Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator

Journal of Biological Chemistry

Volumn 286, Issue 45, 2011, Pages 39247-39258

  Lee, Kuen Haur ^a   Hsu, En Chi ^a   Guh, Jih Hwa ^c   Yang, Hsiao Ching ^d   Wang, Dasheng ^a   Kulp, Samuel K ^a   Shapiro, Charles L ^b   Chen, Ching Shih ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^d FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-PROLIFERATIVE; ANTI-TUMOR ACTIVITIES; AUTOPHAGY; BREAST CANCER; BROAD SPECTRUM; COACTIVATORS; DEPHOSPHORYLATIONS; E-CADHERINS; ENERGY HOMEOSTASIS; FATTY ACID BIOSYNTHESIS; HYPOXIA-INDUCIBLE FACTORS; IN-VITRO; IN-VIVO; KEY REGULATORS; KINASE ACTIVITY; LIPOGENESIS; MAMMALIAN TARGET; MITOCHONDRIAL BIOGENESIS; NUCLEAR RESPIRATORY FACTORS; ORAL ADMINISTRATION; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR; PROTEIN KINASE; PROTEIN PHOSPHATASE 2A; SIGNALING PATHWAYS; TUMOR GROWTH;

ANTIBIOTICS; BIOCHEMISTRY; BIOSYNTHESIS; CYTOLOGY; DISEASES; ENZYMES; FATTY ACIDS; IMMUNOLOGY; MAMMALS; METABOLISM; PHYSIOLOGY; SIGNALING; TRANSCRIPTION FACTORS; TUMORS;

CHEMICAL ACTIVATION;

ADENOSINE MONOPHOSPHATE ACTIVATED PROTEIN KINASE; ADENOSINE PHOSPHATE; ANTINEOPLASTIC AGENT; CHLOROQUINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 6; MAMMALIAN TARGET OF RAPAMYCIN; NUCLEAR RESPIRATORY FACTOR 1; OSU 53; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; STAT3 PROTEIN; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CARCINOGENICITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG BIOAVAILABILITY; DRUG DETERMINATION; DRUG STRUCTURE; ENERGY METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; FATTY ACID SYNTHESIS; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LIPOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; TRIPLE NEGATIVE BREAST CANCER;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; ENERGY METABOLISM; ENZYME ACTIVATORS; FATTY ACIDS; FEMALE; HUMANS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MICE; MICE, NUDE; MITOCHONDRIA; NEOPLASM PROTEINS; PROTEIN PHOSPHATASE 2; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTORS;

GASTROPODA; MAMMALIA; MUS;

EID: 80655125020     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.264598     Document Type: Article

References (62)

1. Hardie, D. G. (2007) Nat. Rev. Mol. Cell Biol. 8, 774-785
2. Hardie, D. G. (2007) Annu. Rev. Pharmacol. Toxicol. 47, 185-210
3. Hardie, D. G., and Sakamoto, K. (2006) Physiology 21, 48-60
4. Kahn, B. B., Alquier, T., Carling, D., and Hardie, D. G. (2005) Cell Metab. 1, 15-25
5. Shackelford, D. B., and Shaw, R. J. (2009) Nat. Rev. Cancer 9, 563-575
6. Inoki, K., Zhu, T., and Guan, K. L. (2003) Cell 115, 577-590
7. Hadad, S. M., Fleming, S., and Thompson, A. M. (2008) Crit. Rev. Oncol. Hematol. 67, 1-7
8. Zadra, G., Priolo, C., Patnaik, A., and Loda, M. (2010) Clin. Cancer Res. 16, 3322-3328
9. Guo, D., Hildebrandt, I. J., Prins, R. M., Soto, H., Mazzotta, M. M., Dang, J., Czernin, J., Shyy, J. Y., Watson, A. D., Phelps, M., Radu, C. G., Cloughesy, T. F., and Mischel, P. S. (2009) Proc. Natl. Acad. Sci. U.S.A. 106, 12932-12937
10. Memmott, R. M., Mercado, J. R., Maier, C. R., Kawabata, S., Fox, S. D., and Dennis, P. A. (2010) Cancer Prev. Res. 3, 1066-1076
11. Bodmer, M., Meier, C., Krähenbühl, S., Jick, S. S., and Meier, C. R. (2010) Diabetes Care 33, 1304-1308
12. Evans, J. M., Donnelly, L. A., Emslie-Smith, A. M., Alessi, D. R., and Morris, A. D. (2005) BMJ 330, 1304-1305
13. Goodwin, P. J., Ligibel, J. A., and Stambolic, V. (2009) J. Clin. Oncol. 27, 3271-3273
14. Jiralerspong, S., Palla, S. L., Giordano, S. H., Meric-Bernstam, F., Liedtke, C., Barnett, C. M., Hsu, L., Hung, M. C., Hortobagyi, G. N., and Gonzalez-Angulo, A. M. (2009) J. Clin. Oncol. 27, 3297-3302
15. Zakikhani, M., Blouin, M. J., Piura, E., and Pollak, M. N. (2010) Breast Cancer Res. Treat. 123, 271-279
16. Fryer, L. G., Parbu-Patel, A., and Carling, D. (2002) J. Biol. Chem. 277, 25226-25232
17. Xie, Z., Dong, Y., Scholz, R., Neumann, D., and Zou, M. H. (2008) Circulation 117, 952-962
18. Guh, J. H., Chang, W. L., Yang, J., Lee, S. L., Wei, S., Wang, D., Kulp, S. K., and Chen, C. S. (2010) J. Med. Chem. 53, 2552-2561
19. Sun, Y., Connors, K. E., and Yang, D. Q. (2007) Mol. Cell. Biochem. 306, 239-245
20. Zhang, L., He, H., and Balschi, J. A. (2007) Am. J. Physiol. Heart Circ. Physiol. 293, H457-H466
21. Zang, Y., Yu, L. F., Pang, T., Fang, L. P., Feng, X., Wen, T. Q., Nan, F. J., Feng, L. Y., and Li, J. (2008) J. Biol. Chem. 283, 6201-6208
22. Foretz, M., Hébrard, S., Leclerc, J., Zarrinpashneh, E., Soty, M., Mithieux, G., Sakamoto, K., Andreelli, F., and Viollet, B. (2010) J. Clin. Invest. 120, 2355-2369
23. Reis-Filho, J. S., and Tutt, A. N. (2008) Histopathology 52, 108-118
24. Carey, L. A., Dees, E. C., Sawyer, L., Gatti, L., Moore, D. T., Collichio, F., Ollila, D. W., Sartor, C. I., Graham, M. L., and Perou, C. M. (2007) Clin. Cancer Res. 13, 2329-2334
25. Kuznetsov, J. N., Leclerc, G. J., Leclerc, G. M., and Barredo, J. C. (2011) Mol. Cancer Ther. 10, 437-447
26. Dowling, R. J., Zakikhani, M., Fantus, I. G., Pollak, M., and Sonenberg, N. (2007) Cancer Res. 67, 10804-10812
27. Meijer, A. J., and Codogno, P. (2007) Autophagy 3, 238-240
28. Weinstein, I. B., and Joe, A. (2008) Cancer Res. 68, 3077-3080
29. Dyck, J. R., Gao, G., Widmer, J., Stapleton, D., Fernandez, C. S., Kemp, B. E., and Witters, L. A. (1996) J. Biol. Chem. 271, 17798-17803
30. Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., Musi, N., Hirshman, M. F., Goodyear, L. J., and Moller, D. E. (2001) J. Clin. Invest. 108, 1167-1174
31. Jornayvaz, F. R., and Shulman, G. I. (2010) Essays Biochem. 47, 69-84
32. Yu, L., and Yang, S. J. (2010) Neuroscience 169, 23-38
33. Ma, Y., Bai, R. K., Trieu, R., and Wong, L. J. (2010) Biochim. Biophys. Acta 1797, 29-37
34. Kim, K. Y., Baek, A., Hwang, J. E., Choi, Y. A., Jeong, J., Lee, M. S., Cho, D. H., Lim, J. S., Kim, K. I., and Yang, Y. (2009) Cancer Res. 69, 4018-4026
35. Bayascas, J. R., and Alessi, D. R. (2005) Mol. Cell 18, 143-145
36. Lihn, A. S., Pedersen, S. B., Lund, S., and Richelsen, B. (2008) Mol. Cell. Endocrinol. 292, 36-41
37. Sag, D., Carling, D., Stout, R. D., and Suttles, J. (2008) J. Immunol. 181, 8633-8641
38. Nerstedt, A., Johansson, A., Andersson, C. X., Cansby, E., Smith, U., and Mahlapuu, M. (2010) Diabetologia 53, 2406-2416
39. Bromberg, J., and Wang, T. C. (2009) Cancer Cell 15, 79-80
40. Sullivan, N. J., Sasser, A. K., Axel, A. E., Vesuna, F., Raman, V., Ramirez, N., Oberyszyn, T. M., and Hall, B. M. (2009) Oncogene 28, 2940-2947
41. Tse, J. C., and Kalluri, R. (2007) J. Cell. Biochem. 101, 816-829
42. Kalluri, R., and Weinberg, R. A. (2009) J. Clin. Invest. 119, 1420-1428
43. Yang, M. H., Wu, M. Z., Chiou, S. H., Chen, P. M., Chang, S. Y., Liu, C. J., Teng, S. C., and Wu, K. J. (2008) Nat. Cell Biol. 10, 295-305
44. Bernardi, R., Guernah, I., Jin, D., Grisendi, S., Alimonti, A., Teruya-Feldstein, J., Cordon-Cardo, C., Simon, M. C., Rafii, S., and Pandolfi, P. P. (2006) Nature 442, 779-785
45. Flügel, D., Görlach, A., Michiels, C., and Kietzmann, T. (2007) Mol. Cell. Biol. 27, 3253-3265
46. Mbalaviele, G., Dunstan, C. R., Sasaki, A., Williams, P. J., Mundy, G. R., and Yoneda, T. (1996) Cancer Res. 56, 4063-4070
47. Batlle, E., Sancho, E., Francí, C., Domínguez, D., Monfar, M., Baulida, J., and García De Herreros, A. (2000) Nat. Cell Biol. 2, 84-89
48. Vesuna, F., van Diest, P., Chen, J. H., and Raman, V. (2008) Biochem. Biophys. Res. Commun. 367, 235-241
49. Foubert, E., De Craene, B., and Berx, G. (2010) Breast Cancer Res. 12, 206
50. Codogno, P., and Meijer, A. J. (2005) Cell Death Differ. 12, Suppl. 2, 1509-1518
51. Fan, Q. W., Cheng, C., Hackett, C., Feldman, M., Houseman, B. T., Nicolaides, T., Haas-Kogan, D., James, C. D., Oakes, S. A., Debnath, J., Shokat, K. M., and Weiss, W. A. (2010) Sci. Signal. 3, ra81
52. Pang, T., Zhang, Z. S., Gu, M., Qiu, B. Y., Yu, L. F., Cao, P. R., Shao, W., Su, M. B., Li, J. Y., Nan, F. J., and Li, J. (2008) J. Biol. Chem. 283, 16051-16060
53. Sanders, M. J., Ali, Z. S., Hegarty, B. D., Heath, R., Snowden, M. A., and Carling, D. (2007) J. Biol. Chem. 282, 32539-32548
54. Shen, Z., Wen, X. F., Lan, F., Shen, Z. Z., and Shao, Z. M. (2002) Clin. Cancer Res. 8, 2085-2090
55. Memmott, R. M., and Dennis, P. A. (2009) J. Clin. Oncol. 27, e226
56. Vilar, E., Perez-Garcia, J., and Tabernero, J. (2011) Mol. Cancer Ther. 10, 395-403
57. Leclerc, G. M., Leclerc, G. J., Fu, G., and Barredo, J. C. (2010) J. Mol. Signal. 5, 15
58. Zhang, B. B., Zhou, G., and Li, C. (2009) Cell Metab. 9, 407-416
59. Thomson, D. M., and Winder, W. W. (2009) Acta Physiol. 196, 147-154
60. Zhou, W., Simpson, P. J., McFadden, J. M., Townsend, C. A., Medghalchi, S. M., Vadlamudi, A., Pinn, M. L., Ronnett, G. V., and Kuhajda, F. P. (2003) Cancer Res. 63, 7330-7337
61. Berishaj, M., Gao, S. P., Ahmed, S., Leslie, K., Al-Ahmadie, H., Gerald, W. L., Bornmann, W., and Bromberg, J. F. (2007) Breast Cancer Res. 9, R32
62. Diaz, N., Minton, S., Cox, C., Bowman, T., Gritsko, T., Garcia, R., Eweis, I., Wloch, M., Livingston, S., Seijo, E., Cantor, A., Lee, J. H., Beam, C. A., Sullivan, D., Jove, R., and Muro-Cacho, C. A. (2006) Clin. Cancer Res. 12, 20-28