abdallah WM, Clarke MF, Wicha MS. Stem cells in normal breast development and breast cancer. Cell Prolif 2003;36 (Suppl 1):59-72.
2. Kim C, Bryant J, horne Z. Trastuzumab sensitivity of breast cancer with co-amplification of HER2 and cMYC suggest pro-apoptotic function of dysregulated cMYC in vivo. Proceedings from the 28th annual San Antonio Breast Cancer Symposium. December 2005. Abstract #46.
3. Evan MJ, Kaufman MH. Establishment of culture of pluripotential cells from mouse embryos. Nature 1981;292:154-6.
4. Thomson J, Itskovitz-Eldor J, Shapiro S, Waknitz M, Swiergiel J, Marshall V, et al. Embryonic stem cell lines derived from human blastocyts. Science 1998;282:1145-7.
5. Reya T, Morrison S, Clarke M, Weissman I. Stem cells, cancer and cancer stem cells. Nature 2001;414:105-11.
6. Domen J, Cheshier SH, Weissman IL. The role of apaptosis in the regulation of hematopoitic stem cells: Overexpression of BCL-2 increases both their number and repopulation potential. J Exp Med 2000;191:253-64.
7. Lemischka IR, Morre KA. Stem cell: Interactive niches. Nature 2003;425:778-9.
8. Calvi LM, Adams GB, Weibrecht KW, Weber JM, Olson DP, Knight MC, et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003;425:841-6.
9. Zhang J, Niu C, Ye L, Huang H, He X, Tong WG, et al. Identification of the haematopoietic stem cell niche and control of the niche size. Nature 2003;425:836-41.
10. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res 1961;25:585-621.
11. Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp Cell 1965;37:614-36.
12. Olovnikov AM. Telomeres, telomerase and aging: Origin of the theory. Exp Gerontol 1996;31:443-8.
13. Cairns J. Mutation selection and the natural history of cancer. Nature 1975;255:197-200.
14. Karpowicz P, Morshead C, Kam A, Jervis E, Ramunas J, Cheng V, et al. Support for the immortal strand hypothesis: Neural stem cells partition DNA asymmetrically in vitro. J Cell Biol 2005;170:721-32.
15. Shinin V, Gayraud-Morel B, Gomes D, Tajbakhsh S. Asymmetric division and cosegregation of template DNA strands in adult muscle satellite cells. Nature Cell Biology 2006;8:677-87.
16. Jang YY, Collector MI, Baylin SB, diehl AM, Sharkis SJ. Hematopoietic stem cells convert into liver cells within days without fusion. Nat Cell Biol 2004;6:532-9.
17. Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz- Gonzalez XR, et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002;418:41-9.
18. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B, et al. Bone marrow cells regenerate infarcted myocardium. Nature 2001;410:701-4.
19. Beltrami AP, Barlucchi L, Torella D, Baker M, Limana F, Chimenti S, et al. Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell 2003;114:763-6.
20. Alison MR, Poulsom R, Forbes S, Wright NA. An introduction to stem cells. J Pathol 2002;197:419-23.
21. Zangani 2007-07-17. Available from: http://www.zangani.com/node/735.Human stem cells may be produced without embryos "within months".
22. Embryonic stem cells made without embryos. Reuters. 2007-11-21.
23. Rick Weiss (2007-12-07). Scientists cure Mice of sickle cell using stem cell technique: New approach is from skin, not embryos. Washington post. Pp; A02. Available from: http://www.washingtonpost.com/wpyn/content/article/2007/12/ 06/AR200712062444.html.
24. Korinek V, Baker N, Moerer P, van Donselaar E, Huls G, Peters PJ, et al. Depletion of epithelial stem cell compartment in small intestine of mice lacking Tcf-4. Nat Genet 1998;19:379-83.
25. He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, et al. BMP signaling inhibits intestinal stem cell self renewal through suppression of Wnt-beta-catenin signaling. Nat Genet 2004;36:1117-21.
26. Bienz M, Clevers H. Linking colorectal cancer to Wnt signaling. Cell 2000;103:311-20.19.
27. Park IK, Morrison SJ, Clarke MF. Bmil, stem cells and senescence regulation. J Clin Invest 2004;113:175-9.
28. Tanos T, Brisken C. What signals operate in mammary niche? Breast Dis 2008;29:69-82.
29. Ganggemi R, Paleari L, Orengo AM, Cesario A, Chessa L, Ferrini S, et al. Cancer stem cells: A new paradigm for understanding tumour growth and progression and drug resistance. Curr Med Chem 2009;16:1688-903.
30. Bonnet D, Dick JE. Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med 1997;3:730-7.
31. Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF. Prospective identification of tumorigenic breast cancer cells. Proc Natl Aca Sci USA 2003;100:3983-8.
32. Singh SK, Clarke ID, Terasaki M, Bonn VE, Hawkins C, Squire J, et al. Identification of a cancer stem cell in human brain tumors. Cancer Res 2003;63:5821-8.
33. Tu LC, Folz G, Lin E, Hood L, Tian Q. Targeting stem cells- clinical implications for cancer therapy. Curr Stem Cell Ther 2009;4:147-53.
34. Korkaya H, Wicha MS. Selective targeting of cancer stem cells: A new concept in cancer therapeutics. BioDrugs 2007;21:299-310.
35. Christophe G, Min Hee Hur, Emmanuelle CJ. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem cell 2007;1:555-67 Available from: http://www.ncbi.nlm.nih.gov.
36. Vaillant F, Asselin-Labat ML, Shackleton M, Forrest NC, Lindeman GJ, Visvader JE. The mammary progenitor marker CD61/b3 integrin identifies cancer stem cells in mouse models of mammary tumorigenesis. Cancer Res 2008;68:7711-7.
37. Wicha MS, Liu S, Dontu G. Cancer stem cells: An old idea-A paradigm shift. Cancer Res 2006;66:1883-90.
38. Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin- Labat ML, et al. Generation of a functional mammary gland from a single stem cell. Nature 2006;439:84-8.
39. Farnie G, Clarke RB. Mammary stem cells and breast cancer- role of notch signaling. Stem Cell Rev 2007;3:169-75.
40. Shimono Y, Zabala M, Cho RW, Lobo N, Dalerba P, Qian D, et al. Down regulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell 2009;138:592-603.
41. Li Y, Welm B, Podsypanina K, Huang S, Chamorro M, Zhang X, et al. Evidence that transgenes encoding components of the Wnt signaling pathway preferentially induce mammary cancers from progenitor cells. Proc Natl Acad Sci USA 2003;100:15853-8.
42. Dimri GP, Martinez JL, Jacobs JJ, Keblusek P, Itahana K, Van Lohuizen M, et al. The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelia cells. Cancer Res 2002;62:4736-45.
43. Jönsson G, Staaf J, Vallon-Christersson J, Ringner M, Holm K, Hegardt C, et al. Genomic subtypes of breast cancer by array-comparative genomic hybridization display distinct molecular and clinical characteristics. Breast Cancer Res 2010;12:R42.
44. Rizzo P, Miao H, D'Souza G, Osipo C, Song LL, Yun J, et al. Cross-talk between Notch and the estrogen receptor in breast cancer suggests novel therapeutic approaches. Cancer Res 2008;68:5226-35.
45. Lim E, Wu D, Pal B, Bouras T, Asselin-Labat ML, Vaillant F, et al. Transcription analysises of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res 2010;12:R21.
46. Brisken C, Duss S. Stem cells and the stem cell niche in the breast: An integrated hormonal and developmental perspective. Stem Cell Rev 2007;3:147-56.
47. Joshi PA, Jackson HW, Beristain AG, Di Grappa MA, Mote PA, Clarke CL, et al. Progesterone induces adult mammary stem cell expansion. Nature 2010;465:803-7.
48. Asselin-Labat ML, Vaillant F, Sherdan JM, Pal B, Wu D, Simpson ER, et al. Control of mammary stem cell function by steroid hormone signaling. Nature 2010;465:798-802.
49. Luragnuiz NS, Yong T, Yin H. Sun A. Targeting Notch signaling and estrogen receptor pathways in human breast cancer stem cells. J Clin Oncol 2008;26(May suppl):abstract 22066.
50. Ezeh UI, Turek PJ, Reijo RA, Clark AT. Human embryonic stem cell genes OCT4, NANOG, STELLAT and GDF3 are expressed in both seminoma and breast carcinoma. Cancer 2005;104:2255-65.
51. Bourguignon LY, Peyrollier K, Xia W, Gilad E. Hyaluronon-CD44- interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression and ankyrin-regulated multidrug efflux in breast and ovarian tumour cells. J Biol Chem 2008;283:17635-51.
52. Liu S, Dontu G, Wicha MS. Mammary stem cells, self renewal pathways and carcinogenesis. Breast Cancer Res 2005;7:86-95.
53. Charafe-Jauffret E, Monville F, Ginestier C, Dontu G, Birnbaum D, Wicha MS. Cancer stem cells in breast: Current opinion and future challenges. Pathobiology 2008;75:75-84.
54. Farnie G, Clarke RB. Breast stem cells and cancer. Ernst Schering Found Sym Proc 2006;5:141-53.
55. Lin T, Meng L, Li Y, Tsai RY. Tumour-initating function of nucleosteminenriched mammary tumour cells. Cancer Res 2010;70:9444-52.
56. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, da Costa LT, et al. Identification of c-MYC as a target of the APC pathway. Science 1998;281:1509-12.
57. Cowling VH, D'Cruz CM, Chodosh LA, Cole MD. C-MYC transforms human mammary epithelial cells through repression of the Wnt inhibitors DKK1 and SFRP1. Mol Cell Biol 2007;27:5135-46.
58. Bouras T, Pal B, Vaillant F, Harburg G, Asselin-Labat ML, Oakes SR, et al. Notch signaling regulates mammary stem cell function and luminal cell-fate commitment. Cell Stem Cell 2008;3:429-41.
59. Philipp A, Schneider A, Väsrik I, Finke K, Xiong Y, Beach D, et al. Repression of cyclin D1: Anovel function of MYC. Mol Cell Biol 1994;14:4032-43.
60. Sandgren EP, Scroeder JA, Qui TH, Palmiter RD, Brinster RL, Lee DC. Inhibition of mammary gland involution is associated with transforming growth factor alpha but not c-myc-induced tumorigenesis in transgenic mice. Cancer Res 1995;55:3915-27.
61. Schoenenberger CA, Andes AC, Groner B, van der valk M, LeMeur M, Gerlinger P. Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription. EMBO J 1988;7:169-75.
62. Woodward WA, Chen MS, Behbod F, Rosen JM. On mammary stem cells. J Cell Sci 2005;118:3585-94.
63. Kakarala M, Wicha MS. Implication of cancer stem cell hypothesis for breast cancer prevention and therapy. J Clin Oncol 2008;26:2813-20.
64. Barabe F, Kennedy JA, Hope KJ, Dick JE. Modelling the initiation and progression of human acute leukemia in mice. Science 2007;316:600-4.