Reduced expression of fumarate hydratase in clear cell renal cancer mediates HIF-2α accumulation and promotes migration and invasion

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Sudarshan, Sunil ^a,c   Shanmugasundaram, Karthigayan ^a,c   Naylor, Susan L ^b,c   Lin, Shu ^b,c   Livi, Carolina B ^a,c   O'Neill, Christine F ^a,c   Parekh, Dipen J ^a,c   Yeh, I Tien ^a,c   Sun, Lu Zhe ^b,c   Block, Karen ^a,c  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b University of Texas Health Science Center   (United States)

^c SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FUMARATE HYDRATASE; HYPOXIA INDUCIBLE FACTOR 2ALPHA; MESSENGER RNA; PROTEIN KINASE B; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; ENDOTHELIAL PAS DOMAIN CONTAINING PROTEIN 1; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1;

ARTICLE; CANCER INHIBITION; CANCER INVASION; CELL INVASION; CLEAR CELL CARCINOMA; CONTROLLED STUDY; DOWN REGULATION; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KIDNEY CANCER; MIGRATION INHIBITION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; CELL MOTION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; KIDNEY CARCINOMA; KIDNEY TUMOR; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CARCINOMA, RENAL CELL; CELL LINE, TUMOR; CELL MOVEMENT; FUMARATE HYDRATASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KIDNEY NEOPLASMS; NEOPLASM INVASIVENESS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 79958795339     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021037     Document Type: Article

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