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Volumn 1, Issue 2, 2010, Pages 124-128

p21-activated kinases in ErbB2-positive breast cancer: A new therapeutic target?

Author keywords

Breast cancer; ErbB2; Inhibitor; Oncogene; Protein kinase; Signal transduction; Small GTPase

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE; P21 ACTIVATED KINASE; P21 ACTIVATED KINASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN CDC42; PROTEIN KINASE B; RAC PROTEIN; RAF PROTEIN; RAS PROTEIN;

EID: 79952066460     PISSN: 21541248     EISSN: 21541256     Source Type: Journal    
DOI: 10.4161/sgtp.1.2.14109     Document Type: Article
Times cited : (25)

References (47)
  • 1
    • 0030919509 scopus 로고    scopus 로고
    • Neuregulins and their receptors: A versatile signaling module in organogenesis and oncogenesis
    • Burden S, Yarden Y. Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesis. Neuron 1997; 18:847-55.
    • (1997) Neuron , vol.18 , pp. 847-855
    • Burden, S.1    Yarden, Y.2
  • 4
    • 0035230358 scopus 로고    scopus 로고
    • Regulation of mouse mammary gland development and tumorigenesis by the ERBB signaling network
    • Troyer KL, Lee DC. Regulation of mouse mammary gland development and tumorigenesis by the ERBB signaling network. J Mammary Gland Biol Neoplasia 2001; 6:7-21.
    • (2001) J Mammary Gland Biol Neoplasia , vol.6 , pp. 7-21
    • Troyer, K.L.1    Lee, D.C.2
  • 5
    • 1642421130 scopus 로고    scopus 로고
    • Target-based agents against ErbB receptors and their ligands: A novel approach to cancer treatment
    • Normanno N, Bianco C, De Luca A, Maiello MR, Salomon DS. Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment. Endocr Relat Cancer 2003; 10:1-21.
    • (2003) Endocr Relat Cancer , vol.10 , pp. 1-21
    • Normanno, N.1    Bianco, C.2    De Luca, A.3    Maiello, M.R.4    Salomon, D.S.5
  • 6
    • 0026604793 scopus 로고
    • Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene
    • Shalaby MR, Shepard HM, Presta L, Rodrigues ML, Beverley PC, Feldmann M, Carter P. Development of humanized bispecific antibodies reactive with cytotoxic lymphocytes and tumor cells overexpressing the HER2 protooncogene. J Exp Med 1992; 175:217-25.
    • (1992) J Exp Med , vol.175 , pp. 217-225
    • Shalaby, M.R.1    Shepard, H.M.2    Presta, L.3    Rodrigues, M.L.4    Beverley, P.C.5    Feldmann, M.6    Carter, P.7
  • 7
    • 0029814271 scopus 로고    scopus 로고
    • A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor
    • Tzahar E, Waterman H, Chen X, Levkowitz G, Karunagaran D, Lavi S, et al. A hierarchical network of interreceptor interactions determines signal transduction by Neu differentiation factor/neuregulin and epidermal growth factor. Mol Cell Biol 1996; 16:5276-87.
    • (1996) Mol Cell Biol , vol.16 , pp. 5276-5287
    • Tzahar, E.1    Waterman, H.2    Chen, X.3    Levkowitz, G.4    Karunagaran, D.5    Lavi, S.6
  • 8
    • 30544449081 scopus 로고    scopus 로고
    • A quantitative protein interaction network for the ErbB receptors using protein microarrays
    • Jones RB, Gordus A, Krall JA, MacBeath G. A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature 2006; 439:168-74.
    • (2006) Nature , vol.439 , pp. 168-174
    • Jones, R.B.1    Gordus, A.2    Krall, J.A.3    McBeath, G.4
  • 9
    • 0029912203 scopus 로고    scopus 로고
    • All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired
    • Baulida J, Kraus MH, Alimandi M, Di Fiore PP, Carpenter G. All ErbB receptors other than the epidermal growth factor receptor are endocytosis impaired. J Biol Chem 1996; 271:5251-7.
    • (1996) J Biol Chem , vol.271 , pp. 5251-5257
    • Baulida, J.1    Kraus, M.H.2    Alimandi, M.3    Di Fiore, P.P.4    Carpenter, G.5
  • 10
    • 0032526729 scopus 로고    scopus 로고
    • Differential endocytic routing of homo- and heterodimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers
    • Lenferink AE, Pinkas-Kramarski R, van de Poll ML, van Vugt MJ, Klapper LN, Tzahar E, et al. Differential endocytic routing of homo- and heterodimeric ErbB tyrosine kinases confers signaling superiority to receptor heterodimers. EMBO J 1998; 17:3385-97.
    • (1998) EMBO J , vol.17 , pp. 3385-3397
    • Lenferink, A.E.1    Pinkas-Kramarski, R.2    van de Poll, M.L.3    van Vugt, M.J.4    Klapper, L.N.5    Tzahar, E.6
  • 11
    • 2142843806 scopus 로고    scopus 로고
    • Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions
    • Pinkas-Kramarski R, Soussan L, Waterman H, Levkowitz G, Alroy I, Klapper L, et al. Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions. EMBO J 1996; 15:2452-67.
    • (1996) EMBO J , vol.15 , pp. 2452-2467
    • Pinkas-Kramarski, R.1    Soussan, L.2    Waterman, H.3    Levkowitz, G.4    Alroy, I.5    Klapper, L.6
  • 12
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 1995; 19:183-232.
    • (1995) Crit Rev Oncol Hematol , vol.19 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3    Normanno, N.4
  • 13
    • 68049085887 scopus 로고    scopus 로고
    • In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basallike breast cancer models
    • Hoeflich KP, O'Brien C, Boyd Z, Cavet G, Guerrero S, Jung K, et al. In vivo antitumor activity of MEK and phosphatidylinositol 3-kinase inhibitors in basallike breast cancer models. Clin Cancer Res 2009; 15:4649-64.
    • (2009) Clin Cancer Res , vol.15 , pp. 4649-4664
    • Hoeflich, K.P.1    O'Brien, C.2    Boyd, Z.3    Cavet, G.4    Guerrero, S.5    Jung, K.6
  • 14
    • 38849139580 scopus 로고    scopus 로고
    • ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
    • Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, Xie X, et al. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol 2008; 10:138-48.
    • (2008) Nat Cell Biol , vol.10 , pp. 138-148
    • Yang, J.Y.1    Zong, C.S.2    Xia, W.3    Yamaguchi, H.4    Ding, Q.5    Xie, X.6
  • 15
    • 27744521323 scopus 로고    scopus 로고
    • Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors
    • Beeser A, Jaffer ZM, Hofmann C, Chernoff J. Role of group A p21-activated kinases in activation of extracellular-regulated kinase by growth factors. J Biol Chem 2005; 280:36609-15.
    • (2005) J Biol Chem , vol.280 , pp. 36609-36615
    • Beeser, A.1    Jaffer, Z.M.2    Hofmann, C.3    Chernoff, J.4
  • 16
    • 0036333485 scopus 로고    scopus 로고
    • Rac- PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEKI-ERK complexes
    • Eblen ST, Slack JK, Weber MJ, Catling AD. Rac- PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEKI-ERK complexes. Mol Cell Biol 2002; 22:6023-33.
    • (2002) Mol Cell Biol , vol.22 , pp. 6023-6033
    • Eblen, S.T.1    Slack, J.K.2    Weber, M.J.3    Catling, A.D.4
  • 18
    • 55549119209 scopus 로고    scopus 로고
    • Scaffolding function of PAK in the PDK1-Akt pathway
    • Higuchi M, Onishi K, Kikuchi C, Gotoh Y. Scaffolding function of PAK in the PDK1-Akt pathway. Nat Cell Biol 2008; 10:1356-64.
    • (2008) Nat Cell Biol , vol.10 , pp. 1356-1364
    • Higuchi, M.1    Onishi, K.2    Kikuchi, C.3    Gotoh, Y.4
  • 23
    • 36749014033 scopus 로고    scopus 로고
    • Phosphorylated Pak1 level in the cytoplasm correlates with shorter survival time in patients with glioblastoma
    • Aoki H, Yokoyama T, Fujiwara K, Tari AM, Sawaya R, Suki D, et al. Phosphorylated Pak1 level in the cytoplasm correlates with shorter survival time in patients with glioblastoma. Clin Cancer Res 2007; 13:6603-9.
    • (2007) Clin Cancer Res , vol.13 , pp. 6603-6609
    • Aoki, H.1    Yokoyama, T.2    Fujiwara, K.3    Tari, A.M.4    Sawaya, R.5    Suki, D.6
  • 24
    • 34248531653 scopus 로고    scopus 로고
    • p21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation
    • Ching YP, Leong VY, Lee MF, Xu HT, Jin DY, Ng IO. p21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation. Cancer Res 2007; 67:3601-8.
    • (2007) Cancer Res , vol.67 , pp. 3601-3608
    • Ching, Y.P.1    Leong, V.Y.2    Lee, M.F.3    Xu, H.T.4    Jin, D.Y.5    Ng, I.O.6
  • 25
    • 6944222706 scopus 로고    scopus 로고
    • High-resolution genomic and expression profiling reveals 105 putative amplification target genes in pancreatic cancer
    • Mahlamaki EH, Kauraniemi P, Monni O, Wolf M, Hautaniemi S, Kallioniemi A. High-resolution genomic and expression profiling reveals 105 putative amplification target genes in pancreatic cancer. Neoplasia 2004; 6:432-9.
    • (2004) Neoplasia , vol.6 , pp. 432-439
    • Mahlamaki, E.H.1    Kauraniemi, P.2    Monni, O.3    Wolf, M.4    Hautaniemi, S.5    Kallioniemi, A.6
  • 27
    • 34547753507 scopus 로고    scopus 로고
    • p21-activated kinase 1: A new molecular marker for intravesical recurrence after transurethral resection of bladder cancer
    • Ito M, Nishiyama H, Kawanishi H, Matsui S, Guilford P, Reeve A, Ogawa O. p21-activated kinase 1: a new molecular marker for intravesical recurrence after transurethral resection of bladder cancer. J Urol 2007; 178:1073-9.
    • (2007) J Urol , vol.178 , pp. 1073-1079
    • Ito, M.1    Nishiyama, H.2    Kawanishi, H.3    Matsui, S.4    Guilford, P.5    Reeve, A.6    Ogawa, O.7
  • 28
    • 0041423391 scopus 로고    scopus 로고
    • Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma
    • Schraml P, Schwerdtfeger G, Burkhalter F, Raggi A, Schmidt D, Ruffalo T, et al. Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma. Am J Pathol 2003; 163:985-92.
    • (2003) Am J Pathol , vol.163 , pp. 985-992
    • Schraml, P.1    Schwerdtfeger, G.2    Burkhalter, F.3    Raggi, A.4    Schmidt, D.5    Ruffalo, T.6
  • 29
    • 53849096674 scopus 로고    scopus 로고
    • Different clinical roles for p21-activated kinase-1 in primary and recurrent ovarian carcinoma
    • Davidson B, Shih Ie M, Wang TL. Different clinical roles for p21-activated kinase-1 in primary and recurrent ovarian carcinoma. Hum Pathol 2008; 39:1630-6.
    • (2008) Hum Pathol , vol.39 , pp. 1630-1636
    • Davidson, B.1    Shih Ie, M.2    Wang, T.L.3
  • 31
    • 35549002845 scopus 로고    scopus 로고
    • Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer
    • Bostner J, Ahnstrom Waltersson M, Fornander T, Skoog L, Nordenskjold B, Stal O. Amplification of CCND1 and PAK1 as predictors of recurrence and tamoxifen resistance in postmenopausal breast cancer. Oncogene 2007; 26:6997-7005.
    • (2007) Oncogene , vol.26 , pp. 6997-7005
    • Bostner, J.1    Ahnstrom Waltersson, M.2    Fornander, T.3    Skoog, L.4    Nordenskjold, B.5    Stal, O.6
  • 32
    • 33646682385 scopus 로고    scopus 로고
    • PAK1 hyperactivation is sufficient for mammary gland tumor formation
    • Wang RA, Zhang H, Balasenthil S, Medina D, Kumar R. PAK1 hyperactivation is sufficient for mammary gland tumor formation. Oncogene 2006; 25:2931-6.
    • (2006) Oncogene , vol.25 , pp. 2931-2936
    • Wang, R.A.1    Zhang, H.2    Balasenthil, S.3    Medina, D.4    Kumar, R.5
  • 33
    • 0034680834 scopus 로고    scopus 로고
    • Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells
    • Vadlamudi RK, Adam L, Wang RA, Mandal M, Nguyen D, Sahin A, et al. Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J Biol Chem 2000; 275:36238-44.
    • (2000) J Biol Chem , vol.275 , pp. 36238-36244
    • Vadlamudi, R.K.1    Adam, L.2    Wang, R.A.3    Mandal, M.4    Nguyen, D.5    Sahin, A.6
  • 34
    • 23244467708 scopus 로고    scopus 로고
    • Active p21-activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis
    • Menard RE, Jovanovski AP, Mattingly RR. Active p21-activated kinase 1 rescues MCF10A breast epithelial cells from undergoing anoikis. Neoplasia 2005; 7:638-45.
    • (2005) Neoplasia , vol.7 , pp. 638-645
    • Menard, R.E.1    Jovanovski, A.P.2    Mattingly, R.R.3
  • 35
    • 36248998112 scopus 로고    scopus 로고
    • alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NFkappaB-dependent resistance to apoptosis in 3D mammary acini
    • Friedland JC, Lakins JN, Kazanietz MG, Chernoff J, Boettiger D, Weaver VM. alpha6beta4 integrin activates Rac-dependent p21-activated kinase 1 to drive NFkappaB-dependent resistance to apoptosis in 3D mammary acini. J Cell Sci 2007; 120:3700-12.
    • (2007) J Cell Sci , vol.120 , pp. 3700-3712
    • Friedland, J.C.1    Lakins, J.N.2    Kazanietz, M.G.3    Chernoff, J.4    Boettiger, D.5    Weaver, V.M.6
  • 36
    • 41649085584 scopus 로고    scopus 로고
    • p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer
    • Li Q, Mullins SR, Sloane BF, Mattingly RR. p21-Activated kinase 1 coordinates aberrant cell survival and pericellular proteolysis in a three-dimensional culture model for premalignant progression of human breast cancer. Neoplasia 2008; 10:314-29.
    • (2008) Neoplasia , vol.10 , pp. 314-329
    • Li, Q.1    Mullins, S.R.2    Sloane, B.F.3    Mattingly, R.R.4
  • 37
    • 0034697303 scopus 로고    scopus 로고
    • Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1
    • Adam L, Vadlamudi R, Mandal M, Chernoff J, Kumar R. Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1. J Biol Chem 2000; 275:12041-50.
    • (2000) J Biol Chem , vol.275 , pp. 12041-12050
    • Adam, L.1    Vadlamudi, R.2    Mandal, M.3    Chernoff, J.4    Kumar, R.5
  • 38
    • 0032561206 scopus 로고    scopus 로고
    • Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase
    • Adam L, Vadlamudi R, Kondapaka SB, Chernoff J, Mendelsohn J, Kumar R. Heregulin regulates cytoskeletal reorganization and cell migration through the p21-activated kinase-1 via phosphatidylinositol-3 kinase. J Biol Chem 1998; 273:28238-46.
    • (1998) J Biol Chem , vol.273 , pp. 28238-28246
    • Adam, L.1    Vadlamudi, R.2    Kondapaka, S.B.3    Chernoff, J.4    Mendelsohn, J.5    Kumar, R.6
  • 39
    • 0034854417 scopus 로고    scopus 로고
    • ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini
    • Muthuswamy SK, Li D, Lelievre S, Bissell MJ, Brugge JS. ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini. Nat Cell Biol 2001; 3:785-92.
    • (2001) Nat Cell Biol , vol.3 , pp. 785-792
    • Muthuswamy, S.K.1    Li, D.2    Lelievre, S.3    Bissell, M.J.4    Brugge, J.S.5
  • 40
    • 0030830220 scopus 로고    scopus 로고
    • Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
    • Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, Shaw PE, Cobb MH. Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. EMBO J 1997; 16:6426-38.
    • (1997) EMBO J , vol.16 , pp. 6426-6438
    • Frost, J.A.1    Steen, H.2    Shapiro, P.3    Lewis, T.4    Ahn, N.5    Shaw, P.E.6    Cobb, M.H.7
  • 41
    • 0142027033 scopus 로고    scopus 로고
    • Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways
    • Menard RE, Mattingly RR. Cell surface receptors activate p21-activated kinase 1 via multiple Ras and PI3-kinase-dependent pathways. Cellular Signalling 2003; 15:1099-109.
    • (2003) Cellular Signalling , vol.15 , pp. 1099-1109
    • Menard, R.E.1    Mattingly, R.R.2
  • 42
    • 2442664118 scopus 로고    scopus 로고
    • Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
    • Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci USA 2004; 101:7618-23.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7618-7623
    • Gao, Y.1    Dickerson, J.B.2    Guo, F.3    Zheng, J.4    Zheng, Y.5
  • 43
    • 41949100602 scopus 로고    scopus 로고
    • An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase
    • Deacon SW, Beeser A, Fukui JA, Rennefahrt UE, Myers C, Chernoff J, Peterson JR. An isoform-selective, small-molecule inhibitor targets the autoregulatory mechanism of p21-activated kinase. Chem Biol 2008; 15:322-31.
    • (2008) Chem Biol , vol.15 , pp. 322-331
    • Deacon, S.W.1    Beeser, A.2    Fukui, J.A.3    Rennefahrt, U.E.4    Myers, C.5    Chernoff, J.6    Peterson, J.R.7
  • 44
    • 53249142641 scopus 로고    scopus 로고
    • p21-activated kinase signaling regulates oxidantdependent NFkappaB activation by flow
    • Orr AW, Hahn C, Blackman BR, Schwartz MA. p21-activated kinase signaling regulates oxidantdependent NFkappaB activation by flow. Circ Res 2008; 103:671-9.
    • (2008) Circ Res , vol.103 , pp. 671-679
    • Orr, A.W.1    Hahn, C.2    Blackman, B.R.3    Schwartz, M.A.4
  • 45
    • 67649464367 scopus 로고    scopus 로고
    • Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development
    • Lightcap CM, Kari G, Arias-Romero LE, Chernoff J, Rodeck U, Williams JC. Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. PLoS One 2009; 4:6025.
    • (2009) PLoS One , vol.4 , pp. 6025
    • Lightcap, C.M.1    Kari, G.2    Arias-Romero, L.E.3    Chernoff, J.4    Rodeck, U.5    Williams, J.C.6
  • 46
    • 54849437262 scopus 로고    scopus 로고
    • Phosphorylation of estrogen receptor alpha, serine residue 305 enhances activity
    • Tharakan R, Lepont P, Singleton D, Kumar R, Khan S. Phosphorylation of estrogen receptor alpha, serine residue 305 enhances activity. Mol Cell Endocrinol 2008; 295:70-8.
    • (2008) Mol Cell Endocrinol , vol.295 , pp. 70-78
    • Tharakan, R.1    Lepont, P.2    Singleton, D.3    Kumar, R.4    Khan, S.5
  • 47
    • 33644932610 scopus 로고    scopus 로고
    • Comprehensive copy number profiles of breast cancer cell model genomes
    • Shadeo A, Lam WL. Comprehensive copy number profiles of breast cancer cell model genomes. Breast Cancer Res 2006; 8:9.
    • (2006) Breast Cancer Res , vol.8 , pp. 9
    • Shadeo, A.1    Lam, W.L.2


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