Increased oxidative DNA products in patients with acute promyelocytic leukemia during arsenic therapy

Haematologica

Volumn 91, Issue 11, 2006, Pages 1571-1572

  Ninomiya, Manabu ^a   Kajiguchi, Tomohiro ^a   Yamamoto, Kazuhito ^a   Kinoshita, Tomohiro ^a   Emi, Nobuhiko ^a   Naoe, Tomoki ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

8 hydroxy 2 deoxyguanosine (8 UHdG); Acute promyelocytic leukemia (APL); Arsenic trioxide; Reactive oxygen species (ROS)

Indexed keywords

6 HYDROXY 2' DEOXYGUANOSINE; ARSENIC; ARSENIC TRIOXIDE; DEOXYGUANOSINE; DNA; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CHEMOLUMINESCENCE; DNA DAMAGE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; PROMYELOCYTIC LEUKEMIA;

ARSENICALS; DEOXYGUANOSINE; DNA; HUMANS; LEUKEMIA, PROMYELOCYTIC, ACUTE; OXIDATION-REDUCTION; OXIDES; REACTIVE OXYGEN SPECIES;

EID: 33750947280     PISSN: 03906078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Douer D, Tallman MS. Arsenic trioxide: new clinical experience with an old medication in hematological malignancies. J Clin Oncol 2005;23:2396-410.
2. Miller WH Jr, Schipper HM, Lee JS, Singer J, Waxman S. Mechanisms of action of arsenic trioxide. Cancer Res 2002;62:3893-903.
3. Zhang TD, Chen GQ, Wang ZG, Wang ZY, Chen SJ, Chen Z. Arsenic trioxide, a therapeutic agent for APL. Oncogene 2001;20:7146-53.
4. Chen F, Shi X. Intracellular signal transduction of cells in response to carcinogenic metals. Crit Rev Oncol Hematol 2002;42:105-21.
5. Kitamura K, Minami Y, Yamamoto K, Akao Y, Kiyoi H, Saito H, et al. Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis. Leukemia 2000;14:1743-50.
6. Liu SX, Athar M, Lippai I, Waldren C, Hei TK. Induction of oxyradicals by arsenic: implication for mechanism of genotoxicity. Proc Natl Acad Sci USA 2001;98:1643-8.
7. Chou WC, Jie C, Kenedy AA, Jones RJ, Trush MA, Dang CV. Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci USA 2004;101:4578-83.
8. Ercal N, Gurer-Orhan H, Aykin-Burns N. Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage. Curr Top Med Chem 2001;1:529-39.
9. Qian Y, Castranova V, Shi X. New perspectives in arsenic-induced cell signal transduction. J Inorg Biochem 2003;96:271-8.
10. Honda M, Yamada Y, Tomonaga M, Ichinose H, Kamihira S. Correlation of urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, and clinical features of hematological disorders: a pilot study. Leuk Res 2000;24:461-8.