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Volumn 7, Issue 5, 2013, Pages 395-403

How does cancer cell metabolism affect tumor migration and invasion?

Author keywords

Cancer cell metabolism; Cell migration; Glutamine; Glycolysis; Metastasis

Indexed keywords

GLUTAMINE;

EID: 84891846840     PISSN: 19336918     EISSN: 19336926     Source Type: Journal    
DOI: 10.4161/cam.26345     Document Type: Review
Times cited : (163)

References (111)
  • 1
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • PMID:12154349
    • Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev Cancer 2002; 2:563-72; PMID:12154349; http://dx.doi.org/10.1038/nrc865
    • (2002) Nat Rev Cancer , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 2
    • 81855169565 scopus 로고    scopus 로고
    • Cancer invasion and the microenvironment: Plasticity and reciprocity
    • PMID:22118458
    • Friedl P, Alexander S. Cancer invasion and the microenvironment: plasticity and reciprocity. Cell 2011; 147:992-1009; PMID:22118458; http://dx.doi.org/10.1016/j.cell.2011.11.016
    • (2011) Cell , vol.147 , pp. 992-1009
    • Friedl, P.1    Alexander, S.2
  • 3
    • 0034635513 scopus 로고    scopus 로고
    • Polarization of chemoattractant receptor signaling during neutrophil chemotaxis
    • PMID:10669415
    • Servant G, Weiner OD, Herzmark P, Balla T, Sedat JW, Bourne HR. Polarization of chemoattractant receptor signaling during neutrophil chemotaxis. Science 2000; 287:1037-40; PMID:10669415; http://dx.doi.org/10.1126/science. 287.5455.1037
    • (2000) Science , vol.287 , pp. 1037-1040
    • Servant, G.1    Weiner, O.D.2    Herzmark, P.3    Balla, T.4    Sedat, J.W.5    Bourne, H.R.6
  • 4
    • 85006768050 scopus 로고
    • The Metabolism of Tumors in the Body
    • PMID:19872213
    • Warburg O, Wind F, Negelein E. The Metabolism of Tumors in the Body. J Gen Physiol 1927; 8:519-30; PMID:19872213; http://dx.doi.org/10.1085/jgp.8.6.519
    • (1927) J Gen Physiol , vol.8 , pp. 519-530
    • Warburg, O.1    Wind, F.2    Negelein, E.3
  • 5
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • PMID:21508971
    • Koppenol WH, Bounds PL, Dang CV. Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 2011; 11:325-37; PMID:21508971; http://dx.doi.org/10.1038/nrc3038
    • (2011) Nat Rev Cancer , vol.11 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 6
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: A cancer hallmark even warburg did not anticipate
    • PMID:22439925
    • Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012; 21:297-308; PMID:22439925; http://dx.doi.org/10.1016/j.ccr.2012.02.014
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 7
    • 0042242676 scopus 로고    scopus 로고
    • The glycolytic phenotype in carcinogenesis and tumor invasion: Insights through mathematical models
    • PMID:12873971
    • Gatenby RA, Gawlinski ET. The glycolytic phenotype in carcinogenesis and tumor invasion: insights through mathematical models. Cancer Res 2003; 63:3847-54; PMID:12873971
    • (2003) Cancer Res , vol.63 , pp. 3847-3854
    • Gatenby, R.A.1    Gawlinski, E.T.2
  • 8
    • 0033609365 scopus 로고    scopus 로고
    • An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: Implications for clonal selection during colorectal carcinogenesis
    • PMID:10359525
    • Williams AC, Collard TJ, Paraskeva C. An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis. Oncogene 1999; 18:3199-204; PMID:10359525; http://dx.doi.org/10.1038/sj.onc.1202660
    • (1999) Oncogene , vol.18 , pp. 3199-3204
    • Williams, A.C.1    Collard, T.J.2    Paraskeva, C.3
  • 9
    • 0035071662 scopus 로고    scopus 로고
    • The effects of extracellular pH on immune function
    • PMID:11310837
    • Lardner A. The effects of extracellular pH on immune function. J Leukoc Biol 2001; 69:522-30; PMID:11310837
    • (2001) J Leukoc Biol , vol.69 , pp. 522-530
    • Lardner, A.1
  • 10
    • 33846199233 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: Central regulators of the tumor phenotype
    • PMID:17208433
    • Gordan JD, Simon MC. Hypoxia-inducible factors: central regulators of the tumor phenotype. Curr Opin Genet Dev 2007; 17:71-7; PMID:17208433; http://dx.doi.org/10.1016/j.gde.2006.12.006
    • (2007) Curr Opin Genet Dev , vol.17 , pp. 71-77
    • Gordan, J.D.1    Simon, M.C.2
  • 11
    • 24344440832 scopus 로고    scopus 로고
    • Hypoxia-induced dedifferentiation of tumor cells - A mechanism behind heterogeneity and aggressiveness of solid tumors
    • PMID:16144692
    • Axelson H, Fredlund E, Ovenberger M, Landberg G, Påhlman S. Hypoxia-induced dedifferentiation of tumor cells - a mechanism behind heterogeneity and aggressiveness of solid tumors. Semin Cell Dev Biol 2005; 16:554-63; PMID:16144692; http://dx.doi.org/10.1016/j.semcdb.2005.03.007
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 554-563
    • Axelson, H.1    Fredlund, E.2    Ovenberger, M.3    Landberg, G.4    Påhlman, S.5
  • 12
    • 0029858079 scopus 로고    scopus 로고
    • Identification of hypoxically inducible mRNAs in HeLa cells using differential-display PCR. Role of hypoxia-inducible factor-1
    • PMID:8917436
    • O'Rourke JF, Pugh CW, Bartlett SM, Ratcliffe PJ. Identification of hypoxically inducible mRNAs in HeLa cells using differential-display PCR. Role of hypoxia-inducible factor-1. Eur J Biochem 1996; 241:403-10; PMID:8917436; http://dx.doi.org/10.1111/j.1432-1033.1996.00403.x
    • (1996) Eur J Biochem , vol.241 , pp. 403-410
    • O'Rourke, J.F.1    Pugh, C.W.2    Bartlett, S.M.3    Ratcliffe, P.J.4
  • 13
    • 0028068606 scopus 로고
    • Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
    • PMID:8089148
    • Semenza GL, Roth PH, Fang HM, Wang GL. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J Biol Chem 1994; 269:23757-63; PMID:8089148
    • (1994) J Biol Chem , vol.269 , pp. 23757-23763
    • Semenza, G.L.1    Roth, P.H.2    Fang, H.M.3    Wang, G.L.4
  • 14
    • 40949108800 scopus 로고    scopus 로고
    • Carrot and stick: HIF-alpha engages c-Myc in hypoxic adaptation
    • PMID:18188166
    • Huang LE. Carrot and stick: HIF-alpha engages c-Myc in hypoxic adaptation. Cell Death Differ 2008; 15: 672-7; PMID:18188166; http://dx.doi.org/10.1038/sj.cdd.4402302
    • (2008) Cell Death Differ , vol.15 , pp. 672-677
    • Huang, L.E.1
  • 15
    • 70350728803 scopus 로고    scopus 로고
    • MYC-induced cancer cell energy metabolism and therapeutic opportunities
    • PMID:19861459
    • Dang CV, Le A, Gao P. MYC-induced cancer cell energy metabolism and therapeutic opportunities. Clin Cancer Res 2009; 15:6479-83; http://dx.doi.org/10.1158/1078-0432.CCR-09-0889; PMID:19861459
    • (2009) Clin Cancer Res , vol.15 , pp. 6479-6483
    • Dang, C.V.1    Le, A.2    Gao, P.3
  • 16
    • 55949125948 scopus 로고    scopus 로고
    • Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes
    • PMID:18939998
    • Fan TW, Kucia M, Jankowski K, Higashi RM, Ratajczak J, Ratajczak MZ, Lane AN. Rhabdomyosarcoma cells show an energy producing anabolic metabolic phenotype compared with primary myocytes. Mol Cancer 2008; 7:79; PMID:18939998; http://dx.doi.org/10.1186/1476-4598-7-79
    • (2008) Mol Cancer , vol.7 , pp. 79
    • Fan, T.W.1    Kucia, M.2    Jankowski, K.3    Higashi, R.M.4    Ratajczak, J.5    Ratajczak, M.Z.6    Lane, A.N.7
  • 17
    • 0035927544 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells
    • PMID:11439338
    • Shi Q, Le X, Wang B, Abbruzzese JL, Xiong Q, He Y, Xie K. Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells. Oncogene 2001; 20:3751-6; PMID:11439338; http://dx.doi.org/10.1038/sj.onc. 1204500
    • (2001) Oncogene , vol.20 , pp. 3751-3756
    • Shi, Q.1    Le, X.2    Wang, B.3    Abbruzzese, J.L.4    Xiong, Q.5    He, Y.6    Xie, K.7
  • 18
    • 84865976786 scopus 로고    scopus 로고
    • Anticancer targets in the glycolytic metabolism of tumors: A comprehensive review
    • PMID:21904528
    • Porporato PE, Dhup S, Dadhich RK, Copetti T, Sonveaux P. Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. Front Pharmacol 2011; 2:49; http://dx.doi.org/10.3389/fphar.2011.00049; PMID:21904528
    • (2011) Front Pharmacol , vol.2 , pp. 49
    • Porporato, P.E.1    Dhup, S.2    Dadhich, R.K.3    Copetti, T.4    Sonveaux, P.5
  • 19
    • 34249790593 scopus 로고    scopus 로고
    • Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma
    • PMID:17540003
    • Kato Y, Ozawa S, Tsukuda M, Kubota E, Miyazaki K, St-Pierre Y, Hata R. Acidic extracellular pH increases calcium influx-triggered phospholipase D activity along with acidic sphingomyelinase activation to induce matrix metalloproteinase-9 expression in mouse metastatic melanoma. FEBS J 2007; 274:3171-83; PMID:17540003; http://dx.doi.org/10.1111/j.1742-4658.2007.05848.x
    • (2007) FEBS J , vol.274 , pp. 3171-3183
    • Kato, Y.1    Ozawa, S.2    Tsukuda, M.3    Kubota, E.4    Miyazaki, K.5    St-Pierre, Y.6    Hata, R.7
  • 21
    • 0035870263 scopus 로고    scopus 로고
    • An intracellular form of cathepsin B contributes to invasiveness in cancer
    • PMID:11309313
    • Szpaderska AM, Frankfater A. An intracellular form of cathepsin B contributes to invasiveness in cancer. Cancer Res 2001; 61:3493-500; PMID:11309313
    • (2001) Cancer Res , vol.61 , pp. 3493-3500
    • Szpaderska, A.M.1    Frankfater, A.2
  • 22
    • 0030872194 scopus 로고    scopus 로고
    • Release of the aspartyl protease cathepsin D is associated with and facilitates human breast cancer cell invasion
    • PMID:9271363
    • Tedone T, Correale M, Barbarossa G, Casavola V, Paradiso A, Reshkin SJ. Release of the aspartyl protease cathepsin D is associated with and facilitates human breast cancer cell invasion. FASEB J 1997; 11:785-92; PMID:9271363
    • (1997) FASEB J , vol.11 , pp. 785-792
    • Tedone, T.1    Correale, M.2    Barbarossa, G.3    Casavola, V.4    Paradiso, A.5    Reshkin, S.J.6
  • 23
    • 33749017931 scopus 로고    scopus 로고
    • Cysteine cathepsins: Multifunctional enzymes in cancer
    • PMID:16990854
    • Mohamed MM, Sloane BF. Cysteine cathepsins: multifunctional enzymes in cancer. Nat Rev Cancer 2006; 6:764-75; PMID:16990854; http://dx.doi.org/10.1038/ nrc1949
    • (2006) Nat Rev Cancer , vol.6 , pp. 764-775
    • Mohamed, M.M.1    Sloane, B.F.2
  • 24
    • 33744942376 scopus 로고    scopus 로고
    • Acid-mediated tumor invasion: A multidisciplinary study
    • PMID:16707446
    • Gatenby RA, Gawlinski ET, Gmitro AF, Kaylor B, Gillies RJ. Acid-mediated tumor invasion: a multidisciplinary study. Cancer Res 2006; 66:5216-23; PMID:16707446; http://dx.doi.org/10.1158/0008-5472.CAN-05-4193
    • (2006) Cancer Res , vol.66 , pp. 5216-5223
    • Gatenby, R.A.1    Gawlinski, E.T.2    Gmitro, A.F.3    Kaylor, B.4    Gillies, R.J.5
  • 25
    • 79960029992 scopus 로고    scopus 로고
    • Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release
    • PMID:21617859
    • Goetze K, Walenta S, Ksiazkiewicz M, Kunz-Schughart LA, Mueller-Klieser W. Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release. Int J Oncol 2011; 39:453-63; PMID:21617859
    • (2011) Int J Oncol , vol.39 , pp. 453-463
    • Goetze, K.1    Walenta, S.2    Ksiazkiewicz, M.3    Kunz-Schughart, L.A.4    Mueller-Klieser, W.5
  • 26
    • 0034652620 scopus 로고    scopus 로고
    • High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
    • PMID:10706105
    • Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfør K, Rofstad EK, Mueller-Klieser W. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 2000; 60:916-21; PMID:10706105
    • (2000) Cancer Res , vol.60 , pp. 916-921
    • Walenta, S.1    Wetterling, M.2    Lehrke, M.3    Schwickert, G.4    Sundfør, K.5    Rofstad, E.K.6    Mueller-Klieser, W.7
  • 27
    • 34247892289 scopus 로고    scopus 로고
    • Lactate, choline, and creatine levels measured by vitro 1H-MRS as prognostic parameters in patients with non-small-cell lung cancer
    • PMID:17410583
    • Yokota H, Guo J, Matoba M, Higashi K, Tonami H, Nagao Y. Lactate, choline, and creatine levels measured by vitro 1H-MRS as prognostic parameters in patients with non-small-cell lung cancer. J Magn Reson Imaging 2007; 25:992-9; PMID:17410583; http://dx.doi.org/10.1002/jmri.20902
    • (2007) J Magn Reson Imaging , vol.25 , pp. 992-999
    • Yokota, H.1    Guo, J.2    Matoba, M.3    Higashi, K.4    Tonami, H.5    Nagao, Y.6
  • 28
    • 34547790342 scopus 로고    scopus 로고
    • Lactate sensitive transcription factor network in L6 cells: Activation of MCT1 and mitochondrial biogenesis
    • PMID:17395833
    • Hashimoto T, Hussien R, Oommen S, Gohil K, Brooks GA. Lactate sensitive transcription factor network in L6 cells: activation of MCT1 and mitochondrial biogenesis. FASEB J 2007; 21:2602-12; PMID:17395833; http://dx.doi.org/10.1096/ fj.07-8174com
    • (2007) FASEB J , vol.21 , pp. 2602-2612
    • Hashimoto, T.1    Hussien, R.2    Oommen, S.3    Gohil, K.4    Brooks, G.A.5
  • 29
    • 0037189542 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis
    • PMID:11943784
    • Lu H, Forbes RA, Verma A. Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis. J Biol Chem 2002; 277:23111-5; PMID:11943784; http://dx.doi.org/10.1074/jbc.M202487200
    • (2002) J Biol Chem , vol.277 , pp. 23111-23115
    • Lu, H.1    Forbes, R.A.2    Verma, A.3
  • 30
    • 29644442625 scopus 로고    scopus 로고
    • Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1
    • PMID:16223732
    • Lu H, Dalgard CL, Mohyeldin A, McFate T, Tait AS, Verma A. Reversible inactivation of HIF-1 prolyl hydroxylases allows cell metabolism to control basal HIF-1. J Biol Chem 2005; 280:41928-39; PMID:16223732; http://dx.doi.org/ 10.1074/jbc.M508718200
    • (2005) J Biol Chem , vol.280 , pp. 41928-41939
    • Lu, H.1    Dalgard, C.L.2    Mohyeldin, A.3    McFate, T.4    Tait, A.S.5    Verma, A.6
  • 31
    • 33748849657 scopus 로고    scopus 로고
    • The role of the hypoxia-inducible factor in tumor metabolism growth and invasion
    • PMID:16935775
    • Brahimi-Horn C, Pouysségur J. The role of the hypoxia-inducible factor in tumor metabolism growth and invasion. Bull Cancer 2006; 93:E73-80; PMID:16935775
    • (2006) Bull Cancer , vol.93
    • Brahimi-Horn, C.1    Pouysségur, J.2
  • 32
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • PMID:13130303
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3:721-32; PMID:13130303; http://dx.doi.org/10.1038/nrc1187
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 33
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • PMID:16724055
    • Pouysségur J, Dayan F, Mazure NM. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006; 441:437-43; PMID:16724055; http://dx.doi.org/10.1038/nature04871
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouysségur, J.1    Dayan, F.2    Mazure, N.M.3
  • 34
    • 84872198918 scopus 로고    scopus 로고
    • Mitochondrial redox signaling and cancer invasiveness
    • PMID:22886605
    • Enns L, Ladiges W. Mitochondrial redox signaling and cancer invasiveness. J Bioenerg Biomembr 2012; 44:635-8; PMID:22886605; http://dx.doi.org/10.1007/ s10863-012-9467-7
    • (2012) J Bioenerg Biomembr , vol.44 , pp. 635-638
    • Enns, L.1    Ladiges, W.2
  • 35
    • 84867589382 scopus 로고    scopus 로고
    • Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration
    • PMID:22895781
    • Caneba CA, Bellance N, Yang L, Pabst L, Nagrath D. Pyruvate uptake is increased in highly invasive ovarian cancer cells under anoikis conditions for anaplerosis, mitochondrial function, and migration. Am J Physiol Endocrinol Metab 2012; 303:E1036-52; PMID:22895781; http://dx.doi.org/10.1152/ajpendo. 00151.2012
    • (2012) Am J Physiol Endocrinol Metab , vol.303
    • Caneba, C.A.1    Bellance, N.2    Yang, L.3    Pabst, L.4    Nagrath, D.5
  • 37
    • 0030012538 scopus 로고    scopus 로고
    • Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide
    • PMID:8674049
    • Watanabe H, Takehana K, Date M, Shinozaki T, Raz A. Tumor cell autocrine motility factor is the neuroleukin/phosphohexose isomerase polypeptide. Cancer Res 1996; 56:2960-3; PMID:8674049
    • (1996) Cancer Res , vol.56 , pp. 2960-2963
    • Watanabe, H.1    Takehana, K.2    Date, M.3    Shinozaki, T.4    Raz, A.5
  • 38
    • 0032800602 scopus 로고    scopus 로고
    • The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein
    • PMID:10456327
    • Shimizu K, Tani M, Watanabe H, Nagamachi Y, Niinaka Y, Shiroishi T, Ohwada S, Raz A, Yokota J. The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein. FEBS Lett 1999; 456:295-300; PMID:10456327; http://dx.doi.org/10.1016/S0014-5793(99)00966-7
    • (1999) FEBS Lett , vol.456 , pp. 295-300
    • Shimizu, K.1    Tani, M.2    Watanabe, H.3    Nagamachi, Y.4    Niinaka, Y.5    Shiroishi, T.6    Ohwada, S.7    Raz, A.8    Yokota, J.9
  • 39
    • 0242363599 scopus 로고    scopus 로고
    • Autocrine motility factor signaling induces tumor apoptotic resistance by regulations Apaf-1 and Caspase-9 apoptosome expression
    • PMID:14566819
    • Haga A, Funasaka T, Niinaka Y, Raz A, Nagase H. Autocrine motility factor signaling induces tumor apoptotic resistance by regulations Apaf-1 and Caspase-9 apoptosome expression. Int J Cancer 2003; 107:707-14; PMID:14566819; http://dx.doi.org/10.1002/ijc.11449
    • (2003) Int J Cancer , vol.107 , pp. 707-714
    • Haga, A.1    Funasaka, T.2    Niinaka, Y.3    Raz, A.4    Nagase, H.5
  • 40
    • 9344260855 scopus 로고    scopus 로고
    • Autocrine motility factor signaling enhances pancreatic cancer metastasis
    • PMID:15570012
    • Tsutsumi S, Yanagawa T, Shimura T, Kuwano H, Raz A. Autocrine motility factor signaling enhances pancreatic cancer metastasis. Clin Cancer Res 2004; 10:7775-84; PMID:15570012; http://dx.doi.org/10.1158/1078-0432.CCR-04-1015
    • (2004) Clin Cancer Res , vol.10 , pp. 7775-7784
    • Tsutsumi, S.1    Yanagawa, T.2    Shimura, T.3    Kuwano, H.4    Raz, A.5
  • 41
    • 70450245233 scopus 로고    scopus 로고
    • Phosphoglucose isomerase/autocrine motility factor promotes melanoma cell migration through ERK activation dependent on autocrine production of interleukin-8
    • PMID:19801670
    • Araki K, Shimura T, Yajima T, Tsutsumi S, Suzuki H, Okada K, Kobayashi T, Raz A, Kuwano H. Phosphoglucose isomerase/autocrine motility factor promotes melanoma cell migration through ERK activation dependent on autocrine production of interleukin-8. J Biol Chem 2009; 284:32305-11; PMID:19801670; http://dx.doi.org/10.1074/jbc.M109.008250
    • (2009) J Biol Chem , vol.284 , pp. 32305-32311
    • Araki, K.1    Shimura, T.2    Yajima, T.3    Tsutsumi, S.4    Suzuki, H.5    Okada, K.6    Kobayashi, T.7    Raz, A.8    Kuwano, H.9
  • 42
    • 0030047239 scopus 로고    scopus 로고
    • Expression and growth-promoting function of the IL-8 receptor beta in human melanoma cells
    • PMID:8557989
    • Norgauer J, Metzner B, Schraufstätter I. Expression and growth-promoting function of the IL-8 receptor beta in human melanoma cells. J Immunol 1996; 156:1132-7; PMID:8557989
    • (1996) J Immunol , vol.156 , pp. 1132-1137
    • Norgauer, J.1    Metzner, B.2    Schraufstätter, I.3
  • 43
    • 0037448628 scopus 로고    scopus 로고
    • IL-8 expression and its possible relationship with estrogen-receptor- negative status of breast cancer cells
    • PMID:12527894
    • Freund A, Chauveau C, Brouillet JP, Lucas A, Lacroix M, Licznar A, Vignon F, Lazennec G. IL-8 expression and its possible relationship with estrogen-receptor-negative status of breast cancer cells. Oncogene 2003; 22:256-65; PMID:12527894; http://dx.doi.org/10.1038/sj.onc.1206113
    • (2003) Oncogene , vol.22 , pp. 256-265
    • Freund, A.1    Chauveau, C.2    Brouillet, J.P.3    Lucas, A.4    Lacroix, M.5    Licznar, A.6    Vignon, F.7    Lazennec, G.8
  • 44
    • 0036682378 scopus 로고    scopus 로고
    • Activation of small GTPase Rho is required for autocrine motility factor signaling
    • PMID:12154059
    • Tsutsumi S, Gupta SK, Hogan V, Collard JG, Raz A. Activation of small GTPase Rho is required for autocrine motility factor signaling. Cancer Res 2002; 62:4484-90; PMID:12154059
    • (2002) Cancer Res , vol.62 , pp. 4484-4490
    • Tsutsumi, S.1    Gupta, S.K.2    Hogan, V.3    Collard, J.G.4    Raz, A.5
  • 45
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • PMID:12189386
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2:442-54; PMID:12189386; http://dx.doi.org/10.1038/nrc822
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 46
    • 0025293067 scopus 로고
    • Induction of haptotactic migration of melanoma cells by neutrophil activating protein/interleukin-8
    • PMID:2190552
    • Wang JM, Taraboletti G, Matsushima K, Van Damme J, Mantovani A. Induction of haptotactic migration of melanoma cells by neutrophil activating protein/interleukin-8. Biochem Biophys Res Commun 1990; 169:165-70; PMID:2190552; http://dx.doi.org/10.1016/0006-291X(90)91449-3
    • (1990) Biochem Biophys Res Commun , vol.169 , pp. 165-170
    • Wang, J.M.1    Taraboletti, G.2    Matsushima, K.3    Van Damme, J.4    Mantovani, A.5
  • 47
    • 33749024777 scopus 로고    scopus 로고
    • Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis
    • PMID:16951136
    • Christiansen JJ, Rajasekaran AK. Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res 2006; 66:8319-26; PMID:16951136; http://dx.doi.org/10.1158/0008-5472.CAN-06-0410
    • (2006) Cancer Res , vol.66 , pp. 8319-8326
    • Christiansen, J.J.1    Rajasekaran, A.K.2
  • 48
    • 23144442645 scopus 로고    scopus 로고
    • Regulation of cadherin-mediated adhesion in morphogenesis
    • PMID:16025097
    • Gumbiner BM. Regulation of cadherin-mediated adhesion in morphogenesis. Nat Rev Mol Cell Biol 2005; 6:622-34; PMID:16025097; http://dx.doi.org/10.1038/ nrm1699
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 622-634
    • Gumbiner, B.M.1
  • 49
    • 0031034469 scopus 로고    scopus 로고
    • Activation of the nuclear factorkappaB by Rho, CDC42, and Rac-1 proteins
    • PMID:9042860
    • Perona R, Montaner S, Saniger L, Sánchez-Pérez I, Bravo R, Lacal JC. Activation of the nuclear factorkappaB by Rho, CDC42, and Rac-1 proteins. Genes Dev 1997; 11:463-75; PMID:9042860; http://dx.doi.org/10.1101/ gad.11.4.463
    • (1997) Genes Dev , vol.11 , pp. 463-475
    • Perona, R.1    Montaner, S.2    Saniger, L.3    Sánchez-Pérez, I.4    Bravo, R.5    Lacal, J.C.6
  • 50
    • 4344612243 scopus 로고    scopus 로고
    • NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
    • PMID:15314694
    • Huber MA, Azoitei N, Baumann B, Grünert S, Sommer A, Pehamberger H, Kraut N, Beug H, Wirth T. NF-kappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 2004; 114:569-81; PMID:15314694
    • (2004) J Clin Invest , vol.114 , pp. 569-581
    • Huber, M.A.1    Azoitei, N.2    Baumann, B.3    Grünert, S.4    Sommer, A.5    Pehamberger, H.6    Kraut, N.7    Beug, H.8    Wirth, T.9
  • 51
    • 79955497173 scopus 로고    scopus 로고
    • Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells
    • PMID:21389093
    • Ahmad A, Aboukameel A, Kong D, Wang Z, Sethi S, Chen W, Sarkar FH, Raz A. Phosphoglucose isomerase/autocrine motility factor mediates epithelial-mesenchymal transition regulated by miR-200 in breast cancer cells. Cancer Res 2011; 71:3400-9; PMID:21389093; http://dx.doi.org/10.1158/0008-5472. CAN-10-0965
    • (2011) Cancer Res , vol.71 , pp. 3400-3409
    • Ahmad, A.1    Aboukameel, A.2    Kong, D.3    Wang, Z.4    Sethi, S.5    Chen, W.6    Sarkar, F.H.7    Raz, A.8
  • 52
    • 33846828787 scopus 로고    scopus 로고
    • NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: Potential involvement of ZEB-1 and ZEB-2
    • PMID:16862183
    • Chua HL, Bhat-Nakshatri P, Clare SE, Morimiya A, Badve S, Nakshatri H. NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2. Oncogene 2007; 26:711-24; PMID:16862183; http://dx.doi.org/10.1038/sj. onc.1209808
    • (2007) Oncogene , vol.26 , pp. 711-724
    • Chua, H.L.1    Bhat-Nakshatri, P.2    Clare, S.E.3    Morimiya, A.4    Badve, S.5    Nakshatri, H.6
  • 53
    • 84876434755 scopus 로고    scopus 로고
    • Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer
    • PMID:23453623
    • Dong C, Yuan T, Wu Y, Wang Y, Fan TW, Miriyala S, Lin Y, Yao J, Shi J, Kang T, et al. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell 2013; 23:316-31; PMID:23453623; http://dx.doi.org/10.1016/j.ccr.2013.01.022
    • (2013) Cancer Cell , vol.23 , pp. 316-331
    • Dong, C.1    Yuan, T.2    Wu, Y.3    Wang, Y.4    Fan, T.W.5    Miriyala, S.6    Lin, Y.7    Yao, J.8    Shi, J.9    Kang, T.10
  • 54
    • 79958103961 scopus 로고    scopus 로고
    • Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells
    • PMID:20156581
    • Mazurek S. Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. Int J Biochem Cell Biol 2011; 43:969-80; PMID:20156581; http://dx.doi.org/10.1016/j.biocel.2010.02.005
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 969-980
    • Mazurek, S.1
  • 55
    • 23044500915 scopus 로고    scopus 로고
    • Pyruvate kinase type M2 and its role in tumor growth and spreading
    • PMID:15908230
    • Mazurek S, Boschek CB, Hugo F, Eigenbrodt E. Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol 2005; 15:300-8; PMID:15908230; http://dx.doi.org/10.1016/j.semcancer.2005.04.009
    • (2005) Semin Cancer Biol , vol.15 , pp. 300-308
    • Mazurek, S.1    Boschek, C.B.2    Hugo, F.3    Eigenbrodt, E.4
  • 56
    • 84879512941 scopus 로고    scopus 로고
    • Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependent manner in gastric cancer cells
    • PMID:23840737
    • Wang LY, Liu YP, Chen LG, Chen YL, Tan L, Liu JJ, Jazag A, Ren JL, Guleng B. Pyruvate kinase M2 plays a dual role on regulation of the EGF/EGFR signaling via E-cadherin-dependent manner in gastric cancer cells. PLoS One 2013; 8:e67542; PMID:23840737; http://dx.doi.org/10.1371/journal.pone.0067542
    • (2013) PLoS One , vol.8
    • Wang, L.Y.1    Liu, Y.P.2    Chen, L.G.3    Chen, Y.L.4    Tan, L.5    Liu, J.J.6    Jazag, A.7    Ren, J.L.8    Guleng, B.9
  • 57
    • 84865321569 scopus 로고    scopus 로고
    • Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells
    • PMID:22807066
    • Zhou CF, Li XB, Sun H, Zhang B, Han YS, Jiang Y, Zhuang QL, Fang J, Wu GH. Pyruvate kinase type M2 is upregulated in colorectal cancer and promotes proliferation and migration of colon cancer cells. IUBMB Life 2012; 64:775-82; PMID:22807066; http://dx.doi.org/10.1002/iub.1066
    • (2012) IUBMB Life , vol.64 , pp. 775-782
    • Zhou, C.F.1    Li, X.B.2    Sun, H.3    Zhang, B.4    Han, Y.S.5    Jiang, Y.6    Zhuang, Q.L.7    Fang, J.8    Wu, G.H.9
  • 58
    • 0029778381 scopus 로고    scopus 로고
    • Usefulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammation
    • PMID:8866602
    • Drent M, Cobben NA, Henderson RF, Wouters EF, van Dieijen-Visser M. Usefulness of lactate dehydrogenase and its isoenzymes as indicators of lung damage or inflammation. Eur Respir J 1996; 9:1736-42; PMID:8866602; http://dx.doi.org/10.1183/09031936.96.09081736
    • (1996) Eur Respir J , vol.9 , pp. 1736-1742
    • Drent, M.1    Cobben, N.A.2    Henderson, R.F.3    Wouters, E.F.4    Van Dieijen-Visser, M.5
  • 59
    • 23944498840 scopus 로고    scopus 로고
    • Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer
    • PMID:16132575
    • Koukourakis MI, Giatromanolaki A, Simopoulos C, Polychronidis A, Sivridis E. Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer. Clin Exp Metastasis 2005; 22:25-30; PMID:16132575; http://dx.doi.org/10.1007/s10585-005-2343-7
    • (2005) Clin Exp Metastasis , vol.22 , pp. 25-30
    • Koukourakis, M.I.1    Giatromanolaki, A.2    Simopoulos, C.3    Polychronidis, A.4    Sivridis, E.5
  • 60
    • 84857716739 scopus 로고    scopus 로고
    • Multiple biological activities of lactic acid in cancer: Influences on tumor growth, angiogenesis and metastasis
    • PMID:22360558
    • Dhup S, Dadhich RK, Porporato PE, Sonveaux P. Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis. Curr Pharm Des 2012; 18:1319-30; PMID:22360558; http://dx.doi.org/10.2174/138161212799504902
    • (2012) Curr Pharm des , vol.18 , pp. 1319-1330
    • Dhup, S.1    Dadhich, R.K.2    Porporato, P.E.3    Sonveaux, P.4
  • 62
    • 33644868712 scopus 로고    scopus 로고
    • Transforming growth factor-beta: A molecular target for the future therapy of glioblastoma
    • PMID:16454748
    • Wick W, Naumann U, Weller M. Transforming growth factor-beta: a molecular target for the future therapy of glioblastoma. Curr Pharm Des 2006; 12:341-9; PMID:16454748; http://dx.doi.org/10.2174/138161206775201901
    • (2006) Curr Pharm des , vol.12 , pp. 341-349
    • Wick, W.1    Naumann, U.2    Weller, M.3
  • 63
    • 0001125655 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 activation modulates glioma cell migration
    • PMID:9410885
    • Deryugina EI, Bourdon MA, Luo GX, Reisfeld RA, Strongin A. Matrix metalloproteinase-2 activation modulates glioma cell migration. J Cell Sci 1997; 110:2473-82; PMID:9410885
    • (1997) J Cell Sci , vol.110 , pp. 2473-2482
    • Deryugina, E.I.1    Bourdon, M.A.2    Luo, G.X.3    Reisfeld, R.A.4    Strongin, A.5
  • 64
    • 34248599025 scopus 로고    scopus 로고
    • The role of versican isoforms V0/V1 in glioma migration mediated by transforming growth factor-beta2
    • PMID:17453002
    • Arslan F, Bosserhoff AK, Nickl-Jockschat T, Doerfelt A, Bogdahn U, Hau P. The role of versican isoforms V0/V1 in glioma migration mediated by transforming growth factor-beta2. Br J Cancer 2007; 96:1560-8; PMID:17453002; http://dx.doi.org/10.1038/sj.bjc.6603766
    • (2007) Br J Cancer , vol.96 , pp. 1560-1568
    • Arslan, F.1    Bosserhoff, A.K.2    Nickl-Jockschat, T.3    Doerfelt, A.4    Bogdahn, U.5    Hau, P.6
  • 65
    • 0035864376 scopus 로고    scopus 로고
    • MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells
    • PMID:11161720
    • Deryugina EI, Ratnikov B, Monosov E, Postnova TI, DiScipio R, Smith JW, Strongin AY. MT1-MMP initiates activation of pro-MMP-2 and integrin alphavbeta3 promotes maturation of MMP-2 in breast carcinoma cells. Exp Cell Res 2001; 263:209-23; PMID:11161720; http://dx.doi.org/10.1006/excr.2000.5118
    • (2001) Exp Cell Res , vol.263 , pp. 209-223
    • Deryugina, E.I.1    Ratnikov, B.2    Monosov, E.3    Postnova, T.I.4    DiScipio, R.5    Smith, J.W.6    Strongin, A.Y.7
  • 66
    • 0034673243 scopus 로고    scopus 로고
    • Transforming growth factors beta(1) (TGF-beta(1)) and TGF-beta(2) promote glioma cell migration via Up-regulation of alpha(V) beta(3) integrin expression
    • PMID:10679251
    • Platten M, Wick W, Wild-Bode C, Aulwurm S, Dichgans J, Weller M. Transforming growth factors beta(1) (TGF-beta(1)) and TGF-beta(2) promote glioma cell migration via Up-regulation of alpha(V) beta(3) integrin expression. Biochem Biophys Res Commun 2000; 268:607-11; PMID:10679251; http://dx.doi.org/ 10.1006/bbrc.2000.2176
    • (2000) Biochem Biophys Res Commun , vol.268 , pp. 607-611
    • Platten, M.1    Wick, W.2    Wild-Bode, C.3    Aulwurm, S.4    Dichgans, J.5    Weller, M.6
  • 67
    • 79953073914 scopus 로고    scopus 로고
    • Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects
    • PMID:21356207
    • Kim JH, Kim EL, Lee YK, Park CB, Kim BW, Wang HJ, Yoon CH, Lee SJ, Yoon G. Decreased lactate dehydrogenase B expression enhances claudin 1-mediated hepatoma cell invasiveness via mitochondrial defects. Exp Cell Res 2011; 317:1108-18; PMID:21356207; http://dx.doi.org/10.1016/j.yexcr.2011.02.011
    • (2011) Exp Cell Res , vol.317 , pp. 1108-1118
    • Kim, J.H.1    Kim, E.L.2    Lee, Y.K.3    Park, C.B.4    Kim, B.W.5    Wang, H.J.6    Yoon, C.H.7    Lee, S.J.8    Yoon, G.9
  • 68
    • 35448982216 scopus 로고    scopus 로고
    • Hypoxia, glucose metabolism and the Warburg's effect
    • PMID:17661163
    • Bartrons R, Caro J. Hypoxia, glucose metabolism and the Warburg's effect. J Bioenerg Biomembr 2007; 39:223-9; PMID:17661163; http://dx.doi.org/10.1007/ s10863-007-9080-3
    • (2007) J Bioenerg Biomembr , vol.39 , pp. 223-229
    • Bartrons, R.1    Caro, J.2
  • 70
    • 0002951660 scopus 로고
    • The specific amino acid requirements of a human carcinoma cell (Stain HeLa) in tissue culture
    • PMID:14392239
    • Eagle H. The specific amino acid requirements of a human carcinoma cell (Stain HeLa) in tissue culture. J Exp Med 1955; 102:37-48; PMID:14392239; http://dx.doi.org/10.1084/jem.102.1.37
    • (1955) J Exp Med , vol.102 , pp. 37-48
    • Eagle, H.1
  • 71
    • 37449034854 scopus 로고    scopus 로고
    • Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
    • PMID:18032601
    • DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB. Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A 2007; 104:19345-50; PMID:18032601; http://dx.doi.org/10.1073/pnas.0709747104
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19345-19350
    • DeBerardinis, R.J.1    Mancuso, A.2    Daikhin, E.3    Nissim, I.4    Yudkoff, M.5    Wehrli, S.6    Thompson, C.B.7
  • 74
    • 14544267669 scopus 로고    scopus 로고
    • Specific amino acid restriction inhibits attachment and spreading of human melanoma via modulation of the integrin/focal adhesion kinase pathway and actin cytoskeleton remodeling
    • PMID:15787096
    • Fu YM, Zhang H, Ding M, Li YQ, Fu X, Yu ZX, Meadows GG. Specific amino acid restriction inhibits attachment and spreading of human melanoma via modulation of the integrin/focal adhesion kinase pathway and actin cytoskeleton remodeling. Clin Exp Metastasis 2004; 21:587-98; PMID:15787096; http://dx.doi.org/10.1007/s10585-004-5515-y
    • (2004) Clin Exp Metastasis , vol.21 , pp. 587-598
    • Fu, Y.M.1    Zhang, H.2    Ding, M.3    Li, Y.Q.4    Fu, X.5    Yu, Z.X.6    Meadows, G.G.7
  • 75
    • 0036732391 scopus 로고    scopus 로고
    • Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells
    • PMID:12172541
    • Ishiuchi S, Tsuzuki K, Yoshida Y, Yamada N, Hagimura N, Okado H, Miwa A, Kurihara H, Nakazato Y, Tamura M, et al. Blockage of Ca(2+)-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells. Nat Med 2002; 8:971-8; PMID:12172541; http://dx.doi.org/10.1038/nm746
    • (2002) Nat Med , vol.8 , pp. 971-978
    • Ishiuchi, S.1    Tsuzuki, K.2    Yoshida, Y.3    Yamada, N.4    Hagimura, N.5    Okado, H.6    Miwa, A.7    Kurihara, H.8    Nakazato, Y.9    Tamura, M.10
  • 77
    • 0037107574 scopus 로고    scopus 로고
    • Glutamate antagonists limit tumor growth
    • PMID:12234599
    • Rzeski W, Ikonomidou C, Turski L. Glutamate antagonists limit tumor growth. Biochem Pharmacol 2002; 64:1195-200; PMID:12234599; http://dx.doi.org/ 10.1016/S0006-2952(02)01218-2
    • (2002) Biochem Pharmacol , vol.64 , pp. 1195-1200
    • Rzeski, W.1    Ikonomidou, C.2    Turski, L.3
  • 79
    • 34547135698 scopus 로고    scopus 로고
    • ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells
    • PMID:17329400
    • Fuchs BC, Finger RE, Onan MC, Bode BP. ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells. Am J Physiol Cell Physiol 2007; 293:C55-63; PMID:17329400; http://dx.doi.org/10.1152/ajpcell.00330.2006
    • (2007) Am J Physiol Cell Physiol , vol.293
    • Fuchs, B.C.1    Finger, R.E.2    Onan, M.C.3    Bode, B.P.4
  • 80
    • 77953844482 scopus 로고    scopus 로고
    • mTOR signaling in cancer cell motility and tumor metastasis
    • PMID:20528734
    • Zhou H, Huang S. mTOR signaling in cancer cell motility and tumor metastasis. Crit Rev Eukaryot Gene Expr 2010; 20:1-16; PMID:20528734; http://dx.doi.org/10.1615/CritRevEukarGeneExpr.v20.i1.10
    • (2010) Crit Rev Eukaryot Gene Expr , vol.20 , pp. 1-16
    • Zhou, H.1    Huang, S.2
  • 82
    • 84862779787 scopus 로고    scopus 로고
    • Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTOR
    • PMID:22305748
    • Chen SM, Liu JL, Wang X, Liang C, Ding J, Meng LH. Inhibition of tumor cell growth, proliferation and migration by X-387, a novel active-site inhibitor of mTOR. Biochem Pharmacol 2012; 83:1183-94; PMID:22305748; http://dx.doi.org/10.1016/j.bcp.2012.01.019
    • (2012) Biochem Pharmacol , vol.83 , pp. 1183-1194
    • Chen, S.M.1    Liu, J.L.2    Wang, X.3    Liang, C.4    Ding, J.5    Meng, L.H.6
  • 85
    • 19944374798 scopus 로고    scopus 로고
    • Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
    • PMID:15806173
    • Wang HQ, Altomare DA, Skele KL, Poulikakos PI, Kuhajda FP, Di Cristofano A, Testa JR. Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene 2005; 24:3574-82; PMID:15806173; http://dx.doi.org/10.1038/sj.onc.1208463
    • (2005) Oncogene , vol.24 , pp. 3574-3582
    • Wang, H.Q.1    Altomare, D.A.2    Skele, K.L.3    Poulikakos, P.I.4    Kuhajda, F.P.5    Di Cristofano, A.6    Testa, J.R.7
  • 86
    • 84861403179 scopus 로고    scopus 로고
    • TOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer
    • PMID:21996732
    • Shih MC, Chen JY, Wu YC, Jan YH, Yang BM, Lu PJ, Cheng HC, Huang MS, Yang CJ, Hsiao M, et al. TOPK/PBK promotes cell migration via modulation of the PI3K/PTEN/AKT pathway and is associated with poor prognosis in lung cancer. Oncogene 2012; 31:2389-400; PMID:21996732; http://dx.doi.org/10.1038/onc.2011. 419
    • (2012) Oncogene , vol.31 , pp. 2389-2400
    • Shih, M.C.1    Chen, J.Y.2    Wu, Y.C.3    Jan, Y.H.4    Yang, B.M.5    Lu, P.J.6    Cheng, H.C.7    Huang, M.S.8    Yang, C.J.9    Hsiao, M.10
  • 87
    • 84872674705 scopus 로고    scopus 로고
    • Expression of TGFβ3 and its effects on migratory and invasive behavior of prostate cancer cells: Involvement of PI3-kinase/AKT signaling pathway
    • PMID:22678424
    • Walker L, Millena AC, Strong N, Khan SA. Expression of TGFβ3 and its effects on migratory and invasive behavior of prostate cancer cells: involvement of PI3-kinase/AKT signaling pathway. Clin Exp Metastasis 2013; 30:13-23; PMID:22678424; http://dx.doi.org/10.1007/s10585-012-9494-0
    • (2013) Clin Exp Metastasis , vol.30 , pp. 13-23
    • Walker, L.1    Millena, A.C.2    Strong, N.3    Khan, S.A.4
  • 88
    • 33749495312 scopus 로고    scopus 로고
    • Estradiol stimulates the biosynthetic pathways of breast cancer cells: Detection by metabolic flux analysis
    • PMID:16904360
    • Forbes NS, Meadows AL, Clark DS, Blanch HW. Estradiol stimulates the biosynthetic pathways of breast cancer cells: detection by metabolic flux analysis. Metab Eng 2006; 8:639-52; PMID:16904360; http://dx.doi.org/10.1016/j. ymben.2006.06.005
    • (2006) Metab Eng , vol.8 , pp. 639-652
    • Forbes, N.S.1    Meadows, A.L.2    Clark, D.S.3    Blanch, H.W.4
  • 89
    • 33746930794 scopus 로고    scopus 로고
    • Succinate dehydrogenase and fumarate hydratase: Linking mitochondrial dysfunction and cancer
    • PMID:16892081
    • King A, Selak MA, Gottlieb E. Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer. Oncogene 2006; 25:4675-82; PMID:16892081; http://dx.doi.org/10.1038/sj.onc.1209594
    • (2006) Oncogene , vol.25 , pp. 4675-4682
    • King, A.1    Selak, M.A.2    Gottlieb, E.3
  • 90
    • 23644448721 scopus 로고    scopus 로고
    • HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
    • PMID:16098467
    • Isaacs JS, Jung YJ, Mole DR, Lee S, Torres-Cabala C, Chung YL, Merino M, Trepel J, Zbar B, Toro J, et al. HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability. Cancer Cell 2005; 8:143-53; PMID:16098467; http://dx.doi.org/10.1016/j.ccr.2005.06.017
    • (2005) Cancer Cell , vol.8 , pp. 143-153
    • Isaacs, J.S.1    Jung, Y.J.2    Mole, D.R.3    Lee, S.4    Torres-Cabala, C.5    Chung, Y.L.6    Merino, M.7    Trepel, J.8    Zbar, B.9    Toro, J.10
  • 91
    • 79958795339 scopus 로고    scopus 로고
    • Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion
    • PMID:21695080
    • Sudarshan S, Shanmugasundaram K, Naylor SL, Lin S, Livi CB, O'Neill CF, Parekh DJ, Yeh IT, Sun LZ, Block K. Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion. PLoS One 2011; 6:e21037; PMID:21695080; http://dx.doi.org/10.1371/journal.pone.0021037
    • (2011) PLoS One , vol.6
    • Sudarshan, S.1    Shanmugasundaram, K.2    Naylor, S.L.3    Lin, S.4    Livi, C.B.5    O'Neill, C.F.6    Parekh, D.J.7    Yeh, I.T.8    Sun, L.Z.9    Block, K.10
  • 92
    • 84879693403 scopus 로고    scopus 로고
    • Effect of silencing HIF-1α on proliferation, invasion and migration of glioblastoma U87 cells
    • PMID:22454035
    • Shen SH, Kwan AL, Chen YY, Wang ZX. Effect of silencing HIF-1α on proliferation, invasion and migration of glioblastoma U87 cells. Neurol Sci 2013; 34:365-71; http://dx.doi.org/10.1007/s10072-012-1010-4; PMID:22454035
    • (2013) Neurol Sci , vol.34 , pp. 365-371
    • Shen, S.H.1    Kwan, A.L.2    Chen, Y.Y.3    Wang, Z.X.4
  • 93
    • 64949087598 scopus 로고    scopus 로고
    • Glutamine in neoplastic cells: Focus on the expression and roles of glutaminases
    • PMID:19428809
    • Szeliga M, Obara-Michlewska M. Glutamine in neoplastic cells: focus on the expression and roles of glutaminases. Neurochem Int 2009; 55:71-5; PMID:19428809; http://dx.doi.org/10.1016/j.neuint.2009.01.008
    • (2009) Neurochem Int , vol.55 , pp. 71-75
    • Szeliga, M.1    Obara-Michlewska, M.2
  • 94
    • 67650757162 scopus 로고    scopus 로고
    • Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells
    • PMID:19062176
    • Szeliga M, Obara-Michlewska M, Matyja E, Łazarczyk M, Lobo C, Hilgier W, Alonso FJ, Márquez J, Albrecht J. Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells. Glia 2009; 57:1014-23; PMID:19062176; http://dx.doi.org/10.1002/glia.20825
    • (2009) Glia , vol.57 , pp. 1014-1023
    • Szeliga, M.1    Obara-Michlewska, M.2    Matyja, E.3    Łazarczyk, M.4    Lobo, C.5    Hilgier, W.6    Alonso, F.J.7    Márquez, J.8    Albrecht, J.9
  • 95
    • 77952212178 scopus 로고    scopus 로고
    • Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
    • PMID:20378837
    • Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A 2010; 107:7455-60; PMID:20378837; http://dx.doi.org/10.1073/pnas. 1001006107
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 7455-7460
    • Hu, W.1    Zhang, C.2    Wu, R.3    Sun, Y.4    Levine, A.5    Feng, Z.6
  • 96
    • 84861975431 scopus 로고    scopus 로고
    • Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis
    • PMID:22349059
    • Daye D, Wellen KE. Metabolic reprogramming in cancer: unraveling the role of glutamine in tumorigenesis. Semin Cell Dev Biol 2012; 23:362-9; PMID:22349059; http://dx.doi.org/10.1016/j.semcdb.2012.02.002
    • (2012) Semin Cell Dev Biol , vol.23 , pp. 362-369
    • Daye, D.1    Wellen, K.E.2
  • 97
    • 84859484538 scopus 로고    scopus 로고
    • Critical role of O-Linked β-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis
    • PMID:22275356
    • Lynch TP, Ferrer CM, Jackson SR, Shahriari KS, Vosseller K, Reginato MJ. Critical role of O-Linked β-N-acetylglucosamine transferase in prostate cancer invasion, angiogenesis, and metastasis. J Biol Chem 2012; 287:11070-81; PMID:22275356; http://dx.doi.org/10.1074/jbc.M111.302547
    • (2012) J Biol Chem , vol.287 , pp. 11070-11081
    • Lynch, T.P.1    Ferrer, C.M.2    Jackson, S.R.3    Shahriari, K.S.4    Vosseller, K.5    Reginato, M.J.6
  • 98
    • 84878225772 scopus 로고    scopus 로고
    • Hyper-OGlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells
    • PMID:23592772
    • Ma Z, Vocadlo DJ, Vosseller K. Hyper-OGlcNAcylation is anti-apoptotic and maintains constitutive NF-κB activity in pancreatic cancer cells. J Biol Chem 2013; 288:15121-30; PMID:23592772; http://dx.doi.org/10.1074/jbc.M113. 470047
    • (2013) J Biol Chem , vol.288 , pp. 15121-15130
    • Ma, Z.1    Vocadlo, D.J.2    Vosseller, K.3
  • 99
    • 42549156713 scopus 로고    scopus 로고
    • Metastasis is promoted by a bioenergetic switch: New targets for progressive renal cell cancer
    • PMID:18302154
    • Langbein S, Frederiks WM, zur Hausen A, Popa J, Lehmann J, Weiss C, Alken P, Coy JF. Metastasis is promoted by a bioenergetic switch: new targets for progressive renal cell cancer. Int J Cancer 2008; 122:2422-8; http://dx.doi.org/10.1002/ijc.23403; PMID:18302154
    • (2008) Int J Cancer , vol.122 , pp. 2422-2428
    • Langbein, S.1    Frederiks, W.M.2    Zur Hausen, A.3    Popa, J.4    Lehmann, J.5    Weiss, C.6    Alken, P.7    Coy, J.F.8
  • 100
    • 84863486244 scopus 로고    scopus 로고
    • The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate
    • PMID:22580150
    • Riganti C, Gazzano E, Polimeni M, Aldieri E, Ghigo D. The pentose phosphate pathway: an antioxidant defense and a crossroad in tumor cell fate. Free Radic Biol Med 2012; 53:421-36; PMID:22580150; http://dx.doi.org/10.1016/j. freeradbiomed.2012.05.006
    • (2012) Free Radic Biol Med , vol.53 , pp. 421-436
    • Riganti, C.1    Gazzano, E.2    Polimeni, M.3    Aldieri, E.4    Ghigo, D.5
  • 102
    • 84868286808 scopus 로고    scopus 로고
    • A δ38 deletion variant of human transketolase as a model of transketolase-like protein 1 exhibits no enzymatic activity
    • PMID:23118983
    • Schneider S, Lüdtke S, Schröder-Tittmann K, Wechsler C, Meyer D, Tittmann K. A δ38 deletion variant of human transketolase as a model of transketolase-like protein 1 exhibits no enzymatic activity. PLoS One 2012; 7:e48321; PMID:23118983; http://dx.doi.org/10.1371/journal.pone.0048321
    • (2012) PLoS One , vol.7
    • Schneider, S.1    Lüdtke, S.2    Schröder-Tittmann, K.3    Wechsler, C.4    Meyer, D.5    Tittmann, K.6
  • 104
  • 105
    • 50849094215 scopus 로고    scopus 로고
    • TKTL1 is overexpressed in a large portion of non-small cell lung cancer specimens
    • PMID:18700018
    • Schultz H, Kähler D, Branscheid D, Vollmer E, Zabel P, Goldmann T. TKTL1 is overexpressed in a large portion of non-small cell lung cancer specimens. Diagn Pathol 2008; 3:35; PMID:18700018; http://dx.doi.org/10.1186/ 1746-1596-3-35
    • (2008) Diagn Pathol , vol.3 , pp. 35
    • Schultz, H.1    Kähler, D.2    Branscheid, D.3    Vollmer, E.4    Zabel, P.5    Goldmann, T.6
  • 106
    • 60549110886 scopus 로고    scopus 로고
    • Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells
    • PMID:19065656
    • Xu X, Zur Hausen A, Coy JF, Löchelt M. Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells. Int J Cancer 2009; 124:1330-7; http://dx.doi.org/10.1002/ijc.24078; PMID:19065656
    • (2009) Int J Cancer , vol.124 , pp. 1330-1337
    • Xu, X.1    Zur Hausen, A.2    Coy, J.F.3    Löchelt, M.4
  • 107
    • 34249905885 scopus 로고    scopus 로고
    • Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells
    • PMID:17321041
    • Zhang S, Yang JH, Guo CK, Cai PC. Gene silencing of TKTL1 by RNAi inhibits cell proliferation in human hepatoma cells. Cancer Lett 2007; 253:108-14; PMID:17321041; http://dx.doi.org/10.1016/j.canlet.2007.01.010
    • (2007) Cancer Lett , vol.253 , pp. 108-114
    • Zhang, S.1    Yang, J.H.2    Guo, C.K.3    Cai, P.C.4
  • 108
    • 77950672300 scopus 로고    scopus 로고
    • Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1
    • PMID:20385008
    • Kayser G, Kassem A, Sienel W, Schulte-Uentrop L, Mattern D, Aumann K, Stickeler E, Werner M, Passlick B, zur Hausen A. Lactate-dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1. Diagn Pathol 2010; 5:22; PMID:20385008; http://dx.doi.org/10.1186/1746-1596-5-22
    • (2010) Diagn Pathol , vol.5 , pp. 22
    • Kayser, G.1    Kassem, A.2    Sienel, W.3    Schulte-Uentrop, L.4    Mattern, D.5    Aumann, K.6    Stickeler, E.7    Werner, M.8    Passlick, B.9    Zur Hausen, A.10
  • 109
    • 0036347515 scopus 로고    scopus 로고
    • Lactate stimulates fibroblast expression of hyaluronan and CD44: The Warburg effect revisited
    • PMID:11978005
    • Stern R, Shuster S, Neudecker BA, Formby B. Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited. Exp Cell Res 2002; 276:24-31; PMID:11978005; http://dx.doi.org/10.1006/excr.2002.5508
    • (2002) Exp Cell Res , vol.276 , pp. 24-31
    • Stern, R.1    Shuster, S.2    Neudecker, B.A.3    Formby, B.4
  • 110
    • 81155126061 scopus 로고    scopus 로고
    • Lactate: A metabolic key player in cancer
    • PMID:22084445
    • Hirschhaeuser F, Sattler UG, Mueller-Klieser W. Lactate: a metabolic key player in cancer. Cancer Res 2011; 71:6921-5; PMID:22084445; http://dx.doi.org/10.1158/0008-5472.CAN-11-1457
    • (2011) Cancer Res , vol.71 , pp. 6921-6925
    • Hirschhaeuser, F.1    Sattler, U.G.2    Mueller-Klieser, W.3
  • 111
    • 76049104247 scopus 로고    scopus 로고
    • TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization
    • PMID:20103683
    • Sun W, Liu Y, Glazer CA, Shao C, Bhan S, Demokan S, Zhao M, Rudek MA, Ha PK, Califano JA. TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization. Clin Cancer Res 2010; 16:857-66; http://dx.doi.org/10.1158/1078-0432.CCR-09-2604; PMID:20103683
    • (2010) Clin Cancer Res , vol.16 , pp. 857-866
    • Sun, W.1    Liu, Y.2    Glazer, C.A.3    Shao, C.4    Bhan, S.5    Demokan, S.6    Zhao, M.7    Rudek, M.A.8    Ha, P.K.9    Califano, J.A.10


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