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Volumn 5, Issue 4, 2009, Pages 472-483

Combination treatment with arsenic trioxide and irradiation enhances autophagic effects in U118-MG cells through increased mitotic arrest and regulation of PI3K/Akt and ERK1/2 signaling pathways

Author keywords

Arsenic trioxide; Autophagy; Malignant gliomas; Mitotic arrest; Radiation

Indexed keywords

ARSENIC TRIOXIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

EID: 66349090851     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.5.4.7759     Document Type: Article
Times cited : (97)

References (80)
  • 1
    • 4444346338 scopus 로고    scopus 로고
    • Increased cure rate of glioblastoma using concurrent therapy with radiotherapy and arsenic trioxide
    • DOI 10.1016/j.ijrobp.2004.02.013, PII S0360301604002536
    • Ning S, Knox SJ. Increased cure rate of glioblastoma using concurrent therapy with radiotherapy and arsenic trioxide. Int J Radiat Oncol Biol Phys 2004; 60:197-203. (Pubitemid 39165485)
    • (2004) International Journal of Radiation Oncology Biology Physics , vol.60 , Issue.1 , pp. 197-203
    • Ning, S.1    Knox, S.J.2
  • 2
    • 33847776789 scopus 로고    scopus 로고
    • Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601)
    • DOI 10.1517/17425247.4.2.175
    • Mamelak AN, Jacoby DB. Targeted delivery of antitumoral therapy to glioma and other malignancies with synthetic chlorotoxin (TM-601). Expert Opin Drug Deliv 2007; 4:175-186 (Pubitemid 46389915)
    • (2007) Expert Opinion on Drug Delivery , vol.4 , Issue.2 , pp. 175-186
    • Mamelak, A.N.1    Jacoby, D.B.2
  • 3
    • 33646244984 scopus 로고    scopus 로고
    • Optimization of combination therapy of arsenic trioxide and fractionated radiotherapy for malignant glioma
    • Ning S, Knox SJ. Optimization of combination therapy of arsenic trioxide and fractionated radiotherapy for malignant glioma. Int J Radiat Oncol Biol Phys 2006; 65:493-498
    • (2006) Int J Radiat Oncol Biol Phys , vol.65 , pp. 493-498
    • Ning, S.1    Knox, S.J.2
  • 4
    • 0038743077 scopus 로고    scopus 로고
    • Induction of autophagic cell death in malignant glioma cells by arsenic trioxide
    • Kanzawa T, Kondo Y, Ito H, Kondo S, Germano I. Induction of autophagic cell death in malignant glioma cells by arsenic trioxide. Cancer Res 2003; 63:2103-2108 (Pubitemid 36538613)
    • (2003) Cancer Research , vol.63 , Issue.9 , pp. 2103-2108
    • Kanzawa, T.1    Kondo, Y.2    Ito, H.3    Kondo, S.4    Germano, I.5
  • 5
    • 0030610686 scopus 로고    scopus 로고
    • Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells
    • Chen GQ, Shi XG, Tang W, Xiong SM, Zhu J, Cai X, et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): I. As2O3 exerts dose-dependent dual effects on APL cells. Blood 1997; 89:3345-3353
    • (1997) Blood , vol.89 , pp. 3345-3353
    • Chen, G.Q.1    Shi, X.G.2    Tang, W.3    Xiong, S.M.4    Zhu, J.5    Cai, X.6
  • 6
    • 0030610687 scopus 로고    scopus 로고
    • Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients
    • Shen ZX, Chen GQ, Ni JH, Li XS, Xiong SM, Qiu QY, et al. Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 1997; 89:3354-3360
    • (1997) Blood , vol.89 , pp. 3354-3360
    • Shen, Z.X.1    Chen, G.Q.2    Ni, J.H.3    Li, X.S.4    Xiong, S.M.5    Qiu, Q.Y.6
  • 9
    • 0035879016 scopus 로고    scopus 로고
    • 3) in the orthotopic metastasis model of androgen-independent prostate cancer
    • Maeda H, Hori S, Nishitoh H, Ichijo H, Ogawa O, Kakehi Y, et al. Tumor growth inhibition by arsenic trioxide (As2O3) in the orthotopic metastasis model of androgenindependent prostate cancer. Cancer Res 2001; 61:5432-5440 (Pubitemid 32694923)
    • (2001) Cancer Research , vol.61 , Issue.14 , pp. 5432-5440
    • Maeda, H.1    Hori, S.2    Nishitoh, H.3    Ichijo, H.4    Ogawa, O.5    Kakehi, Y.6    Kakizuka, A.7
  • 11
    • 0036682021 scopus 로고    scopus 로고
    • Synergistic interaction with arsenic trioxide and fractionated radiation in locally advanced murine tumor
    • Lew YS, Kolozsvary A, Brown SL, Kim JH. Synergistic interaction with arsenic trioxide and fractionated radiation in locally advanced murine tumor. Cancer Res 2002; 62:4202-4205 (Pubitemid 34827272)
    • (2002) Cancer Research , vol.62 , Issue.15 , pp. 4202-4205
    • Lew, Y.S.1    Kolozsvary, A.2    Brown, S.L.3    Kim, J.H.4
  • 12
    • 13944256602 scopus 로고    scopus 로고
    • Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3
    • DOI 10.1038/sj.onc.1208095
    • Kanzawa T, Zhang L, Xiao L, Germano IM, Kondo Y, Kondo S. Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene 2005; 24:980-991 (Pubitemid 40313875)
    • (2005) Oncogene , vol.24 , Issue.6 , pp. 980-991
    • Kanzawa, T.1    Zhang, L.2    Xiao, L.3    Germano, I.M.4    Kondo, Y.5    Kondo, S.6
  • 13
    • 33947725524 scopus 로고    scopus 로고
    • Protection against arsenic trioxide-induced autophagic cell death in U118 human glioma cells by use of lipoic acid
    • DOI 10.1016/j.fct.2006.12.014, PII S0278691506003693
    • Cheng TJ, Wang YJ, Kao WW, Chen RJ, Ho YS. Protection against arsenic trioxide-induced autophagic cell death in U118 human glioma cells by use of lipoic acid. Food Chem Toxicol 2007; 45:1027-1038 (Pubitemid 46507693)
    • (2007) Food and Chemical Toxicology , vol.45 , Issue.6 , pp. 1027-1038
    • Cheng, T.-J.1    Wang, Y.-J.2    Kao, W.-W.3    Chen, R.-J.4    Ho, Y.-S.5
  • 14
    • 0028114913 scopus 로고
    • Bcl-2 protein expression in tumors of the central nervous system
    • DOI 10.1007/s004010050194
    • Nakasu S, Nakasu Y, Nioka H, Nakajima M, Handa J. bcl-2 protein expression in tumors of the central nervous system. Acta Neuropathol (Berl) 1994; 88:520-526 (Pubitemid 24364699)
    • (1994) Acta Neuropathologica , vol.88 , Issue.6 , pp. 520-526
    • Nakasu, S.1    Nakasu, Y.2    Nioka, H.3    Nakajima, M.4    Handa, J.5
  • 15
    • 0032542505 scopus 로고    scopus 로고
    • BCL-2 family protein expression in human malignant glioma: A clinical- Pathological correlative study
    • DOI 10.1016/S0022-510X(97)00277-3, PII S0022510X97002773
    • Rieger L, Weller M, Bornemann A, Schabet M, Dichgans J, Meyermann R. BCL-2 family protein expression in human malignant glioma: a clinical-pathological correlative study. J Neurol Sci 1998; 155:68-75. (Pubitemid 28141061)
    • (1998) Journal of the Neurological Sciences , vol.155 , Issue.1 , pp. 68-75
    • Rieger, L.1    Weller, M.2    Bornemann, A.3    Schabet, M.4    Dichgans, J.5    Meyermann, R.6
  • 16
    • 0037306785 scopus 로고    scopus 로고
    • Molecular response of human glioblastoma multiforme cells to ionizing radiation: Cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy
    • Yao KC, Komata T, Kondo Y, Kanzawa T, Kondo S, Germano IM. Molecular response of human glioblastoma multiforme cells to ionizing radiation: cell cycle arrest, modulation of the expression of cyclin-dependent kinase inhibitors, and autophagy. J Neurosurg 2003; 98:378-384 (Pubitemid 36151035)
    • (2003) Journal of Neurosurgery , vol.98 , Issue.2 , pp. 378-384
    • Yao, K.C.1    Komata, T.2    Kondo, Y.3    Kanzawa, T.4    Kondo, S.5    Germano, I.M.6
  • 17
    • 21444442926 scopus 로고    scopus 로고
    • Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells
    • Ito H, Daido S, Kanzawa T, Kondo S, Kondo Y. Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells. Int J Oncol 2005; 26:1401-1410
    • (2005) Int J Oncol , vol.26 , pp. 1401-1410
    • Ito, H.1    Daido, S.2    Kanzawa, T.3    Kondo, S.4    Kondo, Y.5
  • 18
    • 0032126541 scopus 로고    scopus 로고
    • Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines
    • Aldridge DR, Radford IR. Explaining differences in sensitivity to killing by ionizing radiation between human lymphoid cell lines. Cancer Res 1998; 58:2817-2824 (Pubitemid 28311913)
    • (1998) Cancer Research , vol.58 , Issue.13 , pp. 2817-2824
    • Aldridge, D.R.1    Radford, I.R.2
  • 19
    • 0027499524 scopus 로고
    • Prolonged cell cycle delay in radioresistant human cell lines transfected with activated ras oncogene and/or simian virus 40 T-antigen
    • Su LN, Little JB. Prolonged cell cycle delay in radioresistant human cell lines transfected with activated ras oncogene and/or simian virus 40 T-antigen. Radiat Res 1993; 133:73-79 (Pubitemid 23070028)
    • (1993) Radiation Research , vol.133 , Issue.1 , pp. 73-79
    • Su, L.-N.1    Little, J.B.2
  • 20
    • 0036765344 scopus 로고    scopus 로고
    • Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines
    • DOI 10.1124/mol.62.3.529
    • Ling YH, Jiang JD, Holland JF, Perez-Soler R. Arsenic trioxide produces polymerization of microtubules and mitotic arrest before apoptosis in human tumor cell lines. Mol Pharmacol 2002; 62:529-538 (Pubitemid 36329371)
    • (2002) Molecular Pharmacology , vol.62 , Issue.3 , pp. 529-538
    • Ling, Y.-H.1    Jiang, J.-D.2    Holland, J.F.3    Perez-Soler, R.4
  • 21
    • 0000928694 scopus 로고    scopus 로고
    • Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells
    • Li YM, Broome JD. Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells. Cancer Res 1999; 59:776-780 (Pubitemid 29086725)
    • (1999) Cancer Research , vol.59 , Issue.4 , pp. 776-780
    • Li, Y.M.1    Broome, J.D.2
  • 22
    • 0038103842 scopus 로고    scopus 로고
    • Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells
    • DOI 10.1038/sj.leu.2402983
    • Cai X, Yu Y, Huang Y, Zhang L, Jia PM, Zhao Q, et al. Arsenic trioxide-induced mitotic arrest and apoptosis in acute promyelocytic leukemia cells. Leukemia 2003; 17:1333-1337 (Pubitemid 36857340)
    • (2003) Leukemia , vol.17 , Issue.7 , pp. 1333-1337
    • Cai, X.1    Yu, Y.2    Huang, Y.3    Zhang, L.4    Jia, P.-M.5    Zhao, Q.6    Chen, Z.7    Tong, J.-H.8    Dai, W.9    Chen, G.-Q.10
  • 24
    • 33645464728 scopus 로고    scopus 로고
    • Mechanisms of apoptosis induction and cell cycle regulation in irradiated leukemia U937 cells and enhancement by arsenic trioxide
    • Ho SY, Huang PC, Guo HR, Chang WH, Chen RJ, Wei BL, et al. Mechanisms of apoptosis induction and cell cycle regulation in irradiated leukemia U937 cells and enhancement by arsenic trioxide. Radiat Res 2006; 165:390-399
    • (2006) Radiat Res , vol.165 , pp. 390-399
    • Ho, S.Y.1    Huang, P.C.2    Guo, H.R.3    Chang, W.H.4    Chen, R.J.5    Wei, B.L.6
  • 27
    • 2142752480 scopus 로고    scopus 로고
    • Cellular autophagy: Surrender, avoidance and subversion by microorganisms
    • DOI 10.1038/nrmicro865
    • Kirkegaard K, Taylor MP, Jackson WT. Cellular autophagy: surrender, avoidance and subversion by microorganisms. Nat Rev Microbiol 2004; 2:301-314 (Pubitemid 39490100)
    • (2004) Nature Reviews Microbiology , vol.2 , Issue.4 , pp. 301-314
    • Kirkegaard, K.1    Taylor, M.P.2    Jackson, W.T.3
  • 29
    • 0036463736 scopus 로고    scopus 로고
    • Autophagy in the eukaryotic cell
    • DOI 10.1128/EC.01.1.11-21.2002
    • Reggiori F, Klionsky DJ. Autophagy in the eukaryotic cell. Eukaryot Cell 2002; 1:11-21. (Pubitemid 36562345)
    • (2002) Eukaryotic Cell , vol.1 , Issue.1 , pp. 11-21
    • Reggiori, F.1    Klionsky, D.J.2
  • 30
  • 31
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • DOI 10.1126/science.290.5497.1717
    • Klionsky D, Emr S. Autophagy as a regulated pathway of cellular degradation. Science 2000; 290:1717-1721 (Pubitemid 32004796)
    • (2000) Science , vol.290 , Issue.5497 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 33
    • 0035929650 scopus 로고    scopus 로고
    • The Tumor Suppressor PTEN Positively Regulates Macroautophagy by Inhibiting the Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway
    • DOI 10.1074/jbc.C100319200
    • Arico S, Petiot A, Bauvy C, Dubbelhuis PF, Meijer AJ, Codogno P, et al. The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway. J Biol Chem 2001; 276:35243-35246 (Pubitemid 37384313)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.38 , pp. 35243-35246
    • Arico, S.1    Petiot, A.2    Bauvy, C.3    Dubbelhuis, P.F.4    Meijer, A.J.5    Codogno, P.6    Ogier-Denis, E.7
  • 34
    • 0028985249 scopus 로고
    • A heterotrimeric Gi3-protein controls autophagic sequestration in the human colon cancer cell line HT-29
    • Ogier-Denis E, Couvineau A, Maoret JJ, Houri JJ, Bauvy C, De Stefanis D, et al. A heterotrimeric Gi3-protein controls autophagic sequestration in the human colon cancer cell line HT-29. J Biol Chem 1995; 270:13-16
    • (1995) J Biol Chem , vol.270 , pp. 13-16
    • Ogier-Denis, E.1    Couvineau, A.2    Maoret, J.J.3    Houri, J.J.4    Bauvy, C.5    De Stefanis, D.6
  • 36
    • 0028978778 scopus 로고
    • 2 and mitotic cells by flow cytometry based on different expression of cyclins a and B1
    • 2 and mitotic cells by flow cytometry based on different expression of cyclins A and B1. Exp Cell Res 1995; 220:226-231
    • (1995) Exp Cell Res , vol.220 , pp. 226-231
    • Gong, J.1    Traganos, F.2    Darzynkiewicz, Z.3
  • 37
    • 0035853811 scopus 로고    scopus 로고
    • Bax Is Present as a High Molecular Weight Oligomer/Complex in the Mitochondrial Membrane of Apoptotic Cells
    • DOI 10.1074/jbc.M010810200
    • Antonsson B, Montessuit S, Sanchez B, Martinou JC. Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells. J Biol Chem 2001; 276:11615-11623 (Pubitemid 37385313)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.15 , pp. 11615-11623
    • Antonsson, B.1    Montessuit, S.2    Sanchez, B.3    Martinou, J.-C.4
  • 38
    • 0035937751 scopus 로고    scopus 로고
    • Role of Mitochondria and Caspases in Vitamin D-mediated Apoptosis of MCF-7 Breast Cancer Cells
    • DOI 10.1074/jbc.M006876200
    • Narvaez CJ, Welsh J. Role of mitochondria and caspases in vitamin D-mediated apoptosis of MCF-7 breast cancer cells. J Biol Chem 2001; 276:9101-9107 (Pubitemid 37385490)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.12 , pp. 9101-9107
    • Narvaez, C.J.1    Welsh, J.2
  • 39
    • 33645552166 scopus 로고    scopus 로고
    • Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins
    • Lee DH, Park T, Kim HW. Induction of apoptosis by disturbing mitochondrial-membrane potential and cleaving PARP in Jurkat T cells through treatment with acetoxyscirpenol mycotoxins. Biol Pharm Bull 2006; 29:648-654
    • (2006) Biol Pharm Bull , vol.29 , pp. 648-654
    • Lee, D.H.1    Park, T.2    Kim, H.W.3
  • 41
    • 50249168137 scopus 로고    scopus 로고
    • Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: Implications for Parkinson's disease
    • Dagda RK, Zhu J, Kulich SM, Chu CT. Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease. Autophagy 2008; 4:770-782
    • (2008) Autophagy , vol.4 , pp. 770-782
    • Dagda, R.K.1    Zhu, J.2    Kulich, S.M.3    Chu, C.T.4
  • 42
    • 33746166864 scopus 로고    scopus 로고
    • Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity
    • DOI 10.1158/0008-5472.CAN-05-3557
    • Corcelle E, Nebout M, Bekri S, Gauthier N, Hofman P, Poujeol P, et al. Disruption of autophagy at the maturation step by the carcinogen lindane is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity. Cancer Res 2006; 66:6861-6870 (Pubitemid 44085647)
    • (2006) Cancer Research , vol.66 , Issue.13 , pp. 6861-6870
    • Corcelle, E.1    Nebout, M.2    Bekri, S.3    Gauthier, N.4    Hofman, P.5    Poujeol, P.6    Fenichel, P.7    Mograbi, B.8
  • 43
    • 48249090416 scopus 로고    scopus 로고
    • Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer
    • Kim KW, Hwang M, Moretti L, Jaboin JJ, Cha YI, Lu B. Autophagy upregulation by inhibitors of caspase-3 and mTOR enhances radiotherapy in a mouse model of lung cancer. Autophagy 2008; 4:659-668
    • (2008) Autophagy , vol.4 , pp. 659-668
    • Kim, K.W.1    Hwang, M.2    Moretti, L.3    Jaboin, J.J.4    Cha, Y.I.5    Lu, B.6
  • 44
    • 31544461235 scopus 로고    scopus 로고
    • Inhibition of Akt signaling and enhanced ERK1/2 activity are involved in induction of macroautophagy by triterpenoid B-group soyasaponins in colon cancer cells
    • DOI 10.1093/carcin/bgi214
    • Ellington AA, Berhow MA, Singletary KW. Inhibition of Akt signaling and enhanced ERK1/2 activity are involved in induction of macroautophagy by triterpenoid B-group soyasaponins in colon cancer cells. Carcinogenesis 2006; 27:298-306. (Pubitemid 43159883)
    • (2006) Carcinogenesis , vol.27 , Issue.2 , pp. 298-306
    • Ellington, A.A.1    Berhow, M.A.2    Singletary, K.W.3
  • 45
    • 34347238938 scopus 로고    scopus 로고
    • Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: Role of akt and extracellular signal-regulated kinase signaling pathways
    • DOI 10.1124/mol.106.033167
    • Aoki H, Takada Y, Kondo S, Sawaya R, Aggarwal BB, Kondo Y. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Mol Pharmacol 2007; 72:29-39. (Pubitemid 46998522)
    • (2007) Molecular Pharmacology , vol.72 , Issue.1 , pp. 29-39
    • Aoki, H.1    Takada, Y.2    Kondo, S.3    Sawaya, R.4    Aggarwal, B.B.5    Kondo, Y.6
  • 46
    • 0036021225 scopus 로고    scopus 로고
    • Phase II trial of arsenic trioxide in patients with metastatic renal cell carcinoma
    • DOI 10.1023/A:1016270206374
    • Vuky J, Yu R, Schwartz L, Motzer RJ. Phase II trial of arsenic trioxide in patients with metastatic renal cell carcinoma. Invest New Drugs 2002; 20:327-330 (Pubitemid 34823761)
    • (2002) Investigational New Drugs , vol.20 , Issue.3 , pp. 327-330
    • Vuky, J.1    Yu, R.2    Schwartz, L.3    Motzer, R.J.4
  • 47
    • 2642553881 scopus 로고    scopus 로고
    • Regulation of an ATG7-beclin 1 program of autophaglic cell death by caspase-8
    • DOI 10.1126/science.1096645
    • Yu L, Alva A, Su H, Dutt P, Freundt E, Welsh S, et al. Regulation of an ATG7-beclin 1 program of autophagic cell death by caspase-8. Science 2004; 304:1500-1502 (Pubitemid 38720930)
    • (2004) Science , vol.304 , Issue.5676 , pp. 1500-1502
    • Yu, L.1    Alva, A.2    Su, H.3    Dutt, P.4    Freundt, E.5    Welsh, S.6    Baehrecke, E.H.7    Lenardo, M.J.8
  • 48
    • 33745845126 scopus 로고    scopus 로고
    • Autophagy contributes to caspase-independent macrophage cell death
    • DOI 10.1074/jbc.M513377200
    • Xu Y, Kim SO, Li Y, Han J. Autophagy contributes to caspase-independent macrophage cell death. J Biol Chem 2006; 281:19179-19187 (Pubitemid 44035422)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.28 , pp. 19179-19187
    • Xu, Y.1    Sung, O.K.2    Li, Y.3    Han, J.4
  • 49
    • 33645521571 scopus 로고    scopus 로고
    • Autophagic programmed cell death by selective catalase degradation
    • Yu L, Wan F, Dutta S, Welsh S, Liu Z, Freundt E, et al. Autophagic programmed cell death by selective catalase degradation. Proc Natl Acad Sci USA 2006; 103:4952-4957
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4952-4957
    • Yu, L.1    Wan, F.2    Dutta, S.3    Welsh, S.4    Liu, Z.5    Freundt, E.6
  • 50
    • 48249156591 scopus 로고    scopus 로고
    • Autophagy: An emerging target for cancer therapy
    • Hoyer-Hansen M, Jaattela M. Autophagy: an emerging target for cancer therapy. Autophagy 2008; 4:574-580
    • (2008) Autophagy , vol.4 , pp. 574-580
    • Hoyer-Hansen, M.1    Jaattela, M.2
  • 51
    • 23644443068 scopus 로고    scopus 로고
    • The significance of autophagy in cancer
    • DOI 10.1002/mc.20097
    • Ng G, Huang J. The significance of autophagy in cancer. Mol Carcinog 2005; 43:183-187 (Pubitemid 41134425)
    • (2005) Molecular Carcinogenesis , vol.43 , Issue.4 , pp. 183-187
    • Ng, G.1    Huang, J.2
  • 52
    • 2142749539 scopus 로고    scopus 로고
    • p53-induced gene 11 (PIG11) involved in arsenic trioxide-induced apoptosis in human gastric cancer MGC-803 cells
    • Liang XQ, Cao EH, Zhang Y, Qin JF. p53-induced gene 11 (PIG11) involved in arsenic trioxide-induced apoptosis in human gastric cancer MGC-803 cells. Oncol Rep 2003; 10:1265-1269
    • (2003) Oncol Rep , vol.10 , pp. 1265-1269
    • Liang, X.Q.1    Cao, E.H.2    Zhang, Y.3    Qin, J.F.4
  • 53
    • 0036653125 scopus 로고    scopus 로고
    • Effect of As2O3 on cell cycle progression and cyclins D1 and B1 expression in two glioblastoma cell lines differing in p53 status
    • Zhao S, Tsuchida T, Kawakami K, Shi C, Kawamoto K. Effect of As2O3 on cell cycle progression and cyclins D1 and B1 expression in two glioblastoma cell lines differing in p53 status. Int J Oncol 2002; 21:49-55.
    • (2002) Int J Oncol , vol.21 , pp. 49-55
    • Zhao, S.1    Tsuchida, T.2    Kawakami, K.3    Shi, C.4    Kawamoto, K.5
  • 54
    • 20444362353 scopus 로고    scopus 로고
    • Cell cycle effects of topotecan alone and in combination with irradiation
    • DOI 10.1016/j.radonc.2005.03.025, PII S0167814005001155
    • Ohneseit PA, Prager D, Kehlbach R, Rodemann HP. Cell cycle effects of topotecan alone and in combination with irradiation. Radiother Oncol 2005; 75:237-245 (Pubitemid 40805256)
    • (2005) Radiotherapy and Oncology , vol.75 , Issue.2 , pp. 237-245
    • Ohneseit, P.A.1    Prager, D.2    Kehlbach, R.3    Rodemann, H.P.4
  • 56
    • 0141757479 scopus 로고    scopus 로고
    • DNA damage checkpoint control in cells exposed to ionizing radiation
    • DOI 10.1038/sj.onc.1206682
    • Iliakis G, Wang Y, Guan J, Wang H. DNA damage checkpoint control in cells exposed to ionizing radiation. Oncogene 2003; 22:5834-5847 (Pubitemid 37176704)
    • (2003) Oncogene , vol.22 , Issue.37 REV. ISS. 3 , pp. 5834-5847
    • Iliakis, G.1    Wang, Y.2    Guan, J.3    Wang, H.4
  • 57
    • 0035195557 scopus 로고    scopus 로고
    • The evolution of diverse biological responses to DNA damage: Insights from yeast and p53
    • DOI 10.1038/ncb1201-e277
    • Wahl GM, Carr AM. The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat Cell Biol 2001; 3:277-286 (Pubitemid 33130452)
    • (2001) Nature Cell Biology , vol.3 , Issue.12
    • Wahl, G.M.1    Carr, A.M.2
  • 58
    • 34848918885 scopus 로고    scopus 로고
    • New alternative phosphorylation sites on the cyclin dependent kinase 1/cyclin a complex in p53-deficient human cells treated with etoposide: Possible association with etoposide-induced apoptosis
    • DOI 10.1007/s10495-007-0104-6
    • Higginbottom K, Jahnke U, Newland AC, Cotter FE, Allen PD. New alternative phosphorylation sites on the cyclin dependent kinase 1/cyclin a complex in p53-deficient human cells treated with etoposide: possible association with etoposide-induced apoptosis. Apoptosis 2007; 12:1847-1855 (Pubitemid 47498240)
    • (2007) Apoptosis , vol.12 , Issue.10 , pp. 1847-1855
    • Higginbottom, K.1    Jahnke, U.2    Newland, A.C.3    Cotter, F.E.4    Allen, P.D.5
  • 59
    • 1642430703 scopus 로고    scopus 로고
    • Microtubule-targeted anticancer agents and apoptosis
    • DOI 10.1038/sj.onc.1207233, Apoptosis - Part 2
    • Bhalla KN. Microtubule-targeted anticancer agents and apoptosis. Oncogene 2003; 22:9075-9086 (Pubitemid 38121708)
    • (2003) Oncogene , vol.22 , Issue.56 REV. ISS. 8 , pp. 9075-9086
    • Bhalla, K.N.1
  • 60
    • 33645760938 scopus 로고    scopus 로고
    • Chemotherapeutic approaches for targeting cell death pathways
    • Ricci MS, Zong WX. Chemotherapeutic approaches for targeting cell death pathways. Oncologist 2006; 11:342-357
    • (2006) Oncologist , vol.11 , pp. 342-357
    • Ricci, M.S.1    Zong, W.X.2
  • 61
    • 0017337493 scopus 로고
    • Reduced rates of proteolysis in transformed cells
    • Gunn JM, Clark MG, Knowles SE, Hopgood MF, Ballard FJ. Reduced rates of proteolysis in transformed cells. Nature 1977; 266:58-60. (Pubitemid 8050013)
    • (1977) Nature , vol.266 , Issue.5597 , pp. 58-60
    • Gunn, J.M.1    Clark, M.G.2    Knowles, S.E.3
  • 63
    • 0034754073 scopus 로고    scopus 로고
    • Design of new anticancer therapies targeting cell cycle checkpoint pathways
    • DOI 10.1097/00001622-200111000-00011
    • Sampath D, Plunkett W. Design of new anticancer therapies targeting cell cycle checkpoint pathways. Curr Opin Oncol 2001; 13:484-490 (Pubitemid 33027901)
    • (2001) Current Opinion in Oncology , vol.13 , Issue.6 , pp. 484-490
    • Sampath, D.1    Plunkett, W.2
  • 64
    • 0034012322 scopus 로고    scopus 로고
    • Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments
    • Bursch W, Hochegger K, Torok L, Marian B, Ellinger A, Hermann RS. Autophagic and apoptotic types of programmed cell death exhibit different fates of cytoskeletal filaments. J Cell Sci 2000; 113:1189-1198 (Pubitemid 30229536)
    • (2000) Journal of Cell Science , vol.113 , Issue.7 , pp. 1189-1198
    • Bursch, W.1    Hochegger, K.2    Torok, L.3    Marian, B.4    Ellinger, A.5    Hermann, R.S.6
  • 65
    • 0034006921 scopus 로고    scopus 로고
    • The effects of arsenic trioxide (As2O3) on human megakaryocytic leukemia cell lines. With a comparison of its effects on other cell lineages
    • Alemany M, Levin J. The effects of arsenic trioxide (As2O3) on human megakaryocytic leukemia cell lines. With a comparison of its effects on other cell lineages. Leuk Lymphoma 2000; 38:153-163
    • (2000) Leuk Lymphoma , vol.38 , pp. 153-163
    • Alemany, M.1    Levin, J.2
  • 66
    • 0036634059 scopus 로고    scopus 로고
    • Tantalizing Thanatos: Unexpected links in death pathways
    • Cohen I, Castedo M, Kroemer G. Tantalizing Thanatos: unexpected links in death pathways. Trends Cell Biol 2002; 12:293-295
    • (2002) Trends Cell Biol , vol.12 , pp. 293-295
    • Cohen, I.1    Castedo, M.2    Kroemer, G.3
  • 68
    • 34447132925 scopus 로고    scopus 로고
    • Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells
    • DOI 10.1158/0008-5472.CAN-06-4217
    • Kim EH, Sohn S, Kwon HJ, Kim SU, Kim MJ, Lee SJ, et al. Sodium selenite induces superoxide-mediated mitochondrial damage and subsequent autophagic cell death in malignant glioma cells. Cancer Res 2007; 67:6314-6324 (Pubitemid 47037514)
    • (2007) Cancer Research , vol.67 , Issue.13 , pp. 6314-6324
    • Eun, H.K.1    Sohn, S.2    Hyuk, J.K.3    Kim, S.U.4    Kim, M.-J.5    Lee, S.-J.6    Kyeong, S.C.7
  • 69
    • 0038269032 scopus 로고    scopus 로고
    • Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells
    • DOI 10.1074/jbc.M210998200
    • Pattingre S, Bauvy C, Codogno P. Amino acids interfere with the ERK1/2-dependent control of macroautophagy by controlling the activation of Raf-1 in human colon cancer HT-29 cells. J Biol Chem 2003; 278:16667-16674 (Pubitemid 36799530)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.19 , pp. 16667-16674
    • Pattingre, S.1    Bauvy, C.2    Codogno, P.3
  • 70
    • 0034672063 scopus 로고    scopus 로고
    • Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells
    • DOI 10.1074/jbc.M006198200
    • Ogier-Denis E, Pattingre S, El Benna J, Codogno P. Erk1/2-dependent phosphorylation of Galpha-interacting protein stimulates its GTPase accelerating activity and autophagy in human colon cancer cells. J Biol Chem 2000; 275:39090-39095 (Pubitemid 32058923)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.50 , pp. 39090-39095
    • Ogier-Denis, E.1    Pattingre, S.2    El Benna, J.3    Codogno, P.4
  • 71
    • 2442482810 scopus 로고    scopus 로고
    • Autophagy as a cell death and tumor suppressor mechanism
    • DOI 10.1038/sj.onc.1207521
    • Gozuacik D, Kimchi A. Autophagy as a cell death and tumor suppressor mechanism. Oncogene 2004; 23:2891-2906 (Pubitemid 38638851)
    • (2004) Oncogene , vol.23 , Issue.16 REV. ISS. 2 , pp. 2891-2906
    • Gozuacik, D.1    Kimchi, A.2
  • 72
    • 0033781987 scopus 로고    scopus 로고
    • Sensitivity of myelomonocytic leukemia cells to arsenite-induced cell cycle disruption, apoptosis and enhanced differentiation is dependent on the inter-relationship between arsenic concentration, duration of treatment and cell cycle phase
    • McCabe MJ Jr, Singh KP, Reddy SA, Chelladurai B, Pounds JG, Reiners JJ Jr, et al. Sensitivity of myelomonocytic leukemia cells to arsenite-induced cell cycle disruption, apoptosis and enhanced differentiation is dependent on the inter-relationship between arsenic concentration, duration of treatment and cell cycle phase. J Pharmacol Exp Ther 2000; 295:724-733
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 724-733
    • McCabe Jr., M.J.1    Singh, K.P.2    Reddy, S.A.3    Chelladurai, B.4    Pounds, J.G.5    Reiners Jr., J.J.6
  • 76
    • 0029942290 scopus 로고    scopus 로고
    • Induction of p53 and p21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells
    • DOI 10.1002/(SICI)1098-2744(199605)16:1<20::AID-MC4>3.0.CO;2-S
    • Ho YS, Wang YJ, Lin JK. Induction of p53 and p21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells. Mol Carcinog 1996; 16:20-31. (Pubitemid 26191258)
    • (1996) Molecular Carcinogenesis , vol.16 , Issue.1 , pp. 20-31
    • Ho, Y.-S.1    Wang, Y.-J.2    Lin, J.-K.3
  • 77
    • 0028708948 scopus 로고
    • Lysosomal proton pump activity: Supravital cell staining with acridine orange differentiates leukocyte subpopulations
    • Traganos F, Darzynkiewicz Z. Lysosomal proton pump activity: supravital cell staining with acridine orange differentiates leukocyte subpopulations. Methods Cell Biol 1994; 41:185-194
    • (1994) Methods Cell Biol , vol.41 , pp. 185-194
    • Traganos, F.1    Darzynkiewicz, Z.2
  • 78
    • 35848967804 scopus 로고    scopus 로고
    • How to interpret LC3 immunoblotting
    • Mizushima N, Yoshimori T. How to interpret LC3 immunoblotting. Autophagy 2007; 3:542-545 (Pubitemid 350060049)
    • (2007) Autophagy , vol.3 , Issue.6 , pp. 542-545
    • Mizushima, N.1    Yoshimori, T.2
  • 79
    • 48249148726 scopus 로고    scopus 로고
    • Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells
    • Yokoyama T, Miyazawa K, Naito M, Toyotake J, Tauchi T, Itoh M, et al. Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells. Autophagy 2008; 4:629-640
    • (2008) Autophagy , vol.4 , pp. 629-640
    • Yokoyama, T.1    Miyazawa, K.2    Naito, M.3    Toyotake, J.4    Tauchi, T.5    Itoh, M.6
  • 80
    • 38149008948 scopus 로고    scopus 로고
    • Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: The contribution of autophagic cell death
    • Peng PL, Kuo WH, Tseng HC, Chou FP. Synergistic tumor-killing effect of radiation and berberine combined treatment in lung cancer: the contribution of autophagic cell death. Int J Radiat Oncol Biol Phys 2008; 70:529-542
    • (2008) Int J Radiat Oncol Biol Phys , vol.70 , pp. 529-542
    • Peng, P.L.1    Kuo, W.H.2    Tseng, H.C.3    Chou, F.P.4


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