-
1
-
-
0035720354
-
Origins of cancer therapy
-
Papac, R. J. Origins of cancer therapy. Yale J. Biol. Med. 74, 391-398 (2001).
-
(2001)
Yale J. Biol. Med.
, vol.74
, pp. 391-398
-
-
Papac, R.J.1
-
2
-
-
0000636701
-
The initial clinical trial of nitrogen mustard
-
Gilman, A. The initial clinical trial of nitrogen mustard. Am. J. Surg. 105, 574-578 (1963).
-
(1963)
Am. J. Surg.
, vol.105
, pp. 574-578
-
-
Gilman, A.1
-
3
-
-
0001060019
-
The biological actions and therapeutic applications of the B-chloroethyl amines and sulfides
-
Gilman, A. The biological actions and therapeutic applications of the B-chloroethyl amines and sulfides. Science 103, 409-436 (1946).
-
(1946)
Science
, vol.103
, pp. 409-436
-
-
Gilman, A.1
-
4
-
-
0001220742
-
A new factor in the production and cure of macrocytic anaemias and its relation to other haemopoietic principles curative in pernicious anaemia
-
Wills, L., Clutterbuch, P. & Evans, B. D. F. A new factor in the production and cure of macrocytic anaemias and its relation to other haemopoietic principles curative in pernicious anaemia. Biochem. J. 31, 2136-2147 (1937).
-
(1937)
Biochem. J.
, vol.31
, pp. 2136-2147
-
-
Wills, L.1
Clutterbuch, P.2
Evans, B.D.F.3
-
5
-
-
78651010566
-
Temporary remissions in acute leukemia in children produced by folic antagonist, 4-aminopteroylglutamic acid (aminopterin)
-
Farber, S., Diamond, L. K., Mercer, R. D., Sylvester, R. F. & Wolff, J. A. Temporary remissions in acute leukemia in children produced by folic antagonist, 4-aminopteroylglutamic acid (aminopterin). N. Engl. J. Med. 238, 787-793 (1948).
-
(1948)
N. Engl. J. Med.
, vol.238
, pp. 787-793
-
-
Farber, S.1
Diamond, L.K.2
Mercer, R.D.3
Sylvester, R.F.4
Wolff, J.A.5
-
6
-
-
0017234739
-
Combination chemotherapy as an adjuvant treatment in operable breast cancer
-
Bonadonna, G. et al. Combination chemotherapy as an adjuvant treatment in operable breast cancer. N. Engl. J. Med. 294, 405-410 (1976).
-
(1976)
N. Engl. J. Med.
, vol.294
, pp. 405-410
-
-
Bonadonna, G.1
-
7
-
-
11144234188
-
Therapy of choriocarcinoma and related trophoblastic tumors with folic acid and purine antagonists
-
Li, M. C., Hertz, R. & Bergenstal, D. M. Therapy of choriocarcinoma and related trophoblastic tumors with folic acid and purine antagonists. N. Engl. J. Med. 259, 66-74 (1958).
-
(1958)
N. Engl. J. Med.
, vol.259
, pp. 66-74
-
-
Li, M.C.1
Hertz, R.2
Bergenstal, D.M.3
-
8
-
-
0016242550
-
Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma
-
Jaffe, N., Frei, E. 3rd, Traggis, D. & Bishop, Y. Adjuvant methotrexate and citrovorum-factor treatment of osteogenic sarcoma. N. Engl. J. Med. 291, 994-997 (1974).
-
(1974)
N. Engl. J. Med.
, vol.291
, pp. 994-997
-
-
Jaffe, N.1
Frei III, E.2
Traggis, D.3
Bishop, Y.4
-
9
-
-
0019801740
-
High-dose methotrexate in osteogenic sarcoma
-
Jaffe, N. et al. High-dose methotrexate in osteogenic sarcoma. Natl Cancer Inst. Monogr. 56, 201-206 (1981).
-
(1981)
Natl Cancer Inst. Monogr.
, vol.56
, pp. 201-206
-
-
Jaffe, N.1
-
10
-
-
84914454996
-
Inhibition of dihydrofolic reductase by aminopterin and amethopterin
-
Osbom, M. J., Freeman, M. & Huennekens, F M. Inhibition of dihydrofolic reductase by aminopterin and amethopterin. Proc. Soc. Exp. Biol. Med. 97, 429-431 (1958).
-
(1958)
Proc. Soc. Exp. Biol. Med.
, vol.97
, pp. 429-431
-
-
Osbom, M.J.1
Freeman, M.2
Huennekens, F.M.3
-
11
-
-
0011338950
-
Enzymatic reduction of dihydrofolic acid
-
Osborn, M. J. & Huennekens, F. M. Enzymatic reduction of dihydrofolic acid. J. Biol. Chem. 233, 969-974 (1958).
-
(1958)
J. Biol. Chem.
, vol.233
, pp. 969-974
-
-
Osborn, M.J.1
Huennekens, F.M.2
-
12
-
-
0020554087
-
The pharmacology and clinical use of methotrexate
-
Jolivet, J., Cowan, K. H., Curt, G. A., Clendeninn, N. J. & Chabner, B. A. The pharmacology and clinical use of methotrexate. N. Engl. J. Med. 309, 1094-104 (1983).
-
(1983)
N. Engl. J. Med.
, vol.309
, pp. 1094-1104
-
-
Jolivet, J.1
Cowan, K.H.2
Curt, G.A.3
Clendeninn, N.J.4
Chabner, B.A.5
-
13
-
-
0013065232
-
-
eds Chabner, B. A. & Longo, D. Lippincott Williams &Wilkins, Philadelphia
-
Messmann, R. A. & Allegra, C. J. In Cancer Chemotherapy and Biotherapy (eds Chabner, B. A. & Longo, D.) 139-184 (Lippincott Williams &Wilkins, Philadelphia, 2001).
-
(2001)
Cancer Chemotherapy and Biotherapy
, pp. 139-184
-
-
Messmann, R.A.1
Allegra, C.J.2
-
14
-
-
0021359861
-
Drug resistance in cancer
-
Curt, G. A., Clendeninn, N. J. & Chabner, B. A. Drug resistance in cancer. Cancer Treat. Rep. 68, 87-99 (1984).
-
(1984)
Cancer Treat. Rep.
, vol.68
, pp. 87-99
-
-
Curt, G.A.1
Clendeninn, N.J.2
Chabner, B.A.3
-
15
-
-
0017745663
-
Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity
-
Stoller, R. G., Hande, K. R., Jacobs, S. A., Rosenberg, S. A. & Chabner, B. A. Use of plasma pharmacokinetics to predict and prevent methotrexate toxicity. N. Engl. J. Med. 297, 630-634 (1977).
-
(1977)
N. Engl. J. Med.
, vol.297
, pp. 630-634
-
-
Stoller, R.G.1
Hande, K.R.2
Jacobs, S.A.3
Rosenberg, S.A.4
Chabner, B.A.5
-
16
-
-
1342317380
-
Observations on the anticancer activity of 6-mercaptopurine
-
Skipper, H. E., Thomson, J. R., Elion, G. B. & Hitchings, G. H. Observations on the anticancer activity of 6-mercaptopurine. Cancer Res. 14, 294-298 (1954).
-
(1954)
Cancer Res.
, vol.14
, pp. 294-298
-
-
Skipper, H.E.1
Thomson, J.R.2
Elion, G.B.3
Hitchings, G.H.4
-
17
-
-
0003183507
-
The chemistry and biochemistry of purine analogs
-
Hitchings, G. H. & Elion, G. B. The chemistry and biochemistry of purine analogs. Ann. NY Acad. Sci. 60, 195-199 (1954).
-
(1954)
Ann. NY Acad. Sci.
, vol.60
, pp. 195-199
-
-
Hitchings, G.H.1
Elion, G.B.2
-
18
-
-
0000502679
-
The Vinca alkaloids: A new class of oncolytic agents
-
Johnson, I. S., Armstrong, J. G., Gorman, M. & Burnett, J. P. Jr. The Vinca alkaloids: a new class of oncolytic agents. Cancer Res. 23, 1390-1427 (1963).
-
(1963)
Cancer Res.
, vol.23
, pp. 1390-1427
-
-
Johnson, I.S.1
Armstrong, J.G.2
Gorman, M.3
Burnett Jr., J.P.4
-
19
-
-
0014426710
-
Microtubule crystals: A new biophysical phenomenon induced by Vinca alkaloids
-
Bensch, K. G. & Malawista, S. E. Microtubule crystals: a new biophysical phenomenon induced by Vinca alkaloids. Nature 218, 1176-1177 (1968).
-
(1968)
Nature
, vol.218
, pp. 1176-1177
-
-
Bensch, K.G.1
Malawista, S.E.2
-
20
-
-
0013811894
-
The effectiveness of combinations of antileukemic agents in inducing and maintaining remission in children with acute leukemia
-
Frei, E. 3rd et al. The effectiveness of combinations of antileukemic agents in inducing and maintaining remission in children with acute leukemia. Blood 26, 642-656 (1965).
-
(1965)
Blood
, vol.26
, pp. 642-656
-
-
Frei III, E.1
-
21
-
-
0020481727
-
The National Cancer Chemotherapy Program
-
Frei, E. 3rd. The National Cancer Chemotherapy Program. Science 217, 600-606 (1982).
-
(1982)
Science
, vol.217
, pp. 600-606
-
-
Frei III, E.1
-
22
-
-
0021326738
-
The preclinical new drug research program of the National Cancer Institute
-
Driscoll, J. S. The preclinical new drug research program of the National Cancer Institute. Cancer Treat. Rep. 68, 63-76 (1984).
-
(1984)
Cancer Treat. Rep.
, vol.68
, pp. 63-76
-
-
Driscoll, J.S.1
-
23
-
-
0026676380
-
The National Cancer Institute: Cancer drug discovery and development program
-
Grever, M. R., Schepartz, S. A. & Chabner, B. A. The National Cancer Institute: cancer drug discovery and development program. Semin. Oncol. 19, 622-638 (1992).
-
(1992)
Semin. Oncol.
, vol.19
, pp. 622-638
-
-
Grever, M.R.1
Schepartz, S.A.2
Chabner, B.A.3
-
24
-
-
78651156947
-
Experimental evaluation of potential anticancer agents. Xiii. On the criteria and kinetics associated with 'curability' of experimental leukemia
-
Skipper, H. E., Schabel, F. M. Jr. & Wilcox, W. S. Experimental evaluation of potential anticancer agents. Xiii. On the criteria and kinetics associated with 'curability' of experimental leukemia. Cancer Chemother. Rep. 35, 1-111 (1964).
-
(1964)
Cancer Chemother. Rep.
, vol.35
, pp. 1-111
-
-
Skipper, H.E.1
Schabel Jr., F.M.2
Wilcox, W.S.3
-
25
-
-
0021381097
-
Frank M. Schabel 1918-1983
-
Skipper, H. E. & Griswold, D. P. Frank M. Schabel 1918-1983. Cancer Res. 44, 871-872 (1984).
-
(1984)
Cancer Res.
, vol.44
, pp. 871-872
-
-
Skipper, H.E.1
Griswold, D.P.2
-
26
-
-
0014102092
-
Intensive combination chemotherapy and X-irradiation in Hodgkin's disease
-
Moxley, J. H. 3rd, De Vita, V. T., Brace, K. & Frei, E. 3rd. Intensive combination chemotherapy and X-irradiation in Hodgkin's disease. Cancer Res. 27, 1258-1263 (1967).
-
(1967)
Cancer Res.
, vol.27
, pp. 1258-1263
-
-
Moxley III, J.H.1
De Vita, V.T.2
Brace, K.3
Frei III, E.4
-
27
-
-
0014893444
-
Combination chemotherapy in the treatment of advanced Hodgkin's disease
-
Devita, V. T. Jr., Serpick. A. A. & Carbone, P. P. Combination chemotherapy in the treatment of advanced Hodgkin's disease. Ann. Intern. Med. 73, 881-695 (1970).
-
(1970)
Ann. Intern. Med.
, vol.73
, pp. 881-1695
-
-
Devita Jr., V.T.1
Serpick, A.A.2
Carbone, P.P.3
-
28
-
-
0015305553
-
Combination sequential chemotherapy in advanced reticulum cell sarcoma
-
Levitt, M. et al. Combination sequential chemotherapy in advanced reticulum cell sarcoma. Cancer 29, 630-636 (1972).
-
(1972)
Cancer
, vol.29
, pp. 630-636
-
-
Levitt, M.1
-
29
-
-
0016799379
-
Long-term remission in diffuse histiocytic lymphoma treated with combination sequential chemotherapy
-
Berd, D., Comog, J., DeConti, R. C., Levitt, M. & Bertino, J. R. Long-term remission in diffuse histiocytic lymphoma treated with combination sequential chemotherapy. Cancer 35, 1050-1054 (1975).
-
(1975)
Cancer
, vol.35
, pp. 1050-1054
-
-
Berd, D.1
Comog, J.2
DeConti, R.C.3
Levitt, M.4
Bertino, J.R.5
-
30
-
-
0025060806
-
Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma
-
Moertel, C. G. et al. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N. Engl. J. Med. 322, 352-358 (1990).
-
(1990)
N. Engl. J. Med.
, vol.322
, pp. 352-358
-
-
Moertel, C.G.1
-
31
-
-
0024327106
-
Taxol: A unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms
-
McGuire, W. P. et al. Taxol: a unique antineoplastic agent with significant activity in advanced ovarian epithelial neoplasms. Ann. Intern. Med. 111, 273-279 (1989).
-
(1989)
Ann. Intern. Med.
, vol.111
, pp. 273-279
-
-
McGuire, W.P.1
-
33
-
-
0034727063
-
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer
-
Irinotecan Study Group
-
Saltz, L. B. et al. Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N. Engl. J. Med. 343, 905-914 (2000).
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 905-914
-
-
Saltz, L.B.1
-
34
-
-
0037050354
-
Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer
-
Noda, K. et al. Irinotecan plus cisplatin compared with etoposide plus cisplatin for extensive small-cell lung cancer. N. Engl. J. Med. 346, 85-91 (2002).
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 85-91
-
-
Noda, K.1
-
35
-
-
0037440035
-
Phase II trial of irinotecan in patients with metastatic epithelial ovarian cancer or peritoneal cancer
-
Bodurka, D. C. et al. Phase II trial of irinotecan in patients with metastatic epithelial ovarian cancer or peritoneal cancer. J. Clin. Oncol. 21, 291-297 (2003).
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 291-297
-
-
Bodurka, D.C.1
-
36
-
-
0031896592
-
There are no bad anticancer agents, only bad clinical trial designs - Twenty-first Richard and Hinda Rosenthal Foundation Award Lecture
-
Von Hoff, D. D. There are no bad anticancer agents, only bad clinical trial designs - twenty-first Richard and Hinda Rosenthal Foundation Award Lecture. Clin. Cancer Res. 4, 1079-1086 (1998).
-
(1998)
Clin. Cancer Res.
, vol.4
, pp. 1079-1086
-
-
Von Hoff, D.D.1
-
37
-
-
2042458747
-
Relationships between drug activity in NCl preclinical in vitro and in vivo models and early clinical trials
-
Johnson, J. I. et al. Relationships between drug activity in NCl preclinical in vitro and in vivo models and early clinical trials. Br. J. Cancer 84, 1424-1431 (2001).
-
(2001)
Br. J. Cancer
, vol.84
, pp. 1424-1431
-
-
Johnson, J.I.1
-
38
-
-
37049053957
-
Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode
-
Rosenberg, B., Vancamp, L. & Krigas, T. Inhibition of cell division in Escherichia coli by electrolysis products from a platinum electrode. Nature 205, 698-699 (1965).
-
(1965)
Nature
, vol.205
, pp. 698-699
-
-
Rosenberg, B.1
Vancamp, L.2
Krigas, T.3
-
39
-
-
0022981480
-
VAB-6: An effective chemotherapy regimen for patients with germ-cell tumors
-
Bosl, G. J. et al. VAB-6: an effective chemotherapy regimen for patients with germ-cell tumors. J. Clin. Oncol. 4, 1493-1499 (1986).
-
(1986)
J. Clin. Oncol.
, vol.4
, pp. 1493-1499
-
-
Bosl, G.J.1
-
40
-
-
0021048258
-
Phase II study of JM8, a new platinum analog, in advanced ovarian carcinoma
-
Evans, B. D., Raju, K. S., Calvert, A. H., Hartand, S. J. & Wiltshaw, E. Phase II study of JM8, a new platinum analog, in advanced ovarian carcinoma. Cancer Treat. Rep. 67, 997-1000 (1983).
-
(1983)
Cancer Treat. Rep.
, vol.67
, pp. 997-1000
-
-
Evans, B.D.1
Raju, K.S.2
Calvert, A.H.3
Hartand, S.J.4
Wiltshaw, E.5
-
41
-
-
0017128229
-
Chemistry and structure-activity studies of the nitrosoureas
-
Montgomery, J. A. Chemistry and structure-activity studies of the nitrosoureas. Cancer Treat. Rep. 60, 651-664 (1976).
-
(1976)
Cancer Treat. Rep.
, vol.60
, pp. 651-664
-
-
Montgomery, J.A.1
-
42
-
-
0014825328
-
BCNU (1,3-biS(2-chloroethyl)-1-nitrosourea; NSC-409962) in the treatment of malignant brain tumor - A preliminary report
-
Walker, M. D. & Hurwitz, B. S. BCNU (1,3-biS(2-chloroethyl)-1- nitrosourea; NSC-409962) in the treatment of malignant brain tumor - a preliminary report. Cancer Chemother. Rep. 54, 263-271 (1970).
-
(1970)
Cancer Chemother. Rep.
, vol.54
, pp. 263-271
-
-
Walker, M.D.1
Hurwitz, B.S.2
-
43
-
-
0014825362
-
1,3-bis (2-chloroethyl)-1-nitrosourea (NSC-409962) in the treatment of brain tumors
-
Wilson, C. B., Boldrey, E. B. & Enot, K. J. 1,3-bis (2-chloroethyl)-1-nitrosourea (NSC-409962) in the treatment of brain tumors. Cancer Chemother. Rep. 54, 273-281 (1970).
-
(1970)
Cancer Chemother. Rep.
, vol.54
, pp. 273-281
-
-
Wilson, C.B.1
Boldrey, E.B.2
Enot, K.J.3
-
44
-
-
0034649696
-
Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
-
Rai, K. R. et al. Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia. N. Engl. J. Med. 343, 1750-1757 (2000).
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 1750-1757
-
-
Rai, K.R.1
-
45
-
-
0021240783
-
Inhibition of the DNA catenation activity of type II topoisomerase by VP16-213 and VM26
-
Minocha, A. & Long, B. H. Inhibition of the DNA catenation activity of type II topoisomerase by VP16-213 and VM26. Biochem. Biophys. Res. Commun. 122, 165-170 (1984).
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.122
, pp. 165-170
-
-
Minocha, A.1
Long, B.H.2
-
46
-
-
0007424513
-
A comparative study of the effect of transfusion of fresh and preserved whole blood on bleeding in patients with acute leukemia
-
Freireich, E. J., Schmidt, P. J., Schneiderman, M. A. & Frei, E. 3rd. A comparative study of the effect of transfusion of fresh and preserved whole blood on bleeding in patients with acute leukemia. N. Engl. J. Med. 260, 6-11 (1959).
-
(1959)
N. Engl. J. Med.
, vol.260
, pp. 6-11
-
-
Freireich, E.J.1
Schmidt, P.J.2
Schneiderman, M.A.3
Frei III, E.4
-
47
-
-
0000979612
-
The quantitative relation between platelet count and hemorrhage in patients with acute leukema
-
Gaydos, L. A., Freireich, E. J. & Mantel, N. The quantitative relation between platelet count and hemorrhage in patients with acute leukema. N. Engl. J. Med. 266, 905-909 (1962).
-
(1962)
N. Engl. J. Med.
, vol.266
, pp. 905-909
-
-
Gaydos, L.A.1
Freireich, E.J.2
Mantel, N.3
-
48
-
-
0021713210
-
Granulocytopenia and cancer therapy. Past problems, current solutions, future challenges
-
Pizzo, P. A. Granulocytopenia and cancer therapy. Past problems, current solutions, future challenges. Cancer 54, 2649-2661 (1984).
-
(1984)
Cancer
, vol.54
, pp. 2649-2661
-
-
Pizzo, P.A.1
-
49
-
-
0026740918
-
Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor (1)
-
Lieschke, G. J. & Burgess, A. W. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor (1). N. Engl. J. Med. 327, 28-35 (1992).
-
(1992)
N. Engl. J. Med.
, vol.327
, pp. 28-35
-
-
Lieschke, G.J.1
Burgess, A.W.2
-
50
-
-
0026681514
-
Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor (2)
-
Lieschke, G. J. & Burgess, A. W. Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor (2). N. Engl. J. Med. 327, 99-106 (1992).
-
(1992)
N. Engl. J. Med.
, vol.327
, pp. 99-106
-
-
Lieschke, G.J.1
Burgess, A.W.2
-
51
-
-
0026697096
-
Risk of leukemia after chemotherapy and radiation treatment for breast cancer
-
Curtis, R. E. et al. Risk of leukemia after chemotherapy and radiation treatment for breast cancer. N. Engl. J. Med. 326, 1745-1751 (1992).
-
(1992)
N. Engl. J. Med.
, vol.326
, pp. 1745-1751
-
-
Curtis, R.E.1
-
52
-
-
0034641832
-
Primary care for survivors of breast cancer
-
Burstein, H. J. & Winer, E. P. Primary care for survivors of breast cancer. N. Engl. J. Med. 343, 1086-1094 (2000).
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 1086-1094
-
-
Burstein, H.J.1
Winer, E.P.2
-
53
-
-
11144233659
-
-
eds Chabner, B. A. & Longo, D. Lippincott Williams & Wilkins, Philadelphia
-
Johnson, J., Monks, A., Hollingshead, M. & Sausville, E. in Cancer Chemotherapy and Biotherapy (eds Chabner, B. A. & Longo, D.) 17-36 (Lippincott Williams & Wilkins, Philadelphia, 2001).
-
(2001)
Cancer Chemotherapy and Biotherapy
, pp. 17-36
-
-
Johnson, J.1
Monks, A.2
Hollingshead, M.3
Sausville, E.4
-
54
-
-
0028064940
-
Inhibition of heat shock protein HSP90-pp60V-src heteroprotein complex formation by benzoquinone ansamycins: Essential role for stress proteins in oncogenic transformation
-
Whitesell, L., Mimnaugh, E. G., DeCosta, B., Myers, C. E. & Neckers, L. M. Inhibition of heat shock protein HSP90-pp60V-src heteroprotein complex formation by benzoquinone ansamycins: essential role for stress proteins in oncogenic transformation. Proc. Natl Acad. Sci. USA 91, 8324-8328 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 8324-8328
-
-
Whitesell, L.1
Mimnaugh, E.G.2
DeCosta, B.3
Myers, C.E.4
Neckers, L.M.5
-
55
-
-
0027433237
-
cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity
-
cdc2 kinase by the flavone L86-8275 in breast carcinoma cells. Correlation with decreased H1 kinase activity. Biochem. Pharmacol. 46, 1831-1840 (1993).
-
(1993)
Biochem. Pharmacol.
, vol.46
, pp. 1831-1840
-
-
Worland, P.J.1
-
56
-
-
0021061819
-
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
-
Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63 (1983).
-
(1983)
J. Immunol. Methods
, vol.65
, pp. 55-63
-
-
Mosmann, T.1
-
57
-
-
0024312538
-
Display and analysis of patterns of differential activity of drugs against human tumor cell lines: Development of mean graph and COMPARE algortthm
-
Paull, K. D. et al. Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algortthm. J. Natl Cancer Inst. 81, 1088-1092 (1989).
-
(1989)
J. Natl. Cancer Inst.
, vol.81
, pp. 1088-1092
-
-
Paull, K.D.1
-
58
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan, D. & Weinberg, R. A. The hallmarks of cancer. Cell 100, 57-70 (2000).
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
59
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker, B. J. et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344, 1031-1037 (2001).
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
-
60
-
-
0037186915
-
Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
-
Kantarjian, H. et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N. Engl. J. Med. 346, 645-652 (2002).
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 645-652
-
-
Kantarjian, H.1
-
61
-
-
10744229080
-
Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia
-
Hughes, T. P. et al. Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N. Engl. J. Med. 349, 1423-1432 (2003).
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 1423-1432
-
-
Hughes, T.P.1
-
62
-
-
0001686739
-
Multiple BCR-ABL kinase domain mutations confer potyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
-
Shah, N. P. et al. Multiple BCR-ABL kinase domain mutations confer potyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell 2, 117-125 (2002).
-
(2002)
Cancer Cell
, vol.2
, pp. 117-125
-
-
Shah, N.P.1
-
63
-
-
0036682481
-
Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
-
Roche-Lestienne, C. et al. Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood 100, 1014-1018 (2002).
-
(2002)
Blood
, vol.100
, pp. 1014-1018
-
-
Roche-Lestienne, C.1
-
64
-
-
10744232328
-
Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis
-
Branford, S. et al. Detection of BCR-ABL mutations in patients with CML treated with imatinib is virtually always accompanied by clinical resistance, and mutations in the ATP phosphate-binding loop (P-loop) are associated with a poor prognosis. Blood 102, 276-283 (2003).
-
(2003)
Blood
, vol.102
, pp. 276-283
-
-
Branford, S.1
-
65
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
-
Kris, M. G. et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 290, 2149-2158 (2003).
-
(2003)
JAMA
, vol.290
, pp. 2149-2158
-
-
Kris, M.G.1
-
66
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 1
-
Giaccone, G. et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 1. J. Clin. Oncol. 22, 777-784 (2004).
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 777-784
-
-
Giaccone, G.1
-
67
-
-
1542713370
-
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial - INTACT 2
-
Herbst, R. S. et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial - INTACT 2. J. Clin. Oncol. 22, 785-794 (2004).
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 785-794
-
-
Herbst, R.S.1
-
68
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham, D. et al. Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N. Engl. J. Med. 351, 337-345 (2004).
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
-
69
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch, T. J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139 (2004).
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2129-2139
-
-
Lynch, T.J.1
-
70
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez, J. G. et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304, 1497-1500 (2004).
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
-
71
-
-
3342964433
-
Beyond fast track for drug approvals
-
Roberts, T. G. Jr. & Chabner, B. A. Beyond fast track for drug approvals. N. Engl. J. Med. 351, 501-505 (2004).
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 501-505
-
-
Roberts Jr., T.G.1
Chabner, B.A.2
-
72
-
-
0038362742
-
Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer
-
Adjei, A. A. et al. Phase II study of the farnesyl transferase inhibitor R115777 in patients with advanced non-small-cell lung cancer. J. Clin. Oncol. 21, 1760-1766 (2003).
-
(2003)
J. Clin. Oncol.
, vol.21
, pp. 1760-1766
-
-
Adjei, A.A.1
-
73
-
-
0035990832
-
A phase II trial of farnesyl protein transferase inhibitor SCH 66336, given by twice-daily oral administration, in patients with metastatic colorectal cancer refractory to 5-fluorouracll and irinotecan
-
Sharma, S. et al. A phase II trial of farnesyl protein transferase inhibitor SCH 66336, given by twice-daily oral administration, in patients with metastatic colorectal cancer refractory to 5-fluorouracll and irinotecan. Ann. Oncol. 13, 1067-1071 (2002).
-
(2002)
Ann. Oncol.
, vol.13
, pp. 1067-1071
-
-
Sharma, S.1
-
74
-
-
85013312416
-
Tumor angiogenesis: Therapeutic implications
-
Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 285, 1182-1186 (1971).
-
(1971)
N. Engl. J. Med.
, vol.285
, pp. 1182-1186
-
-
Folkman, J.1
-
75
-
-
0027954044
-
Mutations of the VHL tumour suppressor gene in renal carcinoma
-
Gnarra, J. R. et al. Mutations of the VHL tumour suppressor gene in renal carcinoma. Nature Genet. 7, 85-90 (1994).
-
(1994)
Nature Genet.
, vol.7
, pp. 85-90
-
-
Gnarra, J.R.1
-
76
-
-
2542561964
-
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
-
Hurwitz, H. et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N. Engl. J. Med. 350, 2335-2342 (2004).
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2335-2342
-
-
Hurwitz, H.1
-
77
-
-
0000598335
-
Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells
-
Roninson, I. B. et al. Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells. Proc. Natl Acad. Sci. USA 83, 4538-4542 (1986).
-
(1986)
Proc. Natl. Acad. Sci. USA
, vol.83
, pp. 4538-4542
-
-
Roninson, I.B.1
-
78
-
-
0037165261
-
CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma
-
Coiffier, B. et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N. Engl. J. Med. 346, 235-242 (2002).
-
(2002)
N. Engl. J. Med.
, vol.346
, pp. 235-242
-
-
Coiffier, B.1
-
79
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon, D. J. et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344, 783-792 (2001).
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
-
80
-
-
0032877668
-
Dysregulation of apoptosis in cancer
-
Reed, J. C. Dysregulation of apoptosis in cancer. J. Clin. Oncol. 17, 2941-2953 (1999).
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 2941-2953
-
-
Reed, J.C.1
-
81
-
-
0015526345
-
The national program for cancer chemotherapy
-
Zubrod, C. G. The national program for cancer chemotherapy. JAMA 222, 1161-1162 (1972).
-
(1972)
JAMA
, vol.222
, pp. 1161-1162
-
-
Zubrod, C.G.1
-
82
-
-
0042827295
-
Anticancer drug development at the US National Cancer Institute
-
Takimoto, C. H. Anticancer drug development at the US National Cancer Institute. Cancer Chemother. Pharmacol. 52 (Suppl. 1), 29-33 (2003).
-
(2003)
Cancer Chemother. Pharmacol.
, vol.52
, Issue.1 SUPPL.
, pp. 29-33
-
-
Takimoto, C.H.1
-
83
-
-
1942422743
-
Of mice and men: Values and liabilities of the athymic nude mouse model in anticancer drug development
-
Kelland, L. R. Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development. Eur. J. Cancer 40, 827-836 (2004).
-
(2004)
Eur. J. Cancer
, vol.40
, pp. 827-836
-
-
Kelland, L.R.1
-
84
-
-
0003582572
-
-
ed. Teicher, B. Humana, Totowa
-
Boyd, M. R. in Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval (ed. Teicher, B.) 23 (Humana, Totowa, 1997).
-
(1997)
Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval
, vol.23
-
-
Boyd, M.R.1
-
86
-
-
3242686833
-
The price tag on progress - Chemotherapy for colorectal cancer
-
Schrag, D. The price tag on progress - chemotherapy for colorectal cancer. N. Engl. J. Med. 351, 317-319 (2004).
-
(2004)
N. Engl. J. Med.
, vol.351
, pp. 317-319
-
-
Schrag, D.1
-
87
-
-
11144219993
-
Annual Biotechnology Industry Report, 2001
-
Parexel, Walthan
-
Ernst & Young LLP, Annual Biotechnology Industry Report, 2001. In Parexel's Pharmaceutical R&D Statistical Sourcebook (Parexel, Walthan, 2002/2003).
-
(2002)
Parexel's Pharmaceutical R&D Statistical Sourcebook
-
-
-
90
-
-
0035133718
-
The traveling oncologist and the wages of sin
-
Chabner, B. The traveling oncologist and the wages of sin. Oncologist 6, 1-2 (2001).
-
(2001)
Oncologist
, vol.6
, pp. 1-2
-
-
Chabner, B.1
-
91
-
-
0029846176
-
Intrinsic and acquired resistance to methotrexate in acute leukemia
-
Gorlick, R. et al. Intrinsic and acquired resistance to methotrexate in acute leukemia. New Engl. J. Med. 335, 1041-1048 (1996).
-
(1996)
New Engl. J. Med.
, vol.335
, pp. 1041-1048
-
-
Gorlick, R.1
|