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Volumn 14, Issue 10, 2013, Pages 1029-1041

Double-Edged effects of arsenic compounds: Anticancer and carcinogenic effects

Author keywords

Anticancer; Apoptosis; Arsenic; Carcinogenesis; Differentiation

Indexed keywords

ARSENIC; ARSENIC DERIVATIVE; BUTHIONINE SULFOXIMINE; CASPASE; CYTOCHROME C; HYBRID PROTEIN; ORGANOARSENIC DERIVATIVE; REACTIVE OXYGEN METABOLITE; RETINOIC ACID RECEPTOR ALPHA;

EID: 84891286488     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/13892002113146660116     Document Type: Article
Times cited : (23)

References (187)
  • 1
    • 0003771986 scopus 로고    scopus 로고
    • National Research Council, National Academy Press, Washington, DC
    • National Research Council, Arsenic in Drinking Water, National Academy Press, Washington, DC, 1999.
    • (1999) Arsenic in Drinking Water
  • 2
    • 0003771986 scopus 로고    scopus 로고
    • National Research Council, National Academy Press, Washington, DC
    • National Research Council, Arsenic in Drinking Water 2001 Update, National Academy Press, Washington, DC, 2001.
    • (2001) Arsenic in Drinking Water
  • 4
    • 77249109455 scopus 로고    scopus 로고
    • Arsenic species in seafood: Origin and human health implications
    • Francesconi, K.A. Arsenic species in seafood: Origin and human health implications. Pure Appl. Chem., 2010, 82, 373-381.
    • (2010) Pure Appl. Chem. , vol.82 , pp. 373-381
    • Francesconi, K.A.1
  • 5
    • 80455137210 scopus 로고    scopus 로고
    • Genetic and epigenetic effects of environmental arsenicals
    • Rossman, T.G.; Klein, C.B. Genetic and epigenetic effects of environmental arsenicals. Metallomics, 2011, 3, 1135-1141.
    • (2011) Metallomics , vol.3 , pp. 1135-1141
    • Rossman, T.G.1    Klein, C.B.2
  • 6
    • 49249109498 scopus 로고    scopus 로고
    • Liver is a target of arsenic carcinogenesis
    • Liu, J.; Waalkes, M.P. Liver is a target of arsenic carcinogenesis. Toxicol. Sci., 2008, 105, 24-32.
    • (2008) Toxicol. Sci. , vol.105 , pp. 24-32
    • Liu, J.1    Waalkes, M.P.2
  • 7
    • 22544460259 scopus 로고    scopus 로고
    • Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot diseasehyperendemic villages in taiwan
    • Tseng, C.H.; Huang, Y.K.; Huang, Y.L.; Chung, C.J.; Yang, M.H.; Chen, C.J.; Hsueh, Y.M. Arsenic exposure, urinary arsenic speciation, and peripheral vascular disease in blackfoot diseasehyperendemic villages in Taiwan. Toxicol. Appl. Pharmacol., 2005, 206, 299-308.
    • (2005) Toxicol. Appl. Pharmacol. , vol.206 , pp. 299-308
    • Tseng, C.H.1    Huang, Y.K.2    Huang, Y.L.3    Chung, C.J.4    Yang, M.H.5    Chen, C.J.6    Hsueh, Y.M.7
  • 10
    • 0035038845 scopus 로고    scopus 로고
    • History of the development of arsenic derivatives in cancer therapy
    • Waxman, S.; Anderson, K.C. History of the development of arsenic derivatives in cancer therapy, Oncologist., 2001, 6, 3-10.
    • (2001) Oncologist. , vol.6 , pp. 3-10
    • Waxman, S.1    Anderson, K.C.2
  • 11
    • 0035341195 scopus 로고    scopus 로고
    • Recent advances in arsenic carcinogenesis: Modes of action, animal model systems, and methylated arsenic metabolites
    • Kitchin, K.T. Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Toxicol. Appl. Pharmacol., 2001, 172, 249-261.
    • (2001) Toxicol. Appl. Pharmacol. , vol.172 , pp. 249-261
    • Kitchin, K.T.1
  • 12
    • 0037184792 scopus 로고    scopus 로고
    • Mechanisms of arsenic biotransformation
    • 211-217
    • Vahter, M. Mechanisms of arsenic biotransformation. Toxicology, 2002, 181-182, 211-217.
    • (2002) Toxicology , pp. 181-182
    • Vahter, M.1
  • 13
    • 34547561268 scopus 로고    scopus 로고
    • Molecular processes in cellular arsenic metabolism
    • Thomas, D.J. Molecular processes in cellular arsenic metabolism. Toxicol. Appl. Pharmacol., 2007, 222, 365-373.
    • (2007) Toxicol. Appl. Pharmacol. , vol.222 , pp. 365-373
    • Thomas, D.J.1
  • 14
    • 34547598210 scopus 로고    scopus 로고
    • Insights into the carcinogenic mode of action of arsenic
    • Kligerman, A.D.; Tennant, A.H. Insights into the carcinogenic mode of action of arsenic. Toxicol. Appl. Pharmacol., 2007, 222, 281-288.
    • (2007) Toxicol. Appl. Pharmacol. , vol.222 , pp. 281-288
    • Kligerman, A.D.1    Tennant, A.H.2
  • 15
    • 84862257199 scopus 로고    scopus 로고
    • Arsenic metabolism and thioarsenicals
    • Rehman, K.; Naranmandura, H. Arsenic Metabolism and Thioarsenicals. Metallomics, 2012, 4, 881-892.
    • (2012) Metallomics , vol.4 , pp. 881-892
    • Rehman, K.1    Naranmandura, H.2
  • 18
    • 0031022263 scopus 로고    scopus 로고
    • Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols
    • Styblo, M.; Serves, S.V.; Cullen, W.R.; Thomas, D.J. Comparative inhibition of yeast glutathione reductase by arsenicals and arsenothiols. Chem. Res. Toxicol., 1997, 10, 27-33.
    • (1997) Chem. Res. Toxicol. , vol.10 , pp. 27-33
    • Styblo, M.1    Serves, S.V.2    Cullen, W.R.3    Thomas, D.J.4
  • 19
    • 0029026498 scopus 로고
    • Differential susceptibility of filarial and human erythrocyte glutathione-Reductase to inhibition by the trivalent organic arsenical melarsenoxide
    • Muller, S.; Walter, R.D.; Fairlamb, A.H. Differential susceptibility of filarial and human erythrocyte glutathione-reductase to inhibition by the trivalent organic arsenical melarsenoxide. Mol. Biochem. Parasitol., 1995, 71, 211-219.
    • (1995) Mol. Biochem. Parasitol. , vol.71 , pp. 211-219
    • Muller, S.1    Walter, R.D.2    Fairlamb, A.H.3
  • 21
    • 0032853219 scopus 로고    scopus 로고
    • Cellular and molecular biology of the aquaporin water channels
    • Borgnia, M.; Nielsen, S.; Engel, A.; Agre, P.; Cellular and molecular biology of the aquaporin water channels. Annu. Rev. Biochem., 1999, 68, 425-458.
    • (1999) Annu. Rev. Biochem. , vol.68 , pp. 425-458
    • Borgnia, M.1    Nielsen, S.2    Engel, A.3    Agre, P.4
  • 22
    • 0034865564 scopus 로고    scopus 로고
    • Effect of phosphate transporter and methylation inhibitor drugs on the disposition of arsenate and arsenite in rats
    • Csanaky, I.; Gregus, Z. Effect of Phosphate Transporter and Methylation Inhibitor Drugs on the Disposition of Arsenate and Arsenite in Rats. Toxicol. Sci., 2001, 63, 29-36.
    • (2001) Toxicol. Sci. , vol.63 , pp. 29-36
    • Csanaky, I.1    Gregus, Z.2
  • 24
    • 33750515253 scopus 로고    scopus 로고
    • Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid
    • Liu, Z.; Sanchez, M.A.; Jiang, X.; Boles, E.; Landfear, S.M.; Rosen, B.P. Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid. Biochem. Biophys. Res. Commun., 2006, 351, 424-430.
    • (2006) Biochem. Biophys. Res. Commun. , vol.351 , pp. 424-430
    • Liu, Z.1    Sanchez, M.A.2    Jiang, X.3    Boles, E.4    Landfear, S.M.5    Rosen, B.P.6
  • 25
    • 77953657278 scopus 로고    scopus 로고
    • Trivalent arsenicals and glucose use different translocation pathways in mammalian GLUT1
    • Jiang, X.; McDermott, J.R.; Jees, A.A.; Rosen, B.P.; Liu, Z. Trivalent arsenicals and glucose use different translocation pathways in mammalian GLUT1. Metallomics, 2010, 2, 211-219.
    • (2010) Metallomics , vol.2 , pp. 211-219
    • Jiang, X.1    McDermott, J.R.2    Jees, A.A.3    Rosen, B.P.4    Liu, Z.5
  • 26
    • 0032739871 scopus 로고    scopus 로고
    • Functional and molecular characterization of the human neutral solute channel aquaporin-9
    • Tsukaguchi, H.; Weremowicz, S.; Morton, C.C.; Hediger, M.A. Functional and molecular characterization of the human neutral solute channel aquaporin-9, Am. J. Physiol., 1999, 277, F685-F696.
    • (1999) Am. J. Physiol. , vol.277
    • Tsukaguchi, H.1    Weremowicz, S.2    Morton, C.C.3    Hediger, M.A.4
  • 27
    • 0035663466 scopus 로고    scopus 로고
    • Glutathioneconjugated arsenics in the potential hepato-Enteric circulation in rats
    • Suzuki, K.T.; Tomita, T.; Ogra, Y.; Ohmachi, M. Glutathioneconjugated arsenics in the potential hepato-enteric circulation in rats. Chem. Res. Toxicol., 2001, 14, 1604-1611.
    • (2001) Chem. Res. Toxicol. , vol.14 , pp. 1604-1611
    • Suzuki, K.T.1    Tomita, T.2    Ogra, Y.3    Ohmachi, M.4
  • 28
    • 0034721764 scopus 로고    scopus 로고
    • The MRP2/cMOAT transporter and arsenic-Glutathione complex formation are required for biliary excretion of arsenic
    • Kala, S.V.; Neely, M.W.; Kala, G.; Prater, C.I.; Atwood, D.W.; Rice, J.S.; Lieberman, M.W. The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic. J. Biol. Chem., 2000, 275, 33404-33408.
    • (2000) J. Biol. Chem. , vol.275 , pp. 33404-33408
    • Kala, S.V.1    Neely, M.W.2    Kala, G.3    Prater, C.I.4    Atwood, D.W.5    Rice, J.S.6    Lieberman, M.W.7
  • 29
    • 3543045528 scopus 로고    scopus 로고
    • Arsenic transport by the human multidrug resistance protein 1 (MRP1/ABCC1)
    • Leslie, E.M.; Haimeur, A.; Waalkes, M.P. Arsenic Transport by the Human Multidrug Resistance Protein 1 (MRP1/ABCC1). J. Biol. Chem. 2004, 279, 32700-32708.
    • (2004) J. Biol. Chem. , vol.279 , pp. 32700-32708
    • Leslie, E.M.1    Haimeur, A.2    Waalkes, M.P.3
  • 30
    • 0346848892 scopus 로고    scopus 로고
    • The metabolism of inorganic arsenic oxides, gallium arsenide, and arsine: A toxicochemical review
    • Carter, D.E.; Aposhian H.V.; Gandolfi, A.J. The metabolism of inorganic arsenic oxides, gallium arsenide, and arsine: A toxicochemical review. Toxicol. Appl. Pharmacol., 2003, 193, 309-334.
    • (2003) Toxicol. Appl. Pharmacol. , vol.193 , pp. 309-334
    • Carter, D.E.1    Aposhian, H.V.2    Gandolfi, A.J.3
  • 32
    • 33947111420 scopus 로고    scopus 로고
    • Phosphate transport: Molecular basis regulation and pathophysiology
    • Tenenhouse, H.S. Phosphate transport: Molecular basis regulation and pathophysiology. J. Steroid Biochem. Mol. Bio., 2007, 103, 572-577.
    • (2007) J. Steroid Biochem. Mol. Bio. , vol.103 , pp. 572-577
    • Tenenhouse, H.S.1
  • 33
    • 67349159047 scopus 로고    scopus 로고
    • The roles of Na/Pi-2 transporters in phosphate metabolism
    • Sagawa, H.; Aranami, F.; Kaneko, J.; Tomoe, Y.; Miyamoto, K. The roles of Na/Pi-2 transporters in phosphate metabolism. Bone, 2009, 45, S2-S7.
    • (2009) Bone , vol.45
    • Sagawa, H.1    Aranami, F.2    Kaneko, J.3    Tomoe, Y.4    Miyamoto, K.5
  • 34
    • 33747357184 scopus 로고    scopus 로고
    • Arsenate reduction: Thiol cascade chemistry with convergent evolution
    • Messens, J.; Silver, S. Arsenate Reduction: Thiol Cascade Chemistry with Convergent Evolution. J. Mol. Bio., 2006, 362, 1-17.
    • (2006) J. Mol. Bio. , vol.362 , pp. 1-17
    • Messens, J.1    Silver, S.2
  • 35
    • 0038346303 scopus 로고    scopus 로고
    • Difference in uptake and toxicity of trivalent and pentavalent inorganic arsenic in rat heart microvessel endothelial cells
    • Hirano, S.; Cui, X.; Li, S.; Kanno, S.; Kobayashi, Y.; Hayakawa, T.; Shraim, A. Difference in uptake and toxicity of trivalent and pentavalent inorganic arsenic in rat heart microvessel endothelial cells. Arch. Toxicol., 2003, 77, 305-312.
    • (2003) Arch. Toxicol. , vol.77 , pp. 305-312
    • Hirano, S.1    Cui, X.2    Li, S.3    Kanno, S.4    Kobayashi, Y.5    Hayakawa, T.6    Shraim, A.7
  • 36
    • 34548499361 scopus 로고    scopus 로고
    • Toxicity of dimethylmonothioarsinic acid toward human epidermoid carcinoma A431 cells
    • Naranmandura, H.; Ibata, K.; Suzuki, K.T. Toxicity of dimethylmonothioarsinic acid toward human epidermoid carcinoma A431 cells. Chem. Res. Toxicol., 2007, 20, 1120-1125.
    • (2007) Chem. Res. Toxicol. , vol.20 , pp. 1120-1125
    • Naranmandura, H.1    Ibata, K.2    Suzuki, K.T.3
  • 37
    • 0030247067 scopus 로고    scopus 로고
    • Enzymatic methylation of arsenic compounds. 3. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic
    • Zakharyan, R.A.; Wildfang, E.; Aposhian, H.V. Enzymatic methylation of arsenic compounds. 3. The marmoset and tamarin, but not the rhesus, monkeys are deficient in methyltransferases that methylate inorganic arsenic. Toxicol. Appl. Pharmacol., 1996, 140, 77-84.
    • (1996) Toxicol. Appl. Pharmacol. , vol.140 , pp. 77-84
    • Zakharyan, R.A.1    Wildfang, E.2    Aposhian, H.V.3
  • 39
    • 84873742796 scopus 로고    scopus 로고
    • Formation of methylated oxyarsenicals and thioarsenicals in wild-type and arsenic (+ 3 oxidation state) methyltransferase knockout mice exposed to arsenate
    • Analytical and Bioanalytical Chemistry, DOI 10.1007/s00216-012-6207-0
    • Naranmandura, H.; Rehman, K.; Le, X.C.; Thomas, D.J. Analytical and Bioanalytical Chemistry. Formation of methylated oxyarsenicals and thioarsenicals in wild-type and arsenic (+ 3 oxidation state) methyltransferase knockout mice exposed to arsenate. Anal. Bioanal. Chem., 2012. DOI 10.1007/s00216-012-6207-0.
    • (2012) Anal. Bioanal. Chem.
    • Naranmandura, H.1    Rehman, K.2    Le, X.C.3    Thomas, D.J.4
  • 40
    • 33748659234 scopus 로고    scopus 로고
    • Trivalent arsenicals are bound to proteins during reductive methylation
    • Naranmandura, H.; Suzuki, N.; Suzuki, K.T. Trivalent Arsenicals Are Bound to Proteins during Reductive Methylation. Chem. Res. Toxicol, 2006, 19, 1010-1018.
    • (2006) Chem. Res. Toxicol , vol.19 , pp. 1010-1018
    • Naranmandura, H.1    Suzuki, N.2    Suzuki, K.T.3
  • 41
    • 0037119139 scopus 로고    scopus 로고
    • Arsenic round the world: A review
    • Mandal, B.K.; Suzuki, K.T. Arsenic round the world: A review. Talanta., 2002, 58, 201-235.
    • (2002) Talanta , vol.58 , pp. 201-235
    • Mandal, B.K.1    Suzuki, K.T.2
  • 42
    • 70350241787 scopus 로고    scopus 로고
    • Disruption of the arsenic (+3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention of orally administered arsenate
    • Drobna, Z.; Naranmandura, H.; Kubachka, K.M.; Edwards, B.C.; Herbin-Davis, K.; Styblo, M.; Le, X.C.; Creed, J.T.; Maeda, N.; Hughes, M.F.; Thomas, D.J. Disruption of the arsenic (+3 oxidation state) methyltransferase gene in the mouse alters the phenotype for methylation of arsenic and affects distribution and retention of orally administered arsenate. Chem. Res. Toxicol., 2009, 22, 1713-1720.
    • (2009) Chem. Res. Toxicol. , vol.22 , pp. 1713-1720
    • Drobna, Z.1    Naranmandura, H.2    Kubachka, K.M.3    Edwards, B.C.4    Herbin-Davis, K.5    Styblo, M.6    Le, X.C.7    Creed, J.T.8    Maeda, N.9    Hughes, M.F.10    Thomas, D.J.11
  • 43
    • 33947435182 scopus 로고
    • Biological methylation
    • Challenger, F. Biological methylation. Chem. Rev., 1945, 36, 315-361.
    • (1945) Chem. Rev. , vol.36 , pp. 315-361
    • Challenger, F.1
  • 44
    • 33644977000 scopus 로고    scopus 로고
    • Methylated arsenicals: The implications of metabolism and carcinogenicity studies in rodents to human risk assessment
    • Cohen, S.M.; Arnold, L.L.; Eldan, M.; Lewis, A.S.; Beck, B.D. Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Crit. Rev. Toxicol., 2006, 36, 99-133.
    • (2006) Crit. Rev. Toxicol. , vol.36 , pp. 99-133
    • Cohen, S.M.1    Arnold, L.L.2    Eldan, M.3    Lewis, A.S.4    Beck, B.D.5
  • 46
    • 18044372615 scopus 로고    scopus 로고
    • A new metabolic pathway of arsenite: Arsenic-Glutathione complexes are substrates for human arsenic methyltransferase Cyt19
    • Hayakawa, T.; Kobayashi, Y.; Cui, X.; Hirano, S. A new metabolic pathway of arsenite: Arsenic-glutathione complexes are substrates for human arsenic methyltransferase Cyt19. Arch. Toxicol., 2005, 79, 183-191.
    • (2005) Arch. Toxicol. , vol.79 , pp. 183-191
    • Hayakawa, T.1    Kobayashi, Y.2    Cui, X.3    Hirano, S.4
  • 48
    • 79960494435 scopus 로고    scopus 로고
    • Mitochondria are the main target organelle for trivalent monomethylarsonous acid (MMAIII)-Induced cytotoxicity
    • Naranmandura, H.; Xu, S.; Sawata, T.; Hao, W.H.; Liu, H.; Bu, N.; Ogra, Y.; Lou, Y.J.; Suzuki, N. Mitochondria are the Main Target Organelle for Trivalent Monomethylarsonous Acid (MMAIII)- Induced Cytotoxicity. Chem. Res. Toxicol., 2011, 24, 1094-1103.
    • (2011) Chem. Res. Toxicol. , vol.24 , pp. 1094-1103
    • Naranmandura, H.1    Xu, S.2    Sawata, T.3    Hao, W.H.4    Liu, H.5    Bu, N.6    Ogra, Y.7    Lou, Y.J.8    Suzuki, N.9
  • 52
    • 4344559397 scopus 로고    scopus 로고
    • RIP kinase is involved in arsenic-Induced apoptosis in multiple myeloma cells
    • Bajenova, O.; Tang, B.; Pearse, R.; Feinman, R.; Childs, B.H.; Michaeli, J. RIP kinase is involved in arsenic-induced apoptosis in multiple myeloma cells. Apoptosis, 2004, 9, 561-571.
    • (2004) Apoptosis , vol.9 , pp. 561-571
    • Bajenova, O.1    Tang, B.2    Pearse, R.3    Feinman, R.4    Childs, B.H.5    Michaeli, J.6
  • 54
    • 0036566529 scopus 로고    scopus 로고
    • Tetra-Arsenic tetra-Sulfide for the treatment of acute promyelocytic leukemia: A pilot report
    • Lu, D.P.; Qiu, J.Y.; Jiang, B.; Wang Q, Liu KY, Liu YR, Chen SS. Tetra-arsenic tetra-sulfide for the treatment of acute promyelocytic leukemia: A pilot report. Blood, 2002, 99, 3136-3143.
    • (2002) Blood , vol.99 , pp. 3136-3143
    • Lu, D.P.1    Qiu, J.Y.2    Jiang, B.3    Wang, Q.4    Liu, K.Y.5    Liu, Y.R.6    Chen, S.S.7
  • 55
    • 7744239015 scopus 로고    scopus 로고
    • Comparison of effects of As2O3 and As4O6 on cell growth inhibition and gene expression profiles by cDNA microarray ana lysis in SiHa cells
    • Ahn, W.S.; Bae, S.M.; Lee, K.H.; Kim, Y.W.; Lee, J.M.; Namkoong, S.E.; Lee, I.P.; Kim, C.K.; Seo, J.S.; Sin, J.I.; Kim, Y.W. Comparison of effects of As2O3 and As4O6 on cell growth inhibition and gene expression profiles by cDNA microarray ana lysis in SiHa cells. Oncol. Rep., 2004, 12, 573-580.
    • (2004) Oncol. Rep. , vol.12 , pp. 573-580
    • Ahn, W.S.1    Bae, S.M.2    Lee, K.H.3    Kim, Y.W.4    Lee, J.M.5    Namkoong, S.E.6    Lee, I.P.7    Kim, C.K.8    Seo, J.S.9    Sin, J.I.10    Kim, Y.W.11
  • 56
  • 62
    • 0033974883 scopus 로고    scopus 로고
    • Arsenic trioxide-Induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia
    • Cai, X.; Shen, Y.L.; Zhu, Q.; Jia, P.M.; Yu, Y.; Zhou, L.; Huang, Y.; Zhang, J.W.; Xiong, S.M.; Chen, S.J.; Wang, Z.Y.; Chen, Z.; Chen, G.Q. Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. Leukemia, 2000, 14, 262-270.
    • (2000) Leukemia , vol.14 , pp. 262-270
    • Cai, X.1    Shen, Y.L.2    Zhu, Q.3    Jia, P.M.4    Yu, Y.5    Zhou, L.6    Huang, Y.7    Zhang, J.W.8    Xiong, S.M.9    Chen, S.J.10    Wang, Z.Y.11    Chen, Z.12    Chen, G.Q.13
  • 63
    • 1442327526 scopus 로고    scopus 로고
    • Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide
    • Zheng, Y.; Shi, Y.; Tian, C.; Jiang, C.; Jin, H.; Chen, J.; Almasan, A.; Tang, H.; Chen, Q. Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide. Oncogene,2004, 23,1239-1247.
    • (2004) Oncogene , vol.23 , pp. 1239-1247
    • Zheng, Y.1    Shi, Y.2    Tian, C.3    Jiang, C.4    Jin, H.5    Chen, J.6    Almasan, A.7    Tang, H.8    Chen, Q.9
  • 66
    • 0141453490 scopus 로고    scopus 로고
    • The molecular mechanism of arsenic trioxide-Induced apoptosis and oncosis in leukemia/lymphoma cell lines
    • Zhu, J.; Okumura, H.; Ohtake, S.; Nakamura, S.; Nakao, S. The molecular mechanism of arsenic trioxide-induced apoptosis and oncosis in leukemia/lymphoma cell lines. Acta Haematol., 2003, 110, 1-10.
    • (2003) Acta Haematol. , vol.110 , pp. 1-10
    • Zhu, J.1    Okumura, H.2    Ohtake, S.3    Nakamura, S.4    Nakao, S.5
  • 68
  • 69
    • 0034142368 scopus 로고    scopus 로고
    • Arsenic induces apoptosis of multidrug-Resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x L
    • Perkins, C.; Kim, C.N.; Fang, G.; Bhalla, K.N. Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x L. Blood, 2000, 95, 1014-1022.
    • (2000) Blood , vol.95 , pp. 1014-1022
    • Perkins, C.1    Kim, C.N.2    Fang, G.3    Bhalla, K.N.4
  • 70
    • 34249940036 scopus 로고    scopus 로고
    • Optimal first-Line treatment of chronic myeloid leukemia-How to use imatinib and what role for newer drugs
    • Jabbour, E.; Cortes, J.; Kantarjian, H. Optimal first-line treatment of chronic myeloid leukemia-how to use imatinib and what role for newer drugs. Oncology, 2007, 21, 653-662.
    • (2007) Oncology , vol.21 , pp. 653-662
    • Jabbour, E.1    Cortes, J.2    Kantarjian, H.3
  • 72
    • 0033041916 scopus 로고    scopus 로고
    • Reactive oxygen species-Induced molecular damage and its application in pathology
    • Toyokuni, S. Reactive oxygen species-induced molecular damage and its application in pathology. Pathol. Int., 1999, 49, 91-102.
    • (1999) Pathol. Int. , vol.49 , pp. 91-102
    • Toyokuni, S.1
  • 75
    • 2442583335 scopus 로고    scopus 로고
    • Arsenic trioxideinduced death of neuroblastoma cells involves activation of Bax and does not require p53
    • Karlsson, J.; Ora, I.; Porn-Ares, I.; Pahlman, S. Arsenic trioxideinduced death of neuroblastoma cells involves activation of Bax and does not require p53. Clin. Cancer Res., 2004, 10, 3179-3188.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 3179-3188
    • Karlsson, J.1    Ora, I.2    Porn-Ares, I.3    Pahlman, S.4
  • 76
    • 13244268334 scopus 로고    scopus 로고
    • Effect of arsenic trioxide (ATO) on human lung carcinoma PG cell line: ATO induced apoptosis of PG cells and decreased expression of Bcl-2
    • Han, B.; Zhou, G.; Zhang, Q.; Zhang J, Wang X, Tang W, Kakudo K. Effect of arsenic trioxide (ATO) on human lung carcinoma PG cell line: ATO induced apoptosis of PG cells and decreased expression of Bcl-2, Pgp. J. Exp. Ther. Oncol., 2004, 4, 335-342.
    • (2004) Pgp. J. Exp. Ther. Oncol. , vol.4 , pp. 335-342
    • Han, B.1    Zhou, G.2    Zhang, Q.3    Zhang, J.4    Wang, X.5    Tang, W.6    Kakudo, K.7
  • 78
    • 0034490080 scopus 로고    scopus 로고
    • Arsenic trioxide-Mediated cytotoxicity and apoptosis in prostate and ovarian carcinoma cell lines
    • Uslu, R.; Sanli, U.A.; Sezgin, C.; Karabulut B, Terzioglu E, Omay SB, Goker E. Arsenic trioxide-mediated cytotoxicity and apoptosis in prostate and ovarian carcinoma cell lines. Clin. Cancer Res., 2000, 6, 4957-4964.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 4957-4964
    • Uslu, R.1    Sanli, U.A.2    Sezgin, C.3    Karabulut, B.4    Terzioglu, E.5    Omay, S.B.6    Goker, E.7
  • 79
    • 33747017589 scopus 로고    scopus 로고
    • Pilot results from a phase 2 trial of arsenic trioxide in hormone-refractory prostate cancer
    • Gallagher, R.; Ferrari, A.; Makower, D. Pilot results from a phase 2 trial of arsenic trioxide in hormone-refractory prostate cancer. Cancer Invest., 2002, 20, 84-85.
    • (2002) Cancer Invest. , vol.20 , pp. 84-85
    • Gallagher, R.1    Ferrari, A.2    Makower, D.3
  • 80
    • 0036339964 scopus 로고    scopus 로고
    • Arsenic trioxide inhibits proliferation and induces apoptosis in pancreatic cancer cells
    • Li, X.; Ding, X.; Adrian, T.E. Arsenic trioxide inhibits proliferation and induces apoptosis in pancreatic cancer cells. Anticancer Res., 2002, 22, 2205-2213.
    • (2002) Anticancer Res. , vol.22 , pp. 2205-2213
    • Li, X.1    Ding, X.2    Adrian, T.E.3
  • 81
  • 85
    • 0038456210 scopus 로고    scopus 로고
    • Death receptors and melanoma resistance to apoptosis
    • Ivanov, V.N.; Bhoumik, A.; Ronai, Z. Death receptors and melanoma resistance to apoptosis. Oncogene, 2003, 22, 3152-3161.
    • (2003) Oncogene , vol.22 , pp. 3152-3161
    • Ivanov, V.N.1    Bhoumik, A.2    Ronai, Z.3
  • 86
    • 2542443312 scopus 로고    scopus 로고
    • Arsenite sensitizes human melanomas to apoptosis via tumor necrosis factor alpha-Mediated pathway
    • Ivanov, V.N.; Hei, T.K. Arsenite sensitizes human melanomas to apoptosis via tumor necrosis factor alpha-mediated pathway. J. Biol. Chem., 2004, 279, 22747-22758.
    • (2004) J. Biol. Chem. , vol.279 , pp. 22747-22758
    • Ivanov, V.N.1    Hei, T.K.2
  • 87
    • 58149260050 scopus 로고    scopus 로고
    • Arsenic trioxide in patients with adenocarcinoma of the pancreas refractory to gemcitabine
    • Kindler, H.L.; Aklilu, M.; Nattam, S.; Vokes, E.E. Arsenic Trioxide in Patients With Adenocarcinoma of the Pancreas Refractory to Gemcitabine. Am. J. Clin. Oncol., 2008, 31, 553-556.
    • (2008) Am. J. Clin. Oncol. , vol.31 , pp. 553-556
    • Kindler H.L.1    2    Aklilu M.3    4    Nattam S.5    6    Vokes, E.E.7
  • 88
    • 34248549243 scopus 로고    scopus 로고
    • Arsenic trioxide/ascorbic acid therapy in patients with refractory metastatic colorectal carcinoma: A clinical experience
    • Subbarayan, P.R.; Lima, M.; Ardalan, B. Arsenic trioxide/ascorbic acid therapy in patients with refractory metastatic colorectal carcinoma: A clinical experience. Acta Oncologica, 2007, 46, 557-561.
    • (2007) Acta Oncologica , vol.46 , pp. 557-561
    • Subbarayan, P.R.1    Lima, M.2    Ardalan, B.3
  • 89
    • 0036021225 scopus 로고    scopus 로고
    • Phase 2 trial of arsenic trioxide in patients with metastatic renal cell carcinoma
    • Vuky, J.; Yu, R.; Schwartz, L.; Motzer, R.J. Phase 2 trial of arsenic trioxide in patients with metastatic renal cell carcinoma. Invest New Drugs, 2002, 20, 327-330.
    • (2002) Invest New Drugs , vol.20 , pp. 327-330
    • Vuky, J.1    Yu, R.2    Schwartz, L.3    Motzer, R.J.4
  • 91
    • 40849116266 scopus 로고    scopus 로고
    • Phase 2 trial of arsenic trioxide and ascorbic acid with temozolomide in patients with metastatic melanoma with or without central nervous system metastases
    • Bael, T.E.; Peterson, B.L.; Gollob, J.A. Phase 2 trial of arsenic trioxide and ascorbic acid with temozolomide in patients with metastatic melanoma with or without central nervous system metastases. Melanoma Res., 2008, 18, 147-151.
    • (2008) Melanoma Res. , vol.18 , pp. 147-151
    • Bael, T.E.1    Peterson, B.L.2    Gollob, J.A.3
  • 92
    • 33750445933 scopus 로고    scopus 로고
    • Arsenic trioxide in patients with hepatocellular carcinoma: A phase 2 trial
    • Lin, C.C.; Hsu, C.; Hsu, C.H.; Hsu, W.L.; Cheng, A.L.; Yang, C.H. Arsenic trioxide in patients with hepatocellular carcinoma: A phase 2 trial. Invest. New. Drugs, 2006, 25, 77-84.
    • (2006) Invest. New. Drugs , vol.25 , pp. 77-84
    • Lin, C.C.1    Hsu, C.2    Hsu, C.H.3    Hsu, W.L.4    Cheng, A.L.5    Yang, C.H.6
  • 95
    • 0027272622 scopus 로고
    • Glutathione levels and variability in breast tumors and normal tissue
    • Perry, R.R.; Mazetta, J.A.; Levin, M.; Barranco, S.C. Glutathione levels and variability in breast tumors and normal tissue. Cancer, 1993, 72, 783-787.
    • (1993) Cancer , vol.72 , pp. 783-787
    • Perry, R.R.1    Mazetta, J.A.2    Levin, M.3    Barranco, S.C.4
  • 98
    • 0036358635 scopus 로고    scopus 로고
    • Arsenic trioxide in multiple myeloma: Rationale and future directions
    • Anderson, K.C.; Boise, L.H.; Louie, R.; Waxman, S. Arsenic trioxide in multiple myeloma: rationale and future directions. Cancer J., 2002, 8, 12-25.
    • (2002) Cancer J. , vol.8 , pp. 12-25
    • Anderson, K.C.1    Boise, L.H.2    Louie, R.3    Waxman, S.4
  • 99
    • 0035437189 scopus 로고    scopus 로고
    • Ascorbic acid enhances arsenic trioxide-Induced cytotoxicity in multiple myeloma cells
    • Grad, J.M.; Bahlis, N.J.; Reis, I.; Oshiro, M.M.; Dalton, W.S.; Boise, L.H. Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells. Blood, 2001, 98, 805-813.
    • (2001) Blood , vol.98 , pp. 805-813
    • Grad, J.M.1    Bahlis, N.J.2    Reis, I.3    Oshiro, M.M.4    Dalton, W.S.5    Boise, L.H.6
  • 101
    • 0141956407 scopus 로고    scopus 로고
    • Arsenic trioxide induces apoptosis of cutaneous T cell lymphoma cells: Evidence for a partially caspase-Independent pathway and potentiation by ascorbic acid (vitamin C)
    • Michel, L.; Dupuy, A.; Jean-Louis, F.; Sors, A.; Poupon, J.; Viguier, M.; Musette, P.; Dubertret, L.; Degos, L.; Dombret, H.; Bachelez, H. Arsenic trioxide induces apoptosis of cutaneous T cell lymphoma cells: evidence for a partially caspase-independent pathway and potentiation by ascorbic acid (vitamin C). J. Invest. Dermatol., 2003, 121, 881-893.
    • (2003) J. Invest. Dermatol. , vol.121 , pp. 881-893
    • Michel, L.1    Dupuy, A.2    Jean-Louis, F.3    Sors, A.4    Poupon, J.5    Viguier, M.6    Musette, P.7    Dubertret, L.8    Degos, L.9    Dombret, H.10    Bachelez, H.11
  • 102
    • 0032933610 scopus 로고    scopus 로고
    • Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system
    • Dai, J.; Weinberg, R.S.; Waxman, S.; Jing, Y. Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system. Blood, 1999, 93, 268-277.
    • (1999) Blood , vol.93 , pp. 268-277
    • Dai, J.1    Weinberg, R.S.2    Waxman, S.3    Jing, Y.4
  • 103
    • 3543084996 scopus 로고    scopus 로고
    • Effective treatment of advanced solid tumors by the combination of arsenic trioxide and l-Buthionine-Sulfoximine
    • Maeda, H.; Hori, S.; Ohizumi, H.; Segawa, T.; Kakehi, Y.; Ogawa, O.; Kakizuka A. Effective treatment of advanced solid tumors by the combination of arsenic trioxide and l-buthionine-sulfoximine. Cell Death Differ., 2004, 11, 737-746.
    • (2004) Cell Death Differ. , vol.11 , pp. 737-746
    • Maeda, H.1    Hori, S.2    Ohizumi, H.3    Segawa, T.4    Kakehi, Y.5    Ogawa, O.6    Kakizuka, A.7
  • 105
    • 66349090851 scopus 로고    scopus 로고
    • Combination treatment with arsenic trioxide and irradiation enhances autophagic effects in U118-MG cells through increased mitotic arrest and regulation of PI3K/Akt and ERK1/2 signaling pathways
    • Chiu, H.W.; Ho, S.Y.; Guo, H.R.; Wang, Y.J. Combination treatment with arsenic trioxide and irradiation enhances autophagic effects in U118-MG cells through increased mitotic arrest and regulation of PI3K/Akt and ERK1/2 signaling pathways. Autophagy, 2009, 5, 472-483.
    • (2009) Autophagy , vol.5 , pp. 472-483
    • Chiu, H.W.1    Ho, S.Y.2    Guo, H.R.3    Wang, Y.J.4
  • 106
    • 77953712305 scopus 로고    scopus 로고
    • Combination treatment with arsenic trioxide and irradiation enhances cellkilling effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis
    • Chiu, H.W.; Lin, J.H.; Chen, Y.A.; Ho, S.Y.; Wang, Y.J. Combination treatment with arsenic trioxide and irradiation enhances cellkilling effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis. Autophagy, 2010, 6, 353-365.
    • (2010) Autophagy , vol.6 , pp. 353-365
    • Chiu, H.W.1    Lin, J.H.2    Chen, Y.A.3    Ho, S.Y.4    Wang, Y.J.5
  • 107
    • 79955416811 scopus 로고    scopus 로고
    • Synergistic effects of arsenic trioxide and radiation in osteosarcoma cells through the induction of both autophagy and apoptosis
    • Chiu, H.W.; Lin, W.; Ho, S.Y.; Wang, Y.J. Synergistic Effects of Arsenic Trioxide and Radiation in Osteosarcoma Cells through the Induction of Both Autophagy and Apoptosis. Radiat. Res., 2011, 175, 547-560.
    • (2011) Radiat. Res. , vol.175 , pp. 547-560
    • Chiu, H.W.1    Lin, W.2    Ho, S.Y.3    Wang, Y.J.4
  • 108
    • 84857411790 scopus 로고    scopus 로고
    • Arsenic trioxide enhances the radiation sensitivity of androgen-Dependent andindependent human prostate cancer cells
    • Chiu, H.W.; Chen, Y.A.; Ho, S.Y.; Wang, Y.J. Arsenic trioxide enhances the radiation sensitivity of androgen-dependent andindependent human prostate cancer cells. PloS One, 2012, 7, e31579.
    • (2012) PloS One , vol.7
    • Chiu, H.W.1    Chen, Y.A.2    Ho, S.Y.3    Wang, Y.J.4
  • 110
  • 111
    • 10844245622 scopus 로고    scopus 로고
    • Evidence of hemoglobin binding to arsenic as a basis for the accumulation of arsenic in rat blood
    • Lu, M.; Wang, H.; Li, X.F.; Lu, X.; Cullen, W.R.; Arnold, L.L.; Cohen, S.M.; Le, X.C. Evidence of hemoglobin binding to arsenic as a basis for the accumulation of arsenic in rat blood. Chem. Res. Toxicol., 2004, 17, 1733-1742.
    • (2004) Chem. Res. Toxicol. , vol.17 , pp. 1733-1742
    • Lu, M.1    Wang, H.2    Li, X.F.3    Lu, X.4    Cullen, W.R.5    Arnold, L.L.6    Le Cohen, S.M.7    Le, X.C.8
  • 112
    • 0037447171 scopus 로고    scopus 로고
    • Methylated metabolites of arsenic trioxide are more potent than arsenic trioxide as apoptotic but not differentiation inducers in leukemia and lymphoma cells
    • Chen, G.Q.; Zhou, L.; Styblo, M.; Walton, F.; Jing, Y.; Weinberg, R.; Chen, Z.; Waxman, S. Methylated Metabolites of Arsenic Trioxide Are More Potent than Arsenic Trioxide as Apoptotic but not Differentiation Inducers in Leukemia and Lymphoma Cells. Cancer Research, 2003, 63, 1853-1859.
    • (2003) Cancer Research , vol.63 , pp. 1853-1859
    • Chen, G.Q.1    Zhou, L.2    Styblo, M.3    Walton, F.4    Jing, Y.5    Weinberg, R.6    Chen, Z.7    Waxman, S.8
  • 115
    • 0036220360 scopus 로고    scopus 로고
    • Molecular targets of arsenic trioxide in malignant cells
    • Miller, W.H.Jr. Molecular Targets of Arsenic Trioxide in Malignant Cells. The Oncologist, 2002, 7, 14-19.
    • (2002) The Oncologist , vol.7 , pp. 14-19
    • Miller, Jr.W.H.1
  • 116
    • 41949111045 scopus 로고    scopus 로고
    • Acute promyelocytic leukemia: From highly fatal to highly curable
    • Wang, Z.Y., Chen, Z.; Acute promyelocytic leukemia: from highly fatal to highly curable. Blood, 2008, 111, 2505-2515.
    • (2008) Blood , vol.111 , pp. 2505-2515
    • Wang, Z.Y.1    Chen, Z.2
  • 117
    • 84863347837 scopus 로고    scopus 로고
    • Realgar-Induced apoptosis and differentiation in all-Trans retinoic acid (ATRA)-Sensitive NB4 and ATRA-Resistant MR2 cells
    • Chen, S.; Fang, Y.; Ma, L.; Liu, S.; Li, X. Realgar-induced apoptosis and differentiation in all-trans retinoic acid (ATRA)-sensitive NB4 and ATRA-resistant MR2 cells. Int. J. Oncol., 2012, 40, 1089-1096.
    • (2012) Int. J. Oncol. , vol.40 , pp. 1089-1096
    • Chen, S.1    Fang, Y.2    Ma, L.3    Liu, S.4    Li, X.5
  • 118
    • 0010740572 scopus 로고    scopus 로고
    • In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB 4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR α /PML proteins
    • Chen, G.Q.; Zhu, J.; Shi, X.G.; Ni, J.H.; Zhong, H.J.; Si, G.Y.; Jin, X.L.; Tang, W.; Li, X.S.; Xong, S.M.; Shen, Z.X.; Sun, G.L.; Ma, J.; Zhang, P.; Zhang, T.D.; Gazin, C.; Naoe, T.; Chen, S.J.; Wang, Z.Y.; Chen, Z. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB 4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR α /PML proteins. Blood, 1996, 88, 1052-1061.
    • (1996) Blood , vol.88 , pp. 1052-1061
    • Chen, G.Q.1    Zhu, J.2    Shi, X.G.3    Ni, J.H.4    Zhong, H.J.5    Si, G.Y.6    Jin, X.L.7    Tang, W.8    Li, X.S.9    Xong, S.M.10    Shen, Z.X.11    Sun, G.L.12    Ma, J.13    Zhang, P.14    Zhang, T.D.15    Gazin, C.16    Naoe, T.17    Chen, S.J.18    Wang, Z.Y.19    Chen, Z.20    more..
  • 119
    • 0034663032 scopus 로고    scopus 로고
    • Arsenic trioxide induces dose- and time-Dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis
    • Roboz, G.J.; Dias, S.; Lam, G.; Lane, W.J.; Soignet, S.L.; Warrell, R.P.Jr.; Rafii, S. Arsenic trioxide induces dose- and time-dependent apoptosis of endothelium and may exert an antileukemic effect via inhibition of angiogenesis. Blood, 2000, 96, 1525-1530.
    • (2000) Blood , vol.96 , pp. 1525-1530
    • Roboz, G.J.1    Dias, S.2    Lam, G.3    Lane, W.J.4    Soignet, S.L.5    Warrell, Jr.R.P.6    Rafii, S.7
  • 120
    • 0038103842 scopus 로고    scopus 로고
    • Arsenic trioxide-Induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells
    • Cai, X.; Yu, Y.; Huang, Y.; Zhang, L.; Jia, P.M.; Zhao, Q.; Chen, Z.; Tong, J.H.; Dai, W.; Chen, G.Q. Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells. Leukemia, 2003, 17, 1333-1337.
    • (2003) Leukemia , vol.17 , pp. 1333-1337
    • Cai, X.1    Yu, Y.2    Huang, Y.3    Zhang, L.4    Jia, P.M.5    Zhao, Q.6    Chen, Z.7    Tong, J.H.8    Dai, W.9    Chen, G.Q.10
  • 122
    • 33750947280 scopus 로고    scopus 로고
    • Increased oxidative DNA products in patients with acute promyelocytic leukemia during arsenic therapy
    • Ninomiya, M.; Kajiguchi, T.; Yamamoto, K.; Kinoshita, T.; Emi, N.; Naoe, T. Increased oxidative DNA products in patients with acute promyelocytic leukemia during arsenic therapy. Haematologica. 2006, 91, 1571-1572.
    • (2006) Haematologica , vol.91 , pp. 1571-1572
    • Ninomiya, M.1    Kajiguchi, T.2    Yamamoto, K.3    Kinoshita, T.4    Emi, N.5    Naoe, T.6
  • 124
    • 0033013777 scopus 로고    scopus 로고
    • Arsenic trioxide induces apoptosis of HPV16 DNA-Immortalized human cervical epithelial cells and selectively inhibits viral gene expression
    • Zheng, J.; Deng, Y.P.; Lin, C.; Fu, M.; Xiao, P.G.; Wu, M. Arsenic trioxide induces apoptosis of HPV16 DNA-immortalized human cervical epithelial cells and selectively inhibits viral gene expression. Int. J. Cancer, 1999, 82, 286-292.
    • (1999) Int. J. Cancer , vol.82 , pp. 286-292
    • Zheng, J.1    Deng, Y.P.2    Lin, C.3    Fu, M.4    Xiao, P.G.5    Wu, M.6
  • 125
    • 0032923392 scopus 로고    scopus 로고
    • Effect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines
    • Lu, M.; Levin, J.; Sulpice, E.; Sequeira-Le Grand, A.; Alemany, M.; Caen, J.P.; Han, Z.C. Effect of arsenic trioxide on viability, proliferation, and apoptosis in human megakaryocytic leukemia cell lines. Exp. Hematol., 1999, 27, 845-852.
    • (1999) Exp. Hematol. , vol.27 , pp. 845-852
    • Lu, M.1    Levin, J.2    Sulpice, E.3    Sequeira-Le Grand, A.4    Alemany, M.5    Caen, J.P.6    Han, Z.C.7
  • 126
    • 0032170898 scopus 로고    scopus 로고
    • Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RAR α independent manner
    • Wang, Z.G.; Rivi, R.; Delva, L.; König, A.; Scheinberg, D.A.; Gambacorti-Passerini, C.; Gabrilove, J.L.; Warrell, R.P.Jr.; Pandolfi, P.P. Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RAR α independent manner. Blood, 1998, 92, 1497-1504.
    • (1998) Blood , vol.92 , pp. 1497-1504
    • Wang, Z.G.1    Rivi, R.2    Delva, L.3    König, A.4    Scheinberg, D.A.5    Gambacorti-Passerini, C.6    Gabrilove, J.L.7    Warrell, Jr.R.P.8    Pandolfi, P.P.9
  • 128
    • 0029961252 scopus 로고    scopus 로고
    • Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite
    • Liu, Y.; Guyton, K.Z.; Gorospe, M.; Xu, Q.; Lee, J.C.; Holbrook, N.J. Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite. Free Radic. Biol. Med., 1996, 21, 771-781.
    • (1996) Free Radic. Biol. Med. , vol.21 , pp. 771-781
    • Liu, Y.1    Guyton, K.Z.2    Gorospe, M.3    Xu, Q.4    Lee, J.C.5    Holbrook, N.J.6
  • 129
    • 1642498275 scopus 로고    scopus 로고
    • Arsenic speciation in urine from acute promyelocytic leukemia patients undergoing arsenic trioxide treatment
    • Wang, Z.; Zhou, J.; Lu, X.; Gong, Z.; Le, X.C. Arsenic Speciation in Urine from Acute Promyelocytic Leukemia Patients undergoing Arsenic Trioxide Treatment. Chem. Res. Toxicol., 2004, 17, 95-103.
    • (2004) Chem. Res. Toxicol. , vol.17 , pp. 95-103
    • Wang, Z.1    Zhou, J.2    Lu, X.3    Gong, Z.4    Le, X.C.5
  • 130
  • 132
    • 1342281549 scopus 로고    scopus 로고
    • Subchronic exposure to arsenic through drinking water alters expression of cancer-Related genes in rat liver
    • Cui, X.; Li, S.; Shraim, A.; Kobayashi, Y.; Hayakawa, T.; Kanno, S.; Yamamoto, M.; Hirano, S. Subchronic exposure to arsenic through drinking water alters expression of cancer-related genes in rat liver. Toxicol. Pathol., 2004, 32, 64-72.
    • (2004) Toxicol. Pathol. , vol.32 , pp. 64-72
    • Cui, X.1    Li, S.2    Shraim, A.3    Kobayashi, Y.4    Hayakawa, T.5    Kanno, S.6    Yamamoto, M.7    Hirano, S.8
  • 133
    • 3242749112 scopus 로고    scopus 로고
    • Evidence that arsenite acts as a cocarcinogen in skin cancer
    • Rossman, T.G.; Uddin, A.N.; Burns, F.J. Evidence that arsenite acts as a cocarcinogen in skin cancer. Toxicol. Appl. Pharmacol., 2004, 198, 394-404.
    • (2004) Toxicol. Appl. Pharmacol. , vol.198 , pp. 394-404
    • Rossman, T.G.1    Uddin, A.N.2    Burns, F.J.3
  • 135
    • 0035341195 scopus 로고    scopus 로고
    • Recent advances in arsenic carcinogenesis: Modes of action, animal model systems, and methylated arsenic metabolites
    • Kitchin, K.T. Recent advances in arsenic carcinogenesis: Modes of action, animal model systems, and methylated arsenic metabolites. Toxicol. Appl. Pharmacol., 2001, 172, 249-261.
    • (2001) Toxicol. Appl. Pharmacol. , vol.172 , pp. 249-261
    • Kitchin, K.T.1
  • 137
    • 23844496688 scopus 로고    scopus 로고
    • Arsenite-Induced alterations of DNA photodamage repair and apoptosis after solar-Simulation UVR in mouse keratinocytes in vitro
    • Wu, F.; Burns, F.J.; Zhang, R.; Uddin, A.N.; Rossman, T.G. Arsenite-induced alterations of DNA photodamage repair and apoptosis after solar-simulation UVR in mouse keratinocytes in vitro. Environ. Health Perspect., 2005, 113, 983-986.
    • (2005) Environ. Health Perspect. , vol.113 , pp. 983-986
    • Wu, F.1    Burns, F.J.2    Zhang, R.3    Uddin, A.N.4    Rossman, T.G.5
  • 138
    • 12244310169 scopus 로고    scopus 로고
    • Upregulation of glutathione-Related genes and enzyme activities in cultured human cells by sublethal concentrations of inorganic arsenic
    • Schuliga, M.; Chouchane, S.; Snow, E.T. Upregulation of glutathione- related genes and enzyme activities in cultured human cells by sublethal concentrations of inorganic arsenic. Toxicol. Sci., 2002, 70, 183-192.
    • (2002) Toxicol. Sci. , vol.70 , pp. 183-192
    • Schuliga, M.1    Chouchane, S.2    Snow, E.T.3
  • 139
    • 0033863678 scopus 로고    scopus 로고
    • Possible roles of nitric oxide and redox cell signaling in metal-Induced toxicity and carcinogenesis: A review
    • Buzard, G.S.; Kasprzak, K.S. Possible roles of nitric oxide and redox cell signaling in metal-induced toxicity and carcinogenesis: A review. J. Environ. Pathol. Toxicol. Oncol., 2000, 19, 179-199.
    • (2000) J. Environ. Pathol. Toxicol. Oncol. , vol.19 , pp. 179-199
    • Buzard, G.S.1    Kasprzak, K.S.2
  • 141
    • 10844264632 scopus 로고    scopus 로고
    • Caspase-Independent cell death by arsenic trioxide in human cervical cancer cells: Reactive oxygen speciesmediated poly(ADP-Ribose) polymerase-1 activation signals apoptosis-Inducing factor release from mitochondria
    • Kang, Y.H.; Yi, M.J.; Kim, M.J.; Park, M.T.; Bae, S.; Kang, C.M.; Cho, C.K.; Park, I.C.; Park, M.J.; Rhee, C.H.; Hong, S.I.; Chung, H.Y. Lee, Y.S.; Lee, S.J. Caspase-independent cell death by arsenic trioxide in human cervical cancer cells: reactive oxygen speciesmediated poly(ADP-ribose) polymerase-1 activation signals apoptosis-inducing factor release from mitochondria. Cancer Res., 2004, 64, 8960-8967.
    • (2004) Cancer Res. , vol.64 , pp. 8960-8967
    • Kang, Y.H.1    Yi, M.J.2    Kim, M.J.3    Park, M.T.4    Bae, S.5    Kang, C.M.6    Cho, C.K.7    Park, I.C.8    Park, M.J.9    Rhee, C.H.10    Hong, S.I.11    Chung, H.Y.12    Lee, Y.S.13    Lee, S.J.14
  • 142
    • 0033066323 scopus 로고    scopus 로고
    • Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro
    • Akao, Y.; Nakagawa, Y.; Akiyama, K. Arsenic trioxide induces apoptosis in neuroblastoma cell lines through the activation of caspase 3 in vitro. FEBS Lett., 1999,455, 59-62.
    • (1999) FEBS Lett. , vol.455 , pp. 59-62
    • Akao, Y.1    Nakagawa, Y.2    Akiyama, K.3
  • 144
    • 0033600897 scopus 로고    scopus 로고
    • Arsenic disrupts cellular levels of p53 and mdm2: A potential mechanism of carcinogenesis
    • Hamadeh, H.K.; Vargas, M.; Lee, E.; Menzel, D.B. Arsenic disrupts cellular levels of p53 and mdm2: A potential mechanism of carcinogenesis. Biochem. Biophys. Res. Commun., 1999, 263, 446-449.
    • (1999) Biochem. Biophys. Res. Commun. , vol.263 , pp. 446-449
    • Hamadeh, H.K.1    Vargas, M.2    Lee, E.3    Menzel, D.B.4
  • 145
    • 0033168034 scopus 로고    scopus 로고
    • Arsenic induces apoptosis through a c-Jun NH2-Terminal kinase-Dependent, p53-Independent pathway
    • Huang, C.; Ma, W.Y.; Li, J.; Dong, Z. Arsenic induces apoptosis through a c-Jun NH2-terminal kinase-dependent, p53-independent pathway. Cancer Res., 1999, 59, 3053-3058.
    • (1999) Cancer Res. , vol.59 , pp. 3053-3058
    • Huang, C.1    Ma, W.Y.2    Li, J.3    Dong, Z.4
  • 146
    • 0032530999 scopus 로고    scopus 로고
    • Essential role of p53 in phenethyl isothiocyanate-Induced apoptosis
    • Huang, C.; Ma, W.Y.; Li, J.; Hecht, S.S.; Dong, Z. Essential role of p53 in phenethyl isothiocyanate-induced apoptosis. Cancer Res., 1998, 58, 4102-4106.
    • (1998) Cancer Res. , vol.58 , pp. 4102-4106
    • Huang, C.1    Ma, W.Y.2    Li, J.3    Hecht, S.S.4    Dong, Z.5
  • 148
    • 0031892538 scopus 로고    scopus 로고
    • The stress inducer arsenite activates mitogen-Activated protein kinases extracellular signalregulated kinases 1 and 2 via a MAPK kinase 6/p38-Dependent pathway
    • Ludwig, S.; Hoffmeyer, A.; Goebeler, M.; Kilian, K.; Häfner, H.; Neufeld, B.; Han, J, Rapp, U.R. The stress inducer arsenite activates mitogen-activated protein kinases extracellular signalregulated kinases 1 and 2 via a MAPK kinase 6/p38-dependent pathway. J. Biol. Chem., 1998, 273, 1917-1922.
    • (1998) J. Biol. Chem. , vol.273 , pp. 1917-1922
    • Ludwig, S.1    Hoffmeyer, A.2    Goebeler, M.3    Kilian, K.4    Häfner, H.5    Neufeld, B.6    Han, J.7    Rapp, U.R.8
  • 149
    • 0029858594 scopus 로고    scopus 로고
    • The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase
    • Cavigelli, M.; Li, W.W.; Lin, A.; Su, B.; Yoshioka, K.; Karin, M. The tumor promoter arsenite stimulates AP-1 activity by inhibiting a JNK phosphatase. Embo. J., 1996, 15, 6269-6279.
    • (1996) Embo. J. , vol.15 , pp. 6269-6279
    • Cavigelli, M.1    Li, W.W.2    Lin, A.3    Su, B.4    Yoshioka, K.5    Karin, M.6
  • 150
    • 0033044472 scopus 로고    scopus 로고
    • Arsenic trioxide induces apoptosis of myeloid leukemia cells by activation of caspases
    • Huang, X.J.; Wiernik, P.H.; Klein, R.S.; Gallagher, R.E. Arsenic trioxide induces apoptosis of myeloid leukemia cells by activation of caspases. Med. Oncol., 1999, 16, 58-64.
    • (1999) Med. Oncol. , vol.16 , pp. 58-64
    • Huang, X.J.1    Wiernik, P.H.2    Klein, R.S.3    Gallagher, R.E.4
  • 151
    • 0031925205 scopus 로고    scopus 로고
    • Inorganic and methylated arsenic compounds induce cell death in murine macrophages via different mechanisms
    • Sakurai, T.; Kaise, T.; Matsubara, C. Inorganic and methylated arsenic compounds induce cell death in murine macrophages via different mechanisms. Chem. Res. Toxicol., 1998, 11, 273-283.
    • (1998) Chem. Res. Toxicol. , vol.11 , pp. 273-283
    • Sakurai, T.1    Kaise, T.2    Matsubara, C.3
  • 152
    • 0029917374 scopus 로고    scopus 로고
    • Dimethylarsinic acid causes apoptosis in HL-60 cells via interaction with glutathione
    • Ochi, T.; Nakajima, F.; Sakurai, T.; Kaise, T.; Oya-Ohta, Y. Dimethylarsinic acid causes apoptosis in HL-60 cells via interaction with glutathione. Arch Toxicol., 1996, 70, 815-821.
    • (1996) Arch Toxicol. , vol.70 , pp. 815-821
    • Ochi, T.1    Nakajima, F.2    Sakurai, T.3    Kaise, T.4    Oya-Ohta, Y.5
  • 153
    • 0027306031 scopus 로고
    • Gene damage induced in human alveolar type (L-132) cells by exposure to dimethylarsinic acid
    • Tezuka, M.; Hanioka, K.; Yamanaka, K.; Okada, S. Gene damage induced in human alveolar type (L-132) cells by exposure to dimethylarsinic acid. Biochem. Biophys. Res. Commun., 1993, 191, 1178-1183.
    • (1993) Biochem. Biophys. Res. Commun. , vol.191 , pp. 1178-1183
    • Tezuka, M.1    Hanioka, K.2    Yamanaka, K.3    Okada, S.4
  • 154
    • 0029877529 scopus 로고    scopus 로고
    • Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-Nitroquinoline 1-Oxide in the lungs of mice
    • Yamanaka, K.; Ohtsubo, K.; Hasegawa, A.; Hayashi, H.; Ohji, H.; Kanisawa, M.; Okada, S. Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice. Carcinogenesis, 1996, 17, 767-770.
    • (1996) Carcinogenesis , vol.17 , pp. 767-770
    • Yamanaka, K.1    Ohtsubo, K.2    Hasegawa, A.3    Hayashi, H.4    Ohji, H.5    Kanisawa, M.6    Okada, S.7
  • 155
    • 0036104528 scopus 로고    scopus 로고
    • A major human arsenic metabolite, dimethylarsinic acid, requires reduced glutathione to induce apoptosis
    • Sakurai, T.; Qu, W.; Sakurai, M. H.; Waalkes, M.P. A major human arsenic metabolite, dimethylarsinic acid, requires reduced glutathione to induce apoptosis. Chem. Res. Toxicol., 2002, 15, 629-637.
    • (2002) Chem. Res. Toxicol. , vol.15 , pp. 629-637
    • Sakurai, T.1    Qu, W.2    Sakurai, M.H.3    Waalkes, M.P.4
  • 157
    • 39549101455 scopus 로고    scopus 로고
    • The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity
    • Kitchin, K.T.; Wallace, K. The role of protein binding of trivalent arsenicals in arsenic carcinogenesis and toxicity. J. Inorg. Biochem., 2008, 102, 532-539.
    • (2008) J. Inorg. Biochem. , vol.102 , pp. 532-539
    • Kitchin, K.T.1    Wallace, K.2
  • 158
  • 159
    • 0034980906 scopus 로고    scopus 로고
    • Stress-Related gene expression in mice treated with inorganic arsenicals
    • Liu, J.; Kadiiska, M.B.; Liu, Y.; Lu, T.; Qu, W.; Waalkes, M.P. Stress-related gene expression in mice treated with inorganic arsenicals. Toxicol. Sci., 2001, 61, 314-320.
    • (2001) Toxicol. Sci. , vol.61 , pp. 314-320
    • Liu, J.1    Kadiiska, M.B.2    Liu, Y.3    Lu, T.4    Qu, W.5    Waalkes, M.P.6
  • 160
    • 0034071776 scopus 로고    scopus 로고
    • Studies on the mechanisms of arsenic-Induced selftolerance developed in liver epithelial cells through continuous low-Level arsenite exposure
    • Romach, E.H.; Zhao, C.Q.; Del Razo, L.M.; Cebrian, M.E.; Waalkes, M.P. Studies on the mechanisms of arsenic-induced selftolerance developed in liver epithelial cells through continuous low-level arsenite exposure. Toxicol. Sci., 2000, 54, 500-508.
    • (2000) Toxicol. Sci. , vol.54 , pp. 500-508
    • Romach, E.H.1    Zhao, C.Q.2    Del Razo, L.M.3    Cebrian, M.E.4    Waalkes, M.P.5
  • 161
    • 84864131822 scopus 로고    scopus 로고
    • Release of apoptotic cytochrome c from mitochondria by dimethylarsinous acid occurs through interaction with voltage-Dependent anion channel
    • In
    • Naranmandura, H.; Chen, X.; Tanaka, M.; Wang, W.W.; Rehman, K.; Xu, S.; Chen, Z.; Chen, S. Release of Apoptotic Cytochrome c From Mitochondria by Dimethylarsinous Acid Occurs Through Interaction With Voltage-Dependent Anion Channel. In vitro. Toxicol. Sci., 2012, 128, 137-146.
    • (2012) Vitro. Toxicol. Sci. , vol.128 , pp. 137-146
    • Naranmandura, H.1    Chen, X.2    Tanaka, M.3    Wang, W.W.4    Rehman, K.5    Xu, S.6    Chen, Z.7    Chen, S.8
  • 162
    • 20444379238 scopus 로고    scopus 로고
    • Arsenite binding to synthetic peptides based on the Zn finger region and the estrogen binding region of the human estrogen receptor-R
    • Kitchin, K.T.; Wallace, K. Arsenite binding to synthetic peptides based on the Zn finger region and the estrogen binding region of the human estrogen receptor- R. Toxicol. Appl. Pharmacol., 2005, 206, 66-72.
    • (2005) Toxicol. Appl. Pharmacol. , vol.206 , pp. 66-72
    • Kitchin, K.T.1    Wallace, K.2
  • 163
    • 79959544817 scopus 로고    scopus 로고
    • Arsenite interacts selectively with zinc finger proteins containing C3H1 or C4 motifs
    • Zhou, X.; Sun, X.; Cooper, K.L.; Wang, F.; Liu, K.J.; Hudson, L.G. Arsenite Interacts Selectively with Zinc Finger Proteins Containing C3H1 or C4 Motifs. J. Biol. Chem., 2011, 286, 22855-22863.
    • (2011) J. Biol. Chem. , vol.286 , pp. 22855-22863
    • Zhou, X.1    Sun, X.2    Cooper, K.L.3    Wang, F.4    Liu, K.J.5    Hudson, L.G.6
  • 164
    • 41849146417 scopus 로고    scopus 로고
    • Monomethylarsonous acid destroys a tetrathiolate zinc finger much more efficiently than inorganic arsenite: Mechanistic considerations and consequences for DNA repair inhibition
    • Piatek, K.; Schwerdtle, T.; Hartwig, A.; Bal, W. Monomethylarsonous Acid Destroys a Tetrathiolate Zinc Finger Much More Efficiently than Inorganic Arsenite: Mechanistic Considerations and Consequences for DNA Repair Inhibition. Chem. Res. Toxicol., 2008, 21, 600-606.
    • (2008) Chem. Res. Toxicol. , vol.21 , pp. 600-606
    • Piatek, K.1    Schwerdtle, T.2    Hartwig, A.3    Bal, W.4
  • 165
    • 0343775735 scopus 로고    scopus 로고
    • Interference by toxic metal compounds with isolated zinc finger DNA repair protein
    • 227-231
    • Asmuss, M.; Mullenders, L.H.; Hartwig, A. Interference by toxic metal compounds with isolated zinc finger DNA repair protein. Toxicol. Lett., 2000, 112-113, 227-231.
    • (2000) Toxicol. Lett. , pp. 112-113
    • Asmuss, M.1    Mullenders, L.H.2    Hartwig, A.3
  • 166
    • 0345724836 scopus 로고    scopus 로고
    • Arsenite and its biomethylated metabolites interfere with the formation and repair of stable BPDE-Induced DNA adducts in human cells and impair XPAzf and Fpg
    • Schwerdtle, T.; Walter, I.; Hartwig, A. Arsenite and its biomethylated metabolites interfere with the formation and repair of stable BPDE-induced DNA adducts in human cells and impair XPAzf and Fpg. DNA Repair (Amsterdam), 2003, 2, 1449-1463.
    • (2003) DNA Repair (Amsterdam) , vol.2 , pp. 1449-1463
    • Schwerdtle, T.1    Walter, I.2    Hartwig, A.3
  • 167
    • 0030817905 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-Ribose) polymerase by arsenite
    • Yager, J.W.; Wiencke, J.K.; Inhibition of poly(ADP-ribose) polymerase by arsenite. Mutat. Res., 1997, 386, 345-351.
    • (1997) Mutat. Res. , vol.386 , pp. 345-351
    • Yager, J.W.1    Wiencke, J.K.2
  • 168
    • 0037430142 scopus 로고    scopus 로고
    • Very low concentrations of arsenite suppress poly(ADP-Ribosyl)ation in mammalian cells
    • Hartwig, A.; Pelzer, A.; Asmuss, M.; Bürkle, A. Very low concentrations of arsenite suppress poly(ADP-ribosyl)ation in mammalian cells. Int. J. Cancer., 2003, 104, 1-6.
    • (2003) Int. J. Cancer. , vol.104 , pp. 1-6
    • Hartwig, A.1    Pelzer, A.2    Asmuss, M.3    Bürkle, A.4
  • 169
    • 0242362757 scopus 로고    scopus 로고
    • Modulation of DNA repair processes by arsenic and selenium compounds
    • Hartwig, A.; Blessing, H.; Schwerdtle, T.; Walter, I. Modulation of DNA repair processes by arsenic and selenium compounds. Toxicology, 2003, 193, 161-169.
    • (2003) Toxicology , vol.193 , pp. 161-169
    • Hartwig, A.1    Blessing, H.2    Schwerdtle, T.3    Walter, I.4
  • 170
    • 3342889714 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis in metal ion-Induced carcinogenesis
    • Shi, H.; Hudson, L.G.; Liu, K.J. Oxidative stress and apoptosis in metal ion-induced carcinogenesis. Free Radical Biol. Med., 2004, 37, 582-593.
    • (2004) Free Radical Biol. Med. , vol.37 , pp. 582-593
    • Shi, H.1    Hudson, L.G.2    Liu, K.J.3
  • 171
    • 77049126844 scopus 로고    scopus 로고
    • Arsenic-Induced carcinogenesis-Oxidative stress as a possible mode of action and future research needs for more biologically based risk assessment
    • Kitchin, K.T.; Conolly, R. Arsenic-induced carcinogenesis- oxidative stress as a possible mode of action and future research needs for more biologically based risk assessment. Chem. Res. Toxicol., 2010, 23, 327-335.
    • (2010) Chem. Res. Toxicol. , vol.23 , pp. 327-335
    • Kitchin, K.T.1    Conolly, R.2
  • 172
    • 3242760758 scopus 로고    scopus 로고
    • The role of active arsenic species produced by metabolic reduction of dimethylarsinic acid in genotoxicity and tumorigenesis
    • Yamanaka, K.; Kato, K.; Mizoi, M.; An, Y.; Takabayashi, F.; Nakano, M.; Hoshino, M.; Okada, S. The role of active arsenic species produced by metabolic reduction of dimethylarsinic acid in genotoxicity and tumorigenesis. Toxicol. Appl. Pharmacol., 2004, 198, 385 - 393.
    • (2004) Toxicol. Appl. Pharmacol. , vol.198 , pp. 385-393
    • Yamanaka, K.1    Kato, K.2    Mizoi, M.3    An, Y.4    Takabayashi, F.5    Nakano, M.6    Hoshino, M.7    Okada, S.8
  • 173
    • 33744455447 scopus 로고    scopus 로고
    • The role of mitochondria in ageing and carcinogenesis
    • Birch-Machin, M.A. The role of mitochondria in ageing and carcinogenesis. Clin. Exp. Dermatol., 2006, 31, 548 - 552.
    • (2006) Clin. Exp. Dermatol. , vol.31 , pp. 548-552
    • Birch-Machin, M.A.1
  • 174
    • 3242804525 scopus 로고    scopus 로고
    • The accumulation and toxicity of methylated arsenicals in endothelial cells: Important roles of thiol compounds
    • Hirano, S.; Kobayashi, Y.; Cui, X.; Kanno, S.; Hayakawa, T.; Shraim, A. The accumulation and toxicity of methylated arsenicals in endothelial cells: Important roles of thiol compounds. Toxicol. Appl. Pharmacol., 2004, 198, 458-467.
    • (2004) Toxicol. Appl. Pharmacol. , vol.198 , pp. 458-467
    • Hirano, S.1    Kobayashi, Y.2    Cui, X.3    Kanno, S.4    Hayakawa, T.5    Shraim, A.6
  • 176
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • Ron, D.; Walter, P. Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell Biol., 2007, 8, 519-529.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 177
    • 33846548110 scopus 로고    scopus 로고
    • ER stress and diseases
    • Yoshida, H. ER stress and diseases. FEBS J., 2007, 274, 630-658.
    • (2007) FEBS J. , vol.274 , pp. 630-658
    • Yoshida, H.1
  • 178
    • 0345735389 scopus 로고    scopus 로고
    • Urinary 8-OHdG: A marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics
    • Wu, L.L.; Chiou, C.C.p Chang, P.Y.; Wu, J.T. Urinary 8-OHdG: A marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics. Clin. Chim. Acta, 2004, 339, 1-9.
    • (2004) Clin. Chim. Acta , vol.339 , pp. 1-9
    • Wu, L.L.1    Chiou, C.C.P.2    Chang, P.Y.3    Wu, J.T.4
  • 180
    • 0035860357 scopus 로고    scopus 로고
    • Oral administration of dimethylarsinic acid, a main metabolite of inorganic arsenics, promote skin tumorigenesis in mice
    • Yamanaka, K.; Mizoi, M.; Kato, K.; Hasegawa, A.; Nakano, M.; Okada, S. Oral administration of dimethylarsinic acid, a main metabolite of inorganic arsenics, promote skin tumorigenesis in mice. Biochem. Biophys. Res. Commun. 2001, 287, 66-70.
    • (2001) Biochem. Biophys. Res. Commun. , vol.287 , pp. 66-70
    • Yamanaka, K.1    Mizoi, M.2    Kato, K.3    Hasegawa, A.4    Nakano, M.5    Okada, S.6
  • 182
    • 0030742792 scopus 로고    scopus 로고
    • Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: A model for a mechanism of carcinogenesis
    • Mass, M.J.; Wang, L. Arsenic alters cytosine methylation patterns of the promoter of the tumor suppressor gene p53 in human lung cells: A model for a mechanism of carcinogenesis. Mutat. Res., 1997, 386, 263-277.
    • (1997) Mutat. Res. , vol.386 , pp. 263-277
    • Mass, M.J.1    Wang, L.2
  • 184
    • 84855807757 scopus 로고    scopus 로고
    • Microarray analysis revealed dysregulation of multiple genes associated with chemoresistance to As (2)O(3) and increased tumor aggressiveness in a newly established arsenic-Resistant ovarian cancer cell line, OVCAR-3/AsR
    • Ong, P.S.; Chan, S.Y.; Ho, P.C. Microarray analysis revealed dysregulation of multiple genes associated with chemoresistance to As(2)O(3) and increased tumor aggressiveness in a newly established arsenic-resistant ovarian cancer cell line, OVCAR-3/AsR. Eur. J. Pharm. Sci., 2012, 45, 367-378.
    • (2012) Eur. J. Pharm. Sci. , vol.45 , pp. 367-378
    • Ong, P.S.1    Chan, S.Y.2    Ho, P.C.3
  • 187
    • 0037772194 scopus 로고    scopus 로고
    • Arsenic trioxide-Induced apoptosis in myeloma cells: P53-Dependent G1 or G2/M cell cycle arrest, activation of caspase-8 or caspase-9, and synergy with APO2/TRAIL
    • Liu, Q.; Hilsenbeck, S.; Gazitt, Y. Arsenic trioxide-induced apoptosis in myeloma cells: p53-dependent G1 or G2/M cell cycle arrest, activation of caspase-8 or caspase-9, and synergy with APO2/TRAIL. Blood, 2003, 101, 4078-4087.
    • (2003) Blood , vol.101 , pp. 4078-4087
    • Liu, Q.1    Hilsenbeck, S.2    Gazitt, Y.3


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