-
1
-
-
0344550324
-
New cytotoxic sesterterpenoids and norsesterterpenoids from two sponges of the genus Sarcotragus
-
Liu Y, Mansoor TA, Hong J, Lee CO, Sim CJ, et al. (2003) New cytotoxic sesterterpenoids and norsesterterpenoids from two sponges of the genus Sarcotragus. J Nat Prod 66: 1451-1456.
-
(2003)
J Nat Prod
, vol.66
, pp. 1451-1456
-
-
Liu, Y.1
Mansoor, T.A.2
Hong, J.3
Lee, C.O.4
Sim, C.J.5
-
2
-
-
0035914101
-
Probing sponge-derived terpenoids for human 15-lipoxygenase inhibitors
-
Carroll J, Jonsson EN, Ebel R, Hartman MS, Holman TR, et al. (2001) Probing sponge-derived terpenoids for human 15-lipoxygenase inhibitors. J Org Chem 66: 6847-6851.
-
(2001)
J Org Chem
, vol.66
, pp. 6847-6851
-
-
Carroll, J.1
Jonsson, E.N.2
Ebel, R.3
Hartman, M.S.4
Holman, T.R.5
-
3
-
-
0030711053
-
Rhabdastrellic Acid-A, a Novel Triterpenoid from the Marine Sponge Rhabdastrella globostellata
-
Rao Z, Deng S, Wu H, Jiang S (1997) Rhabdastrellic Acid-A, a Novel Triterpenoid from the Marine Sponge Rhabdastrella globostellata. J Nat Prod 60: 1163-1164.
-
(1997)
J Nat Prod
, vol.60
, pp. 1163-1164
-
-
Rao, Z.1
Deng, S.2
Wu, H.3
Jiang, S.4
-
4
-
-
39049097998
-
Rhabdastrellic acid-A inhibited PI3K/Akt pathway and induced apoptosis in human leukemia HL-60 cells
-
Guo JF, Zhou JM, Zhang Y, Deng R, Liu JN, et al. (2008) Rhabdastrellic acid-A inhibited PI3K/Akt pathway and induced apoptosis in human leukemia HL-60 cells. Cell Biol Int 32: 48-54.
-
(2008)
Cell Biol Int
, vol.32
, pp. 48-54
-
-
Guo, J.F.1
Zhou, J.M.2
Zhang, Y.3
Deng, R.4
Liu, J.N.5
-
5
-
-
0036183157
-
Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata
-
Tasdemir D, Mangalindan GC, Concepcion GP, Verbitski SM, Rabindran S, et al. (2002) Bioactive isomalabaricane triterpenes from the marine sponge Rhabdastrella globostellata. J Nat Prod 65: 210-214.
-
(2002)
J Nat Prod
, vol.65
, pp. 210-214
-
-
Tasdemir, D.1
Mangalindan, G.C.2
Concepcion, G.P.3
Verbitski, S.M.4
Rabindran, S.5
-
6
-
-
1842583789
-
Development by self-digestion: Molecular mechanisms and biological functions of autophagy
-
Levine B, Klionsky DJ (2004) Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6: 463-477.
-
(2004)
Dev Cell
, vol.6
, pp. 463-477
-
-
Levine, B.1
Klionsky, D.J.2
-
7
-
-
39049194057
-
The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function
-
Furuya N, Yu J, Byfield M, Pattingre S, Levine B (2005) The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function. Autophagy 1: 46-52.
-
(2005)
Autophagy
, vol.1
, pp. 46-52
-
-
Furuya, N.1
Yu, J.2
Byfield, M.3
Pattingre, S.4
Levine, B.5
-
8
-
-
0141884305
-
Diversity in the mechanisms of neuronal cell death
-
Yuan J, Lipinski M, Degterev A (2003) Diversity in the mechanisms of neuronal cell death. Neuron 40: 401-413.
-
(2003)
Neuron
, vol.40
, pp. 401-413
-
-
Yuan, J.1
Lipinski, M.2
Degterev, A.3
-
9
-
-
0442323561
-
Autophagy: In sickness and in health
-
Cuervo AM (2004) Autophagy: in sickness and in health. Trends Cell Biol 14: 70-77.
-
(2004)
Trends Cell Biol
, vol.14
, pp. 70-77
-
-
Cuervo, A.M.1
-
10
-
-
25144506835
-
Autophagy in cell death: An innocent convict?
-
Levine B, Yuan J (2005) Autophagy in cell death: an innocent convict? J Clin Invest 115: 2679-2688.
-
(2005)
J Clin Invest
, vol.115
, pp. 2679-2688
-
-
Levine, B.1
Yuan, J.2
-
11
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, et al. (1999) Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 402: 672-676.
-
(1999)
Nature
, vol.402
, pp. 672-676
-
-
Liang, X.H.1
Jackson, S.2
Seaman, M.3
Brown, K.4
Kempkes, B.5
-
12
-
-
0035870257
-
Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function
-
Liang XH, Yu J, Brown K, Levine B (2001) Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. Cancer Res 61: 3443-3449.
-
(2001)
Cancer Res
, vol.61
, pp. 3443-3449
-
-
Liang, X.H.1
Yu, J.2
Brown, K.3
Levine, B.4
-
13
-
-
35848947235
-
Beclin 1-independent pathway of damageinduced mitophagy and autophagic stress: Implications for neurodegeneration and cell death
-
Chu CT, Zhu J, Dagda R (2007) Beclin 1-independent pathway of damageinduced mitophagy and autophagic stress: implications for neurodegeneration and cell death. Autophagy 3: 663-666.
-
(2007)
Autophagy
, vol.3
, pp. 663-666
-
-
Chu, C.T.1
Zhu, J.2
Dagda, R.3
-
14
-
-
0001488499
-
Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein
-
Liang XH, Kleeman LK, Jiang HH, Gordon G, Goldman JE, et al. (1998) Protection against fatal Sindbis virus encephalitis by beclin, a novel Bcl-2-interacting protein. J Virol 72: 8586-8596.
-
(1998)
J Virol
, vol.72
, pp. 8586-8596
-
-
Liang, X.H.1
Kleeman, L.K.2
Jiang, H.H.3
Gordon, G.4
Goldman, J.E.5
-
15
-
-
33748456755
-
Pathways that regulate autophagy and their role in mediating tumor response to treatment
-
Paglin S, Yahalom J (2006) Pathways that regulate autophagy and their role in mediating tumor response to treatment. Autophagy 2: 291-293.
-
(2006)
Autophagy
, vol.2
, pp. 291-293
-
-
Paglin, S.1
Yahalom, J.2
-
16
-
-
12944303650
-
Growth factor regulation of autophagy and cell survival in the absence of apoptosis
-
Lum JJ, Bauer DE, Kong M, Harris MH, Li C, et al. (2005) Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 120: 237-248.
-
(2005)
Cell
, vol.120
, pp. 237-248
-
-
Lum, J.J.1
Bauer, D.E.2
Kong, M.3
Harris, M.H.4
Li, C.5
-
17
-
-
34147193472
-
Cell biology: Autophagy and cancer
-
Levine B (2007) Cell biology: autophagy and cancer. Nature 446: 745-747.
-
(2007)
Nature
, vol.446
, pp. 745-747
-
-
Levine, B.1
-
18
-
-
36249025723
-
Autophagy: Process and function
-
Mizushima N (2007) Autophagy: process and function. Genes Dev 21: 2861-2873.
-
(2007)
Genes Dev
, vol.21
, pp. 2861-2873
-
-
Mizushima, N.1
-
19
-
-
2642553881
-
Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8
-
Yu L, Alva A, Su H, Dutt P, Freundt E, et al. (2004) Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 304: 1500-1502.
-
(2004)
Science
, vol.304
, pp. 1500-1502
-
-
Yu, L.1
Alva, A.2
Su, H.3
Dutt, P.4
Freundt, E.5
-
20
-
-
33645038097
-
The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells over expressing MRP1
-
Abdul-Ghani R, Serra V, Gyorffy B, Jurchott K, Solf A, et al. (2006) The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells over expressing MRP1. Oncogene 25: 1743-1752.
-
(2006)
Oncogene
, vol.25
, pp. 1743-1752
-
-
Abdul-Ghani, R.1
Serra, V.2
Gyorffy, B.3
Jurchott, K.4
Solf, A.5
-
21
-
-
2042425906
-
The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors
-
Stitt TN, Drujan D, Clarke BA, Panaro F, Timofeyva Y, et al. (2004) The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Mol Cell 14: 395-403.
-
(2004)
Mol Cell
, vol.14
, pp. 395-403
-
-
Stitt, T.N.1
Drujan, D.2
Clarke, B.A.3
Panaro, F.4
Timofeyva, Y.5
-
22
-
-
0032513053
-
Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factorbinding protein-1 gene expression through a conserved insulin response sequence
-
Cichy SB, Uddin S, Danilkovich A, Guo S, Klippel A, et al. (1998) Protein kinase B/Akt mediates effects of insulin on hepatic insulin-like growth factorbinding protein-1 gene expression through a conserved insulin response sequence. J Biol Chem 273: 6482-6487.
-
(1998)
J Biol Chem
, vol.273
, pp. 6482-6487
-
-
Cichy, S.B.1
Uddin, S.2
Danilkovich, A.3
Guo, S.4
Klippel, A.5
-
23
-
-
0030662419
-
Activation of the PI3K effector protein kinase B following ligation of CD28 or Fas
-
Parry R, Smith G, Reif K, Sansom DM, Ward S (1997) Activation of the PI3K effector protein kinase B following ligation of CD28 or Fas. Biochem Soc Trans 25: S589.
-
(1997)
Biochem Soc Trans
, vol.25
-
-
Parry, R.1
Smith, G.2
Reif, K.3
Sansom, D.M.4
Ward, S.5
-
24
-
-
0030907987
-
PI3K: Downstream AKTion blocks apoptosis
-
Franke TF, Kaplan DR, Cantley LC (1997) PI3K: downstream AKTion blocks apoptosis. Cell 88: 435-437.
-
(1997)
Cell
, vol.88
, pp. 435-437
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
-
25
-
-
32944477371
-
Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression
-
Theodoropoulou M, Zhang J, Laupheimer S, Paez-Pereda M, Erneux C, et al. (2006) Octreotide, a somatostatin analogue, mediates its antiproliferative action in pituitary tumor cells by altering phosphatidylinositol 3-kinase signaling and inducing Zac1 expression. Cancer Res 66: 1576-1582.
-
(2006)
Cancer Res
, vol.66
, pp. 1576-1582
-
-
Theodoropoulou, M.1
Zhang, J.2
Laupheimer, S.3
Paez-Pereda, M.4
Erneux, C.5
-
26
-
-
0037352170
-
Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: A target for cancer chemotherapy
-
Chang F, Lee JT, Navolanic PM, Steelman LS, Shelton JG, et al. (2003) Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 17: 590-603.
-
(2003)
Leukemia
, vol.17
, pp. 590-603
-
-
Chang, F.1
Lee, J.T.2
Navolanic, P.M.3
Steelman, L.S.4
Shelton, J.G.5
-
27
-
-
2342618936
-
Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression
-
Liang J, Slingerland JM (2003) Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression. Cell Cycle 2: 339-345.
-
(2003)
Cell Cycle
, vol.2
, pp. 339-345
-
-
Liang, J.1
Slingerland, J.M.2
-
28
-
-
10744232673
-
Safety and antigenicity of whole virus and subunit influenza A/Hong Kong/1073/99 (H9N2) vaccine in healthy adults: Phase I randomised trial
-
Stephenson I, Nicholson KG, Gluck R, Mischler R, Newman RW, et al. (2003) Safety and antigenicity of whole virus and subunit influenza A/Hong Kong/1073/99 (H9N2) vaccine in healthy adults: phase I randomised trial. Lancet 362: 1959-1966.
-
(2003)
Lancet
, vol.362
, pp. 1959-1966
-
-
Stephenson, I.1
Nicholson, K.G.2
Gluck, R.3
Mischler, R.4
Newman, R.W.5
-
29
-
-
27744534653
-
Inhibition of PI3K/Akt signaling: An emerging paradigm for targeted cancer therapy
-
Chen YL, Law PY, Loh HH (2005) Inhibition of PI3K/Akt signaling: an emerging paradigm for targeted cancer therapy. Curr Med Chem Anticancer Agents 5: 575-589.
-
(2005)
Curr Med Chem Anticancer Agents
, vol.5
, pp. 575-589
-
-
Chen, Y.L.1
Law, P.Y.2
Loh, H.H.3
-
30
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
Hennessy BT, Smith DL, Ram PT, Lu Y, Mills GB (2005) Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4: 988-1004.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
Lu, Y.4
Mills, G.B.5
-
31
-
-
29444456417
-
Targeting the phosphatidylinositol-3 kinase/Akt pathway for the treatment of cancer
-
Kim D, Cheng GZ, Lindsley CW, Yang H, Cheng JQ (2005) Targeting the phosphatidylinositol-3 kinase/Akt pathway for the treatment of cancer. Curr Opin Investig Drugs 6: 1250-1258.
-
(2005)
Curr Opin Investig Drugs
, vol.6
, pp. 1250-1258
-
-
Kim, D.1
Cheng, G.Z.2
Lindsley, C.W.3
Yang, H.4
Cheng, J.Q.5
-
32
-
-
0344844473
-
Growth factor-independent activation of protein kinase B contributes to the inherent resistance of vascular endothelium to radiation-induced apoptotic response
-
Tan J, Hallahan DE (2003) Growth factor-independent activation of protein kinase B contributes to the inherent resistance of vascular endothelium to radiation-induced apoptotic response. Cancer Res 63: 7663-7667.
-
(2003)
Cancer Res
, vol.63
, pp. 7663-7667
-
-
Tan, J.1
Hallahan, D.E.2
-
33
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine B, Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132: 27-42.
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
34
-
-
0034329418
-
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing
-
Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, et al. (2000) LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. Embo J 19: 5720-5728.
-
(2000)
Embo J
, vol.19
, pp. 5720-5728
-
-
Kabeya, Y.1
Mizushima, N.2
Ueno, T.3
Yamamoto, A.4
Kirisako, T.5
-
35
-
-
0347950954
-
Three new triterpenoid saponins from Ixeris sonchifolia and their cytotoxic activity
-
Feng XZ, Dong M, Gao ZJ, Xu SX (2003) Three new triterpenoid saponins from Ixeris sonchifolia and their cytotoxic activity. Planta Med 69: 1036-1040.
-
(2003)
Planta Med
, vol.69
, pp. 1036-1040
-
-
Feng, X.Z.1
Dong, M.2
Gao, Z.J.3
Xu, S.X.4
-
36
-
-
23644443632
-
Five new cytotoxic triterpenoid saponins from the roots of Symplocos chinensis
-
Fu GM, Wang YH, Gao S, Tang MJ, Yu SS (2005) Five new cytotoxic triterpenoid saponins from the roots of Symplocos chinensis. Planta Med 71: 666-672.
-
(2005)
Planta Med
, vol.71
, pp. 666-672
-
-
Fu, G.M.1
Wang, Y.H.2
Gao, S.3
Tang, M.J.4
Yu, S.S.5
-
37
-
-
27744526342
-
A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL-and etoposide-induced apoptosis in breast cancer cells
-
Bockbrader KM, Tan M, Sun Y (2005) A small molecule Smac-mimic compound induces apoptosis and sensitizes TRAIL-and etoposide-induced apoptosis in breast cancer cells. Oncogene 24: 7381-7388.
-
(2005)
Oncogene
, vol.24
, pp. 7381-7388
-
-
Bockbrader, K.M.1
Tan, M.2
Sun, Y.3
-
38
-
-
0032752063
-
Cellular survival: A play in three Akts
-
Datta SR, Brunet A, Greenberg ME (1999) Cellular survival: a play in three Akts. Genes Dev 13: 2905-2927.
-
(1999)
Genes Dev
, vol.13
, pp. 2905-2927
-
-
Datta, S.R.1
Brunet, A.2
Greenberg, M.E.3
-
39
-
-
0026786238
-
The human hepatoma Hep3B cell line as an experimental model in the study of the longterm regulation of acute-phase proteins by cytokines
-
Hiron M, Daveau M, Arnaud P, Bauer J, Lebreton JP (1992) The human hepatoma Hep3B cell line as an experimental model in the study of the longterm regulation of acute-phase proteins by cytokines. Biochem J 287 (Pt 1): 255-259.
-
(1992)
Biochem J
, vol.287
, Issue.1
, pp. 255-259
-
-
Hiron, M.1
Daveau, M.2
Arnaud, P.3
Bauer, J.4
Lebreton, J.P.5
-
40
-
-
0032531145
-
Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism
-
Foster KA, Oster CG, Mayer MM, Avery ML, Audus KL (1998) Characterization of the A549 cell line as a type II pulmonary epithelial cell model for drug metabolism. Exp Cell Res 243: 359-366.
-
(1998)
Exp Cell Res
, vol.243
, pp. 359-366
-
-
Foster, K.A.1
Oster, C.G.2
Mayer, M.M.3
Avery, M.L.4
Audus, K.L.5
|