Possible roles of nitric oxide and redox cell signaling in metal-induced toxicity and carcinogenesis: A review

Journal of Environmental Pathology, Toxicology and Oncology

Volumn 19, Issue 3, 2000, Pages 179-199

  Buzard, G S ^a   Kasprzak, K S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Carcinogenesis; Cell signaling; Nitric oxide; Oxidative damage; Redox reactions; Transition metals

Indexed keywords

ARSENIC; CADMIUM; CHROMIUM; COPPER; HEAVY METAL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRON; LEAD; MERCURY; NICKEL; NITRIC OXIDE; NITROSO DERIVATIVE; PROTEIN P21; PROTEIN P53; THIOL DERIVATIVE; TRANSCRIPTION FACTOR AP 1;

ARTICLE; AUTOOXIDATION; CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CARCINOGENESIS; CELL COMMUNICATION; CELL DAMAGE; DNA METHYLATION; GENE EXPRESSION; OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; CHROMIUM; COPPER; HUMANS; IRON; METALS, HEAVY; NEOPLASMS; NICKEL; NITRIC OXIDE; OXIDATION-REDUCTION; SIGNAL TRANSDUCTION;

EID: 0033863678     PISSN: 07318898     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (211)

1. Oxygen radicals and human disease
2. New perspectives on iron: An introduction
3. Oxidative DNA damage in metal-induced carcinogenesis
4. The role of metals in oxidative damage and redox cell signaling derangement
5. Oxygen free radicals and iron in relation to biology and medicine: Some problems and concepts
6. DNA damage and oxygen radical toxicity
7. Cell nuclei generate DNA-nicking superoxide radicals
8. Production of large amounts of hydrogen peroxide by human tumor cells
9. -·, and HOOH) in biology
10. Copper-dependent site-specific mutagenesis by benzoyl peroxide in the supF gene of the mutation reporter plasmid pS189
11. Oxygen toxicity, oxygen radicals, transition metals, and disease
12. 2 with the ethidium-binding assay
13. Metals and lipid peroxidation
14. Effect of metals on nucleoside hydroperoxide, a product of ionizing radiation in DNA
15. Oxidizing intermediates generated in the Fenton reagent: Kinetic arguments against intermediacy of the hydroxyl radical
16. Manganese-mediated oxidative damage of cellular and isolated DNA by isoniazid and related hydrazines: Non-Fenton type hydroxyl radical formation
17. Mechanism of site-specific DNA damage induced by methyl hydrazines in the presence of copper(II) and manganese(II)
18. Reactions of iron(II) nucleotide complexes with hydrogen peroxide
19. Fenton chemistry: Amino acid oxidation
20. Site-specific DNA damage by phenylhydrazine and phenelzine in the presence of Cu(II) ion or Fe(III) complexes: Roles of active oxygen species and carbon radicals
21. Site-specific DNA damage induced by cobalt(II) ion and hydrogen peroxide: Role of singlet oxygen
22. Site-specific DNA damage and 8-hydroxydeoxyguanosine formation by hydroxylamine and 4-hydroxyaminoquinoline-1-oxide in the presence of Cu(II): Role of active oxygen species
23. Hydroxyl radical and singlet oxygen production and DNA damage induced by carcinogenic metal compounds and hydrogen peroxide
24. Superoxide dismutase inhibits the superoxide-driven Fenton reaction at two different levels: Implications for a wider protective role
25. The role of superoxide radical in chromium(VI)-generated hydroxyl radical: The Cr(VI) Haber-Weiss cycle
26. Fenton's reagent revisited
27. Oxygen reduction and lipid peroxidation by iron chelates with special reference to ferric-nitrilotriacetate
28. o-Phenanthroline protects mammalian cells from hydrogen peroxide-induced gene mutation and morphological transformation
29. Mutagenesis by the autoxidation of iron with isolated DNA
30. Hydroxyl radical production and human DNA damage induced by ferric nitrilotriacetate and hydrogen peroxide
31. Metal ions and hydrogen peroxide. XXIX. On the kinetics and mechanism of the catalase-like activity of nickel(II) and nickel (II)-amine complexes
32. The role of oxidative damage in metal carcinogenicity
33. Possible role of oxidative damage in metal-induced carcinogenesis
34. The oxidative damage hypothesis of metal-induced genotoxicity and carcinogenesis
35. Cobalt(II) ion as a promoter of hydroxyl radical and possible 'crypto-hydroxyl' radical formation under physiological conditions: Differential effects of hydroxyl radical scavengers
36. Mutagenic responses of nickel oxides and sulfides in Chinese hamster V79 cell lines at the xanthine-guanine phosphoribosyl transferase locus
37. Mutagenicity of soluble and insoluble nickel compounds at the gpt locus in G12 Chinese hamster cells
38. Differences in the effect of vitamin E on nickel sulfide or nickel chloride-induced chromosomal aberrations in mammalian cells
39. Mechanisms of dissolution of nickel subsulfide in rat serum
40. Enhanced generation of hydroxyl and sulfur trioxide anion radicals from oxidation of sodium sulfite, nickel(II) sulfite, and nickel subsulfide in the presence of nickel(II) complexes
41. Production of free radicals arising from the surface activity of minerals and oxygen. Part II. Arsenides, sulfides, and sulfoarsenides of iron, nickel, and copper
42. Production of radicals by non-fibrous materials in a cellfree buffer medium
43. Production of free radicals arising from the surface activity of minerals and oxygen. Part I. Iron mine ores
44. Production of radicals arising from surface activity of fibrous materials
45. Radical oxidation reactions of the purine moiety of 2'-deoxyribonucleosides and DNA by iron-containing minerals
46. Asbestos increases mammalian AP-endonuclease gene expression, protein levels, and enzyme activity in mesothelial cells
47. Enhanced generation of free radicals from phagocytes induced by mineral dusts
48. Cell signaling pathways elicited by asbestos
49. The role of oxidative processes in metal carcinogenesis
50. A role for molecular oxygen in the formation of DNA damage during the reduction of the carcinogen chromium(VI) by glutathione
51. Pathways in the chromium(VI)-mediated formation of DNA lesions: A review
52. Epidemiological and experimental aspects of metal carcinogenesis: Physicochemical properties, kinetics, and the active species
53. Metal carcinogenesis: Mechanistic implications
54. Is there a role for reactive oxygen species in the mechanism of chromium(VI) carcinogenesis?
55. Mechanisms of chromium(VI) carcinogenesis. Reactive intermediates and effect on gene expression
56. Relatively longlived chromium(V) species are produced by the action of glutathione on carcinogenic chromium(VI)
57. Chromium(V) and hydroxyl radical formation during the glutathione reductase-catalyzed reduction of chromium (VI)
58. On the hydroxyl radical formation in the reaction between hydrogen peroxide and biologically-generated chromium (V) species
59. One-electron reduction of chromate by NADPH-dependent glutathione reductase
60. Generation of free radicals from hydrogen peroxide and lipid hydroperoxides in the presence of Cr(III)
61. Effect of ascorbic acid on DNA damage, cytotoxicity, glutathione reductase, and formation of paramagnetic chromium in Chinese hamster V-79 cells treated with sodium chromate(VI)
62. Protective effect of vitamin E against chromosomal aberrations and mutation induced by sodium chromate in Chinese hamster V79 cells
63. The genetic toxicology of cobalt
64. Oxidative DNA base damage in renal, hepatic, and pulmonary chromatin of rats after intraperitoneal injection of cobalt(II) acetate
65. Nickel(II)- and cobalt(II)-dependent damage by hydrogen peroxide to the DNA bases in isolated human chromatin
66. 2 by Co(II) in the presence of cysteinyl and histidyl chelators
67. Oxygen-derived free radical and active oxygen complex formation from cobalt(II) chelates in vitro
68. A comparison of cobalt(II) and iron(II) hydroxyl and superoxide free radical formation
69. Occupational exposures to Cd, Ni, and Cr modulate titers of anti-oxidized DNA base antibodies
70. Role of DNA repair inhibition in lead- and cadmium-induced genotoxicity: A review
71. Current aspects in metal genotoxicity
72. Cadmium-induced production of superoxide anion and nitric oxide, DNA single strand breaks and lactate dehydrogenase leakage in J774A. 1 cell cultures
73. Mechanism of oxidative DNA damage induced by δ-aminolevulinic acid in the presence of copper ion
74. Cadmium-induced 8-hydroxydeoxyguanosine formation, DNA strand breaks, and antioxidant enzyme activities in lymphoblastoid cells
75. DNA single-strand breakage in rat lung, liver, and kidney after single and combined treatments of nickel and cadmium
76. Lead/cytokine-mediated oxidative DNA damage in cultured mouse hepatocytes
77. Reactive oxygen species may participate in the mutagenicity and mutational spectrum of cadmium in Chinese hamster ovary-K1 cells
78. Cadmium-induced oxidative cellular damage in human fetal lung fibroblasts (MRC-5 cells)
79. Induction of apoptosis in human T-cells by methyl mercury: Temporal relationship between mitochondrial dysfunction and loss of reductive reserve
80. Enhancement of rat and human phagocyte superoxide anion radical production by cadmium in vitro
81. Participation of active oxygen species in the induction of DNA single-strand scissions by cadmium chloride in cultured Chinese hamster cells
82. Possible role of regional superoxide dismutase activity and lipid peroxide levels in cadmium neurotoxicity: In vivo and in vitro studies in growing rats
83. 2 cytotoxicity in cultured mammalian cells
84. Glutathione peroxidase and myeloperoxidase activity in vitro in the presence of Ni(II)
85. Copper ions and hydrogen peroxide form hypochlorite from NaCl thereby mimicking myeloperoxidase
86. Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase
87. DNA and RNA strand scission by copper, zinc, and manganese superoxide dismutases
88. The reaction of arsenite-complexed xanthine oxidase with oxygen
89. Damage to rat liver mitochondria promoted by δ-aminolevulinic acidgenerated reactive oxygen species: Connections with acute intermittent porphyria and lead poisoning
90. Enhancement by nickel(II) and L-histidine of 2'-deoxyguanosine oxidation with hydrogen peroxide
91. Enhancement of hydroxylation and deglycosylation of 2'-deoxyguanosine by carcinogenic nickel compounds
92. Reversal by nickel(II) of inhibitory effects of some scavengers of active oxygen species upon hydroxylation of 2'-deoxyguanosine in vitro
93. Generation of free radicals from lipid hydroperoxides by Ni2+ in the presence of oligopeptides
94. Generation of free radicals in reactions of Ni(II)-thiol complexes with molecular oxygen and model lipid hydroperoxides
95. Oxidation-reduction reactions of metal ions
96. Enhancement by L-histidine of nickel (II)-induced DNA-protein cross-linking and oxidative DNA base damage in the rat kidney
97. Effect of carnosine, homocarnosine, and anserine on hydroxylation of the guanine moiety in 2'-deoxyguanosine, DNA, and nucleohistone with hydrogen peroxide in the presence of nickel (II)
98. Role of redox potential and reactive oxygen species in stress signaling
99. Gene regulation by active oxygen and other stress inducers: Role in tumor promotion and progression
100. Antioxidant and redox regulation of gene transcription
101. Redox signaling: Hydrogen peroxide as intracellular messenger
102. Intracellular oxidation/reduction status in the regulation of transcription factors NF-κB and AP-1
103. Roles of reactive oxygen species: Signaling and regulation of cellular functions
104. Oxygen radicals and signaling
105. Signal transduction by reactive oxygen species in non-phagocytic cells
106. Nitric oxide, altered DNA, and mammalian disease
107. Modulation by nitric oxide of metallo-protein regulatory activities
108. Cadmium, gene regulation, and cellular signaling in mammalian cells
109. Activation of nuclear factor-κB and gene expression in human endothelial cells by the common haptens nickel and cobalt
110. Nickel-magnesium interactions in carcinogenesis: Dose effects and involvement of natural killer cells
111. Magnesium counteracts nickel-induced suppression of T lymphocyte response to Concanavalin A
112. Chromium(VI)-induced nuclear factor-κB activation in intact cells via free radical reactions
113. The effect of nickel compounds on immunophenotype and natural killer cell function of normal human lymphocytes
114. Free radical activity associated with the surface of particles: A unifying factor in determining biological activity?
115. Activation of the cardiac calcium release channel (ryanodine receptor) by poly-S-nitrosylation
116. Reactions of nitric oxide with metalloproteins
117. How cytotoxic is nitric oxide?
118. Redox modulation of iron regulatory proteins by peroxynitrite
119. Biosynthesis of nitric oxide activates iron regulatory factor in macrophages
120. Regulating the fate of mRNA: The control of cellular iron metabolism
121. Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway
122. Differential regulation of IRP1 and IRP2 by nitric oxide in rat hepatoma cells
123. Superoxide sensitivity of the Escherichia coli aconitase
124. Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not
125. Superoxide accelerates DNA damage by elevating free-iron levels
126. Iron regulates nitric oxide synthase activity by controlling nuclear transcription
127. Nitric oxide as an antioxidant
128. Mechanism of nitric oxide release from Snitrosothiols
129. Xanthine oxidase-mediated decomposition of S-nitrosothiols
130. Redox signalling and the control of cell growth and death
131. Antioxidants and AP-1 activation: A brief overview
132. The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice
133. Redox state regulates binding of p53 to sequence-specific DNA, but not to nonspecific or mismatched DNA
134. Regulation of p53 by metal ions: Dithiocarbamate down-regulates p53 DNA-binding activity by increasing the intracellular level of copper
135. Distinct effects of glutathione disulphide on the nuclear transcription factors κB and the activator protein-1
136. Effect of oxidation and reduction on the binding of transcription factors to cis-regulatory elements located in the FGF-4 gene
137. Inhibition of AP-1 binding and transcription by gold and selenium involving conserved cysteine residues in Jun and Fos
138. Selenium and the thioredoxin and glutaredoxin systems
139. Zinc attenuates tumor necrosis factor-mediated activation of transcription factors in endothelial cells
140. Altered oxidative stress responses in nickel-resistant mammalian cells
141. Heavy metal ion induction of adhesion molecules and cytokines in human endothelial cells: The role of NF-κB, IκB-α, and AP-1
142. Lithium increases transcription factor binding to AP-1 and cyclic AMP-responsive element in cultured neurons and rat brain
143. Lead-induced developmental changes in AP-1 DNA binding in rat brain
144. NF-κB: Ten years after
145. Synergistic activation of NF-κB by tumor necrosis factor alpha and gamma interferon via enhanced IκBα degradation and de novo IκBβ degradation
146. Nuclear factor κB: An oxidative stress-responsive transcription factor of eukaryotic cells (a review)
147. A new member of the IκB protein family, IκBε, inhibits RelA (p65)-mediated NF-κB transcription
148. Regulatory role of a novel human thioredoxin peroxidase in NF-κB activation
149. Inhibition of NF-κB DNA binding and nitric oxide induction in human T cells and lung adenocarcinoma cells by selenite treatment
150. Selenium metabolism, selenoproteins, and mechanisms of cancer prevention: Complexities with thioredoxin reductase
151. Modulation by copper of p53 conformation and sequence-specific DNA binding: Role for Cu(II)/Cu(I) redox mechanism
152. Novel aspects of Ras proteins biology: Regulation and implications
153. p21(ras) as a common signaling target of reactive free radicals and cellular redox stress
154. A molecular redox switch on p21(ras)
155. Cell-specificity and signaling pathway of endothelin-1 gene regulation by hypoxia
156. Endothelial PAS domain 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
157. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha sub-unit
158. The carcinogenicity of metals in humans
159. DNA methylation, heterochromatin, and epigenetic carcinogens
160. Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: A new model for epigenetic carcinogenesis
161. Concepts in nickel carcinogenesis
162. Oxidative mechanisms in the toxicity of metal ions
163. Effects of calcium, magnesium, zinc, and iron on nickel carcinogenesis: Inhibition versus enhancement
164. Evidence that nitric oxide enhances cadmium toxicity by displacing the metal from metallothionein
165. Sensitivity to cadmium-induced genotoxicity in rat testicular cells is associated with minimal expression of the metallothionein gene
166. Downregulation of metallothionein expression in human and murine hepatocellular tumors: Association with the tumor necrotizing and antineoplastic effects of cadmium in mice
167. The multifaceted roles of nitric oxide in cancer
168. The role of oxidative stress in chemical carcinogenesis
169. Hierarchical and cybernetic nature of biologic systems and their relevance to homeostatic adaptation to low-level exposures to oxidative stress-inducing agents
170. Cell-cell communication in carcinogenesis
171. Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient, but not glutathione deficient cells
172. Antioxidant prevention of tumor promoter induced inhibition of intercellular communication in renal cell lines
173. Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea
174. Effects of extracellular calcium and magnesium on junctional intercellular communication in human fibroblasts
175. Inhibition of intercellular communication by nickel(II): Antagonistic effect of magnesium
176. Changes in the gap junctional intercellular communication in renal tubular epithelial cells in vitro treated with renal carcinogens
177. Nickel-induced increases in gap junctional communication in the uterine cell line SK-UT-1
178. Perinatal effects of metals and cancer in offspring
179. Preconception urethane or chromium (III) treatment of male mice: Multiple neoplastic and nonneoplastic changes in off-spring
180. Reversal of loss of imprinting in tumor cells by 5-aza-2'-deoxycytidine
181. Influence of oxygen radical injury on DNA methylation
182. DNA adduct 8-hydroxyl-2'-deoxyguano-sine (8-hydroxyguanosine) affects function of human DNA methyltransferase
183. Free radical adducts induce alterations in DNA cytosine methylation
184. Male-mediated developmental toxicity: Paternal exposures and childhood cancer
185. DNA methylation patterns in tumors derived from F9 cells resemble methylation at the blastula stage
186. 2+ homeostasis and respiration
187. Interaction of reactive oxygen species with ion transport mechanisms
188. The hypoxic response: Huffing and HIFing
189. Carcinogenic nickel targeting calcium-dependent signaling pathway
190. Induction of activating transcription factor 1 by nickel and its role as a negative regulator of thrombospondin I gene expression
191. 2+/calmodulin-dependent protein kinase type I, II, and IV
192. The hypoxia-inducible factor-1 DNA recognition site is cAMP-responsive
193. Erythropoietin: A model system for studying oxygen-dependent gene regulation
194. Iron accelerates while magnesium inhibits nickel-induced carcinogenesis in the rat kidney
195. Association between erythrocytosis and renal cancers in rats following intrarenal injection of nickel compounds
196. Micronucleus test and erythropoiesis: Effect of cobalt on the induction of micronuclei by mutagens
197. Nickel-induced transformation shifts the balance between HIF-1 and p53 transcription factors
198. Thioredoxin, a gene found overexpressed in human cancer, inhibits apoptosis in vitro and in vivo
199. Metal-induced modulation of nitric oxide production in vitro by murine macrophages: Lead, nickel, and cobalt utilize different mechanisms
200. Induction of apoptosis in human T-cells by organomercuric compounds: A flow cytometric analysis
201. Apoptosis is the mode of cell death caused by carcinogenic chromium
202. Vitamin E inhibits apoptosis, DNA modification, and cancer incidence induced by iron-mediated peroxidation in Wistar rat kidney
203. Cell cycle arrest, apoptosis, and p53 expression in nickel (II) acetate-treated Chinese hamster ovary cells
204. Cadmium suppresses apoptosis induced by chromium
205. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1
206. The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
207. Identification of a hypoxia response element in the transferrin receptor gene
208. 2+ ion through modulation of bax, bad, and bcl-2 proteins in human colon carcinoma cells
209. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription